Next-generation sequencing reveals low-dose effects of cationic dendrimers in primary human bronchial epithelial cells

ACS Nano

Volumn 9, Issue 1, 2015, Pages 146-163

  Feliu, Neus ^a   Kohonen, Pekka ^a   Ji, Jie ^b   Zhang, Yuning ^a   Karlsson, Hanna L ^a   Palmberg, Lena ^b   Nyström, Andreas ^a   Fadeel, Bengt ^a  

^a Nanosafety and Nanomedicine Laboratory Division of Molecular Toxicology   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

nanotoxicology; next generation sequencing; poly(amidoamine) dendrimers; systems biology

Indexed keywords

BIOLOGY; CELL CULTURE; CYTOLOGY; DENDRIMERS; GENE EXPRESSION; GENES; NANOSTRUCTURED MATERIALS; RNA; TOXICITY; TRANSCRIPTION;

COMPUTATIONAL APPROACH; GENE EXPRESSION PROFILING; HUMAN BRONCHIAL EPITHELIAL CELLS; NANOTOXICOLOGY; NEXT-GENERATION SEQUENCING; POLYAMIDOAMINE DENDRIMERS; SYSTEMS BIOLOGY; TRANSCRIPTIONAL REGULATOR;

CELLS;

DENDRIMER; PAMAM STARBURST; TRANSCRIPTOME;

BRONCHUS; CELL AGING; CELL CYCLE CHECKPOINT; CYTOLOGY; DOSE RESPONSE; DOWN REGULATION; DRUG EFFECTS; EPITHELIUM CELL; GENE ONTOLOGY; GENETICS; HIGH THROUGHPUT SEQUENCING; HUMAN; METABOLISM; SEQUENCE ANALYSIS; SYSTEMS BIOLOGY; TRANSPORT AT THE CELLULAR LEVEL; UPREGULATION;

BIOLOGICAL TRANSPORT; BRONCHI; CELL AGING; CELL CYCLE CHECKPOINTS; DENDRIMERS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; EPITHELIAL CELLS; GENE ONTOLOGY; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; SEQUENCE ANALYSIS, RNA; SYSTEMS BIOLOGY; TRANSCRIPTOME; UP-REGULATION;

EID: 84921768315     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn5061783     Document Type: Article

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