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Volumn 26, Issue 1, 2011, Pages 147-152

Flow cytometric analysis of micronuclei in mammalian cell cultures: Past, present and future

Author keywords

[No Author keywords available]

Indexed keywords

AUTOMATION; CELL CYCLE; CYTOTOXICITY; FLOW CYTOMETRY; GENOTOXICITY; HUMAN; IN VITRO STUDY; MAMMAL CELL; MICRONUCLEUS; NONHUMAN; PRIORITY JOURNAL; REVIEW; SCORING SYSTEM;

EID: 78650663142     PISSN: 02678357     EISSN: 14643804     Source Type: Journal    
DOI: 10.1093/mutage/geq058     Document Type: Review
Times cited : (54)

References (55)
  • 1
    • 84873799675 scopus 로고
    • The effect of ionizing radiations on the broad bean root. Part IX. Chromosome breakage and the lethality of ionizing radiations to the root meristem
    • and concluded 622-628
    • Thoday, J. M. (1951) The effect of ionizing radiations on the broad bean root. Part IX. Chromosome breakage and the lethality of ionizing radiations to the root meristem. Br. J. Radiol., 24, 527-576 and concluded 622-628.
    • (1951) Br. J. Radiol. , vol.24 , pp. 527-576
    • Thoday, J.M.1
  • 2
    • 84907116010 scopus 로고
    • The relative biological efficiency of single doses of fast neutrons and gamma rays on Vicia faba roots and the effect of oxygen. Part II. Chromosome damage: The production of micronuclei
    • Evans, H. J., Nearly, G. J. and Williamson, F. S. (1959) The relative biological efficiency of single doses of fast neutrons and gamma rays on Vicia faba roots and the effect of oxygen. Part II. Chromosome damage: the production of micronuclei. Int. J. Radiat. Biol., 3, 216-229.
    • (1959) Int. J. Radiat. Biol. , vol.3 , pp. 216-229
    • Evans, H.J.1    Nearly, G.J.2    Williamson, F.S.3
  • 3
    • 0000162623 scopus 로고
    • Early and late cytogenetic effects of whole body irradiation of human marrow
    • Fleidner, T. M., Andrews, G. A., Cronkite, E. P. and Bond, V. P. (1964) Early and late cytogenetic effects of whole body irradiation of human marrow. Blood, 23, 471-487.
    • (1964) Blood , vol.23 , pp. 471-487
    • Fleidner, T.M.1    Andrews, G.A.2    Cronkite, E.P.3    Bond, V.P.4
  • 4
    • 0015106801 scopus 로고
    • Trenimon-induced chromosomal damage in bone marrow cells of six mammalian species, evaluated by the micronucleus test
    • Matter, B. and Schmid, W. (1971) Trenimon-induced chromosomal damage in bone marrow cells of six mammalian species, evaluated by the micronucleus test. Mutat. Res., 12, 417-425.
    • (1971) Mutat. Res. , vol.12 , pp. 417-425
    • Matter, B.1    Schmid, W.2
  • 5
    • 0015623107 scopus 로고
    • A rapid in vivo test for chromosome damage
    • Heddle, J. (1973) A rapid in vivo test for chromosome damage. Mutat. Res., 18, 187-190.
    • (1973) Mutat. Res. , vol.18 , pp. 187-190
    • Heddle, J.1
  • 6
    • 0009832736 scopus 로고
    • Measurement of chromosomal breakage in cultured cells by the micronucleus technique
    • Evans, H. J. and Lloyd, D. C. (eds) Edinburgh University Press, Edinburgh, UK
    • Heddle, J. A. (1978) Measurement of chromosomal breakage in cultured cells by the micronucleus technique. In Evans, H. J. and Lloyd, D. C. (eds), Mutagen-Induced Chromosome Damage in Man. Edinburgh University Press, Edinburgh, UK, pp. 191-200.
    • (1978) Mutagen-Induced Chromosome Damage in Man , pp. 191-200
    • Heddle, J.A.1
  • 7
    • 0017059028 scopus 로고
    • The production of micronuclei from chromosome aberrations in irradiated cultures of human lymphocytes
    • Countryman, P. I. and Heddle, J. A. (1976) The production of micronuclei from chromosome aberrations in irradiated cultures of human lymphocytes. Mutat. Res., 41, 321-332.
    • (1976) Mutat. Res. , vol.41 , pp. 321-332
    • Countryman, P.I.1    Heddle, J.A.2
  • 8
    • 0027299878 scopus 로고
    • The cytochalasin-B micronucleus/ kinetochore assay in vitro: Studies with 10 suspected aneugens
    • Lynch, A. M. and Parry, J. M. (1993) The cytochalasin-B micronucleus/ kinetochore assay in vitro: studies with 10 suspected aneugens. Mutat. Res., 287, 71-86.
    • (1993) Mutat. Res. , vol.287 , pp. 71-86
    • Lynch, A.M.1    Parry, J.M.2
  • 9
    • 0030474094 scopus 로고    scopus 로고
    • A study of the aneugenic activity of trichlorfon detected by centromere-specific probes in human lymphoblastoid cell lines
    • Doherty, A. T., Ellard, S., Parry, E. M. and Parry, J. M. (1996) A study of the aneugenic activity of trichlorfon detected by centromere-specific probes in human lymphoblastoid cell lines. Mutat. Res., 372, 221-231.
    • (1996) Mutat. Res. , vol.372 , pp. 221-231
    • Doherty, A.T.1    Ellard, S.2    Parry, E.M.3    Parry, J.M.4
  • 10
    • 0031202390 scopus 로고    scopus 로고
    • Towards a validation of the micronuclei test
    • Kirsch-Volders, M. (1997) Towards a validation of the micronuclei test. Mutat. Res., 392, 1-4.
    • (1997) Mutat. Res. , vol.392 , pp. 1-4
    • Kirsch-Volders, M.1
  • 11
    • 33745699175 scopus 로고    scopus 로고
    • The use of the in vitro micronucleus assay to detect and assess the aneugenic activity of chemicals
    • Parry, J. M. and Parry, E. M. (2006) The use of the in vitro micronucleus assay to detect and assess the aneugenic activity of chemicals. Mutat. Res., 607, 5-8.
    • (2006) Mutat. Res. , vol.607 , pp. 5-8
    • Parry, J.M.1    Parry, E.M.2
  • 12
    • 34250187067 scopus 로고    scopus 로고
    • The cytokinesis-block micronucleus cytome assay
    • Fenech, M. (2007) The cytokinesis-block micronucleus cytome assay. Nat. Protoc., 2, 1084-1104.
    • (2007) Nat. Protoc. , vol.2 , pp. 1084-1104
    • Fenech, M.1
  • 13
    • 0014212637 scopus 로고
    • Effects of cytochalasins on mammalian cells
    • Carter, S. B. (1967) Effects of cytochalasins on mammalian cells. Nature, 213, 261-264.
    • (1967) Nature , vol.213 , pp. 261-264
    • Carter, S.B.1
  • 14
    • 0021987630 scopus 로고
    • Measurement of micronuclei in lymphocytes
    • Fenech, M. and Morley, A. A. (1985) Measurement of micronuclei in lymphocytes. Mutat. Res., 147, 29-36.
    • (1985) Mutat. Res. , vol.147 , pp. 29-36
    • Fenech, M.1    Morley, A.A.2
  • 15
    • 0022589981 scopus 로고
    • Cytokinesis-block micronucleus method in human lymphocytes: Effect of in-vivo ageing and low dose X-irradiation
    • Fenech, M. and Morley, A. A. (1986) Cytokinesis-block micronucleus method in human lymphocytes: effect of in-vivo ageing and low dose X-irradiation. Mutat. Res., 161, 193-198.
    • (1986) Mutat. Res. , vol.161 , pp. 193-198
    • Fenech, M.1    Morley, A.A.2
  • 16
    • 0033858808 scopus 로고    scopus 로고
    • A mathematical model of the in vitro micronucleus assay predicts false negative results if micronuclei are not specifically scored in binucleated cells or in cells that have completed one nuclear division
    • Fenech, M. (2000) A mathematical model of the in vitro micronucleus assay predicts false negative results if micronuclei are not specifically scored in binucleated cells or in cells that have completed one nuclear division. Mutagenesis, 15, 329-336.
    • (2000) Mutagenesis , vol.15 , pp. 329-336
    • Fenech, M.1
  • 17
    • 33745860070 scopus 로고    scopus 로고
    • SFTG International collaborative study on the in vitro micronucleus test. III. Using CHO cells
    • Aardema, M. J., Snyder, R. D., Spicer, C. et al. (2006) SFTG International collaborative study on the in vitro micronucleus test. III. Using CHO cells. Mutat. Res., 607, 61-87.
    • (2006) Mutat. Res. , vol.607 , pp. 61-87
    • Aardema, M.J.1    Snyder, R.D.2    Spicer, C.3
  • 20
    • 33745841361 scopus 로고    scopus 로고
    • SFTG International collaborative study on the in vitro micronucleus test. V. Using L5178Y cells
    • Oliver, J., Meunier, J.-R., Awogi, T. et al. (2006) SFTG International collaborative study on the in vitro micronucleus test. V. Using L5178Y cells. Mutat. Res., 607, 125-152.
    • (2006) Mutat. Res. , vol.607 , pp. 125-152
    • Oliver, J.1    Meunier, J.-R.2    Awogi, T.3
  • 21
    • 33745821240 scopus 로고    scopus 로고
    • SFTG International collaborative study on the in vitro micronucleus test. IV. Using CHO/IU cells
    • Wakata, A., Matsuoka, A., Yamakage, K. et al. (2006) SFTG International collaborative study on the in vitro micronucleus test. IV. Using CHO/IU cells. Mutat. Res., 607, 88-124.
    • (2006) Mutat. Res. , vol.607 , pp. 88-124
    • Wakata, A.1    Matsuoka, A.2    Yamakage, K.3
  • 22
    • 75149188915 scopus 로고    scopus 로고
    • Concordance analysis of an in vitro micronucleus screening assay and the regulatory chromosome aberration assay using pharmaceutical drug candidates
    • Homiski, M. L., Muehlbauer, P. A., Dobo, K. L., Schuler, M. J. and Aubrecht, J. (2010) Concordance analysis of an in vitro micronucleus screening assay and the regulatory chromosome aberration assay using pharmaceutical drug candidates. Environ. Mol. Mutagen., 51, 39-47.
    • (2010) Environ. Mol. Mutagen. , vol.51 , pp. 39-47
    • Homiski, M.L.1    Muehlbauer, P.A.2    Dobo, K.L.3    Schuler, M.J.4    Aubrecht, J.5
  • 23
    • 0030789581 scopus 로고    scopus 로고
    • Comparative evaluation of the in vitro micronucleus test and the in vitro chromosome aberration test: Industrial experience
    • Miller, B., Albertini, S., Locher, F., Thybaud, V. and Lorge, E. (1997) Comparative evaluation of the in vitro micronucleus test and the in vitro chromosome aberration test: industrial experience. Mutat. Res., 392, 45-59.
    • (1997) Mutat. Res. , vol.392 , pp. 45-59
    • Miller, B.1    Albertini, S.2    Locher, F.3    Thybaud, V.4    Lorge, E.5
  • 24
    • 0032006320 scopus 로고    scopus 로고
    • Evaluation of the in vitro micronucleus test as an alternative to the in vitro chromosomal aberration assay: Position of the GUM Working Group on the in vitro micronucleus test. Gesellschaft fur Umwelt-Mutations-forschung
    • Miller, B., Potter-Locher, F., Seelbach, A., Stopper, H., Utesch, D. and Madle, S. (1998) Evaluation of the in vitro micronucleus test as an alternative to the in vitro chromosomal aberration assay: position of the GUM Working Group on the in vitro micronucleus test. Gesellschaft fur Umwelt-Mutations-forschung. Mutat. Res., 410, 81-116.
    • (1998) Mutat. Res. , vol.410 , pp. 81-116
    • Miller, B.1    Potter-Locher, F.2    Seelbach, A.3    Stopper, H.4    Utesch, D.5    Madle, S.6
  • 27
    • 0023870834 scopus 로고
    • Preliminary studies on scoring micronuclei by computerised image analysis
    • Fenech, M. and Morley, A. A. (1988) Preliminary studies on scoring micronuclei by computerised image analysis. Mutat. Res., 203, 33-38.
    • (1988) Mutat. Res. , vol.203 , pp. 33-38
    • Fenech, M.1    Morley, A.A.2
  • 29
    • 34248523857 scopus 로고    scopus 로고
    • Evaluation of an automated in vitro micronucleus assay in CHO-K1 cells
    • Diaz, D., Scott, A., Carmichael, P., Shi, W. and Costales, C. (2007) Evaluation of an automated in vitro micronucleus assay in CHO-K1 cells. Mutat. Res., 630, 1-13.
    • (2007) Mutat. Res. , vol.630 , pp. 1-13
    • Diaz, D.1    Scott, A.2    Carmichael, P.3    Shi, W.4    Costales, C.5
  • 30
    • 58149140528 scopus 로고    scopus 로고
    • Automated image analysis of cytokinesis-blocked micronuclei: An adapted protocol and a validated scoring procedure for biomonitoring
    • Decordier, I., Papine, A., Plas, G. et al. (2009) Automated image analysis of cytokinesis-blocked micronuclei: an adapted protocol and a validated scoring procedure for biomonitoring. Mutagenesis, 24, 85-93.
    • (2009) Mutagenesis , vol.24 , pp. 85-93
    • Decordier, I.1    Papine, A.2    Plas, G.3
  • 31
    • 0021339858 scopus 로고
    • Flow cytometric analysis of micronuclei found in cells after irradiation
    • Nüsse, M. and Kramer, J. (1984) Flow cytometric analysis of micronuclei found in cells after irradiation. Cytometry, 5, 20-25.
    • (1984) Cytometry , vol.5 , pp. 20-25
    • Nüsse, M.1    Kramer, J.2
  • 32
    • 0023402287 scopus 로고
    • Antikinetochore antibodies and flow karyotyping: New techniques to detect Aneuploidy in mammalian cells induced by ionizing radiation and chemicals
    • Nüsse, M., Kramer, J., Viaggi, S., Bartsch, A. and Bonatti, S. (1987) Antikinetochore antibodies and flow karyotyping: new techniques to detect Aneuploidy in mammalian cells induced by ionizing radiation and chemicals. Mol. Toxicol., 1, 393-405.
    • (1987) Mol. Toxicol. , vol.1 , pp. 393-405
    • Nüsse, M.1    Kramer, J.2    Viaggi, S.3    Bartsch, A.4    Bonatti, S.5
  • 33
    • 78650659850 scopus 로고
    • Validation of flow cytometry analysis and detection of micronuclei in CHO-K1 cell line
    • In Arlett, C. F., Ashby, J., Fielder, R. J. and Scott, D. (eds), Micronuclei: origins applications and methodologies-a workshop sponsored by the Health and Safety Executive. Manchester, May 23-25, 1988. Mutagenesis
    • Melcion, C., Vinterou, P. and Cordier, A. (1989) Validation of flow cytometry analysis and detection of micronuclei in CHO-K1 cell line. Correlation with microscopic analysis and in vitro micronucleus analysis (abstract). In Arlett, C. F., Ashby, J., Fielder, R. J. and Scott, D. (eds), Micronuclei: origins applications and methodologies-a workshop sponsored by the Health and Safety Executive. Manchester, May 23-25, 1988. Mutagenesis, 4, 482-485.
    • (1989) Correlation with Microscopic Analysis and in Vitro Micronucleus Analysis (Abstract) , vol.4 , pp. 482-485
    • Melcion, C.1    Vinterou, P.2    Cordier, A.3
  • 35
    • 0032433849 scopus 로고    scopus 로고
    • Evaluation of a new procedure for the flow cytometric analysis of in- vitro, chemically induced micronuclei in V79 cells
    • Roman, D., Locher, F., Suter, W., Cordier, A. and Bobadilla, M. (1998) Evaluation of a new procedure for the flow cytometric analysis of in- vitro, chemically induced micronuclei in V79 cells. Environ. Mol. Mutagen., 32, 387-396.
    • (1998) Environ. Mol. Mutagen. , vol.32 , pp. 387-396
    • Roman, D.1    Locher, F.2    Suter, W.3    Cordier, A.4    Bobadilla, M.5
  • 36
    • 78650642904 scopus 로고    scopus 로고
    • A flow cytometric method for the analysis of micronuclei in vitro using L5178Y cells (abstract)
    • Nicholas, E., Lambert, T. R., Lynch, A. M. et al. (2001) A flow cytometric method for the analysis of micronuclei in vitro using L5178Y cells (abstract). Mutagenesis, 16, 566.
    • (2001) Mutagenesis , vol.16 , pp. 566
    • Nicholas, E.1    Lambert, T.R.2    Lynch, A.M.3
  • 37
    • 0027522779 scopus 로고
    • Analysis of micronuclei induced by 2-chlorobenzylidene malonitrile (CS) using fluorescence in situ hybridization with telomeric and centromeric DNA probes, and flow cytometry
    • Miller, B. M. and Nüsse, M. (1993) Analysis of micronuclei induced by 2-chlorobenzylidene malonitrile (CS) using fluorescence in situ hybridization with telomeric and centromeric DNA probes, and flow cytometry. Mutagenesis, 8, 35-41.
    • (1993) Mutagenesis , vol.8 , pp. 35-41
    • Miller, B.M.1    Nüsse, M.2
  • 38
    • 0029590246 scopus 로고
    • Indications for a threshold of chemically-induced aneuploidy in vitro in human lymphocytes
    • Elhajouji, A., Van Hummelen, P. and Kirsch-Volders, M. (1995) Indications for a threshold of chemically-induced aneuploidy in vitro in human lymphocytes. Environ. Mol. Mutagen., 26, 292-304.
    • (1995) Environ. Mol. Mutagen. , vol.26 , pp. 292-304
    • Elhajouji, A.1    Van Hummelen, P.2    Kirsch-Volders, M.3
  • 40
    • 0028962227 scopus 로고
    • Flow cytometric detection of micronuclei by combined staining of DNA and membranes
    • Wessels, J. and Nusse, M. (1995) Flow cytometric detection of micronuclei by combined staining of DNA and membranes. Cytometry, 19, 201-208.
    • (1995) Cytometry , vol.19 , pp. 201-208
    • Wessels, J.1    Nusse, M.2
  • 41
    • 32544457702 scopus 로고    scopus 로고
    • In vitro micronucleus scoring by flow cytometry: Differential staining of micronuclei versus apoptotic and necrotic chromatin enhances assay reliability
    • Avlasevich, S. L., Bryce, S. M., Cairns, S. E. and Dertinger, S. D. (2006) In vitro micronucleus scoring by flow cytometry: differential staining of micronuclei versus apoptotic and necrotic chromatin enhances assay reliability. Environ. Mol. Mutagen., 47, 56-66.
    • (2006) Environ. Mol. Mutagen. , vol.47 , pp. 56-66
    • Avlasevich, S.L.1    Bryce, S.M.2    Cairns, S.E.3    Dertinger, S.D.4
  • 42
    • 34248525923 scopus 로고    scopus 로고
    • In vitro micronucleus assay scored by flow cytometry provides a comprehensive evaluation of cytogenetic damage and cytotoxicity
    • Bryce, S. M., Bemis, J. C, Avlasevich, S. L. and Dertinger, S. D. (2007) In vitro micronucleus assay scored by flow cytometry provides a comprehensive evaluation of cytogenetic damage and cytotoxicity. Mutat. Res., 630, 78-91.
    • (2007) Mutat. Res. , vol.630 , pp. 78-91
    • Bryce, S.M.1    Bemis, J.C.2    Avlasevich, S.L.3    Dertinger, S.D.4
  • 43
    • 0025882535 scopus 로고
    • Use of a photolabeling technique to identify nonviable cells in fixed homologous or heterologous cell populations
    • Riedy, M. C, Muirhead, K. A., Jensen, C. P. and Stewart, C. C. (1991) Use of a photolabeling technique to identify nonviable cells in fixed homologous or heterologous cell populations. Cytometry, 12, 133-139.
    • (1991) Cytometry , vol.12 , pp. 133-139
    • Riedy, M.C.1    Muirhead, K.A.2    Jensen, C.P.3    Stewart, C.C.4
  • 44
    • 34548427752 scopus 로고    scopus 로고
    • In vitro approaches to develop weight of evidence (WoE) and mode of action (MoA) discussions with positive in vitro genotoxicity results
    • Kirkland, D. J., Aardema, M., Banduhn, N., Carmichael, P., Fautz, R., Meunier, J.-R. and Pfuhler, S. (2007) In vitro approaches to develop weight of evidence (WoE) and mode of action (MoA) discussions with positive in vitro genotoxicity results. Mutagenesis, 22, 161-175.
    • (2007) Mutagenesis , vol.22 , pp. 161-175
    • Kirkland, D.J.1    Aardema, M.2    Banduhn, N.3    Carmichael, P.4    Fautz, R.5    Meunier, J.-R.6    Pfuhler, S.7
  • 45
    • 0034671209 scopus 로고    scopus 로고
    • Cytofluorometric methods for assessing absolute numbers of cell subsets in blood
    • Brando, B., Barnett, D., Janossy, G. et al. (2000) Cytofluorometric methods for assessing absolute numbers of cell subsets in blood. Cytometry, 42, 327-346.
    • (2000) Cytometry , vol.42 , pp. 327-346
    • Brando, B.1    Barnett, D.2    Janossy, G.3
  • 46
    • 39149095273 scopus 로고    scopus 로고
    • Interlaboratory evaluation of a flow cytometric, high content in vitro micronucleus assay
    • Bryce, S. M., Avlasevich, S. L., Bemis, J. C. et al. (2008) Interlaboratory evaluation of a flow cytometric, high content in vitro micronucleus assay. Mutat. Res., 650, 181-195.
    • (2008) Mutat. Res. , vol.650 , pp. 181-195
    • Bryce, S.M.1    Avlasevich, S.L.2    Bemis, J.C.3
  • 48
    • 78650658372 scopus 로고    scopus 로고
    • Miniaturized flow cytometry-based in vitro micronucleus assay discriminates aneugenic and clastogenic modes of action
    • doi:10.1002/em.20618
    • Avlasevich, S. L., Bryce, S. M., Bemis, J. C. and Dertinger, S. D. (2010) Miniaturized flow cytometry-based in vitro micronucleus assay discriminates aneugenic and clastogenic modes of action. Environ. Mol. Mutagen., doi:10.1002/em.20618.
    • (2010) Environ. Mol. Mutagen.
    • Avlasevich, S.L.1    Bryce, S.M.2    Bemis, J.C.3    Dertinger, S.D.4
  • 49
    • 78549250674 scopus 로고    scopus 로고
    • Miniaturized flow cytometric in vitro micronucleus assay represents an efficient tool for comprehensively characterizing genotoxicity dose-response relationships
    • (in press), doi: 10.1016/j.mrgentox.2010.08.020
    • Bryce, S. M., Avlasevich, S. L., Bemis, J. C, Phonethepswath, S. and Dertinger, S. D. (2010) Miniaturized flow cytometric in vitro micronucleus assay represents an efficient tool for comprehensively characterizing genotoxicity dose-response relationships. Mutat. Res., (in press), doi: 10.1016/j.mrgentox. 2010.08.020.
    • (2010) Mutat. Res.
    • Bryce, S.M.1    Avlasevich, S.L.2    Bemis, J.C.3    Phonethepswath, S.4    Dertinger, S.D.5
  • 51
    • 73649103489 scopus 로고    scopus 로고
    • Further evaluation of a flow cytometric in vitro micronucleus assay in CHO-K1 cells: A reliable platform that detects micronuclei and discriminates apoptotic bodies
    • Shi, J., Bezabhie, R. and Szkudlinska, A. (2010) Further evaluation of a flow cytometric in vitro micronucleus assay in CHO-K1 cells: a reliable platform that detects micronuclei and discriminates apoptotic bodies. Mutagenesis, 25, 33-40.
    • (2010) Mutagenesis , vol.25 , pp. 33-40
    • Shi, J.1    Bezabhie, R.2    Szkudlinska, A.3
  • 52
    • 77955078601 scopus 로고    scopus 로고
    • Advantages of human hepatocyte-derived transformants expressing a series of human cytochrome P450 isoforms for genotoxicity examination
    • Hashizume, T., Yoshitomi, S., Asahi, S., Uematsu, R., Matsumura, S., Chatani, F. and Oda, H. (2010) Advantages of human hepatocyte-derived transformants expressing a series of human cytochrome P450 isoforms for genotoxicity examination. Toxicol. Sci., 116, 488-497.
    • (2010) Toxicol. Sci. , vol.116 , pp. 488-497
    • Hashizume, T.1    Yoshitomi, S.2    Asahi, S.3    Uematsu, R.4    Matsumura, S.5    Chatani, F.6    Oda, H.7
  • 53
    • 46849089321 scopus 로고    scopus 로고
    • Evaluation of the Litron in Vitro MicroFlow® Kit for the flow cytometric enumeration of micronuclei (MN) in mammalian cells
    • Collins, J. E., Ellis, P. C, White, A. T., Booth, A. E. G., Moore, C. E., Burman, M., Rees, R. W. and Lynch, A. M. (2008) Evaluation of the Litron In Vitro MicroFlow® Kit for the flow cytometric enumeration of micronuclei (MN) in mammalian cells. Mutat. Res., 654, 76-81.
    • (2008) Mutat. Res. , vol.654 , pp. 76-81
    • Collins, J.E.1    Ellis, P.C.2    White, A.T.3    Booth, A.E.G.4    Moore, C.E.5    Burman, M.6    Rees, R.W.7    Lynch, A.M.8
  • 54
    • 50349083414 scopus 로고    scopus 로고
    • Comparison of different methods for an accurate assessment of cytotoxicity in the in vitro micronucleus test: I
    • Lorge, E., Hayashi, M., Albertini, S. and Kirkland, D. (2008) Comparison of different methods for an accurate assessment of cytotoxicity in the in vitro micronucleus test: I. Theoretical aspects. Mutat. Res., 655, 1-3.
    • (2008) Theoretical Aspects. Mutat. Res. , vol.655 , pp. 1-3
    • Lorge, E.1    Hayashi, M.2    Albertini, S.3    Kirkland, D.4


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