-
2
-
-
34249945536
-
DNA double-strand break repair: From mechanistic understanding to cancer treatment
-
DOI 10.1016/j.dnarep.2007.02.006, PII S1568786407000560, Replication Fork Repair Processes
-
Helleday T, Lo J, van Gent DC, Engelward BP (2007) DNA double-strand break repair: From mechanistic understanding to cancer treatment. DNA Repair 6:923-935. (Pubitemid 46880473)
-
(2007)
DNA Repair
, vol.6
, Issue.7
, pp. 923-935
-
-
Helleday, T.1
Lo, J.2
Van Gent, D.C.3
Engelward, B.P.4
-
3
-
-
70349859881
-
DNA damage, aging, and cancer
-
Hoeijmakers JHJ (2009) DNA damage, aging, and cancer. New Engl J Med 361:1475-1485.
-
(2009)
New Engl J Med
, vol.361
, pp. 1475-1485
-
-
Hoeijmakers, J.H.J.1
-
4
-
-
39749166975
-
DNA repair pathways as targets for cancer therapy
-
DOI 10.1038/nrc2342, PII NRC2342
-
Helleday T, Petermann E, Lundin C, Hodgson B, Sharma RA (2008) DNA repair pathways as targets for cancer therapy. Nat Rev Cancer 8:193-204. (Pubitemid 351301852)
-
(2008)
Nature Reviews Cancer
, vol.8
, Issue.3
, pp. 193-204
-
-
Helleday, T.1
Petermann, E.2
Lundin, C.3
Hodgson, B.4
Sharma, R.A.5
-
5
-
-
0021193203
-
Microelectrophoretic study of radiation-induced DNA damages in individual mammalian cells
-
Ostling O, Johanson KJ (1984) Microelectrophoretic study of radiation-induced DNA damages in individual mammalian cells. Biochem Bioph Res Co 123:291-298. (Pubitemid 14030137)
-
(1984)
Biochemical and Biophysical Research Communications
, vol.123
, Issue.1
, pp. 291-298
-
-
Ostling, O.1
Johanson, K.J.2
-
6
-
-
0023919963
-
A simple technique for quantitation of low levels of DNA damage in individual cells
-
Singh NP, McCoy MT, Tice RR, Scheider EL (1988) A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 175:184-191.
-
(1988)
Exp Cell Res
, vol.175
, pp. 184-191
-
-
Singh, N.P.1
McCoy, M.T.2
Tice, R.R.3
Scheider, E.L.4
-
8
-
-
34250654965
-
The comet assay: A method to measure DNA damage in individual cells
-
Olive PL, Banath JP (2006) The comet assay: A method to measure DNA damage in individual cells. Nat Protoc 1:23-29.
-
(2006)
Nat Protoc
, vol.1
, pp. 23-29
-
-
Olive, P.L.1
Banath, J.P.2
-
9
-
-
2842526228
-
Detection of oxidised purines and UV-induced photoproducts in DNA of single cells, by inclusion of Lesion-specific enzymes in the comet assay
-
Dusinska M, Collins A (1996) Detection of oxidised purines and uv-induced photoproducts in DNA of single cells, by inclusion of lesion-specific enzymes in the comet assay. Altern Lab Anim 24:405-411. (Pubitemid 126467896)
-
(1996)
ATLA Alternatives to Laboratory Animals
, vol.24
, Issue.3
, pp. 405-411
-
-
Dusinska, M.1
Collins, A.2
-
10
-
-
0029864861
-
Analysis of DNA alkylation damage and repair in mammalian cells by the comet assay
-
DOI 10.1093/mutage/11.2.169
-
Fortini P, Raspaglio G, Falchi M, Dogliotti E (1996) Analysis of DNA alkylation damage and repair in mammalian cells by the comet assay. Mutagenesis 11:169-175. (Pubitemid 26085701)
-
(1996)
Mutagenesis
, vol.11
, Issue.2
, pp. 169-175
-
-
Fortini, P.1
Raspaglio, G.2
Falchi, M.3
Dogliotti, E.4
-
11
-
-
0035753180
-
Detection of alkylation damage in human lymphocyte DNA with the comet assay
-
Collins AR, Dusinska M, Horska A (2001) Detection of alkylation damage in human lymphocyte DNA with the comet assay. Acta Biochim Pol 48:611-614. (Pubitemid 33654015)
-
(2001)
Acta Biochimica Polonica
, vol.48
, Issue.3
, pp. 611-614
-
-
Collins, A.R.1
Dusinska, M.2
Horska, A.3
-
12
-
-
24044551627
-
The in vivo comet assay: Use and status in genotoxicity testing
-
DOI 10.1093/mutage/gei033
-
Brendler-Schwaab S, Hartmann A, Pfuhler S, Speit G (2005) The in vivo comet assay: Use and status in genotoxicity testing. Mutagenesis 20:245-254. (Pubitemid 41399464)
-
(2005)
Mutagenesis
, vol.20
, Issue.4
, pp. 245-254
-
-
Brendler-Schwaab, S.1
Hartmann, A.2
Pfuhler, S.3
Speit, G.4
-
13
-
-
34347229468
-
Genetic toxicity assessment: Employing the best science for human safety evaluation part III: The comet assay as an alternative to in vitro clastogenicity tests for early drug candidate selection
-
DOI 10.1093/toxsci/kfl192
-
Witte I, Plappert U, de Wall H, Hartmann A (2007) Genetic toxicity assessment: Employing the best science for human safety evaluation part iii: The comet assay as an alternative to in vitro clastogenicity tests for early drug candidate selection. Toxicol Sci 97:21-26. (Pubitemid 47072151)
-
(2007)
Toxicological Sciences
, vol.97
, Issue.1
, pp. 21-26
-
-
Witte, I.1
Plappert, U.2
De Wall, H.3
Hartmann, A.4
-
14
-
-
62149133088
-
Environmental and occupational biomonitoring using the comet assay
-
Valverde M, Rojas E (2009) Environmental and occupational biomonitoring using the comet assay. Mutat Res 681:93-109.
-
(2009)
Mutat Res
, vol.681
, pp. 93-109
-
-
Valverde, M.1
Rojas, E.2
-
15
-
-
14244268664
-
Genotoxicity of environmental agents assessed by the alkaline comet assay
-
DOI 10.1111/j.1742-7843.2005.pto960101.x
-
Möller P (2005) Genotoxicity of environmental agents assessed by the alkaline comet assay. Basic Clin Pharmacol 96:1-42. (Pubitemid 40288897)
-
(2005)
Basic and Clinical Pharmacology and Toxicology
, vol.96
, Issue.SUPPL. 1
, pp. 1-42
-
-
Moller, P.1
-
16
-
-
44649174446
-
The comet assay in human biomonitoring: Gene-environment interactions
-
Dusinska M, Collins AR (2008) The comet assay in human biomonitoring: gene-environment interactions. Mutagenesis 23:191-205.
-
(2008)
Mutagenesis
, vol.23
, pp. 191-205
-
-
Dusinska, M.1
Collins, A.R.2
-
17
-
-
58149194988
-
Comet assay: A reliable tool for the assessment of DNA damage in different models
-
Dhawan A, Bajpayee M, Parmar D (2009) Comet assay: a reliable tool for the assessment of DNA damage in different models. Cell Biol Toxicol 25:5-32.
-
(2009)
Cell Biol Toxicol
, vol.25
, pp. 5-32
-
-
Dhawan, A.1
Bajpayee, M.2
Parmar, D.3
-
18
-
-
44649107748
-
Potential use of the comet assay in the clinical management of cancer
-
McKenna DJ, McKeown SR, McKelvey-Martin VJ (2008) Potential use of the comet assay in the clinical management of cancer. Mutagenesis 23:183-190.
-
(2008)
Mutagenesis
, vol.23
, pp. 183-190
-
-
McKenna, D.J.1
McKeown, S.R.2
McKelvey-Martin, V.J.3
-
19
-
-
51649086880
-
Oxidatively generated damage to the guanine moiety of DNA: Mechanistic aspects and formation in cells
-
Cadet J, Douki T, Ravanat J-L (2008) Oxidatively generated damage to the guanine moiety of DNA: Mechanistic aspects and formation in cells. Acc Chem Res 41:1075-1083.
-
(2008)
Acc Chem Res
, vol.41
, pp. 1075-1083
-
-
Cadet, J.1
Douki, T.2
Ravanat, J.-L.3
-
20
-
-
0019476174
-
Fluorometric method for rapid detection of DNA strand breaks in human white blood cells produced by low doses of radiation
-
Birnboim HC, Jevcak JJ (1981) Fluorometric method for rapid detection of DNA strand breaks in human white blood cells produced by low doses of radiation. Cancer Res 41:1889-1892.
-
(1981)
Cancer Res
, vol.41
, pp. 1889-1892
-
-
Birnboim, H.C.1
Jevcak, J.J.2
-
21
-
-
0023756660
-
Techniques to measure DNA single-strand breaks in cells: A review
-
Ahnström G (1988) Techniques to measure DNA single-strand breaks in cells: A review. Int J Radiat Biol 54:695-707.
-
(1988)
Int J Radiat Biol
, vol.54
, pp. 695-707
-
-
Ahnström, G.1
-
22
-
-
45949109186
-
Gamma-H2AX - A novel biomarker for DNA double-strand breaks
-
Kuo LJ, Yang LX (2008) Gamma-H2AX - a novel biomarker for DNA double-strand breaks. In Vivo 22:305-309.
-
(2008)
In Vivo
, vol.22
, pp. 305-309
-
-
Kuo, L.J.1
Yang, L.X.2
-
23
-
-
64249087848
-
Performance of the comet assay in a high-throughput version
-
Stang A, Witte I (2009) Performance of the comet assay in a high-throughput version. Mutat Res 675:5-10.
-
(2009)
Mutat Res
, vol.675
, pp. 5-10
-
-
Stang, A.1
Witte, I.2
-
24
-
-
39049129270
-
A modified alkaline comet assay for measuring DNA repair capacity in human populations
-
DOI 10.1667/RR1101.1
-
Trzeciak AR, Barnes J, Evans MK (2008) A modified alkaline comet assay for measuring DNA repair capacity in human populations. Radiat Res 169:110-121. (Pubitemid 351295098)
-
(2008)
Radiation Research
, vol.169
, Issue.1
, pp. 110-121
-
-
Trzeciak, A.R.1
Barnes, J.2
Evans, M.K.3
-
25
-
-
75649106826
-
Introducing a true internal standard for the comet assay to minimize intra- and inter-experiment variability in measures of DNA damage and repair
-
Zainol M, et al. (2009) Introducing a true internal standard for the comet assay to minimize intra- and inter-experiment variability in measures of DNA damage and repair. Nucleic Acids Res 1-9.
-
(2009)
Nucleic Acids Res
, pp. 1-9
-
-
Zainol, M.1
-
26
-
-
67650892038
-
Systematic random sampling of the comet assay
-
McArt DG, et al. (2009) Systematic random sampling of the comet assay. Mutagenesis 24:373-378.
-
(2009)
Mutagenesis
, vol.24
, pp. 373-378
-
-
McArt, D.G.1
-
27
-
-
0346725082
-
Dielectrophoretic registration of living cells to a microelectrode array
-
DOI 10.1016/j.bios.2003.08.013
-
Gray DS, Tan JL, Voldman J, Chen CS (2004) Dielectrophoretic registration of living cells to a microelectrode array. Biosens Bioelectron 15:1765-1774. (Pubitemid 38058517)
-
(2004)
Biosensors and Bioelectronics
, vol.19
, Issue.7
, pp. 771-780
-
-
Gray, D.S.1
Tan, J.L.2
Voldman, J.3
Chen, C.S.4
-
28
-
-
33845348652
-
Dynamic single-cell analysis for quantitative biology
-
Di Carlo D, Lee LP (2006) Dynamic single-cell analysis for quantitative biology. Anal Chem 78:7918-7925. (Pubitemid 44871754)
-
(2006)
Analytical Chemistry
, vol.78
, Issue.23
, pp. 7918-7925
-
-
Di Carlo, D.1
Lee, L.P.2
-
29
-
-
24644480550
-
Large-scale single-cell trapping and imaging using microwell arrays
-
DOI 10.1021/ac0505977
-
Rettig J, Folch A (2005) Large-scale single-cell trapping and imaging using microwell arrays. Anal Chem 77:5628-5634. (Pubitemid 41266059)
-
(2005)
Analytical Chemistry
, vol.77
, Issue.17
, pp. 5628-5634
-
-
Rettig, J.R.1
Folch, A.2
-
30
-
-
8744292742
-
Microfabricated platform for studying stem cell fates
-
Chin VI, et al. (2004) Microfabricated platform for studying stem cell fates. Biotechnol Bioeng 88:399-415.
-
(2004)
Biotechnol Bioeng
, vol.88
, pp. 399-415
-
-
Chin, V.I.1
-
31
-
-
34247542229
-
Cell patterning chip for controlling the stem cell microenvironment
-
DOI 10.1016/j.biomaterials.2007.03.023, PII S0142961207002402
-
Rosenthal A, MacDonald A, Voldman J (2007) Cell patterning chip for controlling the stem cell microenvironment. Biomaterials 28:3208-3216. (Pubitemid 46654216)
-
(2007)
Biomaterials
, vol.28
, Issue.21
, pp. 3208-3216
-
-
Rosenthal, A.1
Macdonald, A.2
Voldman, J.3
-
32
-
-
1642318046
-
Assessment of individual sensitivity to ionizing radiation and DNA repair efficiency in a healthy population
-
DOI 10.1016/S1383-5718(03)00171-2, PII S1383571803001712
-
Marcon F, et al. (2003) Assessment of individual sensitivity to ionizing radiation and DNA repair efficiency in a healthy population. Mutat Res 541:1-8. (Pubitemid 38368653)
-
(2003)
Mutation Research - Genetic Toxicology and Environmental Mutagenesis
, vol.541
, Issue.1-2
, pp. 1-8
-
-
Marcon, F.1
Andreoli, C.2
Rossi, S.3
Verdina, A.4
Galati, R.5
Crebelli, R.6
-
33
-
-
53549130989
-
Genomic predictors of interindividual differences in response to DNA damaging agents
-
Fry CF, et al. (2008) Genomic predictors of interindividual differences in response to DNA damaging agents. Genes Dev 22:2621-2626.
-
(2008)
Genes Dev
, vol.22
, pp. 2621-2626
-
-
Fry, C.F.1
-
34
-
-
38049112778
-
Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells
-
Hegde ML, Hazra TK, Mitra S (2008) Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells. Cell Res 18:27-47.
-
(2008)
Cell Res
, vol.18
, pp. 27-47
-
-
Hegde, M.L.1
Hazra, T.K.2
Mitra, S.3
-
35
-
-
0023015325
-
Mutagenesis by apurinic/apyrimidinic sites
-
Loeb LA, Preston BD (1986) Mutagenesis by apurinic/apyrimidinic sites. Annu Rev Genet 20:201-230.
-
(1986)
Annu Rev Genet
, vol.20
, pp. 201-230
-
-
Loeb, L.A.1
Preston, B.D.2
-
36
-
-
0036283443
-
Nitric oxide-induced homologous recombination in Escherichia coli is promoted by DNA glycosylases
-
DOI 10.1128/JB.184.13.3501-3507.2002
-
Spek EJ, Vuong LN, Matsuguchi T, Marinus MG, Engelward BP (2002) Nitric oxide induced homologous recombination in Escherichia coliis promoted by DNA glycosylases. J Bacteriol 184:3501-3507. (Pubitemid 34625658)
-
(2002)
Journal of Bacteriology
, vol.184
, Issue.13
, pp. 3501-3507
-
-
Spek, E.J.1
Vuong, L.N.2
Matsuguchi, T.3
Marinus, M.G.4
Engelward, B.P.5
-
38
-
-
5044238690
-
Effects of gemcitabine on APE/ref-1 endonuclease activity in pancreatic cancer cells, and the therapeutic potential of antisense oligonucleotides
-
DOI 10.1038/sj.bjc.6602080
-
Lau JP, Weatherdon KL, Skalski V, Hedley DW (2004) Effects of gemcitabine on APE/ref-1 endonuclease activity in pancreatic cancer cells, and the therapeutic potential of antisense oligonucleotides. Brit J Cancer 91:1166-1173. (Pubitemid 39336258)
-
(2004)
British Journal of Cancer
, vol.91
, Issue.6
, pp. 1166-1173
-
-
Lau, J.P.1
Weatherdon, K.L.2
Skalski, V.3
Hedley, D.W.4
-
39
-
-
4444327784
-
Human apurinic endonuclease 1 (APE1) expression and prognostic significance in osteosarcoma: Enhanced sensitivity of osteosarcoma to DNA damaging agents using silencing RNA APE1 expression inhibition
-
Wang D, Luo M, Kelley MR (2004) Human apurinic endonuclease 1 (APE1) expression and prognostic significance in osteosarcoma: Enhanced sensitivity of osteosarcoma to DNA damaging agents using silencing RNA APE1 expression inhibition. Mol Cancer Ther 3:679-686. (Pubitemid 39193748)
-
(2004)
Molecular Cancer Therapeutics
, vol.3
, Issue.6
, pp. 679-686
-
-
Wang, D.1
Luo, M.2
Kelley, M.R.3
-
40
-
-
27144474248
-
Apurinic/apyrimidinic endonuclease activity is associated with response to radiation and chemotherapy in medulloblastoma and primitive neuroectodermal tumors
-
Bobola MS, et al. (2005) Apurinic/apyrimidinic endonuclease activity is associated with response to radiation and chemotherapy in medulloblastoma and primitive neuroectodermal tumors. Clin Cancer Res 11:7405-7414.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 7405-7414
-
-
Bobola, M.S.1
-
41
-
-
34548276529
-
The DNA base excision repair protein APE1/ref-1 as a therapeutic and chemopreventive target
-
Fishel ML, Kelley MR (2007) The DNA base excision repair protein APE1/ref-1 as a therapeutic and chemopreventive target. Mol Aspects Med 28:375-395.
-
(2007)
Mol Aspects Med
, vol.28
, pp. 375-395
-
-
Fishel, M.L.1
Kelley, M.R.2
-
42
-
-
24044516224
-
Isolation of a small molecule inhibitor of DNA base excision repair
-
DOI 10.1093/nar/gki781
-
Madhusudan S, et al. (2005) Isolation of a small molecule inhibitor of DNA base excision repair. Nucleic Acids Res 33:4711-4724. (Pubitemid 41418873)
-
(2005)
Nucleic Acids Research
, vol.33
, Issue.15
, pp. 4711-4724
-
-
Madhusudan, S.1
Smart, F.2
Shrimpton, P.3
Parsons, J.L.4
Gardiner, L.5
Houlbrook, S.6
Talbot, D.C.7
Hammonds, T.8
Freemont, P.A.9
Sternberg, M.J.E.10
Dianov, G.L.11
Hickson, I.D.12
-
43
-
-
66749155332
-
Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1
-
Simeonov A, et al. (2009) Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1. PLoS One 4:e5740.
-
(2009)
PLoS One
, vol.4
-
-
Simeonov, A.1
-
44
-
-
40849135868
-
Potent inhibition of human apurinic/apyrimidinic endonuclease 1 by arylstibonic acids
-
DOI 10.1124/mol.107.042622
-
Seiple LA, Cardellina JH, Akee R, Stivers JT (2008) Potent inhibition of human apurinic/ apyrimidinic endonuclease 1 by arylstibonic acids. Mol Pharmacol 73:669-677. (Pubitemid 351397872)
-
(2008)
Molecular Pharmacology
, vol.73
, Issue.3
, pp. 669-677
-
-
Seiple, L.A.1
Cardellina II, J.H.2
Akee, R.3
Stivers, J.T.4
-
46
-
-
34249788381
-
Micromechanical control of cell-cell interactions
-
Hui EE, Bhatia SN (2007) Micromechanical control of cell-cell interactions. Proc Natl Acad Sci USA 104:5722-5726.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 5722-5726
-
-
Hui, E.E.1
Bhatia, S.N.2
|