메뉴 건너뛰기




Volumn 123, Issue 1, 2011, Pages 264-280

Safety evaluation of sunscreen formulations containing titanium dioxide and zinc oxide nanoparticles in UVB sunburned skin: An In vitro and in vivo study

Author keywords

Nanoparticles; Skin penetration; Sunburn skin; Sunscreens; Titanium dioxide (TiO2); Zinc oxide (ZnO)

Indexed keywords

NANOPARTICLE; OIL; SUNSCREEN; TITANIUM DIOXIDE; WATER; ZINC OXIDE;

EID: 80052505577     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfr148     Document Type: Article
Times cited : (329)

References (56)
  • 1
    • 0003964363 scopus 로고    scopus 로고
    • American Cancer Society. Available at: Accessed June 23, 2011
    • American Cancer Society. (2009). Cancer Facts & Figures. Available at: http://www.scribd.com/doc/21686287/Cancer-Facts-and-Figures-Report-2009. Accessed June 23, 2011.
    • (2009) Cancer Facts & Figures
  • 2
    • 0027752348 scopus 로고
    • How much melanoma is caused by sun exposure?
    • Armstrong, B. K., and Kricker, A. (1993). How much melanoma is caused by sun exposure? Melanoma Res. 3, 395-401.
    • (1993) Melanoma Res , vol.3 , pp. 395-401
    • Armstrong, B.K.1    Kricker, A.2
  • 3
    • 0033870253 scopus 로고    scopus 로고
    • Skin penetration and stabilization of formulations containing microfine titanium dioxide as physical UV filter
    • Bennat, C., and Müller-Goymann, C. C. (2000). Skin penetration and stabilization of formulations containing microfine titanium dioxide as physical UV filter. Int. J. Cosmet. Sci. 22, 271-283.
    • (2000) Int. J. Cosmet. Sci. , vol.22 , pp. 271-283
    • Bennat, C.1    Müller-Goymann, C.C.2
  • 5
    • 0020067173 scopus 로고
    • Methods for in vitro percutaneous absorption studies II. Animal models for human skin
    • Bronaugh, R., Steward, R., and Congdon, E. (1982). Methods for in vitro percutaneous absorption studies. II. Animal models for human skin. Toxicol. Appl. Pharmacol. 62, 481-488.
    • (1982) Toxicol. Appl. Pharmacol. , vol.62 , pp. 481-488
    • Bronaugh, R.1    Steward, R.2    Congdon, E.3
  • 6
    • 33947308035 scopus 로고    scopus 로고
    • Human skin penetration of sunscreen nanoparticles: in-vitro assessment of a novel micronized zinc oxide formulation
    • Cross, S. E., Innes, B., Roberts, M. S., Tsuzuki, T., Robertson, T. A., and McCormick, P. (2007). Human skin penetration of sunscreen nanoparticles: in-vitro assessment of a novel micronized zinc oxide formulation. Skin Pharmacol Physiol. 20, 148-154.
    • (2007) Skin Pharmacol Physiol , vol.20 , pp. 148-154
    • Cross, S.E.1    Innes, B.2    Roberts, M.S.3    Tsuzuki, T.4    Robertson, T.A.5    McCormick, P.6
  • 7
    • 0000021897 scopus 로고
    • Methods for the study of irritation and toxicity of substances applied to the skin and mucous membranes
    • Draize, J. H., Woodard, G., and Calvery, H. O. (1944). Methods for the study of irritation and toxicity of substances applied to the skin and mucous membranes. J. Pharmacol. Exp. Ther. 82, 377-390.
    • (1944) J. Pharmacol. Exp. Ther. , vol.82 , pp. 377-390
    • Draize, J.H.1    Woodard, G.2    Calvery, H.O.3
  • 8
    • 0030744196 scopus 로고    scopus 로고
    • Characterization of the mineral content of a physical sunscreen emulsion and its distribution onto human stratum corneum
    • Dussert, A.-S., and Gooris, E. (1997). Characterization of the mineral content of a physical sunscreen emulsion and its distribution onto human stratum corneum. Int. J. Cosmet. Sci. 19, 119-129.
    • (1997) Int. J. Cosmet. Sci. , vol.19 , pp. 119-129
    • Dussert, A.-S.1    Gooris, E.2
  • 9
    • 58049200112 scopus 로고    scopus 로고
    • Sunscreen safety: the precautionary principle, the Australian Therapeutic Goods Administration and nanoparticles in sunscreens
    • Faunce, T., Murray, K., Nasu, H., and Bowman, D. (2008). Sunscreen safety: the precautionary principle, the Australian Therapeutic Goods Administration and nanoparticles in sunscreens. Nanoethics. 2, 231-240.
    • (2008) Nanoethics , vol.2 , pp. 231-240
    • Faunce, T.1    Murray, K.2    Nasu, H.3    Bowman, D.4
  • 10
    • 0014057659 scopus 로고
    • Regional variation in percutaneous penetration of 14C cortisol in man
    • Feldman, R. J., and Maibach, H. I. (1967). Regional variation in percutaneous penetration of 14C cortisol in man. J. Invest. Dermatol. 48, 181-183.
    • (1967) J. Invest. Dermatol. , vol.48 , pp. 181-183
    • Feldman, R.J.1    Maibach, H.I.2
  • 11
    • 33644762820 scopus 로고    scopus 로고
    • The in vitro absorption of microfine zinc oxide and titanium dioxide through porcine skin
    • Gamer, A. O., Leibold, E., and van Ravenzwaay, B. (2006). The in vitro absorption of microfine zinc oxide and titanium dioxide through porcine skin. Toxicol. In Vitro. 20, 301-307.
    • (2006) Toxicol. In Vitro. , vol.20 , pp. 301-307
    • Gamer, A.O.1    Leibold, E.2    van Ravenzwaay, B.3
  • 13
    • 0003633755 scopus 로고    scopus 로고
    • Institute of Laboratory Animal Resources. National Academies Press, Washington, DC
    • Institute of Laboratory Animal Resources. (1996). Guide for the Care and Use of Laboratory Animals. National Academies Press, Washington, DC.
    • (1996) Guide for the Care and Use of Laboratory Animals
  • 15
    • 47949098493 scopus 로고    scopus 로고
    • Investigation of micronized titanium dioxide penetration in human skin xenografts and its effect on cellular functions of human skin-derived cells
    • Kiss, B., Bíró, T., Czifra, G., Tóth, B. I., Kertész, Z., Szikszai, Z., Kiss, A. Z., Juhász, I., Zouboulis, C. C., and Hunyadi, J. (2007). Investigation of micronized titanium dioxide penetration in human skin xenografts and its effect on cellular functions of human skin-derived cells. Exp. Dermatol. 17, 659-667.
    • (2007) Exp. Dermatol. , vol.17 , pp. 659-667
    • Kiss, B.1    Bíró, T.2    Czifra, G.3    Tóth, B.I.4    Kertész, Z.5    Szikszai, Z.6    Kiss, A.Z.7    Juhász, I.8    Zouboulis, C.C.9    Hunyadi, J.10
  • 19
    • 0030757590 scopus 로고    scopus 로고
    • Zinc and titanium oxides: promising UV-absorbers but what influence do they have on intact skin?
    • Lansdown, A. B. G., and Taylor, A. (1997). Zinc and titanium oxides: promising UV-absorbers but what influence do they have on intact skin? Int. J. Cosmet. Sci. 19, 167-172.
    • (1997) Int. J. Cosmet. Sci. , vol.19 , pp. 167-172
    • Lansdown, A.B.G.1    Taylor, A.2
  • 25
    • 33845752957 scopus 로고    scopus 로고
    • In vitro percutaneous absorption and in vivo stratum corneum distribution of an organic and a mineral sunscreen
    • Mavon, A., Miquel, C., Lejeune, O., Payre, B., and Moretto, P. (2007). In vitro percutaneous absorption and in vivo stratum corneum distribution of an organic and a mineral sunscreen. Skin Pharmacol. Physiol. 20, 10-20.
    • (2007) Skin Pharmacol. Physiol. , vol.20 , pp. 10-20
    • Mavon, A.1    Miquel, C.2    Lejeune, O.3    Payre, B.4    Moretto, P.5
  • 27
    • 0000686969 scopus 로고
    • Ultrastructural evaluation of the porcine integument
    • (M. E. Tumbleson, Ed.), Plenum Publishing Corp., New York, NY
    • Monteiro-Riviere, N. A. (1986). Ultrastructural evaluation of the porcine integument. In Swine in Biomedical Research (M. E. Tumbleson, Ed.), Vol. 1, pp. 641-655. Plenum Publishing Corp., New York, NY.
    • (1986) Swine in Biomedical Research , vol.1 , pp. 641-655
    • Monteiro-Riviere, N.A.1
  • 28
    • 0002997210 scopus 로고    scopus 로고
    • The integument
    • (W. G. Pond and H. J. Mersmann, Eds.), Cornell University Press, Ithaca, NY
    • Monteiro-Riviere, N. A. (2001). The integument. In The Biology of the Domestic Pig (W. G. Pond and H. J. Mersmann, Eds.), pp. 625-652. Cornell University Press, Ithaca, NY.
    • (2001) The Biology of the Domestic Pig , pp. 625-652
    • Monteiro-Riviere, N.A.1
  • 29
    • 0002458694 scopus 로고    scopus 로고
    • Anatomical factors affecting barrier function
    • 6th ed. (H. Zhai and H. I. Maibach, Eds.), CRC Press, Washington, DC
    • Monteiro-Riviere, N. A. (2004). Anatomical factors affecting barrier function. In Dermatotoxicology, 6th ed. (H. Zhai and H. I. Maibach, Eds.), pp. 42-70. CRC Press, Washington, DC.
    • (2004) Dermatotoxicology , pp. 42-70
    • Monteiro-Riviere, N.A.1
  • 30
    • 44849103444 scopus 로고    scopus 로고
    • Anatomical factors that affect barrier function
    • (H. Zhai, K. P. Wilhelm, and H. I. Maibach, Eds.), CRC Press, New York, NY
    • Monteiro-Riviere, N. A. (2008). Anatomical factors that affect barrier function. In Dermatotoxicology (H. Zhai, K. P. Wilhelm, and H. I. Maibach, Eds.), pp. 39-50. CRC Press, New York, NY.
    • (2008) Dermatotoxicology , pp. 39-50
    • Monteiro-Riviere, N.A.1
  • 31
    • 77958477177 scopus 로고    scopus 로고
    • Nanomaterial penetration
    • (N. A. Monteiro-Riviere, Ed.), Informa Healthcare, New York, NY
    • Monteiro-Riviere, N. A., and Baroli, B. (2010). Nanomaterial penetration. In Toxicology of the Skin-Target Organ Series (N. A. Monteiro-Riviere, Ed.), Vol. 29, pp. 333-346. Informa Healthcare, New York, NY.
    • (2010) Toxicology of the Skin-Target Organ Series , vol.29 , pp. 333-346
    • Monteiro-Riviere, N.A.1    Baroli, B.2
  • 32
    • 77952889776 scopus 로고    scopus 로고
    • Animal skin morphology and dermal absorption
    • (M. S. Roberts and K. A. Walters, Eds.) Informa Healthcare, New York, NY
    • Monteiro-Riviere, N. A., Baynes, R. E., and Riviere, J. E. (2008). Animal skin morphology and dermal absorption. In Dermal Absorption and Toxicity Assessment (M. S. Roberts and K. A. Walters, Eds.), pp. 17-35. Informa Healthcare, New York, NY.
    • (2008) Dermal Absorption and Toxicity Assessment , pp. 17-35
    • Monteiro-Riviere, N.A.1    Baynes, R.E.2    Riviere, J.E.3
  • 34
    • 0000883827 scopus 로고    scopus 로고
    • The pig as a model for cutaneous pharmacology and toxicology research
    • (M. E. Tumbleson and L. B. Schook, Eds.) Plenum Publishing Corp., New York, NY
    • Monteiro-Riviere, N. A., and Riviere, J. E. (1996). The pig as a model for cutaneous pharmacology and toxicology research. In Advances in Swine in Biomedical Research (M. E. Tumbleson and L. B. Schook, Eds.), Vol. II, pp. 425-458. Plenum Publishing Corp., New York, NY.
    • (1996) Advances in Swine in Biomedical Research , vol.2 , pp. 425-458
    • Monteiro-Riviere, N.A.1    Riviere, J.E.2
  • 35
    • 80052456142 scopus 로고    scopus 로고
    • The pig as a model for human skin research
    • (M. Swindle and G. F. Bouchard, Eds.) Sinclair Research Center, Columbia, MO
    • Monteiro-Riviere, N. A., and Riviere, J. E. (2005). The pig as a model for human skin research. In Swine in Biomedical Research: Update on Animal Models (M. Swindle and G. F. Bouchard, Eds.), pp. 17-22. Sinclair Research Center, Columbia, MO.
    • (2005) Swine in Biomedical Research: Update on Animal Models , pp. 17-22
    • Monteiro-Riviere, N.A.1    Riviere, J.E.2
  • 36
    • 0022073869 scopus 로고
    • Ultrastructure of the integument of the domestic pig (Sus scrofa) from one through fourteen weeks of age
    • Monteiro-Riviere, N. A., and Stromberg, M. W. (1985). Ultrastructure of the integument of the domestic pig (Sus scrofa) from one through fourteen weeks of age. Anat. Histol. Embryol. 14, 97-115.
    • (1985) Anat. Histol. Embryol. , vol.14 , pp. 97-115
    • Monteiro-Riviere, N.A.1    Stromberg, M.W.2
  • 37
    • 54549113498 scopus 로고    scopus 로고
    • In vivo skin penetration of quantum dot nanoparticles in the murine model: the effect of UVR
    • Mortensen, L. J., Oberdörster, G., Pentland, A. P., and DeLouise, L. A. (2008). In vivo skin penetration of quantum dot nanoparticles in the murine model: the effect of UVR. Nano Lett. 8, 2779-2787.
    • (2008) Nano Lett , vol.8 , pp. 2779-2787
    • Mortensen, L.J.1    Oberdörster, G.2    Pentland, A.P.3    DeLouise, L.A.4
  • 39
    • 33947322486 scopus 로고    scopus 로고
    • Grey goo on the skin? Nanotechnology, cosmetic sunscreen safety
    • Nohynek, G. J., Lademann, J., Ribaud, C., and Roberts, M. S. (2007). Grey goo on the skin? Nanotechnology, cosmetic sunscreen safety. Crit. Rev. Toxicol. 37, 251-277.
    • (2007) Crit. Rev. Toxicol. , vol.37 , pp. 251-277
    • Nohynek, G.J.1    Lademann, J.2    Ribaud, C.3    Roberts, M.S.4
  • 40
    • 80052503362 scopus 로고    scopus 로고
    • Hair follicle delivery
    • (N. A. Monteiro-Riviere, Ed.), Informa Healthcare, New York, NY
    • Patzelt, A., Sterry, W., and Lademann, J. (2010). Hair follicle delivery. In Toxicology of the Skin (N. A. Monteiro-Riviere, Ed.), pp. 101-109. Informa Healthcare, New York, NY.
    • (2010) Toxicology of the Skin , pp. 101-109
    • Patzelt, A.1    Sterry, W.2    Lademann, J.3
  • 41
    • 0035734318 scopus 로고    scopus 로고
    • The human stratum corneum layer: an effective barrier against dermal uptake of different forms of topically applied micronized titanium dioxide
    • Pflücker, F., Wendel, V., Hohenberg, H., Gärtner, E., Will, T., Pfeiffer, S., Wepf, R., and Gers-Barlag, H. (2001). The human stratum corneum layer: an effective barrier against dermal uptake of different forms of topically applied micronized titanium dioxide. Skin Pharmacol. Appl. Skin Physiol. 14(S1), 92-97.
    • (2001) Skin Pharmacol. Appl. Skin Physiol. , vol.14 , Issue.S1 , pp. 92-97
    • Pflücker, F.1    Wendel, V.2    Hohenberg, H.3    Gärtner, E.4    Will, T.5    Pfeiffer, S.6    Wepf, R.7    Gers-Barlag, H.8
  • 43
    • 0036750534 scopus 로고    scopus 로고
    • Evidence supporting zinc as an important antioxidant for skin
    • Rostan, E. F., DeBuys, H. V., Madey, D. L., and Pinnell, S. R. (2002). Evidence supporting zinc as an important antioxidant for skin. Int. J. Dermatol. 41, 606-611.
    • (2002) Int. J. Dermatol. , vol.41 , pp. 606-611
    • Rostan, E.F.1    DeBuys, H.V.2    Madey, D.L.3    Pinnell, S.R.4
  • 50
    • 84888446157 scopus 로고    scopus 로고
    • Skin Cancer Foundation. Available at: Accessed October 29, 2009
    • Skin Cancer Foundation. (2007). iVillage Survey Results from May 2007. Available at: http://www.skincancer.org/ivillage-survey-results.html. Accessed October 29, 2009.
    • (2007) iVillage Survey Results from May 2007
  • 52
    • 0030279617 scopus 로고    scopus 로고
    • A pilot study on the percutaneous absorption of microfine titanium dioxide from sunscreens
    • Tan, M.-H., Commens, C. A., Burnett, L., and Snitch, P. (1996). A pilot study on the percutaneous absorption of microfine titanium dioxide from sunscreens. Aust. J. Dermatol. 37, 185-187.
    • (1996) Aust. J. Dermatol. , vol.37 , pp. 185-187
    • Tan, M.-H.1    Commens, C.A.2    Burnett, L.3    Snitch, P.4
  • 53
    • 33646163250 scopus 로고    scopus 로고
    • Ubiquinone, idebenone and kinetin provide ineffective photoprotection to skin when compared to a topical antioxidant combination of vitamins C and E with ferulic acid
    • Tournas, J. A., Lin, F. H., Burch, J. A., Selim, M. A., Monteiro-Riviere, N. A., Zielinski, J. E., and Pinnell, S. R. (2006). Ubiquinone, idebenone and kinetin provide ineffective photoprotection to skin when compared to a topical antioxidant combination of vitamins C and E with ferulic acid. J. Invest. Dermatol. 126, 1185-1187.
    • (2006) J. Invest. Dermatol. , vol.126 , pp. 1185-1187
    • Tournas, J.A.1    Lin, F.H.2    Burch, J.A.3    Selim, M.A.4    Monteiro-Riviere, N.A.5    Zielinski, J.E.6    Pinnell, S.R.7
  • 54
    • 0000624759 scopus 로고
    • Percutaneous absorption in man and animal. A perspective
    • (V. Drill and P. Lazar, Eds.) Academic Press, New York, NY
    • Wester, R. C., and Maibach, H. I. (1977). Percutaneous absorption in man and animal. A perspective. In Cutaneous Toxicity (V. Drill and P. Lazar, Eds.), pp. 111-126. Academic Press, New York, NY.
    • (1977) Cutaneous Toxicity , pp. 111-126
    • Wester, R.C.1    Maibach, H.I.2
  • 56
    • 62449098679 scopus 로고    scopus 로고
    • Imaging of zinc oxide nanoparticle penetration in human skin in vitro and in vivo
    • Zvyagin, A. V., Zhao, X., Gierden, A., Sanchez, W., Ross, J. A., and Roberts, M. S. (2008). Imaging of zinc oxide nanoparticle penetration in human skin in vitro and in vivo. J. Biomed. Optics 13, 064031.
    • (2008) J. Biomed. Optics , vol.13 , pp. 064031
    • Zvyagin, A.V.1    Zhao, X.2    Gierden, A.3    Sanchez, W.4    Ross, J.A.5    Roberts, M.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.