Placental ABC Transporters: Biological Impact and Pharmaceutical Significance

Pharmaceutical Research

Volumn 33, Issue 12, 2016, Pages 2847-2878

  Joshi, Anand A ^a   Vaidya, Soniya S ^a,b   St Pierre, Marie V ^c   Mikheev, Andrei M ^d,e   Desino, Kelly E ^f,g   Nyandege, Abner N ^a   Audus, Kenneth L ^f   Unadkat, Jashvant D ^d   Gerk, Phillip M ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^d UNIVERSITY OF WASHINGTON   (United States)

^e UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF KANSAS   (United States)

^g ABBVIE INC   (United States)

Author keywords

breast cancer resistance protein; drug transport; multidrug resistance associated protein; P glycoprotein; placenta; regulation of expression

Indexed keywords

ABC TRANSPORTER; ABC TRANSPORTER A1; ABC TRANSPORTER B5; ABC TRANSPORTER G5; ABCC12 PROTEIN; BETA CATENIN; BILE SALT EXPORT PUMP; BREAST CANCER RESISTANCE PROTEIN; CELL NUCLEUS RECEPTOR; CYTOKINE; HORMONE; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 1; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 2; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 3; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 4; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 6; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 7; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 8; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 5; PROSTAGLANDIN; PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN; ABC TRANSPORTER SUBFAMILY B; DRUG; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN; XENOBIOTIC AGENT;

ENZYME SPECIFICITY; HUMAN; IMMORTALIZED CELL LINE; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PLACENTA; PLACENTA LOCALIZATION; PLACENTA PERFUSION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN POLYMORPHISM; PROTEIN STRUCTURE; REGULATORY MECHANISM; REVIEW; SEQUENCE HOMOLOGY; WNT SIGNALING PATHWAY; ANIMAL; DRUG EFFECTS; FEMALE; FETOMATERNAL TRANSFUSION; GENETIC POLYMORPHISM; GENETICS; METABOLISM; PREGNANCY; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; ATP BINDING CASSETTE TRANSPORTER, SUB-FAMILY B; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; CYTOKINES; FEMALE; HORMONES; HUMANS; MATERNAL-FETAL EXCHANGE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PHARMACEUTICAL PREPARATIONS; PLACENTA; POLYMORPHISM, GENETIC; PREGNANCY; XENOBIOTICS;

EID: 84988378505     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-016-2028-8     Document Type: Review

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