A mutation hot spot in the Bcrp1 (Abcg2) multidrug transporter in mouse cell lines selected for doxorubicin resistance

Cancer Research

Volumn 62, Issue 8, 2002, Pages 2294-2299

  Allen, John D ^a   Jackson, Sonja C ^a   Schinkel, Alfred H ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRACYCLINE DERIVATIVE; ARGININE; BISANTRENE; DAUNORUBICIN; DOXORUBICIN; GLYCOPROTEIN P; MITOXANTRONE; PACLITAXEL; RHODAMINE 123; TOPOTECAN; VINCRISTINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; CROSS RESISTANCE; DRUG RESISTANCE; GENE AMPLIFICATION; GENE MUTATION; GENE OVEREXPRESSION; IC 50; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ACRIDINES; ANIMALS; ANTINEOPLASTIC AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; CELL LINE; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FIBROBLASTS; ISOQUINOLINES; MICE; MUTATION; NEOPLASM PROTEINS; RNA, MESSENGER; SUBSTRATE SPECIFICITY; TETRAHYDROISOQUINOLINES;

EID: 0037089528     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

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13. Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells
14. Episomal vectors rapidly and stably produce high-titer recombinant retrovirus
15. Extensive contribution of the multidrug transporters P-glycoprotein and Mrp1 to basal drug resistance
16. Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins
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18. Reversal of resistance by GF120918 in cell lines expressing the ABC half-transporter, MXR
19. A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance