Antifolate resistance associated with loss of MRP1 expression and function in Chinese hamster ovary cells with markedly impaired export of folate and cholate

Molecular Pharmacology

Volumn 64, Issue 2, 2003, Pages 220-227

  Stark, Michal ^a   Rothem, Lilah ^a   Jansen, Gerrit ^b   Scheffer, George L ^b   Goldman, David I ^c   Assaraf, Yehuda G ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CALCEIN; CHOLIC ACID; DOXORUBICIN; ETOPOSIDE; FOLIC ACID; FOLIC ACID ANTAGONIST; LOMETREXOL; MERCAPTOPURINE; METHOTREXATE; METODICLOROFEN; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 5; N [[5 [2 (2 AMINO 4,6,7,8 TETRAHYDRO 4 OXO 1H PYRIMIDO[5,4 B][1,4]THIAZIN 6 YL)ETHYL] 2 THIENYL]CARBONYL]GLUTAMIC ACID; NOLATREXED; PIRITREXIM; PROBENECID; PROSTAGLANDIN A1; PYRIMETHAMINE; TIOGUANINE; TRIMETREXATE; VINCRISTINE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CHINESE HAMSTER; CROSS RESISTANCE; DRUG SENSITIVITY; FLUORESCENCE; NONHUMAN; OVARY CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; WILD TYPE;

ANIMALS; BIOLOGICAL TRANSPORT; CELL DIVISION; CELLS, CULTURED; CHO CELLS; CHOLATES; CRICETINAE; DRUG RESISTANCE; FLOW CYTOMETRY; FLUORESCEINS; FOLIC ACID; HUMANS; METHOTREXATE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEIN; PROSTAGLANDINS A; PYRIMETHAMINE; TRITIUM;

EID: 0041842584     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.64.2.220     Document Type: Article

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