Functional loss of ABCA1 in mice causes severe placental malformation, aberrant lipid distribution, and kidney glomerulonephritis as well as high-density lipoprotein cholesterol deficiency

American Journal of Pathology

Volumn 157, Issue 3, 2000, Pages 1017-1029

  Christiansen Weber, T A ^a   Voland, J R ^a   Wu, Y ^a   Ngo, K ^a   Roland, B L ^a   Nguyen, S ^a   Peterson, P A ^a   Fung Leung, W P ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOMEGALY; CARDIOVASCULAR DISEASE; CHOLESTEROL BLOOD LEVEL; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; EMBRYOPATHY; FETUS WASTAGE; GENE MUTATION; GENETIC LINKAGE; GLOMERULONEPHRITIS; GROWTH RETARDATION; HEART DILATATION; HEART HYPERTROPHY; IMMUNE COMPLEX DEPOSITION; LIPID METABOLISM; LIPID STORAGE; MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS; MOUSE; NEPHRITIS; NEWBORN DEATH; NONHUMAN; PHENOTYPE; PLACENTA; PLACENTA DISORDER; PRIORITY JOURNAL; STEROIDOGENESIS; TANGIER DISEASE;

EID: 0034490992     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64614-7     Document Type: Article

References (35)

1. ABC-transporters: From microorganisms to man
2. Cloning of two novel ABC transporters mapping on human chromosome 9
3. The cloning of a human ABC gene (ABC3) mapping to chromosome 16p 13.3
4. A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy
5. Identification of the cystic fibrosis gene - Cloning and characterization of complementary DNA
6. Mutations in the 70k peroxisomal membrane-protein gene in Zellweger syndrome
7. Putative X-linked adrenoleukodystrophy gene shares unexpected homology with ABC transporters
8. Biochemistry of multidrug resistance mediated by the multidrug transporter
9. The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway
10. Molecular cloning of the human ATP-binding cassette transporter 1 (hABC1): Evidence for sterol-dependent regulation in macrophages
11. The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease
12. Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency
13. Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1
14. Human ATP-binding cassette transporter 1 (ABC1): Genomic organization and identification of the genetic defect in the original Tangier disease kindred
15. Mutations in the ABC1 gene in familial HDL deficiency with defective cholesterol efflux
16. Familial high density lipoprotein deficiency: Tangier disease
17. Defective removal of cellular cholesterol and phospholipids by apolipoprotein A-I in Tangier disease
18. HDL-mediated efflux of intracellular cholesterol is impaired in fibroblasts from Tangier disease patients
19. In vivo metabolism of proapolipoprotein A-I in Tangier disease
20. Homozygous Tangier disease and cardiovascular disease
21. Glycopeptide enkephalin analogues produce analgesia in mice: Evidence for penetration of the blood-brain barrier
22. M1 receptor agonist activity is not a requirement for muscarinic antinociception
23. A complete protocol for in situ hybridization of messenger RNAs in brain and other tissues with radio-labeled single-stranded RNA probes
24. Effects of ovarian hormones on foetal and placental growth in the mouse
25. Minimal progesterone support required for the maintenance of pregnancy in mice
26. Transport of lipids from Golgi to plasma membrane is defective in Tangier disease patients and ABC1-deficient mice
27. ApoA-I deficiency causes both hypertriglyceridemia and increased atherosclerosis in human apoB transgenic mice
28. Apolipoprotein A-I is required for cholesteryl ester accumulation in steroidogenic cells and for normal adrenal steroid production
29. A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism
30. Influence of the high density lipoprotein receptor SR-BI on reproductive and cardiovascular pathophysiology
31. Adrenal cholesterol uptake from plasma lipoproteins: Regulation by corticotropin
32. Separate mechanisms for the uptake of high and low density lipoproteins by mouse adrenal gland in vivo
33. The ATP binding cassette transporter ABC1 is required for the engulfment of corpses generated by apoptotic cell death
34. Clusterin (complement lysis inhibitor) forms a high density lipoprotein complex with apolipoprotein A-I in human plasma
35. Genetically determined disorders of the complement system