-
2
-
-
0025602894
-
Induction of drug-metabolizing enzymes by xenobiotics
-
Bock, K. W., H. P. Lipp, and B. S. Bock-Hennig. Induction of drug-metabolizing enzymes by xenobiotics. Xenobiotica 20: 1101-1111, 1990.
-
(1990)
Xenobiotica
, vol.20
, pp. 1101-1111
-
-
Bock, K.W.1
Lipp, H.P.2
Bock-Hennig, B.S.3
-
3
-
-
0017184389
-
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
-
Bradford, M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254, 1976.
-
(1976)
Anal. Biochem.
, vol.72
, pp. 248-254
-
-
Bradford, M.M.1
-
4
-
-
0040761368
-
cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats
-
Buchler, M., J. Konig, M. Brom, J. Kartenbeck, H. Spring, T. Horie, and D. Keppler. cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. J. Biol. Chem. 271: 15091-15098, 1996.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 15091-15098
-
-
Buchler, M.1
Konig, J.2
Brom, M.3
Kartenbeck, J.4
Spring, H.5
Horie, T.6
Keppler, D.7
-
5
-
-
0032922395
-
Human MRP3 transporter: Identification of the 5′-flanking region, genomic organization and alternative splice variants
-
Fromm, M. F., B. Leake, D. M. Roden, G. R. Wilkinson, and R. B. Kim. Human MRP3 transporter: identification of the 5′-flanking region, genomic organization and alternative splice variants. Biochim. Biophys. Acta 1415: 369-374, 1999.
-
(1999)
Biochim. Biophys. Acta
, vol.1415
, pp. 369-374
-
-
Fromm, M.F.1
Leake, B.2
Roden, D.M.3
Wilkinson, G.R.4
Kim, R.B.5
-
6
-
-
0026327875
-
Regulation of 2-acetylaminofluorene- and 3-methylcholanthrene-mediated induction of multidrug resistance and cytochrome P450IA gene family expression in primary hepatocyte cultures and rat liver
-
Gant, T. W., J. A. Silverman, H. C. Bisgaard, R. K. Burt, P. A. Marino, and S. S. Thorgeirsson. Regulation of 2-acetylaminofluorene- and 3-methylcholanthrene-mediated induction of multidrug resistance and cytochrome P450IA gene family expression in primary hepatocyte cultures and rat liver. Mol. Carcinog. 4: 499-509, 1991.
-
(1991)
Mol. Carcinog.
, vol.4
, pp. 499-509
-
-
Gant, T.W.1
Silverman, J.A.2
Bisgaard, H.C.3
Burt, R.K.4
Marino, P.A.5
Thorgeirsson, S.S.6
-
7
-
-
0030027622
-
+/bile acid cotransporter in extrahepatic cholestasis
-
+/bile acid cotransporter in extrahepatic cholestasis. Gastroenterology 110: 199-209, 1996.
-
(1996)
Gastroenterology
, vol.110
, pp. 199-209
-
-
Gartung, C.1
Ananthanarayanan, M.2
Rahman, M.A.3
Schuele, S.4
Nundy, S.5
Soroka, C.J.6
Stolz, A.7
Suchy, F.J.8
Boyer, J.L.9
-
8
-
-
0031014582
-
+/taurocholate cotransporter is regulated in vivo by retention of biliary constituents but not their depletion
-
+/taurocholate cotransporter is regulated in vivo by retention of biliary constituents but not their depletion. Hepatology 25: 284-290, 1997.
-
(1997)
Hepatology
, vol.25
, pp. 284-290
-
-
Gartung, C.1
Schuele, S.2
Schlosser, S.F.3
Boyer, J.L.4
-
9
-
-
0001317087
-
Sodium-independent uptake of bile acids is unaffected by down-regulation of an organic anion transporter (oatp) in rat liver during cholestasis produced by common bile duct ligation (CBDL)
-
Gartung, C., M. Trauner, S, F. Schlosser, B. Hagenbuch, P. J. Meier, and J. L. Boyer. Sodium-independent uptake of bile acids is unaffected by down-regulation of an organic anion transporter (oatp) in rat liver during cholestasis produced by common bile duct ligation (CBDL) (Abstract). Hepatology 24: 369A, 1997.
-
(1997)
Hepatology
, vol.24
-
-
Gartung, C.1
Trauner, M.2
Schlosser, S.F.3
Hagenbuch, B.4
Meier, P.J.5
Boyer, J.L.6
-
10
-
-
0032540277
-
The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver
-
Gerloff, T., B. Stieger, B. Hagenbuch, J. Madon, L. Landmann, J. Roth, A. F. Hofmann, P. J. Meier. The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver. J. Biol. Chem. 273: 10046-10050, 1998.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 10046-10050
-
-
Gerloff, T.1
Stieger, B.2
Hagenbuch, B.3
Madon, J.4
Landmann, L.5
Roth, J.6
Hofmann, A.F.7
Meier, P.J.8
-
11
-
-
0031866357
-
Hepatic expression of multidrug resistance-associated protein (MRP)-like proteins maintained in Eisai hyperbilirubinemic rats (EHBR)
-
Hirohashi, T., K. Ito, K. Ogawa, H. Suzuki, K. Kume, T. Shimizu, and Y. Sugiyama. Hepatic expression of multidrug resistance-associated protein (MRP)-like proteins maintained in Eisai hyperbilirubinemic rats (EHBR) Mol. Pharmacol. 53:1068-1075, 1998.
-
(1998)
Mol. Pharmacol.
, vol.53
, pp. 1068-1075
-
-
Hirohashi, T.1
Ito, K.2
Ogawa, K.3
Suzuki, H.4
Kume, K.5
Shimizu, T.6
Sugiyama, Y.7
-
12
-
-
0033591235
-
Characterization of the transport properties of cloned rat multidrug resistance associated protein 3 (MRP3)
-
Hirohashi, T., K. Suzuki, and Y. Sugiyama. Characterization of the transport properties of cloned rat multidrug resistance associated protein 3 (MRP3). J. Biol. Chem. 274: 15181-15485, 1999.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 15181-15485
-
-
Hirohashi, T.1
Suzuki, K.2
Sugiyama, Y.3
-
13
-
-
15844416284
-
Coordinated induction of MRP/GS-X pump and gamma-glutamylcysteine synthetase by heavy metals in human leukemia cells
-
Ishikawa, T., J. J. Bao, Y. Yamane, K. Akimaru, K. Frindrich, C. D. Wright, and M. T. Kuo. Coordinated induction of MRP/GS-X pump and gamma-glutamylcysteine synthetase by heavy metals in human leukemia cells. J. Biol Chem. 271: 14981-14988, 1996.
-
(1996)
J. Biol Chem.
, vol.271
, pp. 14981-14988
-
-
Ishikawa, T.1
Bao, J.J.2
Yamane, Y.3
Akimaru, K.4
Frindrich, K.5
Wright, C.D.6
Kuo, M.T.7
-
14
-
-
0031031247
-
Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR
-
Ito, K., H. Suzuki, T. Hirohashi, K. Kume, T. Shimizu, and Y. Sugiyama. Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR. Am. J. Physiol. Gastrointest. Liver Physiol. 272: G16-G22, 1997.
-
(1997)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.272
-
-
Ito, K.1
Suzuki, H.2
Hirohashi, T.3
Kume, K.4
Shimizu, T.5
Sugiyama, Y.6
-
15
-
-
0032413678
-
Biochemical and molecular aspects of genetic disorders of bilirubin metabolism
-
Iyanagi, T., Y. Emi, and S. Ikushiro. Biochemical and molecular aspects of genetic disorders of bilirubin metabolism. Biochim. Biophys. Acta 1407: 173-184, 1998.
-
(1998)
Biochim. Biophys. Acta
, vol.1407
, pp. 173-184
-
-
Iyanagi, T.1
Emi, Y.2
Ikushiro, S.3
-
16
-
-
0028140393
-
Expression cloning of a rat liver Na(+)-independent organic anion transporter
-
Jacquemin, E., B. Hagenbuch, B. Stieger, A. W. Wolkoff, and P. J. Meier. Expression cloning of a rat liver Na(+)-independent organic anion transporter. Proc. Natl. Acad. Sci. USA 91: 133-137, 1994.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 133-137
-
-
Jacquemin, E.1
Hagenbuch, B.2
Stieger, B.3
Wolkoff, A.W.4
Meier, P.J.5
-
17
-
-
0032540101
-
Sequence analysis and functional characterization of the 5′-flanking region of the rat multidrug resistance protein 2 (mrp2) gene
-
Kauffmann, H. M., and D. Schrenk. Sequence analysis and functional characterization of the 5′-flanking region of the rat multidrug resistance protein 2 (mrp2) gene. Biochem. Biophys. Res. Commun. 245: 325-331, 1998.
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.245
, pp. 325-331
-
-
Kauffmann, H.M.1
Schrenk, D.2
-
18
-
-
0031160517
-
Hepatic canalicular membrane 5: Expression and localization of the conjugate export pump encoded by the MRP2 (cMRP/cMOAT) gene in liver
-
Keppler, D., and J. Konig. Hepatic canalicular membrane 5: expression and localization of the conjugate export pump encoded by the MRP2 (cMRP/cMOAT) gene in liver. FASEB J. 11: 509-516, 1997.
-
(1997)
FASEB J.
, vol.11
, pp. 509-516
-
-
Keppler, D.1
Konig, J.2
-
19
-
-
0031838805
-
cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3)
-
Kiuchi, Y., H. Suzuki, T. Hirohashi, C. A. Tyson, and Y. Sugiyama. cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3). FEBS Lett. 433: 149-152, 1998.
-
(1998)
FEBS Lett.
, vol.433
, pp. 149-152
-
-
Kiuchi, Y.1
Suzuki, H.2
Hirohashi, T.3
Tyson, C.A.4
Sugiyama, Y.5
-
20
-
-
0021233529
-
Mechanisms of bile formation, hepatic uptake, and biliary excretion
-
Klaassen, C. D., and J. B. Watkins. Mechanisms of bile formation, hepatic uptake, and biliary excretion. Pharmacol. Rev. 36: 1-67, 1984.
-
(1984)
Pharmacol. Rev.
, vol.36
, pp. 1-67
-
-
Klaassen, C.D.1
Watkins, J.B.2
-
21
-
-
0032498303
-
An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway
-
Kliewer S. A., J. T. Moore, L. Wade, J. L. Staudinger, M. A. Watson, S. A. Jones, D. D. McKee, B. B. Oliver, T. M. Willson, R. H. Zetterstrom, T. Perlmann, and J. M. Lehmann. An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell 92: 73-82, 1998.
-
(1998)
Cell
, vol.92
, pp. 73-82
-
-
Kliewer, S.A.1
Moore, J.T.2
Wade, L.3
Staudinger, J.L.4
Watson, M.A.5
Jones, S.A.6
McKee, D.D.7
Oliver, B.B.8
Willson, T.M.9
Zetterstrom, R.H.10
Perlmann, T.11
Lehmann, J.M.12
-
22
-
-
0025343017
-
Mechanism of glutathione S-conjugate transport in canalicular and basolateral rat liver plasma membranes
-
Kobayashi, K., Y. Sogame, H. Hara, and K. Hayashi. Mechanism of glutathione S-conjugate transport in canalicular and basolateral rat liver plasma membranes. J. Biol. Chem. 265: 7737-7741, 1990.
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 7737-7741
-
-
Kobayashi, K.1
Sogame, Y.2
Hara, H.3
Hayashi, K.4
-
23
-
-
0031893146
-
Organic cation transporters in intestine, kidney, liver and brain
-
Koepsell, H. Organic cation transporters in intestine, kidney, liver and brain. Annu. Rev. Physiol. 60: 243-266, 1998.
-
(1998)
Annu. Rev. Physiol.
, vol.60
, pp. 243-266
-
-
Koepsell, H.1
-
24
-
-
0032926354
-
Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatoeyte membrane
-
Konig, J., D. Rost, Y. Cui, and D. Keppler. Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatoeyte membrane. Hepatology 29: 1156-1163, 1999.
-
(1999)
Hepatology
, vol.29
, pp. 1156-1163
-
-
Konig, J.1
Rost, D.2
Cui, Y.3
Keppler, D.4
-
25
-
-
0030841332
-
Analysis of expression of cMOAT (MRP2), MEP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines
-
Kool, M., M. de Haas, G. L. Scheffer, R. J. Scheper, M. J. van Eijk, J. A. Juijn, F. Baas, and P. Borst. Analysis of expression of cMOAT (MRP2), MEP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. Cancer Res. 57: 3537-3547, 1998.
-
(1998)
Cancer Res.
, vol.57
, pp. 3537-3547
-
-
Kool, M.1
De Haas, M.2
Scheffer, G.L.3
Scheper, R.J.4
Van Eijk, M.J.5
Juijn, J.A.6
Baas, F.7
Borst, P.8
-
26
-
-
13044294031
-
MRP3, an organic anion transporter able to transport anti-cancer drugs
-
Kool, M., M. van der Linden, M. de Haas, G. L. Scheffer, J. M. de Vree, A. J. Smith, G. Jansen, G. J. Peters, N. Ponne, R. J. Scheper, R. P. Elferink, F. Baas, and P. Borst. MRP3, an organic anion transporter able to transport anti-cancer drugs. Proc. Natl. Acad. Sci. USA 96: 6914-6919, 1999.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 6914-6919
-
-
Kool, M.1
Van Der Linden, M.2
De Haas, M.3
Scheffer, G.L.4
De Vree, J.M.5
Smith, A.J.6
Jansen, G.7
Peters, G.J.8
Ponne, N.9
Scheper, R.J.10
Elferink, R.P.11
Baas, F.12
Borst, P.13
-
27
-
-
0030880647
-
Identification and functional characterization of the promoter region of the human organic anion transporting polypeptide gene
-
Kullak-Ublick, G. A., U. Beuers, C. Fahney, B. Hagenbuch, P. J. Meier, and G. Paumgartner. Identification and functional characterization of the promoter region of the human organic anion transporting polypeptide gene. Hepatology 26: 991-997, 1997.
-
(1997)
Hepatology
, vol.26
, pp. 991-997
-
-
Kullak-Ublick, G.A.1
Beuers, U.2
Fahney, C.3
Hagenbuch, B.4
Meier, P.J.5
Paumgartner, G.6
-
28
-
-
0032169485
-
The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
-
Lehmann, J. M., D. D. McKee, M. A. Watson, T. M. Willson, J. T. Moore, and S. A. Kliewer. The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J. Clin. Invest. 102: 1016-1023, 1998.
-
(1998)
J. Clin. Invest.
, vol.102
, pp. 1016-1023
-
-
Lehmann, J.M.1
McKee, D.D.2
Watson, M.A.3
Willson, T.M.4
Moore, J.T.5
Kliewer, S.A.6
-
29
-
-
0029983801
-
Hepatocellular transport systems: From carrier identification in membrane vesicles to cloned proteins
-
Meier, P. J. Hepatocellular transport systems: from carrier identification in membrane vesicles to cloned proteins. J. Hepatol. 24, Suppl 1: 29-35, 1996.
-
(1996)
J. Hepatol.
, vol.24
, Issue.1 SUPPL.
, pp. 29-35
-
-
Meier, P.J.1
-
30
-
-
0032581363
-
Membrane localization of the electrogenic cation transporter rOCT1 in rat liver
-
Meyer-Wentrup, F., U. Karbach., V. Gorboulev., P. Arndt, and H. Koepsell. Membrane localization of the electrogenic cation transporter rOCT1 in rat liver. Biochem. Biophys. Res. Commun. 248: 673-378, 1998.
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.248
, pp. 673-1378
-
-
Meyer-Wentrup, F.1
Karbach, U.2
Gorboulev, V.3
Arndt, P.4
Koepsell, H.5
-
32
-
-
0029082150
-
Hepatobiliary secretion of organic compounds: Molecular mechanisms of membrane transport
-
Oude Elferink, R. P., D. K. Meijer, F. Kuipers, P. L. Jansen, A. K. Groen, and G. M. Groothuis. Hepatobiliary secretion of organic compounds: molecular mechanisms of membrane transport. Biochim. Biophys. Acta 1241: 215-268, 1995.
-
(1995)
Biochim. Biophys. Acta
, vol.1241
, pp. 215-268
-
-
Oude Elferink, R.P.1
Meijer, D.K.2
Kuipers, F.3
Jansen, P.L.4
Groen, A.K.5
Groothuis, G.M.6
-
33
-
-
0002650888
-
Hepatic canalicular membrane 1: The role of mdr2 P-glycoprotein in hepatobiliary lipid transport
-
Oude Elferink, R. P., G. N. Tytgat, and A. K. Groen. Hepatic canalicular membrane 1: the role of mdr2 P-glycoprotein in hepatobiliary lipid transport. FASEB J. 11:19-28, 1997.
-
(1997)
FASEB J.
, vol.11
, pp. 19-28
-
-
Oude Elferink, R.P.1
Tytgat, G.N.2
Groen, A.K.3
-
34
-
-
0027956677
-
Induction of a dose-related increase in sulfobromophthalein uptake velocity in freshly isolated rat hepatocytes by phenobarbital
-
Potter, B. J., J. Z. Ni, K. Wolfe, D. Stump, and P. D. Berk. Induction of a dose-related increase in sulfobromophthalein uptake velocity in freshly isolated rat hepatocytes by phenobarbital. Hepatology 20: 1078-1085, 1994.
-
(1994)
Hepatology
, vol.20
, pp. 1078-1085
-
-
Potter, B.J.1
Ni, J.Z.2
Wolfe, K.3
Stump, D.4
Berk, P.D.5
-
35
-
-
0027299120
-
Induction of multidrug resistance gene expression during cholestasis in rats and nonhuman primates
-
Schrenk, D., T. W. Gant, J. A. Silverman, K. H. Preisegger, P. A. Marino, and S. S. Thorgeirsson. Induction of multidrug resistance gene expression during cholestasis in rats and nonhuman primates. Hepatology 17: 854-860, 1993.
-
(1993)
Hepatology
, vol.17
, pp. 854-860
-
-
Schrenk, D.1
Gant, T.W.2
Silverman, J.A.3
Preisegger, K.H.4
Marino, P.A.5
Thorgeirsson, S.S.6
-
36
-
-
0030939088
-
Hepatic canalicular membrane 4: Expression of the multidrug resistance genes in the liver
-
Silverman, J. A., and D. Schrenk. Hepatic canalicular membrane 4: expression of the multidrug resistance genes in the liver. FASEB J. 11: 308-313, 1997.
-
(1997)
FASEB J.
, vol.11
, pp. 308-313
-
-
Silverman, J.A.1
Schrenk, D.2
-
37
-
-
0030861704
-
Aryl hydrocarbon receptor-dependent induction of cyp1a1 by bilirubin in mouse hepatoma hepa1c1c7 cells
-
Sinai, C. J., and J. R. Bend. Aryl hydrocarbon receptor-dependent induction of cyp1a1 by bilirubin in mouse hepatoma hepa1c1c7 cells. Mol. Pharmacol. 52: 590-599, 1997.
-
(1997)
Mol. Pharmacol.
, vol.52
, pp. 590-599
-
-
Sinai, C.J.1
Bend, J.R.2
-
38
-
-
0032434272
-
Excretion of GSSG and gluthathione conjugates mediated by MRP1 and cMOAT/MRP2
-
Suzuki, H., and Y. Sugiyama. Excretion of GSSG and gluthathione conjugates mediated by MRP1 and cMOAT/MRP2. Semin. Liver Dis. 18: 359-376, 1998.
-
(1998)
Semin. Liver Dis.
, vol.18
, pp. 359-376
-
-
Suzuki, H.1
Sugiyama, Y.2
-
39
-
-
0030963906
-
The rat canalicular conjugate export pump (MRP2) is down-regulated in intrahepatic and obstructive cholestasis
-
Trauner, M., M. Arrese, C. J. Soroka, M. Ananthanarayanan, T. A. Koeppel, S. F. Schlosser, F. J. Suchy, D. Keppler, and J. L. Boyer. The rat canalicular conjugate export pump (MRP2) is down-regulated in intrahepatic and obstructive cholestasis. Gastroenterology 113: 255-264, 1997.
-
(1997)
Gastroenterology
, vol.113
, pp. 255-264
-
-
Trauner, M.1
Arrese, M.2
Soroka, C.J.3
Ananthanarayanan, M.4
Koeppel, T.A.5
Schlosser, S.F.6
Suchy, F.J.7
Keppler, D.8
Boyer, J.L.9
-
40
-
-
0032524012
-
Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors
-
Trauner, M., M. Arrese, H. Lee, J. L. Boyer, and S. J. Karpen. Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors. J. Clin. Invest. 101: 2092-2100, 1998.
-
(1998)
J. Clin. Invest.
, vol.101
, pp. 2092-2100
-
-
Trauner, M.1
Arrese, M.2
Lee, H.3
Boyer, J.L.4
Karpen, S.J.5
-
41
-
-
0031738416
-
Up-regulation of the multidrug resistance genes, Mrp1 and Mdr1b, and down-regulation of the organic anion transporter, Mrp2, and the bile salt transporter, spgp, in endotoxemic rat liver
-
Vos, T. A., G. J. E. J. Hooiveld, H. Koning, S. Childs, D. K. F. Meijer, H. Moshage, P. L. M. Jansen, and M. Müller. Up-regulation of the multidrug resistance genes, Mrp1 and Mdr1b, and down-regulation of the organic anion transporter, Mrp2, and the bile salt transporter, spgp, in endotoxemic rat liver. Hepatology 28: 1637-1644, 1998.
-
(1998)
Hepatology
, vol.28
, pp. 1637-1644
-
-
Vos, T.A.1
Hooiveld, G.J.E.J.2
Koning, H.3
Childs, S.4
Meijer, D.K.F.5
Moshage, H.6
Jansen, P.L.M.7
Müller, M.8
-
42
-
-
0029926676
-
Recent advances in carrier-mediated hepatic uptake and biliary excretion of xenobiotics
-
Yamazaki, M., H. Suzuki, and Y. Sugiyama. Recent advances in carrier-mediated hepatic uptake and biliary excretion of xenobiotics. Pharm. Res. 13: 497-513, 1996.
-
(1996)
Pharm. Res.
, vol.13
, pp. 497-513
-
-
Yamazaki, M.1
Suzuki, H.2
Sugiyama, Y.3
|