High Doses of Ursodeoxycholic Acid Up-Regulate the Expression of Placental Breast Cancer Resistance Protein in Patients Affected by Intrahepatic Cholestasis of Pregnancy

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Azzaroli, Francesco ^a   Raspanti, Maria Elena ^a   Simoni, Patrizia ^a   Montagnani, Marco ^a   Lisotti, Andrea ^a   Cecinato, Paolo ^a   Arena, Rosario ^a   Simonazzi, Giuliana ^a   Farina, Antonio ^a   Rizzo, Nicola ^a   Mazzella, Giuseppe ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; BREAST CANCER RESISTANCE PROTEIN; MESSENGER RNA; URSODEOXYCHOLIC ACID; ABC TRANSPORTER; ABCG2 PROTEIN, HUMAN; TUMOR PROTEIN;

ADULT; ARTICLE; BREAST CANCER RESISTANCE PROTEIN GENE; CHEMOLUMINESCENCE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; INTRAHEPATIC CHOLESTASIS; INTRAHEPATIC CHOLESTASIS OF PREGNANCY; PLACENTAL TRANSFER; PREGNANCY; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SYNCYTIOTROPHOBLAST; CASE CONTROL STUDY; DELIVERY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PLACENTA; PREGNANCY COMPLICATION; TROPHOBLAST;

ADULT; ATP-BINDING CASSETTE TRANSPORTERS; CASE-CONTROL STUDIES; CHOLESTASIS, INTRAHEPATIC; DELIVERY, OBSTETRIC; FEMALE; GENE EXPRESSION REGULATION; HUMANS; NEOPLASM PROTEINS; PLACENTA; PREGNANCY; PREGNANCY COMPLICATIONS; RNA, MESSENGER; TROPHOBLASTS; URSODEOXYCHOLIC ACID;

EID: 84878122161     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0064101     Document Type: Article

References (27)

1. Lammert F, Marschall HU, Glantz A, Matern S, (2000) Intrahepatic cholestasis of pregnancy: molecular pathogenesis, diagnosis and management. J Hepatol 33: 1012-1021.
2. Ropponen A, Sund R, Riikonen S, Ylikorkala O, Aittomäki K, (2006) Intrahepatic cholestasis of pregnancy as an indicator of liver and biliary diseases: a population-based study. Hepatology 43: 723-728.
3. Geenes V, Williamson C, (2009) Intrahepatic cholestasis of pregnancy. World J Gastroenterol 15: 2049-2066.
4. Mazzella G, Rizzo N, Azzaroli F, Simoni P, Bovicelli L, et al. (2001) Ursodeoxycholic acid administration in patients with cholestasis of pregnancy: effects on primary bile acids in babies and mothers. Hepatology 33: 504-508.
5. Meng LJ, Reyes H, Palma J, Hernandez I, Ribalta J, et al. (1997) Profiles of bile acids and progesterone metabolites in the urine and serum of women with intrahepatic cholestasis of pregnancy. J Hepatol 27: 346-357.
6. Altshuler G, Arizawa M, Molnar-Nadasdy G, (1992) Meconium-induced umbilical cord vascular necrosis and ulceration: a potential link between the placenta and poor pregnancy outcome. Obstet Gynecol 79: 760-766.
7. Sepulveda WH, Gonzalez C, Cruz MA, Rudolph MI, (1991) Vasoconstrictive effect of bile acids on isolated human placental chorionic veins. Eur J Obstet Gynecol Reprod Biol 42: 211-215.
8. Monte MJ, Morales AI, Arevalo M, Alvaro I, Macias RI, et al. (1996) Reversible impairment of neonatal hepatobiliary function by maternal cholestasis. Hepatology 23: 1208-1217.
9. Germain AM, Kato S, Carvajal JA, Valenzuela GJ, Valdes GL, et al. (2003) Bile acids increase response and expression of human myometrial oxytocin receptor. Am J Obstet Gynecol 189: 577-582.
10. Marin JJ, Macias RI, Serrano MA, (2003) The hepatobiliary-like excretory function of the placenta. A review. Placenta 24: 431-438.
11. Janvilisri T, Shahi S, Venter H, Balakrishnan L, van Veen HW, (2005) Arginine-482 is not essential for transport of antibiotics, primary bile acids and unconjugated sterols by the human breast cancer resistance protein (ABCG2). Biochem J 385: 419-426.
12. Grube M, Schwabedissen HM, Draber K, Prager D, Moritz KU, et al. (2005) Expression, localization, and function of the carnitine transporter octn2 (slc22a5) in human placenta. Drug Metab Dispos 33: 31-37.
13. Bowers GN Jr, McComb RB, (1966) A continuous spectrophotometric method for measuring the activity of serum alkaline phosphatase. Clin Chem 12: 70-89.
14. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ, (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275.
15. Serrano MA, Brites D, Larena MG, Monte MJ, Bravo MP, et al. (1998) Beneficial effect of ursodeoxycholic acid on alterations induced by cholestasis of pregnancy in bile acid transport across the human placenta. J Hepatol 28: 829-839.
16. Azzaroli F, Mennone A, Feletti V, Simoni P, Baglivo E, et al. (2007) Clinical trial: modulation of human placental multidrug resistance proteins in cholestasis of pregnancy by ursodeoxycholic acid. Aliment Pharmacol Ther 26: 1139-1146.
17. Akita H, Suzuki H, Ito K, Kinoshita S, Sato N, et al. (2001) Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump. Biochim Biophys Acta 1511: 7-16.
18. Jedlitschky G, Leier I, Buchholz U, Hummel-Eisenbeiss J, Burchell B, et al. (1997) ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2. Biochem J 327 (Pt 1): 305-310.
19. Kumkate S, Chunchob S, Janvilisri T, (2008) Expression of ATP-binding cassette multidrug transporters in the giant liver fluke Fasciola gigantica and their possible involvement in the transport of bile salts and anthelmintics. Mol Cell Biochem 317: 77-84.
20. Imai Y, Asada S, Tsukahara S, Ishikawa E, Tsuruo T, et al. (2003) Breast cancer resistance protein exports sulfated estrogens but not free estrogens. Mol Pharmacol 64: 610-618.
21. Vaidya SS, Gerk PM, (2006) Lack of interaction between tauroursodeoxycholate and ATP-binding cassette transporter isoform G2 (ABCG2). Mol Pharm 3: 303-306.
22. Blazquez AM, Briz O, Romero MR, Rosales R, Monte MJ, et al. (2011) Characterization of the Role of ABCG2 as a Bile Acid Transporter in Liver and Placenta. Mol Pharmacol.
23. Mennone A, Soroka CJ, Harry KM, Boyer JL, (2010) Role of breast cancer resistance protein in the adaptive response to cholestasis. Drug Metab Dispos 38: 1673-1678.
24. Blazquez AG, Briz O, Romero MR, Rosales R, Monte MJ, et al. (2012) Characterization of the role of ABCG2 as a bile acid transporter in liver and placenta. Mol Pharmacol 81: 273-283.
25. Hahnova-Cygalova L, Ceckova M, Staud F, (2011) Fetoprotective activity of breast cancer resistance protein (BCRP, ABCG2): expression and function throughout pregnancy. Drug Metab Rev 43: 53-68.
26. Mao Q, (2008) BCRP/ABCG2 in the placenta: expression, function and regulation. Pharm Res 25: 1244-1255.
27. Geenes VL, Dixon PH, Chambers J, Raguz S, Marin JJ, et al. (2011) Characterisation of the nuclear receptors FXR, PXR and CAR in normal and cholestatic placenta. Placenta 32: 535-537.