Effect of pregnancy on cytochrome P450 3a and P-glycoprotein expression and activity in the mouse: Mechanisms, tissue specificity, and time course

Molecular Pharmacology

Volumn 74, Issue 3, 2008, Pages 714-723

  Zhang, Huixia ^a   Wu, Xiaohui ^a   Wang, Honggang ^a   Mikheev, Andrei M ^a   Mao, Qingcheng ^a   Unadkat, Jashvant D ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

11ALPHA HYDROXYPROGESTERONE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CYTOCHROME P450 3A; ESTROGEN RECEPTOR ALPHA; GLYCOPROTEIN P; HEPATOCYTE NUCLEAR FACTOR 6; NELFINAVIR; PROTEINASE INHIBITOR; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG BLOOD LEVEL; MOUSE; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; TISSUE SPECIFICITY; TRANSGENIC MOUSE;

ANIMALS; CYTOCHROME P-450 CYP3A; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GESTATIONAL AGE; HUMANS; INTESTINES; LIVER; MICE; MICE, TRANSGENIC; ORGAN SPECIFICITY; P-GLYCOPROTEIN; PREGNANCY; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; TIME FACTORS; TRANSCRIPTION FACTORS;

EID: 50449088026     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.107.043851     Document Type: Article

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