cAMP efflux from human trophoblast cell lines: A role for multidrug resistance protein (MRP)1 transporter

Molecular Human Reproduction

Volumn 16, Issue 7, 2010, Pages 481-491

  Biondi, C ^a   Ferretti, M E ^a   Lunghi, L ^a   Medici, S ^a   Cervellati, F ^a   Pavan, B ^a   Vesce, F ^a   Morano, D ^a   Adinolfi, E ^a   Bertoni, F ^a   Abelli, L ^a  

^a UNIVERSITY OF FERRARA   (Italy)

Author keywords

Adenosine; cAMP efflux; Human trophoblast; MRP1

Indexed keywords

ABC TRANSPORTER; ADENOSINE RECEPTOR; CYCLIC AMP; ESTRONE; INTERLEUKIN 1BETA; MULTIDRUG RESISTANCE PROTEIN 1; NUCLEOTIDE; VERLUKAST; FORSKOLIN; GLYCOPROTEIN P; PROBENECID; PROGESTERONE; PROPIONIC ACID DERIVATIVE; QUINOLINE DERIVATIVE;

ARTICLE; CELL LINE; CONTROLLED STUDY; EXPLANT; GENE EXPRESSION; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN TISSUE; PLACENTA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN TRANSPORT; TROPHOBLAST; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; IN VITRO STUDY; METABOLISM; PREGNANCY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE;

CELL LINE, TUMOR; CELLS, CULTURED; CYCLIC AMP; ESTRONE; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; FORSKOLIN; HUMANS; INTERLEUKIN-1BETA; P-GLYCOPROTEIN; PLACENTA; PREGNANCY; PROBENECID; PROGESTERONE; PROPIONATES; QUINOLINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TROPHOBLASTS;

EID: 77954157481     PISSN: 13609947     EISSN: 14602407     Source Type: Journal    
DOI: 10.1093/molehr/gaq023     Document Type: Article

References (42)

1. Ahlström M, Lamberg-Allardt C. Regulation of adenosine 3′,5′-cyclic monophosphate (cAMP) accumulation in UMR-106 osteoblast-like cells: role of cAMP-phosphodiesterase and cAMP efflux. Biochem Pharmacol 1999;58:1335-1340.
2. Alcorn J, Lu X, Moscow JA, Mc Namara PJ. Transporter gene expression in lactating and nonlactating human mammary epithelial cells using real-time reverse transcription-polymerase chain reaction. J Pharmacol Exp Ther 2002;303:487-496.
3. Apps R, Murphy SP, Fernando R, Gardner L, Ahad T, Moffett A. Human leucocyte antigen (HLA) expression of primary trophoblast cells and placental cell lines, determined using single antigen beads to characterize allotype specificities of anti-HLA antibodies. Immunology 2009;127:26-39.
4. Bernatchez B, Bekacemi L, Rassart E, Daoud G, Simoneau L, Lafond J. Differential expression of membrane and soluble adenylyl ciclase isoforms in cytotrophoblast cells and syncytiotrophoblasts of human placenta. Placenta 2003;24:648-657.
5. Biondi C, Ferretti ME, Pavan B, Lunghi L, Gravina B, Nicoloso MS, Vesce F, Baldassarre G. Prostaglandin E2 inhibits proliferation and migration of HTR-8/SVneo cells, a human trophoblast-derived cell line. Placenta 2006;27:592-601.
6. Biondi C, Ferretti ME, Lunghi L, Medici S, Cervellati F, Abelli L, Bertoni F, Adinolfi E, Vesce F, Bartolini G et al. Somatostatin as a regulator of first trimester human trophoblast functions. Placenta 2008;29:660-670.
7. Brown BL, Ekins RP, Albano JDM. Saturation assay for cyclic AMP using endogenous binding protein. Adv Cyclic Nucleotide Res 1972;2:25-40.
8. Chiavegatti T, Costa WL Jr, Araujo MS, Godinho RO. Skeletal muscle expresses the extracellular cyclic AMP-adenosine pathway. Br J Pharmacol 2008;153:1331-1340.
9. Cometti B, Dubey RK, Imthurn B, Jackson EK, Rosselli M. Oviduct cells express the cyclic AMP-adenosine pathway. Biol Reprod 2003;69:868-875.
10. 2b adenosine receptor mediates human chorionic vasoconstriction and signals through arachidonic acid cascade. Am J Physiol Heart Circ Physiol 2005;288:H2439-H2449.
11. Dubey RK, Mi Z, Gillespie DG, Jackson EK. Cyclic AMP-adenosine pathway inhibits vascular smooth muscle cell growth. Hypertension 1996;28:765-771.
12. Dubey RK, Gillespie DG, Mi Z, Jackson EK. Cardiac fibroblasts express the cAMP-adenosine pathway. Hypertension 2000;36:337-342.
13. Evseenko DA, Paxton JW, Keelan JA. ABC drug transporter expression and functional activity in trophoblast-like cell lines and differentiating primary trophoblast. Am J Physiol Regul Integr Comp Physiol 2006; 290:R1357-R1365.
14. Evseenko DA, Paxton JW, Keelan JA. Independent regulation of apical and basolateral drug transporter expression and function in placental trophoblasts by cytokines, steroids, and growth factors. Drug Metab Dispos 2007;35:595-601.
15. Florio C, Frausin F, Vertua R, Gaion RM. Involvement of P1 receptors in the effects of forskolin on cyclic AMP accumulation and export in PC12 cells. Biochem Pharmacol 1999;57:355-364.
16. Godinho RO, Costa VL. Regulation of intracellular cyclic AMP in skeletal muscle cells involves the efflux of cyclic nucleotide to the extracellular compartment. Br J Pharmacol 2003;138:995-1003.
17. Grealy M, Sreenan JM. Effect of adenylyl cyclase activation on intracellular and extracellular cAMP and cGMP in preimplantation cattle blastocysts. J Reprod Fertil 1999;116:355-361.
18. Higuchi T, Fujiwara H, Egawa H, Sato Y, Yoshioka S, Tatsumi K, Itoh K, Maeda M, Fujita J, Fujii S. Cyclic AMP enhances the expression of an extravillous trophoblast marker, melanoma cell adhesion molecule, in choriocarcinoma cell JEG3 and human chorionic villous explant cultures. Mol Hum Reprod 2003;9:359-366.
19. Hofer AM, Lefkimmiatis K. Extracellular calcium and cAMP: second messengers as 'third messengers'? Physiology (Bethesda) 2007;22:320-327.
20. Jackson EK, Dubey RK. Role of the extracellular cAMP-adenosine pathway in renal physiology. Am J Physiol Renal Physiol 2001;281: F597-F612.
21. Jackson EK, Raghvendra DK. The extracellular cyclic AMP-adenosine pathway in renal physiology. Annu Rev Physiol 2004;66:571-599.
22. Keating E, Gonçalves P, Lemos C, Costa F, Campos I, Smith SB, Bridges CC, Martel F. Progesterone inhibits folic acid transport in human trophoblasts. J Membr Biol 2007;216:143-152.
23. Kudo Y, Boyd AR, Sargent IL, Redman WG, Lee JM, Freeman TC. An analysis using DNA microarray of the time course of gene expression during syncytialization of a human placental cell line (BeWo). Placenta 2004;25:479-488.
24. Lee S, Comer FI, Sasaki A, McLeod IX, Duong Y, Okumura K, Yates JR 3rd, Parent CA, Firtel RA. TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium. Mol Biol Cell 2005; 16:4572-4583.
25. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:165-175.
26. McKinnon T, Chakraborty C, Gleeson LM, Chidiac P, Lala PK. Stimulation of human extravillous trophoblast migration by IGF-II is mediated by IGF type 2 receptor involving inhibitory G protein(s) and phosphorylation of MAPK. J Clin Endocrinol Metab 2001;86:3665-3674.
27. Meyer zu Schwabedissen HE, Grube M, Heydrich B, Linnemann K, Fusch C, Kroemer HK, Jedlitschky G. Expression, localization, and function of MRP5 (ABCC5), a transporter for cyclic nucleotides, in human placenta and cultured human trophoblasts: effects of gestational age and cellular differentiation. Am J Pathol 2005;166:39-48.
28. Nagashige M, Ushigome F, Koyabu N, Hirata K, Kawabuchi M, Hirakawa T, Satoh S, Tsukimori K, Nakano H, Uchiumi T et al. Basal membrane localization of MRP1 in human placental trophoblast. Placenta 2003; 24:951-958.
29. Olson DP, Taylor BJ, Ivy SP. Detection of MRP functional activity: calcein AM but not BCECF AM as a Multidrug Resistance-related Protein (MRP1) substrate. Cytometry 2001;46:105-113.
30. Parry S, Zhang J. Multidrug resistance proteins affect drug transmission across the placenta. Am J Obstet Gynecol 2007;196:476.e1-e6.
31. Pattyn F, Hoebeeck J, Robbrecht P, Michels E, De Paepe A, Bottu G, Coornaert D, Herzog R, Speleman F, Vandesompele J. methBLAST and methPrimerDB: web-tools for PCR based methylation analysis. BMC Bioinform 2006;7:496-504.
32. Phelps PT, Anthes JC, Correll CC. Characterization of adenosine receptors in the human bladder carcinoma T24 cell line. Eur J Pharmacol 2006;536:28-37.
33. Qu J, Thomas K. Prostaglandins stimulate the secretion of inhibin from human placental cells. J Clin Endocrinol Metab 1993;77:556-564.
34. Sawai K, Azuma C, Koyama M, Hashimoto K, Kimura T, Samejima Nobunaga T, Takemura M, Saji F. The novel role of 3′,5′-guanosine monophosphate (cGMP) on differentiation of trophoblasts: comparison with the effects of 3′,5′-adenosine monophosphate (cAMP). Early Pregnancy 1996;2:244-252.
35. Schinkel AH, Jonker JV. Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview. Adv Drug Deliv Rev 2003; 55:3-29.
36. Selvey S, Thompson EW, Matthaei K, Lea RA, Irving MG, Griffiths LR. Beta-actin-an unsuitable internal control for RT-PCR. Mol Cell Probes 2001;15:307-311.
37. Sorbera LA, Morad M. Modulation of cardiac sodium channels by cAMP receptors on the myocyte surface. Science 1991;253:1286-1289.
38. St-Pierre MV, Serrano MA, Macias RI, Dubs U, Hoechli M, Lauper U, Meier PJ, Marin JJ. Expression of members of the multidrug resistance protein family in human term placenta. Am J Physiol Regul Integr Comp Physiol 2000;279:R1495-R1503.
39. Ueda K, Okamura N, Hirai M, Tanigawara Y, Saeki T, Kioka N, Komano T, Hori R. Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone. J Biol Chem 1992; 267:24248-24252.
40. Wielinga PR, van der Heijden I, Reid G, Beijnen JH, Wijnholds J, Borst P. Characterization of the MRP4-and MRP5-mediated transport of cyclic nucleotides from intact cells. J Biol Chem 2003;278:17664-17671.
41. Wu PH, Phillis JW, Nye MJ. Alkylxanthines as adenosine receptor antagonists and membrane phosphodiesterase inhibitors in central nervous tissue: evaluation of structure-activity relationships. Life Sci 1982;31:2857-2867.
42. Zygmunt M, Hahn D, Munstedt K, Bischof P, Lang U. Invasion of cytotrophoblastic JEG-3 cells is stimulated by hCG in vitro. Placenta 1998;19:587-593.