The multidrug-resistance transporter abcb5 is expressed in human placenta

International Journal of Gynecological Pathology

Volumn 33, Issue 1, 2014, Pages 45-51

  Volpicelli, Elgida R ^a   Lezcano, Cecilia ^a   Zhan, Qian ^a   Girouard, Sasha D ^b   Kindelberger, David W ^a   Frank, Markus H ^b   Frank, Natasha Y ^a   Crum, Christopher P ^a   Murphy, George F ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b Division of Genetics   (United States)

Author keywords

ABCB5; Cytotrophoblast; MDR transporter; Stem cell; Syncytiotrophoblast; Trophoblast

Indexed keywords

ABC TRANSPORTER; ABCB5 PROTEIN; UNCLASSIFIED DRUG;

ANTIBODY SPECIFICITY; ARTICLE; CANCER CELL; CELL FUNCTION; CHORIOCARCINOMA; CONTROLLED STUDY; CYTOTROPHOBLAST; FIRST TRIMESTER PREGNANCY; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; PLACENTA; PLACENTA DEVELOPMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA PROBE; SECOND TRIMESTER PREGNANCY; SYNCYTIOTROPHOBLAST; THIRD TRIMESTER PREGNANCY; TROPHOBLAST; TROPHOBLASTIC TUMOR;

CHORIOCARCINOMA; FEMALE; HUMANS; HYDATIDIFORM MOLE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; P-GLYCOPROTEIN; PLACENTA; PREGNANCY; TROPHOBLASTIC NEOPLASMS; TROPHOBLASTS; UTERINE NEOPLASMS;

EID: 84890428344     PISSN: 02771691     EISSN: 15387151     Source Type: Journal    
DOI: 10.1097/PGP.0b013e31829c677f     Document Type: Article

References (23)

1. Zhou Y, Fisher SJ, Janatpour M, et al. Human cytotrophoblasts adopt a vascular phenotype as they differentiate. A strategy for successful endovascular invasion? J Clin Invest 1997;99:2139-51.
2. Janatpour MJ, Utset MF, Cross JC, et al. A repertoire of differentially expressed transcription factors that offers insight into mechanisms of human cytotrophoblast differentiation. Dev Genet 1999;25:146-57.
3. Whitley GS, Cartwright JE. Cellular and molecular regulation of spiral artery remodelling: lessons from the cardiovascular field. Placenta 2010;31:465-74.
4. Ceckova-Novotna M, Pavek P, Staud F. P-glycoprotein in the placenta: expression, localization, regulation and function. Reprod Toxicol 2006;22:400-10.
5. Evseenko D, Paxton JW, Keelan JA. Active transport across the human placenta: impact on drug efficacy and toxicity. Expert Opin Drug Metab Toxicol 2006;2:51-69.
6. Mao Q. BCRP/ABCG2 in the placenta: expression, function and regulation. Pharm Res 2008;25:1244-55.
7. Vahakangas K, Myllynen P. Drug transporters in the human blood-placental barrier. Br J Pharmacol 2009;158:665-78.
8. Ni Z, Mao Q. ATP-binding cassette efflux transporters in human placenta. Curr Pharm Biotechnol 2011;12:674-85.
9. Meyer Zu Schwabedissen HE, Grube M, Heydrich B, et al. Expression, localization, and function of MRP5 (ABCC5), a transporter for cyclic nucleotides, in human placenta and cultured human trophoblasts: effects of gestational age and cellular differentiation. Am J Pathol 2005;166:39-48.
10. Sun M, Kingdom J, Baczyk D, et al. Expression of the multidrug resistance P-glycoprotein, (ABCB1 glycoprotein) in the human placenta decreases with advancing gestation. Placenta 2006;27:602-9.
11. Mathias AA, Hitti J, Unadkat JD. P-glycoprotein and breast cancer resistance protein expression in human placentae of various gestational ages. Am J Physiol Regul Integr Comp Physiol 2005;289:R963-9.
12. Meyer zu Schwabedissen HE, Grube M, Dreisbach A, et al. Epidermal growth factor-mediated activation of the map kinase cascade results in altered expression and function of ABCG2 (BCRP). Drug Metab Dispos 2006;34:524-33.
13. Frank NY, Pendse SS, Lapchak PH, et al. Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter. J Biol Chem 2003; 278:47156-65.
14. Schatton T, Murphy GF, Frank NY, et al. Identification of cells initiating human melanomas. Nature 2008;451:345-9.
15. Frank NY, Schatton T, Kim S, et al. VEGFR-1 expressed by malignant melanoma-initiating cells is required for tumor growth. Cancer Res 2011;71:1474-85.
16. Frank NY, Margaryan A, Huang Y, et al. ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma. Cancer Res 2005;65:4320-33.
17. Wright GJ, Jones M, Puklavec MJ, et al. The unusual distribution of the neuronal/lymphoid cell surface CD200 (OX2) glycoprotein is conserved in humans. Immunology 2001;102:173-9.
18. Schatton T, Schutte U, Frank NY, et al. Modulation of T-cell activation by malignant melanoma initiating cells. Cancer Res 2010;70:697-708.
19. Girouard SD, Murphy GF. Melanoma stem cells: not rare, but well done. Lab Invest 2011;91:647-64.
20. Roberts RM, Fisher SJ. Trophoblast stem cells. Biol Reprod 2011;84:412-21.
21. Pfarrer CD, Ruziwa SD, Winther H, et al. Localization of vascular endothelial growth factor (VEGF) and its receptors VEGFR-1 and VEGFR-2 in bovine placentomes from implantation until term. Placenta 2006;27:889-98.
22. Abumaree MH, Al Jumah MA, Kalionis B, et al. Phenotypic and functional characterization of mesenchymal stem cells from chorionic villi of human term placenta. Stem Cell Rev 2013;9:16-31.
23. Wilson BJ, Schatton T, Zhan Q, et al. ABCB5 identifies a therapy-refractory tumor cell population in colorectal cancer patients. Cancer Res 2011;71:5307-16.