Positron emission tomography imaging of tissue P-glycoprotein activity during pregnancy in the non-human primate

British Journal of Pharmacology

Volumn 159, Issue 2, 2010, Pages 394-404

  Chung, F S ^a,c   Eyal, S ^a   Muzi, M ^a   Link, J M ^a   Mankoff, D A ^a   Kaddoumi, A ^a,d   O'Sullivan, F ^b   Hsiao, P ^a   Unadkat, Jashvant D ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY COLLEGE CORK   (Ireland)

^c UNIVERSITY OF THE PHILIPPINES MANILA   (Philippines)

^d UNIVERSITY OF LOUISIANA AT MONROE   (United States)

Author keywords

11C verapamil; ABCB1 (MDR1, P glycoprotein); Blood brain barrier; Non human primates; Pregnancy

Indexed keywords

CARBON MONOXIDE C 11; CYCLOSPORIN A; GLYCOPROTEIN P; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG; VERAPAMIL C 11; WATER O 15;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG BLOOD LEVEL; DRUG METABOLISM; DRUG TRANSPORT; FEMALE; FETUS LIVER; ISOTOPE LABELING; MACACA; MATERNAL SERUM; NONHUMAN; PLACENTA; POSITRON EMISSION TOMOGRAPHY; PREGNANCY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RADIOISOTOPE DISTRIBUTION; TISSUE DISTRIBUTION;

ANIMALS; BLOOD-BRAIN BARRIER; CYCLOSPORINE; FEMALE; GESTATIONAL AGE; MACACA NEMESTRINA; MATERNAL-FETAL EXCHANGE; ORGAN SPECIFICITY; P-GLYCOPROTEIN; PLACENTA; POSITRON-EMISSION TOMOGRAPHY; PREGNANCY; PREGNANCY, ANIMAL; RADIOPHARMACEUTICALS; VERAPAMIL;

EID: 75649083751     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00538.x     Document Type: Article

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