Influence of adenosine triphosphate and ABCB1 (MDR1) genotype on the P-glycoprotein-dependent transfer of saquinavir in the dually perfused human placenta

Human and Experimental Toxicology

Volumn 27, Issue 1, 2008, Pages 65-71

  Rahi, Melissa ^a   Heikkinen, T ^a   Hakkola, J ^b   Hakala, K ^a   Wallerman, O ^c   Wadelius, M ^d   Wadelius, C ^c   Laine, K ^a,e  

^a UNIVERSITY OF TURKU   (Finland)

^b UNIVERSITY OF OULU   (Finland)

^c UPPSALA UNIVERSITY   (Sweden)

^d UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^e TURKU UNIVERSITY HOSPITAL   (Finland)

Author keywords

ABCB1 genotype; Adenosine triphosphate; P glycoprotein; Placenta; Saquinavir

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN 1; SAQUINAVIR;

ALLELE; ARTICLE; BLOOD PLACENTA BARRIER; CORRELATION ANALYSIS; DNA POLYMORPHISM; DOSE RESPONSE; DRUG ABSORPTION; DRUG TRANSPORT; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN TISSUE; PLACENTA PERFUSION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; WILD TYPE;

ADENOSINE TRIPHOSPHATE; ADULT; ALLELES; ANTI-HIV AGENTS; AREA UNDER CURVE; BLOOD GAS ANALYSIS; BLOTTING, WESTERN; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENOTYPE; HALF-LIFE; HUMANS; P-GLYCOPROTEIN; PLACENTA; POLYMORPHISM, SINGLE NUCLEOTIDE; PREGNANCY; SAQUINAVIR;

EID: 44849131506     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1177/0960327108088971     Document Type: Article

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