Pharmacological characterization of the peripheral FAAH inhibitor URB937 in female rodents: Interaction with the Abcg2 transporter in the blood-placenta barrier

British Journal of Pharmacology

Volumn 167, Issue 8, 2012, Pages 1620-1628

  Moreno Sanz, G ^a,b   Sasso, O ^b   Guijarro, A ^a   Oluyemi, O ^a   Bertorelli, R ^b   Reggiani, A ^b   Piomelli, D ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

Author keywords

Abcg2; blood placental barrier; fatty acid amide hydrolase; female; pain; URB937

Indexed keywords

ANANDAMIDE; BREAST CANCER RESISTANCE PROTEIN; CARRAGEENAN; CYCLOHEXYLCARBAMIC ACID 3' CARBAMOYL 6 HYDROXYBIPHENYL 3 YL ESTER; FATTY ACID AMIDASE; FATTY ACID AMIDASE INHIBITOR; INDOMETACIN; MESSENGER RNA; PALMIDROL; UNCLASSIFIED DRUG; URB 937;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; BLOOD PLACENTA BARRIER; CONTROLLED STUDY; DRUG DISPOSITION; DRUG DISTRIBUTION; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; HYPERALGESIA; INFLAMMATORY PAIN; MALE; MOUSE; NONHUMAN; PAW EDEMA; PRIORITY JOURNAL; RAT; RNA EXTRACTION; RODENT; TISSUE DISTRIBUTION; VISCERAL PAIN; WRITHING TEST;

ACETIC ACID; AMIDOHYDROLASES; ANALGESICS; ANIMALS; ARACHIDONIC ACIDS; ATP-BINDING CASSETTE TRANSPORTERS; CANNABINOIDS; CARRAGEENAN; ENDOCANNABINOIDS; ENZYME INHIBITORS; FEMALE; GENE EXPRESSION REGULATION; INFLAMMATION; MALE; MICE; MICE, INBRED C57BL; PAIN; PLACENTA; POLYUNSATURATED ALKAMIDES; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; SEX CHARACTERISTICS; TISSUE DISTRIBUTION;

EID: 84870556440     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2012.02098.x     Document Type: Article

References (34)

1. Allikmets R, Schriml LM, Hutchinson A, Romano-Spica V, Dean M, (1998). A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance. Cancer Res 58: 5337-5339.
2. Astarita G, Ahmed F, Piomelli D, (2008). Identification of biosynthetic precursors for the endocannabinoid anandamide in the rat brain. J Lipid Res 49: 48-57.
3. Cadas H, di Tomaso E, Piomelli D, (1997). Occurrence and biosynthesis of endogenous cannabinoid precursor, N-arachidonoyl phosphatidylethanolamine, in rat brain. J Neurosci 17: 1226-1242.
4. Calignano A, La Rana G, Giuffrida A, Piomelli D, (1998). Control of pain initiation by endogenous cannabinoids. Nature 394: 277-281.
5. Clapper JR, Moreno-Sanz G, Russo R, Guijarro A, Vacondio F, Duranti A, et al,. (2010). Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism. Nat Neurosci 13: 1265-1270.
6. Cole S, Bagal S, El-Kattan A, Fenner K, Hay T, Kempshall S, et al,. (2012). Full efficacy with no CNS side-effects: unachievable panacea or reality? DMPK considerations in design of drugs with limited brain penetration. Xenobiotica 42: 11-27.
7. Craft RM, Leitl MD, (2008). Gonadal hormone modulation of the behavioral effects of delta9-tetrahydrocannabinol in male and female rats. Eur J Pharmacol 578: 37-42.
8. Cravatt BF, Giang DK, Mayfield SP, Boger DL, Lerner RA, Gilula NB, (1996). Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature 384: 83-87.
9. Doyle LA, Yang W, Abruzzo LV, Krogmann T, Gao Y, Rishi AK, et al,. (1998). A multidrug resistance transporter from human MCF-7 breast cancer cells. Proc Natl Acad Sci USA 95: 15665-15670.
10. Duval P, Lenoir V, Moussaoui S, Garret C, Kerdelhue B, (1996). Substance P and neurokinin A variations throughout the rat estrous cycle; comparison with ovariectomized and male rats: II. Trigeminal nucleus and cervical spinal cord. J Neurosci Res 45: 610-616.
11. Fattore L, Fratta W, (2010). How important are sex differences in cannabinoid action? Br J Pharmacol 160: 544-548.
12. Gonzalez S, Bisogno T, Wenger T, Manzanares J, Milone A, Berrendero F, et al,. (2000). Sex steroid influence on cannabinoid CB(1) receptor mRNA and endocannabinoid levels in the anterior pituitary gland. Biochem Biophys Res Commun 270: 260-266.
13. Habayeb OM, Taylor AH, Bell SC, Taylor DJ, Konje JC, (2008). Expression of the endocannabinoid system in human first trimester placenta and its role in trophoblast proliferation. Endocrinology 149: 5052-5060.
14. Hahnova-Cygalova L, Ceckova M, Staud F, (2011). Fetoprotective activity of breast cancer resistance protein (BCRP, ABCG2): expression and function throughout pregnancy. Drug Metab Rev 43: 53-68.
15. Hargreaves K, Dubner R, Brown F, Flores C, Joris J, (1988). A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 32: 77-88.
16. Helliwell RJ, Chamley LW, Blake-Palmer K, Mitchell MD, Wu J, Kearn CS, et al,. (2004). Characterization of the endocannabinoid system in early human pregnancy. J Clin Endocrinol Metab 89: 5168-5174.
17. Kilkenny C, Browne W, Cuthill IC, Emerson M, Altman DG, (2010). NC3Rs Reporting Guidelines Working Group. Br J Pharmacol 160: 1577-1579.
18. Loyd DR, Murphy AZ, (2009). The role of the periaqueductal gray in the modulation of pain in males and females: are the anatomy and physiology really that different? Neural Plast 2009: 462-879.
19. McGrath J, Drummond G, Kilkenny C, Wainwright C, (2010). Guidelines for reporting experiments involving animals: the ARRIVE guidelines. Br J Pharmacol 160: 1573-1576.
20. Maliepaard M, Scheffer GL, Faneyte IF, van Gastelen MA, Pijnenborg AC, Schinkel AH, et al,. (2001). Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues. Cancer Res 61: 3458-3464.
21. Mogil JS, Bailey AL, (2010). Sex and gender differences in pain and analgesia. Prog Brain Res 186: 141-157.
22. Moreno-Sanz G, Barrera B, Guijarro A, d'Elia I, Otero JA, Alvarez AI, et al,. (2011). The ABC membrane transporter ABCG2 prevents access of FAAH inhibitor URB937 to the central nervous system. Pharmacol Res 64: 359-363.
23. Myllynen P, Kummu M, Sieppi E, (2010). ABCB1 and ABCG2 expression in the placenta and fetus: an interspecies comparison. Expert Opin Drug Metab Toxicol 6: 1385-1398.
24. Richardson JD, Kilo S, Hargreaves KM, (1998). Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors. Pain 75: 111-119.
25. Rodriguez de Fonseca F, Cebeira M, Ramos JA, Martin M, Fernandez-Ruiz JJ, (1994). Cannabinoid receptors in rat brain areas: sexual differences, fluctuations during estrous cycle and changes after gonadectomy and sex steroid replacement. Life Sci 54: 159-170.
26. Sasso O, Bertorelli R, Bandiera T, Scarpelli R, Colombano G, Armirotti A, et al,. (2012). Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions. Pharmacol Res 65: 553-563.
27. Tanaka Y, Slitt AL, Leazer TM, Maher JM, Klaassen CD, (2005). Tissue distribution and hormonal regulation of the breast cancer resistance protein (Bcrp/Abcg2) in rats and mice. Biochem Biophys Res Commun 326: 181-187.
28. Tang SC, Lagas JS, Lankheet NA, Poller B, Hillebrand MJ, Rosing H, et al,. (2011). Brain accumulation of sunitinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration. Int J Cancer 130: 223-233.
29. Tseng AH, Craft RM, (2004). CB(1) receptor mediation of cannabinoid behavioral effects in male and female rats. Psychopharmacology (Berl) 172: 25-30.
30. Vlaming ML, Lagas JS, Schinkel AH, (2009). Physiological and pharmacological roles of ABCG2 (BCRP): recent findings in Abcg2 knockout mice. Adv Drug Deliv Rev 61: 14-25.
31. Walker JM, Hohmann AG, (2005). Cannabinoid mechanisms of pain suppression. Handb Exp Pharmacol 168: 509-554.
32. Wang H, Matsumoto H, Guo Y, Paria BC, Roberts RL, Dey SK, (2003). Differential G protein-coupled cannabinoid receptor signaling by anandamide directs blastocyst activation for implantation. Proc Natl Acad Sci USA 100: 14914-14919.
33. Warren MS, Zerangue N, Woodford K, Roberts LM, Tate EH, Feng B, et al,. (2009). Comparative gene expression profiles of ABC transporters in brain microvessel endothelial cells and brain in five species including human. Pharmacol Res 59: 404-413.
34. Yeboah D, Kalabis GM, Sun M, Ou RC, Matthews SG, Gibb W, (2008). Expression and localisation of breast cancer resistance protein (BCRP) in human fetal membranes and decidua and the influence of labour at term. Reprod Fertil Dev 20: 328-334.