Dominant-negative inhibition of breast cancer resistance protein as drug efflux pump through the inhibition of S-S dependent homodimerization

International Journal of Cancer

Volumn 97, Issue 5, 2002, Pages 626-630

  Kage, Kumie ^a   Tsukahara, Satomi ^a   Sugiyama, Tomomi ^a   Asada, Sakiyo ^a   Ishikawa, Etsuko ^a   Tsuruo, Takashi ^a,b   Sugimoto, Yoshikazu ^a  

^a CANCER CHEMOTHERAPY CENTER   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

ABC transporter; CPT 11; Drug resistance; Mitoxantrone; Retrovirus vector; SN 38

Indexed keywords

ABC TRANSPORTER; AMINO ACID; BREAST CANCER RESISTANCE PROTEIN; BREAST CANCER RESISTANCE PROTEIN ANTIBODY; CELL PROTEIN; COMPLEMENTARY DNA; GENE PRODUCT; LEUCINE; MEMBRANE PROTEIN; MERCAPTOETHANOL; MITOXANTRONE; ONCOPROTEIN; PROLINE; PROTEIN ANTIBODY; PROTEIN MYCBRCP; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN ANTIBODY REACTION; ARTICLE; BREAST CARCINOMA; CELL ISOLATION; CELL LYSATE; CONTROLLED STUDY; DIMERIZATION; DISEASE ASSOCIATION; DISSOCIATION; DISULFIDE BOND; DRUG RESISTANCE; GENETIC TRANSFECTION; IMMUNOPRECIPITATION; MUTAGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE MYC; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; REDUCTION; THERMOSTABILITY;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; CELL LINE; DIMERIZATION; DNA, COMPLEMENTARY; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FEMALE; GENES, DOMINANT; GENES, REPORTER; HUMANS; MACROMOLECULAR SUBSTANCES; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NEOPLASM PROTEINS; PRECIPITIN TESTS; RECOMBINANT FUSION PROTEINS; TRANSFECTION;

EID: 0037050736     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.10100     Document Type: Article

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