Expression and localisation of breast cancer resistance protein (BCRP) in human fetal membranes and decidua and the influence of labour at term

Reproduction, Fertility and Development

Volumn 20, Issue 2, 2008, Pages 328-334

  Yeboah, D ^a   Kalabis, G M ^b   Sun, M ^a   Ou, R C ^a   Matthews, S G ^b   Gibb, W ^a,c  

^a UNIVERSITY OF OTTAWA   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN;

AMNION; APICAL MEMBRANE; ARTICLE; BLOOD VESSEL; CELL MEMBRANE; CELLULAR DISTRIBUTION; CHORION; CONTROLLED STUDY; CYTOPLASM; DECIDUA; EPITHELIUM CELL; FEMALE; FETUS; FETUS MEMBRANE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; LABOR; MESENCHYME CELL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; STROMA CELL; TROPHOBLAST; VASCULAR ENDOTHELIUM;

ANALYSIS OF VARIANCE; ATP-BINDING CASSETTE TRANSPORTERS; BLOTTING, WESTERN; DECIDUA; DNA PRIMERS; EXTRAEMBRYONIC MEMBRANES; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; IMMUNOHISTOCHEMISTRY; NEOPLASM PROTEINS; PREGNANCY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 38549168894     PISSN: 10313613     EISSN: None     Source Type: Journal    
DOI: 10.1071/RD07133     Document Type: Article

References (41)

1. Allen, J. D., van Dort, S. C., Buitelaar, M., van Tellingen, O., and Schinkel, A. H. (2003). Mouse breast cancer resistance protein (Bcrp1/Abcg2) mediates etoposide resistance and transport, but etoposide oral availability is limited primarily by P-glycoprotein. Cancer Res. 63, 1339-1344.
2. Aye, I. L., Paxton, J. W., Evseenko, D. A., and Keelan, J. A. (2007). Expression, localisation and activity of ATP binding cassette (ABC) family of drug transporters in human amnion membranes. Placenta 28, 868-877. doi:10.1016/J.PLACENTA.2007.03.001
3. Basso, B., Giménez, F., and López, C. (2005). IL-1beta, IL-6 and IL-8 levels in gyneco-obstetric infections. Infect. Dis. Obstet. Gynecol. 13, 207-211.
4. Bowen, J. M., Chamley, L., Keelan, J. A., and Mitchell, M. D. (2002). Cytokines of the placenta and extra placental membranes: roles and regulation during human pregnancy and parturition. Placenta 23, 257-273. doi:10.1053/PLAC.2001.0782
5. Braunstein, G. D., Zeil, F. H., Allen, A., Van de Velde, R., and Wade, M. E. (1976). Prenatal diagnosis of placental steroid sulfatase deficiency. Am. J. Obstet. Gynecol. 126, 716-719.
6. Ceckova, M., Libra, A., Pavek, P., Nachtigal, P., Brabec, M., Fuchs, R., and Staud, F. (2006). Expression and functional activity of breast cancer resistance protein (BCRP, ABCG2) transporter in the human choriocarcinoma cell line BeWo. Clin. Exp. Pharmacol. Physiol. 33, 58-65. doi:10.1111/J.1440-1681.2006.04324.X
7. Dean, M., Hamon, Y., and Chimini, G. (2001). The human ATP-binding cassette (ABC) transporter superfamily. J. Lipid Res. 42, 1007-1017.
8. Diestra, J. E., Scheffer, G. L., Catala, I., Maliepaard, M., Schellens, J. H., Scheper, R. J., Germa-Lluch, J. R., and Izquierdo, M. A. (2002). Frequent expression of the multi-drug resistance-associated protein BCRP/MXR/ABCP/ABCG2 in human tumours detected by the BXP-21 monoclonal antibody in paraffin-embedded material. J. Pathol. 198, 213-219. doi:10.1002/PATH.1203
9. Doyle, L. A., Yang, W., Abruzzo, L. V., Krogmann, T., Gao, Y., Rishi, A. K., and Ross, D. D. (1998). A multidrug resistant transporter from human MCF-7breast cancer cells. Proc. Natl. Acad. Sci. USA 95, 15 665-15 670. doi:10.1073/PNAS.95.26.15665
10. Ee, P. L., Kamalakaran, S., Tonetti, D., He, X., Ross, D. D., and Beck, W. T. (2004). Identification of a novel estrogen response element in the breast cancer resistance protein (ABCG2) gene. Cancer Res. 64, 1247-1251. doi:10.1158/0008-5472.CAN-03-3583
11. Englund, G., Jacobson, A., Rorsman, F., Artursson, P., Kindmark, A., and Ronnblom, A. (2007). Efflux transporters in ulcerative colitis: decreased expression of BCRP (ABCG2) and Pgp (ABCB1). Inflamm. Bowel Dis. 13, 291-297. doi:10.1002/IBD.20030
12. Evseenko, D. A., Paxton, J. W., and Keelan, J. A. (2006). ABC drug transporter expression and functional activity in trophoblast-like cell lines and differentiating primary trophoblast. Am. J. Physiol. Regul. Integr. Comp. Physiol. 290, R1357-R1365.
13. Evseenko, D. A., Paxton, J. W., and Keelan, J. A. (2007). Independent regulation of apical and basolateral drug transporter expression and function in placental trophoblasts by cytokines, steroids and growth factors. Drug Metab. Dispos. 35, 595-601. doi:10.1124/DMD.106.011478
14. Ifergan, I., Shafran, A., Jansen, G., Hooijberg, J. H., Scheffer, G. L., and Assaraf, Y. G. (2004). Folate deprivation results in the loss of breast cancer resistance protein (BCRP/ABCG2) expression. A role for BCRP in cellular folate homeostasis. J. Biol. Chem. 279, 25 527-25 534. doi:10.1074/JBC.M401725200
15. Ifergan, I., Jansen, G., and Assaraf, Y. G. (2005). Cytoplasmic confinement of breast cancer resistance protein (BCRP/ABCG2) as a novel mechanism of adaptation to short-termfolate deprivation. Mol. Pharmacol. 67, 1349-1359. doi:10.1124/MOL.104.008250
16. Imai, Y., Tsukahara, S., Ishikawa, E., Tsuruo, T., and Sugimoto, Y. (2002). Estrone and 17beta-estradiol reverse breast cancer resistance protein-mediated multidrug resistance. Jpn. J. Cancer Res. 93, 231-235.
17. Imai, Y., Asada, S., Tsukahara, S., Ishikawa, E., Tsuruo, T., and Sugimoto, Y. (2003). Breast cancer resistance protein exports sulfated estrogens but not free estrogens. Mol. Pharmacol. 64, 610-618. doi:10.1124/MOL.64.3.610
18. Johnson, R. F., Mitchell, C. M., Giles, W. B., Bisits, A., and Zakar, T. (2006). Mechanisms regulating prostaglandin H-2 synthase-2 mRNA levels in amnion and chorion during pregnancy. J. Endocrinol. 188, 603-610. doi:10.1677/JOE.1.06488
19. Jonker, J. W., Smit, J. W., Brinkhuis, R. F., Maliepaard, M., Beijnen, J. H., Schellens, J. H., and Schinkel, A. H. (2000). Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan. J. Natl Cancer Inst. 92, 1651-1656. doi:10.1093/JNCI/92.20.1651
20. Kalabis, G. M., Kostaki, A., Andrews, M. H., Petropoulos, S., Gibb, W., and Matthews, S. G. (2005). Multidrug resistance phosphoglycoprotein (ABCB1) in the mouse placenta: fetal protection. Biol. Reprod. 73, 591-597. doi:10.1095/BIOLREPROD.105.042242
21. Keelan, J. A., Blumenstein, M., Helliwell, R. J., Sato, T. A., Marvin, K. W., and Mitchell, M. D. (2003). Cytokines, prostaglandins and parturition: a review. Placenta 24, S33-S46. doi:10.1053/PLAC.2002.0948
22. Litman, T., Jensen, U., Hansen, A., Covitz, K. M., Zhan, Z., et al. (2002). Use of peptide antibodies to probe for the mitoxantrone resistance-associated protein MXR/BCRP/ABCP/ABCG2. Biochim. Biophys. Acta 1565, 6-16. doi:10.1016/S0005-2736(02)00492-3
23. Madsen, G., Zakar, T., Manuelpillai, U., Wallace, E., Kwek, K., Yeo, G. S. H., Smith, R., and Mesiano, S. (2004). Intracrine control of estrogen action in human gestational tissues at parturition. J. Soc. Gynecol. Investig. 11, 213-219. doi:10.1016/J.JSGI.2003.12.003
24. Maliepaard, M., Scheffer, G. L., Faneyte, I. F., van Gastelen, M. A., Pijnenborg, A. C., Schinkel, A. H., van De Vijver, M. J., Scheper, R. J., and Schellens, J. H. (2001). Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues. Cancer Res. 61, 3458-3464.
25. Mathias, A. A., Hitti, J., and Unadkat, J. D. (2005). P-Glycoprotein and breast cancer resistance protein expression in human placentae of various gestational ages. Am. J. Physiol. Regul. Integr. Comp. Physiol. 289, R963-R969.
26. Meyer zu Schwabedissen, H. E., Grube, M., Dreisbach, A., Jedlitschky, G., Meissner, K., Linnemann, K., Fusch, C., Ritter, C. A., Volker, U., and Kroemer, H. K. (2006). Epidermal growth factor-mediated activation of the map kinase cascade results in altered expression and function of ABCG2 (BCRP). Drug Metab. Dispos. 34, 524-533. doi:10.1124/DMD.105.007591
27. Mohrmann, K., van Eijndhoven, M. A., Schinkel, A. H., and Schellens, J. H. (2005). Absence of N-linked glycosylation does not affect plasma membrane localization of breast cancer resistance protein (BCRP/ABCG2). Cancer Chemother. Pharmacol. 56, 344-350. doi:10.1007/S00280-005-1004-5
28. Ross, D. D., Karp, J. E., Chen, T. T., and Doyle, L. A. (2000). Expression of breast cancer resistance protein in blast cells from patients with acute leukemia. Blood 96, 365-368.
29. Sadowsky, D. W., Adams, K. M., Gravett, M. G., Witkin, S. S., and Novy, M. J. (2006). Preterm labor is induced by intraamniotic infusions of interleukin-1beta and tumor necrosis factor-alpha but not by interleukin-6 or interleukin-8 in a nonhuman primate model. Am. J. Obstet. Gynecol. 195, 1578-1589. doi:10.1016/J.AJOG.2006.06.072
30. Sarkadi, B., Ozvegy-Laczka, C., Nemet, K., and Varadi, A. (2004). ABCG2: a transporter for all seasons. FEBS Lett. 567, 116-120. doi:10.1016/J.FEBSLET.2004.03.123
31. Schmitz, G., and Kaminski, W. E. (2001). ABC transporters and cholesterol metabolism. Front. Biosci. 6, D505-D514. doi:10.2741/SCHMITZ
32. Schmitz, G., Langmann, T., and Heimerl, S. (2001). Role of ABCG1 and other ABCG family members in lipid metabolism. J. Lipid Res. 42, 1513-1520.
33. Staud, F., and Pavek, P. (2005). Breast cancer resistance protein (BCRP/ABCG2). Int. J. Biochem. Cell Biol. 37, 720-725. doi:10.1016/J.BIOCEL.2004.11.004
34. Sun, M., Kingdom, J., Baczyk, D., Lye, S. J., Matthews, S. G., and Gibb, W. (2006). Expression of the multidrug resistance P-glycoprotein (ABCB1 glycoprotein) in the human placenta decreases with advancing gestation. Placenta 27, 602-609. doi:10.1016/J.PLACENTA.2005.05.007
35. Suzuki, M., Suzuki, H., Sugimoto, Y., and Sugiyama, Y. (2003). ABCG2 transports sulfated conjugates of steroids and xenobiotics. J. Biol. Chem. 278, 22 644-22 649.
36. Takada, T., Suzuki, H., Gotoh, Y., and Sugiyama, Y. (2005a). Regulation of the cell surface expression of human BCRP/ABCG2 by the phosphorylation state of Akt in polarized cells. Drug Metab. Dispos. 33, 905-909. doi:10.1124/DMD.104.003228
37. Takada, T., Suzuki, H., and Sugiyama, Y. (2005b). Characterization of polarized expression of point- or deletion-mutated human BCRP/ABCG2 in LLC-PK1 cells. Pharm. Res. 22, 458-464. doi:10.1007/S11095-004- 1884-9
38. Volk, E. L., Farley, K. M., Wu, Y., Li, F., Robey, R. W., and Schneider, E. (2002). Overexpression of wild-type breast cancer resistance protein mediates methotrexate resistance. Cancer Res. 62, 5035-5040.
39. Wang, H., Zhou, L., Gupta, A., Vethanayagam, R. R., Zhang, Y., Unadkat, J. D., and Mao, Q. (2006). Regulation of BCRP/ABCG2 expression by progesterone and 17beta-estradiol in human placental BeWo cells. Am. J. Physiol. Endocrinol. Metab. 290, E798-E807. doi:10.1152/AJPENDO.00397.2005
40. Yeboah, D., Sun, M., Kingdom, J., Baczyk, D., Lye, S. J., Matthews, S. G., and Gibb, W. (2006). Expression of breast cancer resistance protein (BCRP/ABCG2) in human placenta throughout gestation and at term before and after labor. Can. J. Physiol. Pharmacol. 84, 1251-1258. doi:10.1139/Y06-078
41. Young, A. M., Allen, C. E., and Audus, K. L. (2003). Efflux transporters of the human placenta. Adv. Drug Deliv. Rev. 55, 125-132. doi:10.1016/S0169-409X(02)00174-6