The effect of acetaminophen on the expression of BCRP in trophoblast cells impairs the placental barrier to bile acids during maternal cholestasis

Toxicology and Applied Pharmacology

Volumn 277, Issue 1, 2014, Pages 77-85

  Blazquez, Alba G ^a,d   Briz, Oscar ^a,d   Gonzalez Sanchez, Ester ^a   Perez, Maria J ^a,b,d   Ghanem, Carolina I ^c   Marin, Jose J G ^a,d  

^a UNIVERSITY OF SALAMANCA   (Spain)

^b HOSPITAL UNIVERSITARIO DE SALAMANCA   (Spain)

^c Instituto de Investigaciones Farmacologicas   (Argentina)

^d INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

BCRP; Drug; Liver; Paracetamol; Pregnancy; Transport

Indexed keywords

BILE ACID; BREAST CANCER RESISTANCE PROTEIN; HEME OXYGENASE 1; MESSENGER RNA; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 1; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 2; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 3; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 4; MULTIDRUG RESISTANCE PROTEIN 1; PARACETAMOL; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); TRANSCRIPTION FACTOR NRF2;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PLACENTA BARRIER; CARCINOMA CELL; CELL VIABILITY; CHOLESTASIS; CHORIOCARCINOMA; CONTROLLED STUDY; FEMALE; FETUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOLOCALIZATION; IN VIVO STUDY; MATERNAL CHOLESTASIS; MATERNAL DISEASE; MATERNAL TREATMENT; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PLACENTAL TRANSFER; PROTEIN EXPRESSION; RAT; TROPHOBLAST;

BCRP; DRUG; LIVER; PARACETAMOL; PREGNANCY; TRANSPORT;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BILE ACIDS AND SALTS; BIOLOGICAL TRANSPORT, ACTIVE; CELL LINE, TUMOR; CHOLESTASIS; DOWN-REGULATION; FEMALE; GENE EXPRESSION; HUMANS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NEOPLASM PROTEINS; OXIDATION-REDUCTION; OXIDATIVE STRESS; P-GLYCOPROTEIN; PLACENTA; PREGNANCY; RATS; RATS, WISTAR; RNA, MESSENGER; TROPHOBLASTS;

EID: 84897948724     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2014.02.019     Document Type: Article

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