Maternal undernutrition reduces P-glycoprotein in guinea pig placenta and developing brain in late gestation

Reproductive Toxicology

Volumn 33, Issue 3, 2012, Pages 374-381

  Soo, Poh S ^a   Hiscock, Jennifer ^a   Botting, Kimberley J ^a,b   Roberts, Claire T ^c   Davey, Andrew K ^a,d   Morrison, Janna L ^a,b  

^a UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

^c UNIVERSITY OF ADELAIDE   (Australia)

^d GRIFFITH UNIVERSITY   (Australia)

Author keywords

Blood brain barrier; Fetus; Guinea pig; Maternal undernutrition; MDR1; P glycoprotein; Placenta

Indexed keywords

GLYCOPROTEIN P;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN CAPILLARY; BRAIN DEVELOPMENT; CONTROLLED STUDY; FEMALE; FETUS WEIGHT; GENE; GESTATION PERIOD; GUINEA PIG; MALNUTRITION; MATERNAL NUTRITION; MDR1 GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLACENTA; PLACENTAL TRANSFER; PREGNANCY; PRENATAL DRUG EXPOSURE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; FEMALE; FETAL GROWTH RETARDATION; GESTATIONAL AGE; GUINEA PIGS; MALNUTRITION; ORGAN SIZE; P-GLYCOPROTEIN; PLACENTA; PREGNANCY; RNA, MESSENGER;

CAVIA;

EID: 84859739594     PISSN: 08906238     EISSN: 18731708     Source Type: Journal    
DOI: 10.1016/j.reprotox.2012.01.013     Document Type: Article

References (50)

1. Henry A., Crowther C. Patterns of medication use during and prior to pregnancy: the MAP study. Australian and New Zealand Journal of Obstetrics and Gynaecology 2000, 40:165-172.
2. Audus K.L. Controlling drug delivery across the placenta. European Journal of Pharmaceutical Sciences 1999, 8:161-165.
3. Ceckova-Novotna M., Pavek P., Staud F. P-glycoprotein in the placenta: expression, localization, regulation and function. Reproductive Toxicology 2006, 22:400-410.
4. Croop J.M., Raymond M., Haber D., Devault A., Arceci R.J., Gros P., et al. The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues. Molecular and Cellular Biology 1989, 9:1346-1350.
5. Schinkel A.H. P-Glycoproteina gatekeeper in the blood-brain barrier. Advanced Drug Delivery Reviews 1999, 36:179-194.
6. Roberts D., Dalziel S. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database of Systematic Reviews 2006, [review].
7. Cordon-Cardo C., O'Brien J.P., Casals D., Rittman-Grauer L., Biedler J.L., Melamed M.R., et al. Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Proceedings of the National Academy of Sciences of the United States of America 1989, 86:695-698.
8. Lankas G.R., Wise L.D., Cartwright M.E., Pippert T., Umbenhauer D.R. Placental P-glycoprotein deficiency enhances susceptibility to chemically induced birth defects in mice. Reproductive Toxicology 1998, 12:457-463.
9. Smit J.W., Huisman M.T., Van Tellingen O., Wiltshire H.R., Schinkel A.H. Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure. Journal of Clinical Investigation 1999, 104:1441-1447.
10. Sun M., Kingdom J., Baczyk D., Lye S.J., Matthews S.G., Gibb W. Expression of the multidrug resistance P-glycoprotein, (ABCB1 glycoprotein) in the human placenta decreases with advancing gestation. Placenta 2006, 27:602-609.
11. Petropoulos S., Kalabis G.M., Gibb W., Matthews S.G. Functional changes of mouse placental multidrug resistance phosphoglycoprotein (ABCB1) with advancing gestation and regulation by progesterone. Reproductive Sciences 2007, 14:321-328.
12. Kalabis G.M., Petropoulos S., Gibb W., Matthews S.G. Multidrug resistance phosphoglycoprotein (ABCB1) expression in the guinea pig placenta: Developmental changes and regulation by betamethasone. Canadian Journal of Physiology and Pharmacology 2009, 87:973-978.
13. Novotna M., Libra A., Kopecky M., Pavek P., Fendrich Z., Semecky V., et al. P-glycoprotein expression and distribution in the rat placenta during pregnancy. Reproductive Toxicology 2004, 18:785-792.
14. McMillen I.C., Adams M.B., Ross J.T., Coulter C.L., Simonetta G., Owens J.A., et al. Fetal growth restriction: adaptations and consequences. Reproduction 2001, 122:195-204.
15. Ergaz Z., Avgil M., Ornoy A. Intrauterine growth restriction - etiology and consequences: what do we know about the human situation and experimental animal models?. Reproductive Toxicology 2005, 20:301-322.
16. Kingdom J., Huppertz B., Seaward G., Kaufmann P. Development of the placental villous tree and its consequences for fetal growth. European Journal of Obstetrics & Gynecology and Reproductive Biology 2000, 92:35-43.
17. Schinkel A.H., Mayer U., Wagenaar E., Mol C.A.A.M., Van Deemter L., Smit J.J.M., et al. Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins. Proceedings of the National Academy of Sciences of the United States of America 1997, 94:4028-4033.
18. Bevilacqua E., Brunelli R., Anceschi M.M. Review and meta-analysis: benefits and risks of multiple courses of antenatal corticosteroids. Journal of Maternal-Fetal and Neonatal Medicine 2010, 23:244-260.
19. Kind K.L., Simonetta G., Clifton P.M., Robinson J.S., Owens J.A. Effect of maternal feed restriction on blood pressure in the adult guinea pig. Experimental Physiology 2002, 87:469-477.
20. Nguyen L.T., Muhlhausler B.S., Botting K.J., Morrison J.L. Maternal undernutrition alters fat cell size distribution, but not lipogenic gene expression, in the visceral fat of the late gestation guinea pig fetus. Placenta 2010, 31:902-909.
21. Roberts C.T., Sohlstrom A., Kind K.L., Earl R.A., Khong T.Y., Robinson J.S., et al. Maternal food restriction reduces the exchange surface area and increases the barrier thickness of the placenta in the guinea-pig. Placenta 2001, 22:177-185.
22. Weibel E.R. Morphometry of the human lung: the state of the art after two decades. Clinical Respiratory Physiology 1979, 15:999-1013.
23. Shi S.R., Imam S.A., Young L., Cote R.J., Taylor C.R. Antigen retrieval immunohistochemistry under the influence of pH using monoclonal antibodies. Journal of Histochemistry and Cytochemistry 1995, 43:193-201.
24. Kwan P., Sills G.J., Butler E., Gant T.W., Brodie M.J. Differential expression of multidrug resistance genes in naïve rat brain. Neuroscience Letters 2003, 339:33-36.
25. Liu H., Liu X., Jia L., Liu Y., Yang H., Wang G., et al. Insulin therapy restores impaired function and expression of P-glycoprotein in blood-brain barrier of experimental diabetes. Biochemical Pharmacology 2008, 75:1649-1658.
26. Vandesompele J., De Preter K., Pattyn F., Poppe B., Van Roy N., De Paepe A., et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome biology 2002, 3.
27. Hellemans J., Mortier G., De Paepe A., Speleman F., Vandesompele J. qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data. Genome Biology 2007, 8.
28. Muhlhausler B.S., Duffield J.A., Ozanne S.E., Pilgrim C., Turner N., Morrison J.L., et al. The transition from fetal growth restriction to accelerated postnatal growth: A potential role for insulin signalling in skeletal muscle. Journal of Physiology 2009, 587:4199-4211.
29. Warren M.S., Zerangue N., Woodford K., Roberts L.M., Tate E.H., Feng B., et al. Comparative gene expression profiles of ABC transporters in brain microvessel endothelial cells and brain in five species including human. Pharmacological Research 2009, 59:404-413.
30. Owen D., Matthews S.G. Prenatal glucocorticoid exposure alters hypothalamic-pituitary-adrenal function in juvenile guinea pigs. Journal of Neuroendocrinology 2007, 19:172-180.
31. Carter A.M. Current topic: restriction of placental and fetal growth in the guinea-pig. Placenta 1993, 14:125-135.
32. Detmer A., Gu W., Carter A.M. The blood supply to the heart and brain in the growth retarded guinea pig fetus. Journal of Developmental Physiology 1991, 15:153-160.
33. Keightley M.C., Fuller P.J. Anomalies in the endocrine axes of the guinea pig: relevance to human physiology and disease. Endocrine Reviews 1996, 17:30-44.
34. Roberts C.T., Kind K.L., Earl R.A., Grant P.A., Robinson J.S., Sohlstrom A., et al. Circulating insulin-like growth factor (IGF)-I and IGF binding proteins -1 and -3 and placental development in the guinea-pig. Placenta 2002, 23:763-770.
35. Coles L.D., Lee I.J., Hassan H.E., Eddington N.D. Distribution of saquinavir, methadone, and buprenorphine in maternal brain, placenta, and fetus during two different gestational stages of pregnancy in mice. Journal of Pharmaceutical Sciences 2009, 98:2832-2846.
36. Scotto K.W. Transcriptional regulation of ABC drug transporters. Oncogene 2003, 22:7496-7511.
37. Callaghan R., Crowley E., Potter S., Kerr I.D. Review/drug metabolism and transport: P-glycoprotein: so many ways to turn it on. Journal of Clinical Pharmacology 2008, 48:365-378.
38. Hartz A.M.S., Bauer B., Block M.L., Hong J.S., Miller D.S. Diesel exhaust particles induce oxidative stress, proinflammatory signaling, and P-glycoprotein up-regulation at the blood-brain barrier. FASEB Journal 2008, 22:2723-2733.
39. Hartz A.M.S., Bauer B., Fricker G., Miller D.S. Rapid modulation of P-glycoprotein-mediated transport at the blood-brain barrier by tumor necrosis factor-α and lipopolysaccharide. Molecular Pharmacology 2006, 69:462-470.
40. Shen Q., Li Z.Q., Sun Y., Wang T., Wan C.L., Li X.W., et al. The role of pro-inflammatory factors in mediating the effects on the fetus of prenatal undernutrition: implications for schizophrenia. Schizophrenia Research 2008, 99:48-55.
41. Dwyer C.M., Stickland N.C. The effects of maternal undernutrition on maternal and fetal serum insulin-like growth factors, thyroid hormones and cortisol in the guinea pig. Journal of Developmental Physiology 1992, 18:303-313.
42. Yagüe E., Armesilla A.L., Harrison G., Elliott J., Sardini A., Higgins C.F., et al. P-glycoprotein (MDR1) expression in leukemic cells is regulated at two distinct steps, mRNA stabilization and translational initiation. Journal of Biological Chemistry 2003, 278:10344-10352.
43. Gómez-Martínez A., García-Morales P., Carrato A., Castro-Galache M.D., Soto J.L., Carrasco-García E., et al. Post-transcriptional regulation of P-glycoprotein expression in cancer cell lines. Molecular Cancer Research 2007, 5:641-653.
44. Zhang H., Wu X., Wang H., Mikheev A.M., Mao Q., Unadkat J.D. Effect of pregnancy on cytochrome P450 3a and P-glycoprotein expression and activity in the mouse: mechanisms, tissue specificity, and time course. Molecular Pharmacology 2008, 74:714-723.
45. Baker E.K., El-Osta A. MDR1, chemotherapy and chromatin remodeling. Cancer Biology and Therapy 2004, 3:819-824.
46. Crowley P.A. Antenatal corticosteroid therapy: a meta-analysis of the randomized trials, 1972 to 1994. American Journal of Obstetrics and Gynecology 1995, 173:322-335.
47. Miller S.L., Chai M., Loose J., Castillo-Meléndez M., Walker D.W., Jenkin G., et al. The effects of maternal betamethasone administration on the intrauterine growth-restricted fetus. Endocrinology 2007, 148:1288-1295.
48. Sloboda D.M., Newnham J.P., Challis J.R.G. Repeated maternal glucocorticoid administration and the developing liver in fetal sheep. Journal of Endocrinology 2002, 175:535-543.
49. Lindsay R.S., Lindsay R.M., Edwards C.R.W., Seckl J.R. Inhibition of 11β-hydroxysteroid dehydrogenase in pregnant rats and the programming of blood pressure in the offspring. Hypertension 1996, 27:1200-1204.
50. Uno H., Eisele S., Sakai A., Shelton S., Baker E., DeJesus O., et al. Neurotoxicity of glucocorticoids in the primate brain. Hormones and Behavior 1994, 28:336-348.