Upregulation in the expression of multidrug resistance protein Mrp1 mRNA and protein by increased bilirubin production in rat

Biochemical and Biophysical Research Communications

Volumn 311, Issue 4, 2003, Pages 891-896

  Cekic, Dean ^a   Bellarosa, Cristina ^a   Garcia Mediavilla, Maria Victoria ^a,c   Rigato, Igino ^a   Pascolo, Lorella ^a   Ostrow, J Donald ^b   Tiribelli, Claudio ^a  

^a UNIVERSITY OF TRIESTE   (Italy)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF LEÓN   (Spain)

Author keywords

Heme oxygenase; Hemolysis; Mrp1; Transport; Unconjugated bilirubin; Upregulation

Indexed keywords

BILIRUBIN; HEME OXYGENASE INHIBITOR; HEMOGLOBIN; MESOPORPHYRIN TIN; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; PHENYLHYDRAZINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; HEMOLYSIS; LIVER HOMOGENATE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPLEEN; TISSUE DISTRIBUTION; UPREGULATION;

EID: 0242437978     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2003.10.081     Document Type: Conference Paper

References (28)

1. Ostrow J.D., Pascolo L., Tiribelli C. Editorial: mechanisms of bilirubin neurotoxicity. Hepatology. 35:2002;1277-1280.
2. Ostrow J.D., Pascolo L., Tiribelli C. Reassessment of the unbound concentrations of unconjugated bilirubin in relation to neurotoxicity in vitro. Pediatr. Res. 54:2003;98-104.
3. Mediavilla M.G., Pascolo L., Rodriguez J.V., Guibert E.E., Ostrow J.D., Tiribelli C. Uptake of [(3)H]bilirubin in freshly isolated rat hepatocytes: role of free bilirubin concentration. FEBS Lett. 463:1999;143-145.
4. Vanstapel F., Blanckaert N. Hepatic bilirubin esterification and its regulation. Vanstapel Tavoloni N., Blanckaert Berk P.D. Hepatic transport and bile secretion: Physiology and Pathophysiology. 1993;477-488 Raven Press, New York.
5. De Matteis F., Trenti T., Gibbs A.H., Greig J.B. Inducible bilirubin-degrading system in the microsomal fraction of rat liver. Mol. Pharmacol. 35:1989;831-838.
6. Kapitulnik J., Ostrow J.D. Stimulation of bilirubin catabolism in jaundiced Gunn rats by an inducer of microsomal mixed-function monoxygenases. Proc. Natl. Acad. Sci. USA. 75:1977;682-685.
7. Kapitulnik J., Gonzalez F.J. Marked endogenous activation of the CYP1A1 and CYP1A2 genes in the congenitally jaundiced Gunn rat. Mol. Pharmacol. 43:1993;722-725.
8. Borst P., Evers R., Kool M., Wijnholds J. The multidrug resistance protein family. Biochim. Biophys. Acta. 1461:1999;347-357.
9. Gottesman M.M., Pastan I. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem. 62:1993;385-427.
10. Petrovic S., Pascolo L., Gallo R., Cupelli F., Ostrow J.D., Goffeau A., Tiribelli C., Bruschi C.V. The products of YCF1 and YLL015w (BPT1) cooperate for the ATP-dependent vacuolar transport of unconjugated bilirubin in Saccharomyces cerevisiae. Yeast. 16:2000;561-571.
11. Pascolo L., Fernetti C., Crivellato E., Garcia-Mediavilla M.V., Ostrow J.D., Tiribelli C. Mechanisms for the transport of unconjugated bilirubin in human trophoblastic BeWo cells. FEBS Lett. 495:2001;94-99.
12. Serrano M.A., Bayón J.E., Pascolo L., Tiribelli C., Ostrow J.D., Gonzalez-Gallego J., Marin J.J.G. Evidence for carrier-mediated transport of unconjugated bilirubin across plasma membrane vesicles from human placental trophoblast. Placenta. 23:2002;527-535.
13. Drummond G.S., Kappas A. Prevention of neonatal hyperbilirubinemia by tin protoporphyrin IX, a potent competitive inhibitor of heme oxidation. Proc. Natl. Acad. Sci. USA. 78:1981;6466-6470.
14. Ostrow J.D. Therapeutic amelioration of jaundice. Hepatology. 8:1988;683-689.
15. Balasubramaniam P., Malathi A., Viswanathan C. A simple technique for hemoglobin estimation to screen for anaemia. Indian J. Physiol. Pharmacol. 36:1992;213-214.
16. Hirrlinger J., Konig J., Dringen R. Expression of mRNAs of multidrug resistance proteins (Mrps) in cultured rat astrocytes, oligodendrocytes, microglial cells and neurones. J. Neurochem. 82:2002;716-719.
17. Smith P.K., Krohn R.I., Hermanson G.T., Mallia A.K., Gartner F.H., Provenzano M.D., Fujimoto E.K., Goecke N.M., Olson B.J., Klein D.C. Measurement of protein using bicinchoninic acid. Anal. Biochem. 150:1985;76-85.
18. Fernetti C., Pascolo L., Podda E., Gennaro R., Stebel M., Tiribelli C. Preparation of an antibody recognizing both human and rodent MRP1. Biochem. Biophys. Res. Commun. 288:2001;1064-1068.
19. Maines M.D., Kappas A. Prematurely evoked synthesis and induction of delta-aminolevulinate synthetase in neonatal liver. Evidence for metal ion repression of enzyme formation. J. Biol. Chem. 253:1978;2321-2326.
20. Martinez J.C., Garcia H.O., Otheguy L.E., Drummond G.S., Kappas A. Control of severe hyperbilirubinemia in full-term newborns with the inhibitor of bilirubin production Sn-mesoporphyrin. Pediatrics. 103:1999;1-5.
21. Drummond G.S., Kappas A. Sn-mesoporphyrin suppression of hyperbilirubinemia in EHBR/Eis rats, an animal model of Dubin-Johnson syndrome. Pharmacology. 56:1998;158-164.
22. Cruz W.O. Acetylphenylhydrazine anemia. 1. The mechanism of erythrocyte destruction and regeneration. Am. J. Med. Sci. 202:1941;781.
23. Wagner H.N. Jr., Caine W.P. Jr., Geagin O.T. Removal of erythrocytes from the circulation. Arch. Intern. Med. 110:1962;90-97.
24. Snyder S.H., Barañano D.E. Heme oxygenase: a font of multiple messengers. Neuropsychopharmacology. 25:2001;294-298.
25. Drummond G.S., Valaes T., Kappas A. Control of bilirubin production by synthetic heme analogs: pharmacologic and toxicologic considerations. J. Perinatol. 16:1996;S72-S79.
26. Tanaka Y., Kobayashi Y., Gabazza E.C., Higuchi K., Kamisako T., Kuroda M., Takeuchi K., Iwasa M., Kaito M., Adachi Y. Increased renal expression of bilirubin glucuronide transporters in a rat model of obstructive jaundice. Am. J. Physiol. Gastrointest. Liver Physiol. 282:2002;G656-G662.
27. Hirohashi T., Suzuki H., Ito K., Ogawa K., Kume K., Shimizu T., Sugiyama Y. Hepatic expression of multidrug resistance-associated protein-like proteins maintained in Eisai hyperbilirubinemic rats. Mol. Pharmacol. 53:1998;1068-1075.
28. Ogawa K., Suzuki H., Hirohashi T., Ishikawa T., Meier P.J., Hirose K., Akizawa T., Yoshioka M., Sugiyama Y. Characterization of inducible nature of MRP3 in rat liver. Am. J. Physiol. Gastrointest. Liver Physiol. 278:2000;G438-G446.