-
1
-
-
0036315888
-
Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: Evidence that β-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated
-
[CrossRef] [PubMed]
-
Lupi, R.; Dotta, F.; Marselli, L.; del Guerra, S.; Masini, M.; Santangelo, C.; Patane, G.; Boggi, U.; Piro, S.; Anello, M. et al. Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: Evidence that β-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated. Diabetes 2002, 51, 1437-1442. [CrossRef] [PubMed]
-
(2002)
Diabetes
, vol.51
, pp. 1437-1442
-
-
Lupi, R.1
Dotta, F.2
Marselli, L.3
Del Guerra, S.4
Masini, M.5
Santangelo, C.6
Patane, G.7
Boggi, U.8
Piro, S.9
Anello, M.10
-
2
-
-
0345354674
-
Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic β-cell turnover and function
-
[CrossRef] [PubMed]
-
Maedler, K.; Oberholzer, J.; Bucher, P.; Spinas, G.A.; Donath, M.Y. Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic β-cell turnover and function. Diabetes 2003, 52, 726-733. [CrossRef] [PubMed]
-
(2003)
Diabetes
, vol.52
, pp. 726-733
-
-
Maedler, K.1
Oberholzer, J.2
Bucher, P.3
Spinas, G.A.4
Donath, M.Y.5
-
3
-
-
33746190686
-
Fatty acid-induced toxicity and neutral lipid accumulation in insulin-producing RINm5F cells
-
[CrossRef] [PubMed]
-
Azevedo-Martins, A.K.; Monteiro, A.P.; Lima, C.L.; Lenzen, S.; Curi, R. Fatty acid-induced toxicity and neutral lipid accumulation in insulin-producing RINm5F cells. Toxicol. In Vitro 2006, 20, 1106-1113. [CrossRef] [PubMed]
-
(2006)
Toxicol. in Vitro
, vol.20
, pp. 1106-1113
-
-
Azevedo-Martins, A.K.1
Monteiro, A.P.2
Lima, C.L.3
Lenzen, S.4
Curi, R.5
-
4
-
-
33745854213
-
Differential protective effects of palmitoleic acid and cAMP on caspase activation and cell viability in pancreatic β-cells exposed to palmitate
-
[CrossRef] [PubMed]
-
Welters, H.J.; Diakogiannaki, E.; Mordue, J.M.; Tadayyon, M.; Smith, S.A.; Morgan, N.G. Differential protective effects of palmitoleic acid and cAMP on caspase activation and cell viability in pancreatic β-cells exposed to palmitate. Apoptosis 2006, 11, 1231-1238. [CrossRef] [PubMed]
-
(2006)
Apoptosis
, vol.11
, pp. 1231-1238
-
-
Welters, H.J.1
Diakogiannaki, E.2
Mordue, J.M.3
Tadayyon, M.4
Smith, S.A.5
Morgan, N.G.6
-
5
-
-
40849099994
-
Comparison of the effect of individual saturated and unsaturated fatty acids on cell growth and death induction in the human pancreatic β-cell line NES2Y
-
[CrossRef]
-
Fürstova, V.; Kopska, T.; James, R.F.; Kovar, J. Comparison of the effect of individual saturated and unsaturated fatty acids on cell growth and death induction in the human pancreatic β-cell line NES2Y. Life Sci. 2008, 82, 684-691. [CrossRef]
-
(2008)
Life Sci
, vol.82
, pp. 684-691
-
-
Fürstova, V.1
Kopska, T.2
James, R.F.3
Kovar, J.4
-
6
-
-
0035156817
-
Distinct effects of saturated and monounsaturated fatty acids on β-cell turnover and function
-
[CrossRef] [PubMed]
-
Maedler, K.; Spinas, G.A.; Dyntar, D.; Moritz W.; Kaiser, N.; Donath, M.Y. Distinct effects of saturated and monounsaturated fatty acids on β-cell turnover and function. Diabetes 2001, 50, 69-76. [CrossRef] [PubMed]
-
(2001)
Diabetes
, vol.50
, pp. 69-76
-
-
Maedler, K.1
Spinas, G.A.2
Dyntar, D.3
Moritz, W.4
Kaiser, N.5
Donath, M.Y.6
-
7
-
-
0042922453
-
Saturated fatty acids synergize with elevated glucose to cause pancreatic β-cell death
-
El-Assaad, W.; Buteau, J.; Peyot, M.L.; Nolan, C.; Roduit, R.; Hardy, S.; Joly, E.; Dbaibo, G.; Rosenberg, L.; Prentki, M. Saturated fatty acids synergize with elevated glucose to cause pancreatic β-cell death. Endocrinology 2003, 144, 4154-4163.
-
(2003)
Endocrinology
, vol.144
, pp. 4154-4163
-
-
El-Assaad, W.1
Buteau, J.2
Peyot, M.L.3
Nolan, C.4
Roduit, R.5
Hardy, S.6
Joly, E.7
Dbaibo, G.8
Rosenberg, L.9
Prentki, M.10
-
8
-
-
9244231766
-
Free fatty acids and cytokines induce pancreatic β-cell apoptosis by different mechanisms: Role of nuclear factor-κB and endoplasmic reticulum stress
-
[CrossRef] [PubMed]
-
Kharroubi, I.; Ladriere, L.; Cardozo, A.K.; Dogusan, Z.; Cnop, M.; Eizirik, D.L. Free fatty acids and cytokines induce pancreatic β-cell apoptosis by different mechanisms: role of nuclear factor-κB and endoplasmic reticulum stress. Endocrinology 2004, 145, 5087-5096. [CrossRef] [PubMed]
-
(2004)
Endocrinology
, vol.145
, pp. 5087-5096
-
-
Kharroubi, I.1
Ladriere, L.2
Cardozo, A.K.3
Dogusan, Z.4
Cnop, M.5
Eizirik, D.L.6
-
9
-
-
1342286820
-
Mono-unsaturated fatty acids protect against β-cell apoptosis induced by saturated fatty acids, serum withdrawal or cytokine exposure
-
[CrossRef]
-
Welters, H.J.; Tadayyon, M.; Scarpello, J.H.; Smith, S.A.; Morgan, N.G. Mono-unsaturated fatty acids protect against β-cell apoptosis induced by saturated fatty acids, serum withdrawal or cytokine exposure. FEBS Lett. 2004, 560, 103-108. [CrossRef]
-
(2004)
FEBS Lett
, vol.560
, pp. 103-108
-
-
Welters, H.J.1
Tadayyon, M.2
Scarpello, J.H.3
Smith, S.A.4
Morgan, N.G.5
-
10
-
-
33646002042
-
Protein kinase B/Akt signaling is required for palmitate-induced β-cell lipotoxicity. Diabetes Obes
-
[CrossRef]
-
Higa, M.; Shimabukuro, M.; Shimajiri, Y.; Takasu, N.; Shinjyo, T.; Inaba, T. Protein kinase B/Akt signaling is required for palmitate-induced β-cell lipotoxicity. Diabetes Obes. Metab. 2006, 8, 228-233. [CrossRef]
-
(2006)
Metab
, vol.8
, pp. 228-233
-
-
Higa, M.1
Shimabukuro, M.2
Shimajiri, Y.3
Takasu, N.4
Shinjyo, T.5
Inaba, T.6
-
11
-
-
33745116619
-
Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic β-cell apoptosis
-
[CrossRef] [PubMed]
-
Karaskov, E.; Scott, C.; Zhang, L.; Teodoro, T.; Ravazzola, M.; Volchuk, A. Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic β-cell apoptosis. Endocrinology 2006, 147, 3398-3407. [CrossRef] [PubMed]
-
(2006)
Endocrinology
, vol.147
, pp. 3398-3407
-
-
Karaskov, E.1
Scott, C.2
Zhang, L.3
Teodoro, T.4
Ravazzola, M.5
Volchuk, A.6
-
12
-
-
77449139439
-
Overexpression of kinase-negative protein kinase Cδ in pancreatic β-cells protects mice from diet-induced glucose intolerance and β-cell dysfunction
-
[CrossRef] [PubMed]
-
Hennige, A.M.; Ranta, F.; Heinzelmann, I.; Dufer, M.; Michael, D.; Braumuller, H.; Lutz, S.Z.; Lammers, R.; Drews, G.; Bosch, F.; et al. Overexpression of kinase-negative protein kinase Cδ in pancreatic β-cells protects mice from diet-induced glucose intolerance and β-cell dysfunction. Diabetes 2010, 59, 119-127. [CrossRef] [PubMed]
-
(2010)
Diabetes
, vol.59
, pp. 119-127
-
-
Hennige, A.M.1
Ranta, F.2
Heinzelmann, I.3
Dufer, M.4
Michael, D.5
Braumuller, H.6
Lutz, S.Z.7
Lammers, R.8
Drews, G.9
Bosch, F.10
-
13
-
-
0036924861
-
Different role of saturated and unsaturated fatty acids in β-cell apoptosis
-
[CrossRef]
-
Eitel, K.; Staiger, H.; Brendel, M.D.; Brandhorst, D.; Bretzel, R.G.; Haring, H.U.; Kellerer, M. Different role of saturated and unsaturated fatty acids in β-cell apoptosis. Biochem. Biophys. Res. Commun. 2002, 299, 853-856. [CrossRef]
-
(2002)
Biochem. Biophys. Res. Commun
, vol.299
, pp. 853-856
-
-
Eitel, K.1
Staiger, H.2
Brendel, M.D.3
Brandhorst, D.4
Bretzel, R.G.5
Haring, H.U.6
Kellerer, M.7
-
14
-
-
12944320856
-
Pancreatic β cell senescence contributes to the pathogenesis of type 2 diabetes in high-fat diet-induced diabetic mice
-
[CrossRef] [PubMed]
-
Sone, H.; Kagawa, Y. Pancreatic β cell senescence contributes to the pathogenesis of type 2 diabetes in high-fat diet-induced diabetic mice. Diabetologia 2005, 48, 58-67. [CrossRef] [PubMed]
-
(2005)
Diabetologia
, vol.48
, pp. 58-67
-
-
Sone, H.1
Kagawa, Y.2
-
15
-
-
44949214679
-
Differential regulation of the endoplasmic reticulum stress response in pancreatic β-cells exposed to long-chain saturated and monounsaturated fatty acids
-
[CrossRef] [PubMed]
-
Diakogiannaki, E.; Welters, H.J.; Morgan, N.G. Differential regulation of the endoplasmic reticulum stress response in pancreatic β-cells exposed to long-chain saturated and monounsaturated fatty acids. J. Endocrinol. 2008, 197, 553-563. [CrossRef] [PubMed]
-
(2008)
J. Endocrinol
, vol.197
, pp. 553-563
-
-
Diakogiannaki, E.1
Welters, H.J.2
Morgan, N.G.3
-
16
-
-
79959402078
-
Inhibitory effect of unsaturated fatty acids on saturated fatty acids-induced apoptosis in human pancreatic β-cells: Activation of caspases and ER stress induction
-
[CrossRef] [PubMed]
-
Nemcova-Fürstova, V.; James, R.F.L.; Kovar, J. Inhibitory effect of unsaturated fatty acids on saturated fatty acids-induced apoptosis in human pancreatic β-cells: Activation of caspases and ER stress induction. Cell. Physiol. Biochem. 2011, 27, 525-538. [CrossRef] [PubMed]
-
(2011)
Cell. Physiol. Biochem
, vol.27
, pp. 525-538
-
-
Nemcova-Fürstova, V.1
James, R.F.L.2
Kovar, J.3
-
17
-
-
42449126643
-
Inhibition of FoxO1 protects pancreatic islet β-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis
-
[CrossRef] [PubMed]
-
Martinez, S.C.; Tanabe, K.; Cras-Méneur, C.; Abumrad, N.A.; Bernal-Mizrachi, E.; Permutt, M.A. Inhibition of FoxO1 protects pancreatic islet β-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis. Diabetes 2008, 57, 846-859. [CrossRef] [PubMed]
-
(2008)
Diabetes
, vol.57
, pp. 846-859
-
-
Martinez, S.C.1
Tanabe, K.2
Cras-Méneur, C.3
Abumrad, N.A.4
Bernal-Mizrachi, E.5
Permutt, M.A.6
-
18
-
-
73649102726
-
Fatty acids induce amylin expression and secretion by pancreatic β-cells
-
[CrossRef] [PubMed]
-
Qi, D.; Cai, K.; Wang, O.; Li, Z.; Chen, J.; Deng, B.; Qian, L.; Le, Y. Fatty acids induce amylin expression and secretion by pancreatic β-cells. Am. J. Physiol. Endocrinol. Metab. 2010, 298, E99-E107. [CrossRef] [PubMed]
-
(2010)
Am. J. Physiol. Endocrinol. Metab
, vol.298
, pp. EE99-E107
-
-
Qi, D.1
Cai, K.2
Wang, O.3
Li, Z.4
Chen, J.5
Deng, B.6
Qian, L.7
Le, Y.8
-
19
-
-
78650852744
-
NADPH Oxidase 2-Derived Reactive Oxygen Species Mediate FFAs-Induced Dysfunction and Apoptosis of β-cells via JNK, p38 MAPK and p53 Pathways
-
[CrossRef] [PubMed]
-
Yuan, H.; Zhang, X.; Huang, X.; Lu, Y.; Tang W.; Man, Y.; Wang, S.; Xi, J.; Li, J. NADPH Oxidase 2-Derived Reactive Oxygen Species Mediate FFAs-Induced Dysfunction and Apoptosis of β-cells via JNK, p38 MAPK and p53 Pathways. PLoS ONE 2010, 5, e15726. [CrossRef] [PubMed]
-
(2010)
Plos ONE
, vol.5
-
-
Yuan, H.1
Zhang, X.2
Huang, X.3
Lu, Y.4
Tang, W.5
Man, Y.6
Wang, S.7
Xi, J.8
Li, J.9
-
20
-
-
84904767484
-
Lipotoxic endoplasmic reticulum stress, β cell failure, and type 2 diabetes mellitus
-
[CrossRef] [PubMed]
-
Biden, T.J.; Boslem, E.; Chu, K.Y.; Sue, N. Lipotoxic endoplasmic reticulum stress, β cell failure, and type 2 diabetes mellitus. Trends Endocrinol. Metab. 2014, 25, 389-398. [CrossRef] [PubMed]
-
(2014)
Trends Endocrinol. Metab
, vol.25
, pp. 389-398
-
-
Biden, T.J.1
Boslem, E.2
Chu, K.Y.3
Sue, N.4
-
21
-
-
84957576127
-
T cells cooperate with palmitic acid in induction of β cell apoptosis
-
[CrossRef] [PubMed]
-
Cvjeticanin, T.; Stojanovic, I.; Timotijevic, G.; Stosic-Grujicic, S.; Miljkovic, D. T cells cooperate with palmitic acid in induction of β cell apoptosis. BMC Immunol. 2009, 29, 1-10. [CrossRef] [PubMed]
-
(2009)
BMC Immunol
, vol.29
, pp. 1-10
-
-
Cvjeticanin, T.1
Stojanovic, I.2
Timotijevic, G.3
Stosic-Grujicic, S.4
Miljkovic, D.5
-
22
-
-
84891048601
-
Toxicity generated through inhibition of pyruvate carboxylase and carnitine palmitoyl transferase-1 is similar to high glucose/palmitate-induced glucolipotoxicity in INS-1 β cells
-
[CrossRef] [PubMed]
-
Lee, J.H.; Jung, I.R.; Choi, S.E.; Lee, S.M.; Lee, S.J.; Han, S.J.; Kim, H.J.; Kim, D.J.; Lee, K.W.; Kang, Y. Toxicity generated through inhibition of pyruvate carboxylase and carnitine palmitoyl transferase-1 is similar to high glucose/palmitate-induced glucolipotoxicity in INS-1 β cells. Mol. Cell. Endocrinol. 2014, 383, 48-59. [CrossRef] [PubMed]
-
(2014)
Mol. Cell. Endocrinol
, vol.383
, pp. 48-59
-
-
Lee, J.H.1
Jung, I.R.2
Choi, S.E.3
Lee, S.M.4
Lee, S.J.5
Han, S.J.6
Kim, H.J.7
Kim, D.J.8
Lee, K.W.9
Kang, Y.10
-
23
-
-
84901299519
-
TRB3 Is Involved in Free Fatty Acid-Induced INS-1-Derived Cell Apoptosis via the Protein Kinase C δ Pathway
-
[CrossRef] [PubMed]
-
Qin, J.; Fang, N.; Lou, J.; Zhang W.; Xu, S.; Liu, H.; Fang, Q.; Wang, Z.; Liu, J.; Men, X. et al. TRB3 Is Involved in Free Fatty Acid-Induced INS-1-Derived Cell Apoptosis via the Protein Kinase C δ Pathway. PLoS ONE 2014, 9, e96089. [CrossRef] [PubMed]
-
(2014)
Plos ONE
, vol.9
-
-
Qin, J.1
Fang, N.2
Lou, J.3
Zhang, W.4
Xu, S.5
Liu, H.6
Fang, Q.7
Wang, Z.8
Liu, J.9
Men, X.10
-
24
-
-
84887620237
-
ER stress-induced cell death mechanisms
-
[CrossRef] [PubMed]
-
Sano, R.; Reed, J.C. ER stress-induced cell death mechanisms. Biochim. Biophys. Acta 2013, 1833, 3460-3470. [CrossRef] [PubMed]
-
(2013)
Biochim. Biophys. Acta
, vol.1833
, pp. 3460-3470
-
-
Sano, R.1
Reed, J.C.2
-
25
-
-
2942530310
-
ERK and p38 MAPK-activated protein kinases: A family of protein kinases with diverse biological functions
-
[CrossRef] [PubMed]
-
Roux, P.P.; Blenis, J. ERK and p38 MAPK-activated protein kinases: A family of protein kinases with diverse biological functions. Microbiol. Mol. Biol. Rev. 2004, 68, 320-344. [CrossRef] [PubMed]
-
(2004)
Microbiol. Mol. Biol. Rev
, vol.68
, pp. 320-344
-
-
Roux, P.P.1
Blenis, J.2
-
26
-
-
34347389002
-
The role of G protein-coupled receptor 40 in lipoapoptosis in mouse β-cell line NIT-1
-
[CrossRef] [PubMed]
-
Zhang, Y.; Xu, M.; Zhang, S.; Yan, L.; Yang, C.; Lu W.; Li, Y.; Cheng, H. The role of G protein-coupled receptor 40 in lipoapoptosis in mouse β-cell line NIT-1. Mol. Cell. Endocrinol. 2007, 38, 651-661. [CrossRef] [PubMed]
-
(2007)
Mol. Cell. Endocrinol
, vol.38
, pp. 651-661
-
-
Zhang, Y.1
Xu, M.2
Zhang, S.3
Yan, L.4
Yang, C.5
Lu, W.6
Li, Y.7
Cheng, H.8
-
27
-
-
84905227308
-
TCF2 attenuates FFA-induced damage in islet β-cells by regulating production of insulin and ROS
-
[CrossRef] [PubMed]
-
Quan, X.; Zhang, L.; Li, Y.; Liang, C. TCF2 attenuates FFA-induced damage in islet β-cells by regulating production of insulin and ROS. Int. J. Mol. Sci. 2014, 15, 13317-13332. [CrossRef] [PubMed]
-
(2014)
Int. J. Mol. Sci
, vol.15
, pp. 13317-13332
-
-
Quan, X.1
Zhang, L.2
Li, Y.3
Liang, C.4
-
28
-
-
0037668996
-
Fatty acid and phorbol ester-mediated interference of mitogenic signaling via novel protein kinase C isoforms in pancreatic β-cells (INS-1)
-
[CrossRef] [PubMed]
-
Wrede, C.E.; Dickson, L.M.; Lingohr, M.K.; Briaud, I.; Rhodes, C.J. Fatty acid and phorbol ester-mediated interference of mitogenic signaling via novel protein kinase C isoforms in pancreatic β-cells (INS-1). J. Mol. Endocrinol. 2003, 30, 271-286. [CrossRef] [PubMed]
-
(2003)
J. Mol. Endocrinol
, vol.30
, pp. 271-286
-
-
Wrede, C.E.1
Dickson, L.M.2
Lingohr, M.K.3
Briaud, I.4
Rhodes, C.J.5
-
29
-
-
0024997935
-
Pp54 Microtubule-associated protein 2 kinase: A novel serine/threonine protein kinase regulated by phosphorylation and stimulated by poly-L-lysine
-
[PubMed]
-
Kyriakis, J.M.; Avruch, J. pp54 Microtubule-associated protein 2 kinase: A novel serine/threonine protein kinase regulated by phosphorylation and stimulated by poly-L-lysine. J. Biol. Chem. 1990, 265, 17355-17363 [PubMed]
-
(1990)
J. Biol. Chem
, vol.265
, pp. 17355-17363
-
-
Kyriakis, J.M.1
Avruch, J.2
-
30
-
-
0025883213
-
Pp54 microtubuleassociated protein-2 kinase requires both tyrosine and threonine phosphorylation for activity
-
[PubMed]
-
Kyriakis, J.M.; Brautigan, D.L.; Ingebritsen, T.S.; Avruch, J. pp54 microtubuleassociated protein-2 kinase requires both tyrosine and threonine phosphorylation for activity. J. Biol. Chem. 1991, 266, 10043-10046. [PubMed]
-
(1991)
J. Biol. Chem
, vol.266
, pp. 10043-10046
-
-
Kyriakis, J.M.1
Brautigan, D.L.2
Ingebritsen, T.S.3
Avruch, J.4
-
31
-
-
0028329953
-
JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
-
[CrossRef]
-
Derijard, B.; Hibi, M.; Wu, I.-H.; Barrett, T.; Su, B.; Deng, T.; Karin, M.; Davis, R.J. JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 1994, 76, 1025-1037. [CrossRef]
-
(1994)
Cell
, vol.76
, pp. 1025-1037
-
-
Derijard, B.1
Hibi, M.2
Wu, I.-H.3
Barrett, T.4
Su, B.5
Deng, T.6
Karin, M.7
Davis, R.J.8
-
32
-
-
0028229012
-
The stress-activated protein kinase subfamily of c-Jun kinases
-
[CrossRef] [PubMed]
-
Kyriakis, J.M.; Banerjee, P.; Nikolakaki, E.; Dai, T.; Rubie, E.A.; Ahmad, M.F.; Avruch, J.; Woodgett, J.R. The stress-activated protein kinase subfamily of c-Jun kinases. Nature 1994, 369, 156-160. [CrossRef] [PubMed]
-
(1994)
Nature
, vol.369
, pp. 156-160
-
-
Kyriakis, J.M.1
Banerjee, P.2
Nikolakaki, E.3
Dai, T.4
Rubie, E.A.5
Ahmad, M.F.6
Avruch, J.7
Woodgett, J.R.8
-
33
-
-
0028609209
-
JNK2 contains a specificity-determining region responsible for efficient C-Jun binding and phosphorylation
-
[CrossRef]
-
Kallunki, T.; Su, B.; Tsigelny, I.; Sluss, H.K.; Derijard, B.; Moore, G.; Davis, R.; Karin, M. JNK2 contains a specificity-determining region responsible for efficient C-Jun binding and phosphorylation. Genes Dev. 1994, 8, 2996-3007. [CrossRef]
-
(1994)
Genes Dev
, vol.8
, pp. 2996-3007
-
-
Kallunki, T.1
Su, B.2
Tsigelny, I.3
Sluss, H.K.4
Derijard, B.5
Moore, G.6
Davis, R.7
Karin, M.8
-
34
-
-
0034644522
-
Signal transduction by the JNK group of MAP kinases
-
[CrossRef]
-
Davis, R.J. Signal transduction by the JNK group of MAP kinases. Cell 2000, 103, 239-252. [CrossRef]
-
(2000)
Cell
, vol.103
, pp. 239-252
-
-
Davis, R.J.1
-
35
-
-
80054722420
-
The unfolded protein response: Integrating stress signals through the stress sensor IRE1
-
[CrossRef] [PubMed]
-
Hetz, C.; Martinon, F.; Rodriguez, D.; Glimcher, L.H. The unfolded protein response: Integrating stress signals through the stress sensor IRE1β. Physiol. Rev. 2011, 91, 1219-1243. [CrossRef] [PubMed]
-
(2011)
Physiol. Rev
, vol.91
, pp. 1219-1243
-
-
Hetz, C.1
Martinon, F.2
Rodriguez, D.3
Glimcher, L.H.4
-
36
-
-
33845653234
-
Uses for JNK: The many and varied substrates of the c-Jun N-terminal kinases
-
[CrossRef] [PubMed]
-
Bogoyevitch, M.A.; Kobe, B. Uses for JNK: The many and varied substrates of the c-Jun N-terminal kinases. Microbiol. Mol. Biol. Rev. 2006, 70, 1061-1095. [CrossRef] [PubMed]
-
(2006)
Microbiol. Mol. Biol. Rev
, vol.70
, pp. 1061-1095
-
-
Bogoyevitch, M.A.1
Kobe, B.2
-
37
-
-
84885856271
-
Exendin-4 protects pancreatic β cells from palmitate-induced apoptosis by interfering with GPR40 and the MKK4/7 stress kinase signalling pathway
-
[CrossRef] [PubMed]
-
Natalicchio, A.; Labarbuta, R.; Tortosa, F.; Biondi, G.; Marrano, N.; Peschechera, A.; Carchia, E.; Orlando, M.R.; Leonardini, A.; Cignarelli, A. et al. Exendin-4 protects pancreatic β cells from palmitate-induced apoptosis by interfering with GPR40 and the MKK4/7 stress kinase signalling pathway. Diabetologia 2013, 56, 2456-2466. [CrossRef] [PubMed]
-
(2013)
Diabetologia
, vol.56
, pp. 2456-2466
-
-
Natalicchio, A.1
Labarbuta, R.2
Tortosa, F.3
Biondi, G.4
Marrano, N.5
Peschechera, A.6
Carchia, E.7
Orlando, M.R.8
Leonardini, A.9
Cignarelli, A.10
-
38
-
-
63349109171
-
Glucose amplifies fatty acid-induced endoplasmic reticulum stress in pancreatic β-cells via activation of mTORC1
-
[CrossRef] [PubMed]
-
Bachar, E.; Ariav, Y.; Ketzinel-Gilad, M.; Cerasi, E.; Kaiser, N.; Leibowitz, G. Glucose amplifies fatty acid-induced endoplasmic reticulum stress in pancreatic β-cells via activation of mTORC1. PLoS ONE 2009, 4, e4954. [CrossRef] [PubMed]
-
(2009)
Plos ONE
, vol.4
-
-
Bachar, E.1
Ariav, Y.2
Ketzinel-Gilad, M.3
Cerasi, E.4
Kaiser, N.5
Leibowitz, G.6
-
39
-
-
49649084031
-
Initiation and execution of lipotoxic ER stress in pancreatic β-cells
-
[CrossRef] [PubMed]
-
Cunha, D.A.; Hekerman, P.; Ladrière, L.; Bazarra-Castro, A.; Ortis, F.; Wakeham, M.C.; Moore, F.; Rasschaert, J.; Cardozo, A.K.; Bellomo, E. et al. Initiation and execution of lipotoxic ER stress in pancreatic β-cells. J. Cell Sci. 2008, 121, 2308-2318. [CrossRef] [PubMed]
-
(2008)
J. Cell Sci
, vol.121
, pp. 2308-2318
-
-
Cunha, D.A.1
Hekerman, P.2
Ladrière, L.3
Bazarra-Castro, A.4
Ortis, F.5
Wakeham, M.C.6
Moore, F.7
Rasschaert, J.8
Cardozo, A.K.9
Bellomo, E.10
-
40
-
-
84868013359
-
Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress—mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis
-
[CrossRef] [PubMed]
-
Cunha, D.A.; Igoillo-Esteve, M.; Gurzov, E.N.; Germano, C.M.; Naamane, N.; Marhfour, I.; Fukaya, M.; Vanderwinden, J.-M.; Gysemans, C.; Mathieu, C. et al. Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress—mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis. Diabetes 2012, 61, 2763-2775. [CrossRef] [PubMed]
-
(2012)
Diabetes
, vol.61
, pp. 2763-2775
-
-
Cunha, D.A.1
Igoillo-Esteve, M.2
Gurzov, E.N.3
Germano, C.M.4
Naamane, N.5
Marhfour, I.6
Fukaya, M.7
Vanderwinden, J.-M.8
Gysemans, C.9
Mathieu, C.10
-
41
-
-
84875069480
-
Exendin-4 inhibits glucolipotoxic ER stress in pancreatic β cells via regulation of SREBP1c and C/EBP_ transcription factors
-
[CrossRef] [PubMed]
-
Oh, Y.S.; Lee, Y.J.; Kang, Y.; Han, J.; Lim, O.K.; Jun, H.S. Exendin-4 inhibits glucolipotoxic ER stress in pancreatic β cells via regulation of SREBP1c and C/EBP_ transcription factors. J. Endocrinol. 2013, 216, 343-352. [CrossRef] [PubMed]
-
(2013)
J. Endocrinol
, vol.216
, pp. 343-352
-
-
Oh, Y.S.1
Lee, Y.J.2
Kang, Y.3
Han, J.4
Lim, O.K.5
Jun, H.S.6
-
42
-
-
84899814979
-
JNK1 protects against glucolipotoxicitymediated β-cell apoptosis
-
Prause, M.; Christensen, D.P.; Billestrup, N.; Mandrup-Poulsen, T. JNK1 protects against glucolipotoxicitymediated β-cell apoptosis. PLoS ONE 2014, 9, e87067.
-
(2014)
Plos ONE
, vol.9
-
-
Prause, M.1
Christensen, D.P.2
Billestrup, N.3
Mandrup-Poulsen, T.4
-
43
-
-
47749122129
-
Rosiglitazone counteracts palmitate-induced β-cell dysfunction by suppression of MAP kinase, inducible nitric oxide synthase and caspase 3 activities
-
[CrossRef] [PubMed]
-
Abaraviciene, S.M.; Lundquist, I.; Salehi, A. Rosiglitazone counteracts palmitate-induced β-cell dysfunction by suppression of MAP kinase, inducible nitric oxide synthase and caspase 3 activities. Cell. Mol. Life Sci. 2008, 65, 2256-2265. [CrossRef] [PubMed]
-
(2008)
Cell. Mol. Life Sci
, vol.65
, pp. 2256-2265
-
-
Abaraviciene, S.M.1
Lundquist, I.2
Salehi, A.3
-
44
-
-
77951929835
-
Protects MIN6N8 pancreatic β-cells against palmitate-induced apoptosis through modulating SAPK/JNK activation
-
[CrossRef] [PubMed]
-
Kim, K.; Kim, D.-H.; Kim, Y.H. Compound K protects MIN6N8 pancreatic β-cells against palmitate-induced apoptosis through modulating SAPK/JNK activation. Cell Biol. Int. 2010, 34, 75-80. [CrossRef] [PubMed]
-
(2010)
Cell Biol. Int
, vol.34
, pp. 75-80
-
-
Kim, K.1
Kim, D.-H.2
Kim, Y.H.3
Compound, K.4
-
45
-
-
4644333142
-
Cross-talk between phosphatidylinositol 3-kinase/AKT and c-jun NH2-terminal kinase mediates survival of isolated human islets
-
[CrossRef] [PubMed]
-
Aikin, R.; Maysinger, D.; Rosenberg, L. Cross-talk between phosphatidylinositol 3-kinase/AKT and c-jun NH2-terminal kinase mediates survival of isolated human islets. Endocrinology 2004, 145, 4522-4531. [CrossRef] [PubMed]
-
(2004)
Endocrinology
, vol.145
, pp. 4522-4531
-
-
Aikin, R.1
Maysinger, D.2
Rosenberg, L.3
-
46
-
-
84874596974
-
Caspase-2 and JNK activated by saturated fatty acids are not involved in apoptosis induction but modulate ER stress in human pancreatic β-cells
-
Nemcova-Fürstova, V.; Balusikova, K.; Sramek, J.; James, R.F.; Kovar, J. Caspase-2 and JNK activated by saturated fatty acids are not involved in apoptosis induction but modulate ER stress in human pancreatic β-cells. Cell. Physiol. Biochem. 2013, 31, 277-289.
-
(2013)
Cell. Physiol. Biochem
, vol.31
, pp. 277-289
-
-
Nemcova-Fürstova, V.1
Balusikova, K.2
Sramek, J.3
James, R.F.4
Kovar, J.5
-
47
-
-
77958484950
-
Free fatty acids stimulate autophagy in pancreatic β-cells via JNK pathway
-
[CrossRef] [PubMed]
-
Komiya, K.; Uchida, T.; Ueno, T.; Koike, M.; Abe, H.; Hirose, T.; Kawamori, R.; Uchiyama, Y.; Kominami, E.; Fujitani, Y. et al. Free fatty acids stimulate autophagy in pancreatic β-cells via JNK pathway. Biochem. Biophys. Res. Commun. 2010, 401, 561-567. [CrossRef] [PubMed]
-
(2010)
Biochem. Biophys. Res. Commun
, vol.401
, pp. 561-567
-
-
Komiya, K.1
Uchida, T.2
Ueno, T.3
Koike, M.4
Abe, H.5
Hirose, T.6
Kawamori, R.7
Uchiyama, Y.8
Kominami, E.9
Fujitani, Y.10
-
48
-
-
77949655879
-
Palmitoleate attenuates palmitate-induced Bim and PUMA up-regulation and hepatocyte lipoapoptosis
-
[CrossRef] [PubMed]
-
Akazawa, Y.; Cazanave, S.; Mott, J.L.; Elmi, N.; Bronk, S.F.; Kohno, S.; Charlton, M.R.; Gores, G.J. Palmitoleate attenuates palmitate-induced Bim and PUMA up-regulation and hepatocyte lipoapoptosis. J. Hepatol. 2010, 52, 586-593. [CrossRef] [PubMed]
-
(2010)
J. Hepatol
, vol.52
, pp. 586-593
-
-
Akazawa, Y.1
Cazanave, S.2
Mott, J.L.3
Elmi, N.4
Bronk, S.F.5
Kohno, S.6
Charlton, M.R.7
Gores, G.J.8
-
49
-
-
84979623366
-
Mechanisms of palmitate-induced cell death in human osteoblasts
-
[CrossRef] [PubMed]
-
Gunaratnam, K.; Vidal, C.; Boadle, R.; Thekkedam, C.; Duque, G. Mechanisms of palmitate-induced cell death in human osteoblasts. Biol. Open 2013, 2, 1382-1389. [CrossRef] [PubMed]
-
(2013)
Biol. Open
, vol.2
, pp. 1382-1389
-
-
Gunaratnam, K.1
Vidal, C.2
Boadle, R.3
Thekkedam, C.4
Duque, G.5
-
50
-
-
84929607060
-
Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity
-
[CrossRef] [PubMed]
-
Win, S.; Than, T.A.; Le, B.H.; Garcia-Ruiz, C.; Fernandez-Checa, J.C.; Kaplowitz, N. Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity. J. Hepatol. 2015, 62, 1367-1374. [CrossRef] [PubMed]
-
(2015)
J. Hepatol
, vol.62
, pp. 1367-1374
-
-
Win, S.1
Than, T.A.2
Le, B.H.3
Garcia-Ruiz, C.4
Fernandez-Checa, J.C.5
Kaplowitz, N.6
-
51
-
-
0032104245
-
The extended protein kinase C superfamily
-
[CrossRef] [PubMed]
-
Mellor, H.; Parker, P.J. The extended protein kinase C superfamily. Biochem. J. 1998, 332, 281-292. [CrossRef] [PubMed]
-
(1998)
Biochem. J
, vol.332
, pp. 281-292
-
-
Mellor, H.1
Parker, P.J.2
-
52
-
-
0026451081
-
Intracellular signaling by hydrolysis of phospholipids and activation of PKC
-
[CrossRef] [PubMed]
-
Nishizuka, Y. Intracellular signaling by hydrolysis of phospholipids and activation of PKC. Science 1992, 258, 607-614. [CrossRef] [PubMed]
-
(1992)
Science
, vol.258
, pp. 607-614
-
-
Nishizuka, Y.1
-
53
-
-
0032421728
-
Signal transduction by protein kinase C in mammalian cells
-
[CrossRef] [PubMed]
-
Kanashiro, C.A.; Khalil, R.A. Signal transduction by protein kinase C in mammalian cells. Clin. Exp. Pharmacol. Physiol. 1998, 25, 974-985. [CrossRef] [PubMed]
-
(1998)
Clin. Exp. Pharmacol. Physiol
, vol.25
, pp. 974-985
-
-
Kanashiro, C.A.1
Khalil, R.A.2
-
54
-
-
36749025313
-
Protein kinase Cdelta and apoptosis
-
[CrossRef] [PubMed]
-
Reyland, M.E. Protein kinase Cdelta and apoptosis. Biochem. Soc. Trans. 2007, 35, 1001-1004. [CrossRef] [PubMed]
-
(2007)
Biochem. Soc. Trans
, vol.35
, pp. 1001-1004
-
-
Reyland, M.E.1
-
55
-
-
84866620547
-
Protein kinase C δ in apoptosis: A brief overview
-
[CrossRef] [PubMed]
-
Zhao, M.; Xia, L.; Chen, G.Q. Protein kinase C δ in apoptosis: A brief overview. Arch. Immunol. Ther. Exp. 2012, 60, 361-372. [CrossRef] [PubMed]
-
(2012)
Arch. Immunol. Ther. Exp
, vol.60
, pp. 361-372
-
-
Zhao, M.1
Xia, L.2
Chen, G.Q.3
-
56
-
-
9144256765
-
Protein kinase C delta activation induces apoptosis in response to cardiac ischemia and reperfusion damage: A mechanism involving BAD and the mitochondria
-
[CrossRef] [PubMed]
-
Murriel, C.L.; Churchill, E.; Inagaki, K.; Szweda, L.I.; Mochly-Rosen, D. Protein kinase C delta activation induces apoptosis in response to cardiac ischemia and reperfusion damage: A mechanism involving BAD and the mitochondria. J. Biol. Chem. 2004, 279, 47985-47991. [CrossRef] [PubMed]
-
(2004)
J. Biol. Chem
, vol.279
, pp. 47985-47991
-
-
Murriel, C.L.1
Churchill, E.2
Inagaki, K.3
Szweda, L.I.4
Mochly-Rosen, D.5
-
57
-
-
0036432931
-
Activation of p38MAPK induces cell cycle arrest via inhibition of C-Raf/ERK pathway during muscle differentiation
-
[CrossRef]
-
Lee, J.; Hong, F.; Kwon, S.; Kim, S.S.; Kim, D.O.; Kang, H.S.; Lee, S.J.; Ha, J.; Kim, S.S. Activation of p38MAPK induces cell cycle arrest via inhibition of C-Raf/ERK pathway during muscle differentiation. Biochem. Biophys. Res. Commun. 2002, 298, 765-771. [CrossRef]
-
(2002)
Biochem. Biophys. Res. Commun
, vol.298
, pp. 765-771
-
-
Lee, J.1
Hong, F.2
Kwon, S.3
Kim, S.S.4
Kim, D.O.5
Kang, H.S.6
Lee, S.J.7
Ha, J.8
Kim, S.S.9
-
58
-
-
4444333436
-
Delta regulates keratinocyte death and survival by regulating activity and subcellular localization of a p38delta-extracellular signal regulated kinase 1/2 complex
-
[CrossRef] [PubMed]
-
Efimova, T.; Broome, A.M.; Eckert, R.L. Protein kinase C delta regulates keratinocyte death and survival by regulating activity and subcellular localization of a p38delta-extracellular signal regulated kinase 1/2 complex. Mol. Cell. Biol. 2004, 24, 8167-8183. [CrossRef] [PubMed]
-
(2004)
Mol. Cell. Biol
, vol.24
, pp. 8167-8183
-
-
Efimova, T.1
Broome, A.M.2
Eckert, R.L.3
Protein Kinase, C.4
-
59
-
-
0037382424
-
Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells
-
[CrossRef] [PubMed]
-
Eitel, K.; Staiger, H.; Rieger, J.; Mischak, H.; Brandhorst, H.; Brendel, M.D.; Bretzel, R.G.; Häring, H.U.; Kellerer, M. Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells. Diabetes 2003, 52, 991-997. [CrossRef] [PubMed]
-
(2003)
Diabetes
, vol.52
, pp. 991-997
-
-
Eitel, K.1
Staiger, H.2
Rieger, J.3
Mischak, H.4
Brandhorst, H.5
Brendel, M.D.6
Bretzel, R.G.7
Häring, H.U.8
Kellerer, M.9
-
60
-
-
41949128158
-
Persistent activation of Akt or ERK prevents the toxicity induced by saturated and polyunsaturated fatty acids in RINm5F β-cells
-
[CrossRef] [PubMed]
-
Simon, M.N.; Azevedo-Martins, A.K.; Amanso, A.M.; Carvalho, C.R.O.; Curi, R. Persistent activation of Akt or ERK prevents the toxicity induced by saturated and polyunsaturated fatty acids in RINm5F β-cells. Toxicol. In Vitro 2008, 22, 1018-1024. [CrossRef] [PubMed]
-
(2008)
Toxicol. in Vitro
, vol.22
, pp. 1018-1024
-
-
Simon, M.N.1
Azevedo-Martins, A.K.2
Amanso, A.M.3
Carvalho, C.R.O.4
Curi, R.5
-
61
-
-
0039910769
-
Stimulation of islet protein kinase C translocation by palmitate requires metabolism of the fatty acid
-
[CrossRef]
-
Alcáazar, O.; Qiu-yue, Z.; Gine, E.; Tamarit-Rodriguez, J. Stimulation of islet protein kinase C translocation by palmitate requires metabolism of the fatty acid. Diabetes 1997, 46, 1153-1158. [CrossRef]
-
(1997)
Diabetes
, vol.46
, pp. 1153-1158
-
-
Alcáazar, O.1
Qiu-Yue, Z.2
Gine, E.3
Tamarit-Rodriguez, J.4
-
62
-
-
0036061642
-
Inhibition of protein kinase C protects rat INS-1 cells against interleukin-1β and streptozotocin-induced apoptosis
-
[CrossRef] [PubMed]
-
Carpenter, L.; Cordery, D.; Biden, T.J. Inhibition of protein kinase C protects rat INS-1 cells against interleukin-1β and streptozotocin-induced apoptosis. Diabetes 2002, 51, 317-324. [CrossRef] [PubMed]
-
(2002)
Diabetes
, vol.51
, pp. 317-324
-
-
Carpenter, L.1
Cordery, D.2
Biden, T.J.3
-
63
-
-
0032491318
-
Protein kinase C δ is activated by caspase-dependent proteolysis during ultraviolet radiation-induced apoptosis of human keratinocytes
-
[CrossRef] [PubMed]
-
Denning, M.F.; Wang, Y.; Nickoloff, B.J.; Wrone-Smith, T. Protein kinase C δ is activated by caspase-dependent proteolysis during ultraviolet radiation-induced apoptosis of human keratinocytes. J. Biol. Chem. 1998, 273, 29995-30002. [CrossRef] [PubMed]
-
(1998)
J. Biol. Chem
, vol.273
, pp. 29995-30002
-
-
Denning, M.F.1
Wang, Y.2
Nickoloff, B.J.3
Wrone-Smith, T.4
-
64
-
-
0033516666
-
Delta is essential for etoposide-induced apoptosis in salivary gland acinar cells
-
[CrossRef] [PubMed]
-
Reyland, M.E.; Anderson, S.M.; Matassa, A.A.; Barzen, K.A.; Quissell, D.O. Protein kinase C delta is essential for etoposide-induced apoptosis in salivary gland acinar cells. J. Biol. Chem. 1999, 274, 19115-19123. [CrossRef] [PubMed]
-
(1999)
J. Biol. Chem
, vol.274
, pp. 19115-19123
-
-
Reyland, M.E.1
Anderson, S.M.2
Matassa, A.A.3
Barzen, K.A.4
Quissell, D.O.5
Protein Kinase, C.6
-
65
-
-
33646765383
-
Protein kinase C δ-mediated proteasomal degradation of MAP kinase phosphatase-1 contributes to glutamate-induced neuronal cell death
-
[CrossRef] [PubMed]
-
Choi, B.H.; Hur, E.M.; Lee, J.H.; Jun, D.J.; Kim, K.T. Protein kinase C δ-mediated proteasomal degradation of MAP kinase phosphatase-1 contributes to glutamate-induced neuronal cell death. J. Cell Sci. 2006, 119, 1329-1340. [CrossRef] [PubMed]
-
(2006)
J. Cell Sci
, vol.119
, pp. 1329-1340
-
-
Choi, B.H.1
Hur, E.M.2
Lee, J.H.3
Jun, D.J.4
Kim, K.T.5
-
66
-
-
0029982565
-
Characterization of the structure and function of a new mitogen-activated protein kinase (P38b)
-
[CrossRef] [PubMed]
-
Jiang, Y.; Chen, C.; Li, Z.; Guo, W.; Gegner, J.A.; Lin, S.; Han, J. Characterization of the structure and function of a new mitogen-activated protein kinase (p38b). J. Biol. Chem. 1996, 271, 17920-17926. [CrossRef] [PubMed]
-
(1996)
J. Biol. Chem
, vol.271
, pp. 17920-17926
-
-
Jiang, Y.1
Chen, C.2
Li, Z.3
Guo, W.4
Gegner, J.A.5
Lin, S.6
Han, J.7
-
67
-
-
0029911710
-
ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation
-
[CrossRef] [PubMed]
-
Lechner, C.; Zahalka, M.A.; Giot, J.F.; Moler, N.P.H.; Ullrich, A. ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation. Proc. Natl. Acad. Sci. USA 1996, 93, 4355-4359. [CrossRef] [PubMed]
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 4355-4359
-
-
Lechner, C.1
Zahalka, M.A.2
Giot, J.F.3
Moler, N.P.H.4
Ullrich, A.5
-
68
-
-
0030581626
-
The primary structure of p38: A new member of p38 group of MAP kinase
-
[CrossRef] [PubMed]
-
Li, Z.; Jiang, Y.; Ulevitch, R.J.; Han, J. The primary structure of p38: A new member of p38 group of MAP kinase. Biochem. Biophys. Res. Commun. 1996, 228, 334-340. [CrossRef] [PubMed]
-
(1996)
Biochem. Biophys. Res. Commun
, vol.228
, pp. 334-340
-
-
Li, Z.1
Jiang, Y.2
Ulevitch, R.J.3
Han, J.4
-
69
-
-
0030828701
-
Characterization of the structure and function of the fourth member of p38 group mitogen activated protein kinases
-
[CrossRef] [PubMed]
-
Jiang, Y.; Gram, H.; Zhao, M.; New, L.; Gu, J.; Feng, L.; Di Padova, F.; Ulevitch, R.J.; Han, J. Characterization of the structure and function of the fourth member of p38 group mitogen activated protein kinases, p38δ. J. Biol. Chem. 1997, 272, 30122-30128. [CrossRef] [PubMed]
-
(1997)
J. Biol. Chem
, vol.272
, pp. 30122-30128
-
-
Jiang, Y.1
Gram, H.2
Zhao, M.3
New, L.4
Gu, J.5
Feng, L.6
Di Padova, F.7
Ulevitch, R.J.8
Han, J.9
-
70
-
-
0031587929
-
Novel homologues of CSBP/p38 MAP kinase: Activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles
-
[CrossRef] [PubMed]
-
Kumar, S.; McDonnell, P.C.; Gum, R.J.; Hand, A.T.; Lee, J.C.; Young, P.R. Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles. Biochem. Biophys. Res. Commun. 1997, 235, 533-538. [CrossRef] [PubMed]
-
(1997)
Biochem. Biophys. Res. Commun
, vol.235
, pp. 533-538
-
-
Kumar, S.1
McDonnell, P.C.2
Gum, R.J.3
Hand, A.T.4
Lee, J.C.5
Young, P.R.6
-
71
-
-
15844431960
-
A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3
-
[PubMed]
-
Moriguchi, T.; Kuroyanagi, N.; Yamaguchi, K.; Gotoh, Y.; Irie, K.; Kano, T.; Shirakabe, K.; Muro, Y.; Shibuya, H.; Matsumoto, K. et al. A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3. J. Biol. Chem. 1996, 271, 13675-13679. [PubMed]
-
(1996)
J. Biol. Chem
, vol.271
, pp. 13675-13679
-
-
Moriguchi, T.1
Kuroyanagi, N.2
Yamaguchi, K.3
Gotoh, Y.4
Irie, K.5
Kano, T.6
Shirakabe, K.7
Muro, Y.8
Shibuya, H.9
Matsumoto, K.10
-
72
-
-
14444281569
-
Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways
-
[CrossRef] [PubMed]
-
Ichijo, H.; Nishida, E.; Irie, K.; ten Dijke, P.; Saitoh, M.; Moriguchi, T.; Takagi, M.; Matsumoto, K.; Miyazono, K.; Gotoh, Y. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science 1997, 275, 90-94. [CrossRef] [PubMed]
-
(1997)
Science
, vol.275
, pp. 90-94
-
-
Ichijo, H.1
Nishida, E.2
Irie, K.3
Ten Dijke, P.4
Saitoh, M.5
Moriguchi, T.6
Takagi, M.7
Matsumoto, K.8
Miyazono, K.9
Gotoh, Y.10
-
73
-
-
0028820587
-
Rho family GTPases regulate p38 MAP kinase through the downstream mediator Pak1
-
[CrossRef] [PubMed]
-
Zhang, S.; Han, J.; Sells, M.A.; Chernoff, J.; Knaus, U.G.; Ulevitch, R.J.; Bokoch, G.M. Rho family GTPases regulate p38 MAP kinase through the downstream mediator Pak1. J. Biol. Chem. 1995, 270, 23934-23936. [CrossRef] [PubMed]
-
(1995)
J. Biol. Chem
, vol.270
, pp. 23934-23936
-
-
Zhang, S.1
Han, J.2
Sells, M.A.3
Chernoff, J.4
Knaus, U.G.5
Ulevitch, R.J.6
Bokoch, G.M.7
-
74
-
-
0032127814
-
Differential activation of stress-activated protein kinase kinases SKK4/MKK7 and SKK1/MKK4 by the mixed-lineage kinase-2 and mitogen-activated protein kinase kinase (MKK) kinase-1
-
[CrossRef] [PubMed]
-
Cuenda, A.; Dorow, D.S. Differential activation of stress-activated protein kinase kinases SKK4/MKK7 and SKK1/MKK4 by the mixed-lineage kinase-2 and mitogen-activated protein kinase kinase (MKK) kinase-1. Biochem. J. 1998, 333, 11-15. [CrossRef] [PubMed]
-
(1998)
Biochem. J
, vol.333
, pp. 11-15
-
-
Cuenda, A.1
Dorow, D.S.2
-
75
-
-
0030851904
-
A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress induced activation of the p38 and JNK pathways
-
[CrossRef] [PubMed]
-
Takekawa, M.; Posas, F.; Saito, H. A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress induced activation of the p38 and JNK pathways. EMBO J. 1997, 16, 4973-4982. [CrossRef] [PubMed]
-
(1997)
EMBO J
, vol.16
, pp. 4973-4982
-
-
Takekawa, M.1
Posas, F.2
Saito, H.3
-
76
-
-
0028875683
-
Cdc42 and PAK mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation
-
[PubMed]
-
Bagrodia, S.; Derijard, B.; Davis, R.J.; Cerione, R.A. Cdc42 and PAK mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation. J. Biol. Chem. 1995, 270, 27995-27998. [PubMed]
-
(1995)
J. Biol. Chem
, vol.270
, pp. 27995-27998
-
-
Bagrodia, S.1
Derijard, B.2
Davis, R.J.3
Cerione, R.A.4
-
77
-
-
19644367000
-
Activation and signaling of the p38 MAP kinase pathway
-
[CrossRef] [PubMed]
-
Zarubin, T.; Han, J. Activation and signaling of the p38 MAP kinase pathway. Cell Res. 2005, 15, 11-18. [CrossRef] [PubMed]
-
(2005)
Cell Res
, vol.15
, pp. 11-18
-
-
Zarubin, T.1
Han, J.2
-
78
-
-
34547154349
-
P38 MAP-kinases pathway regulation, function and role in human diseases
-
[CrossRef] [PubMed]
-
Cuenda, A.; Rousseau, S. p38 MAP-kinases pathway regulation, function and role in human diseases. Biochim. Biophys. Acta 2004, 1773, 1358-1375. [CrossRef] [PubMed]
-
(2004)
Biochim. Biophys. Acta
, vol.1773
, pp. 1358-1375
-
-
Cuenda, A.1
Rousseau, S.2
-
79
-
-
84930930613
-
Palmitate promotes autophagy and apoptosis through ROS-dependent JNK and p38 MAPK
-
[CrossRef] [PubMed]
-
Liu, J.; Chang, F.; Li, F.; Fu, H.; Wang, J.; Zhang, S.; Zhao, J.; Yin, D. Palmitate promotes autophagy and apoptosis through ROS-dependent JNK and p38 MAPK. Biochem. Biophys. Res. Commun. 2015, 463, 262-267. [CrossRef] [PubMed]
-
(2015)
Biochem. Biophys. Res. Commun
, vol.463
, pp. 262-267
-
-
Liu, J.1
Chang, F.2
Li, F.3
Fu, H.4
Wang, J.5
Zhang, S.6
Zhao, J.7
Yin, D.8
-
80
-
-
84957596359
-
P38 MAPK is activated but does not play a key role during apoptosis induction by saturated fatty acid in human pancreatic β-cells
-
[CrossRef] [PubMed]
-
Sramek, J.; Nemcova-Fürstova, V.; Balusikova, K.; Daniel, P.; Jelinek, M.; James, R.F.; Kovar, J. p38 MAPK is activated but does not play a key role during apoptosis induction by saturated fatty acid in human pancreatic β-cells. Int. J. Mol. Sci. 2016, 17, 159. [CrossRef] [PubMed]
-
(2016)
Int. J. Mol. Sci
, vol.17
, pp. 159
-
-
Sramek, J.1
Nemcova-Fürstova, V.2
Balusikova, K.3
Daniel, P.4
Jelinek, M.5
James, R.F.6
Kovar, J.7
-
81
-
-
34447516979
-
H2S, endoplasmic reticulum stress, and apoptosis of insulin-secreting β cells
-
[CrossRef] [PubMed]
-
Yang, G.; Yang, W.; Wu, L.; Wang, R. H2S, endoplasmic reticulum stress, and apoptosis of insulin-secreting β cells. J. Biol. Chem. 2007, 282, 16567-16576. [CrossRef] [PubMed]
-
(2007)
J. Biol. Chem
, vol.282
, pp. 16567-16576
-
-
Yang, G.1
Yang, W.2
Wu, L.3
Wang, R.4
-
82
-
-
76149125754
-
12-Lipoxygenase products reduce insulin secretion and β-cell viability in human islets
-
[CrossRef] [PubMed]
-
Ma, K.; Nunemaker, C.S.; Wu, R.; Chakrabarti, S.K.; Taylor-Fishwick, D.A.; Nadler, J.L. 12-Lipoxygenase products reduce insulin secretion and β-cell viability in human islets. J. Clin. Endocrinol. Metab. 2010, 95, 887-893. [CrossRef] [PubMed]
-
(2010)
J. Clin. Endocrinol. Metab
, vol.95
, pp. 887-893
-
-
Ma, K.1
Nunemaker, C.S.2
Wu, R.3
Chakrabarti, S.K.4
Taylor-Fishwick, D.A.5
Nadler, J.L.6
-
83
-
-
30044444610
-
Role of MKK3 and p38 MAPK in cytokine-induced death of insulin-producing cells
-
[CrossRef] [PubMed]
-
Makeeva, N.; Myers, J.W.; Welsh, N. Role of MKK3 and p38 MAPK in cytokine-induced death of insulin-producing cells. Biochem. J. 2006, 393, 129-139. [CrossRef] [PubMed]
-
(2006)
Biochem. J
, vol.393
, pp. 129-139
-
-
Makeeva, N.1
Myers, J.W.2
Welsh, N.3
-
84
-
-
0035877087
-
Role of p38 mitogen-activated protein kinase (P38 MAPK) in cytokine-induced rat islet cell apoptosis
-
[CrossRef]
-
Saldeen, J.; Lee, J.C.; Welsh, N. Role of p38 mitogen-activated protein kinase (p38 MAPK) in cytokine-induced rat islet cell apoptosis. Biochem. Pharmacol. 2001, 61, 1561-1569. [CrossRef]
-
(2001)
Biochem. Pharmacol
, vol.61
, pp. 1561-1569
-
-
Saldeen, J.1
Lee, J.C.2
Welsh, N.3
-
85
-
-
33947391701
-
P38 mitogen-activated protein kinase mediates palmitate-induced apoptosis but not inhibitor of nuclear factor-kappa B degradation in human coronary artery endothelial cells
-
[CrossRef] [PubMed]
-
Chai, W.; Liu, Z. p38 mitogen-activated protein kinase mediates palmitate-induced apoptosis but not inhibitor of nuclear factor-kappa B degradation in human coronary artery endothelial cells. Endocrinology 2007, 148, 1622-1628. [CrossRef] [PubMed]
-
(2007)
Endocrinology
, vol.148
, pp. 1622-1628
-
-
Chai, W.1
Liu, Z.2
-
86
-
-
65549171108
-
P38 mitogen-activated protein kinase: A critical node linking insulin resistance and cardiovascular diseases in type 2 diabetes mellitus
-
[CrossRef] [PubMed]
-
Liu, Z.; Cao, W. p38 mitogen-activated protein kinase: a critical node linking insulin resistance and cardiovascular diseases in type 2 diabetes mellitus. Endocr. Metab. Immune Disord. Drug Targets 2009, 9, 38-46. [CrossRef] [PubMed]
-
(2009)
Endocr. Metab. Immune Disord. Drug Targets
, vol.9
, pp. 38-46
-
-
Liu, Z.1
Cao, W.2
-
87
-
-
84902372331
-
Non-esterified fatty acids activate the ROS-p38-p53/Nrf2 signaling pathway to induce bovine hepatocyte apoptosis in vitro
-
[CrossRef] [PubMed]
-
Song, Y.; Li, X.; Li, Y.; Li, N.; Shi, X.; Ding, H.; Zhang, Y.; Li, X.; Liu, G.; Wang, Z. Non-esterified fatty acids activate the ROS-p38-p53/Nrf2 signaling pathway to induce bovine hepatocyte apoptosis in vitro. Apoptosis 2014, 19, 984-997. [CrossRef] [PubMed]
-
(2014)
Apoptosis
, vol.19
, pp. 984-997
-
-
Song, Y.1
Li, X.2
Li, Y.3
Li, N.4
Shi, X.5
Ding, H.6
Zhang, Y.7
Li, X.8
Liu, G.9
Wang, Z.10
-
88
-
-
84948075243
-
Modulation of extracellular signal-related kinase, cyclin D1, glial fibrillary acidic protein, and vimentin expression in estradiol-pretreated astrocyte cultures treated with competence and progression growth factors
-
[CrossRef] [PubMed]
-
Bramanti, V.; Grasso, S.; Tibullo, D.; Giallongo, C.; Raciti, G.; Viola, M.; Avola, R. Modulation of extracellular signal-related kinase, cyclin D1, glial fibrillary acidic protein, and vimentin expression in estradiol-pretreated astrocyte cultures treated with competence and progression growth factors. J. Neurosci. Res. 2015, 93, 1378-1387. [CrossRef] [PubMed]
-
(2015)
J. Neurosci. Res
, vol.93
, pp. 1378-1387
-
-
Bramanti, V.1
Grasso, S.2
Tibullo, D.3
Giallongo, C.4
Raciti, G.5
Viola, M.6
Avola, R.7
-
89
-
-
0035230048
-
Multiple pathways of ERK activation by G protein-coupled receptors
-
[PubMed]
-
Gudermann, T. Multiple pathways of ERK activation by G protein-coupled receptors. Novartis Found. Symp. 2001, 239, 68-79. [PubMed]
-
(2001)
Novartis Found. Symp
, vol.239
, pp. 68-79
-
-
Gudermann, T.1
-
90
-
-
0037810249
-
Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: Potential targeting for therapeutic intervention
-
[CrossRef] [PubMed]
-
Chang, F.; Steelman, L.S.; Lee, J.T.; Shelton, J.G.; Navolanic, P.M.; Blalock W.L.; Franklin, R.A.; McCubrey, J.A. Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: Potential targeting for therapeutic intervention. Leukemia 2003, 17, 1263-1293. [CrossRef] [PubMed]
-
(2003)
Leukemia
, vol.17
, pp. 1263-1293
-
-
Chang, F.1
Steelman, L.S.2
Lee, J.T.3
Shelton, J.G.4
Navolanic, P.M.5
Blalock, W.L.6
Franklin, R.A.7
McCubrey, J.A.8
-
91
-
-
0027326410
-
Protein kinase Ca activates RAF-1 by direct phosphorylation
-
[CrossRef] [PubMed]
-
Kolch, W.; Heidecker, G.; Kochs, G.; Hummel, R.; Vahidi, H.; Mischak, H.; Finkenzeller, G.; Marme, D.; Rapp, U.R. Protein kinase Ca activates RAF-1 by direct phosphorylation. Nature 1993, 364, 249-252. [CrossRef] [PubMed]
-
(1993)
Nature
, vol.364
, pp. 249-252
-
-
Kolch, W.1
Heidecker, G.2
Kochs, G.3
Hummel, R.4
Vahidi, H.5
Mischak, H.6
Finkenzeller, G.7
Marme, D.8
Rapp, U.R.9
-
92
-
-
0027364980
-
Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase
-
[CrossRef] [PubMed]
-
Fabian, J.R.; Daar, I.O.; Morrison, D.K. Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase. Mol. Cell. Biol. 1993, 13, 7170-7179. [CrossRef] [PubMed]
-
(1993)
Mol. Cell. Biol
, vol.13
, pp. 7170-7179
-
-
Fabian, J.R.1
Daar, I.O.2
Morrison, D.K.3
-
93
-
-
0030756069
-
Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling
-
[CrossRef] [PubMed]
-
Diaz, B.; Barnard, D.; Filson, A.; MacDonald, S.; King, A.; Marshall, M. Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling. Mol. Cell. Biol. 1997, 17, 4509-4516. [CrossRef] [PubMed]
-
(1997)
Mol. Cell. Biol
, vol.17
, pp. 4509-4516
-
-
Diaz, B.1
Barnard, D.2
Filson, A.3
Macdonald, S.4
King, A.5
Marshall, M.6
-
94
-
-
0035413618
-
-
[CrossRef] [PubMed]
-
Chen, Z.; Gibson, T.B.; Robinson, F.; Silvestro, L.; Pearson, G.; Xu, B.; Wright, A.; Vanderbilt, C.; Cobb, M.H. MAP Kinases. Chem. Rev. 2001, 101, 2449-2476. [CrossRef] [PubMed]
-
(2001)
MAP Kinases. Chem. Rev
, vol.101
, pp. 2449-2476
-
-
Chen, Z.1
Gibson, T.B.2
Robinson, F.3
Silvestro, L.4
Pearson, G.5
Xu, B.6
Wright, A.7
Vanderbilt, C.8
Cobb, M.H.9
-
95
-
-
84945261451
-
Neuroactive molecules and growth factors modulate cytoskeletal protein expression during astroglial cell proliferation and differentiation in culture
-
[CrossRef] [PubMed]
-
Bramanti, V.; Grasso, S.; Tibullo, D.; Giallongo, C.; Pappa, R.; Brundo, M.V.; Tomassoni, D.; Viola, M.; Amenta, F.; Avola, R. Neuroactive molecules and growth factors modulate cytoskeletal protein expression during astroglial cell proliferation and differentiation in culture. J. Neurosci. Res. 2016, 94, 90-98. [CrossRef] [PubMed]
-
(2016)
J. Neurosci. Res
, vol.94
, pp. 90-98
-
-
Bramanti, V.1
Grasso, S.2
Tibullo, D.3
Giallongo, C.4
Pappa, R.5
Brundo, M.V.6
Tomassoni, D.7
Viola, M.8
Amenta, F.9
Avola, R.10
-
96
-
-
73649089980
-
ERK and cell death: Mechanisms of ERK-induced cell death—Apoptosis, autophagy and senescence
-
[CrossRef] [PubMed]
-
Cagnol, S.; Chambard, J.C. ERK and cell death: Mechanisms of ERK-induced cell death—Apoptosis, autophagy and senescence. FEBS J. 2010, 277, 2-21. [CrossRef] [PubMed]
-
(2010)
FEBS J
, vol.277
, pp. 2-21
-
-
Cagnol, S.1
Chambard, J.C.2
-
97
-
-
77951295434
-
Blockage of ceramide metabolism exacerbates palmitate inhibition of pro-insulin gene expression in pancreatic β-cells
-
[CrossRef] [PubMed]
-
Guo, J.; Qian, Y.Y.; Xi, X.X.; Hu, X.H.; Zhu, J.X.; Han, X. Blockage of ceramide metabolism exacerbates palmitate inhibition of pro-insulin gene expression in pancreatic β-cells. Mol. Cell. Biochem. 2010, 338, 283-290. [CrossRef] [PubMed]
-
(2010)
Mol. Cell. Biochem
, vol.338
, pp. 283-290
-
-
Guo, J.1
Qian, Y.Y.2
Xi, X.X.3
Hu, X.H.4
Zhu, J.X.5
Han, X.6
-
98
-
-
67349121773
-
Role of the transcriptional factor C/EBP in free fatty acid-elicited β cell failure
-
[CrossRef] [PubMed]
-
Plaisance, V.; Perret, V.; Favrea, D.; Abderrahmania, A.; Yanga, J.-Y.; Widmanna, C.; Regazzi, R. Role of the transcriptional factor C/EBP in free fatty acid-elicited β cell failure. Mol. Cell. Endocrinol. 2009, 305, 47-55. [CrossRef] [PubMed]
-
(2009)
Mol. Cell. Endocrinol
, vol.305
, pp. 47-55
-
-
Plaisance, V.1
Perret, V.2
Favrea, D.3
Abderrahmania, A.4
Yanga, J.-Y.5
Widmanna, C.6
Regazzi, R.7
-
99
-
-
70349109268
-
Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic β-cells
-
[CrossRef] [PubMed]
-
Fontes, G.; Semache, M.; Hagman, D.K.; Tremblay, C.; Shah, R.; Rhodes, C.J.; Rutter, J.; Poitout, V. Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic β-cells. Diabetes 2009, 58, 2048-2058. [CrossRef] [PubMed]
-
(2009)
Diabetes
, vol.58
, pp. 2048-2058
-
-
Fontes, G.1
Semache, M.2
Hagman, D.K.3
Tremblay, C.4
Shah, R.5
Rhodes, C.J.6
Rutter, J.7
Poitout, V.8
-
100
-
-
80053578696
-
Chronic effects of palmitate overload on nutrient-induced insulin secretion and autocrine signalling in pancreatic MIN6 β cells
-
[CrossRef] [PubMed]
-
Watson, M.L.; Macrae, K.; Marley, A.E.; Hundal, H.S. Chronic effects of palmitate overload on nutrient-induced insulin secretion and autocrine signalling in pancreatic MIN6 β cells. PLoS ONE 2011, 6, e25975. [CrossRef] [PubMed]
-
(2011)
Plos ONE
, vol.6
-
-
Watson, M.L.1
Macrae, K.2
Marley, A.E.3
Hundal, H.S.4
-
101
-
-
0032510838
-
Interleukin-1β-induced rat pancreatic islet nitric oxide synthesis requires both the p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases
-
[CrossRef] [PubMed]
-
Larsen, C.M.; Wadt, K.A.; Juhl, L.F.; Andersen, H.U.; Karlsen, A.E.; Su, M.S.; Seedorf, K.; Shapiro, L.; Dinarello, C.A.; Mandrup-Poulsen, T. Interleukin-1β-induced rat pancreatic islet nitric oxide synthesis requires both the p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases. J. Biol. Chem. 1998, 273, 15294-15300. [CrossRef] [PubMed]
-
(1998)
J. Biol. Chem
, vol.273
, pp. 15294-15300
-
-
Larsen, C.M.1
Wadt, K.A.2
Juhl, L.F.3
Andersen, H.U.4
Karlsen, A.E.5
Su, M.S.6
Seedorf, K.7
Shapiro, L.8
Dinarello, C.A.9
Mandrup-Poulsen, T.10
-
102
-
-
3042825017
-
2+influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets
-
[PubMed]
-
2+influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets. Diabetes 2004, 53, 1706-1713. [PubMed]
-
(2004)
Diabetes
, vol.53
, pp. 1706-1713
-
-
Maedler, K.1
Storling, J.2
Sturis, J.3
Zuellig, R.A.4
Spinas, G.A.5
Arkhammar, P.O.6
Mandrup-Poulsen, T.7
Donath, M.Y.8
-
103
-
-
22844446279
-
ERK1/2-dependent activation of transcription factors required for acute and chronic effects of glucose on the insulin gene promoter
-
[CrossRef] [PubMed]
-
Lawrence, M.C.; McGlynn, K.; Park, B.H.; Cobb, M.H. ERK1/2-dependent activation of transcription factors required for acute and chronic effects of glucose on the insulin gene promoter. J. Biol. Chem. 2005, 280, 26751-26759. [CrossRef] [PubMed]
-
(2005)
J. Biol. Chem
, vol.280
, pp. 26751-26759
-
-
Lawrence, M.C.1
McGlynn, K.2
Park, B.H.3
Cobb, M.H.4
-
104
-
-
84885848704
-
The aryl receptor inhibitor epigallocatechin-3-gallate protects INS-1E β-cell line against acute dioxin toxicity
-
[CrossRef] [PubMed]
-
Martino, L.; Masini, M.; Novelli, M.; Giacopelli, D.; Beffy, P.; Masiello, P.; de Tata, V. The aryl receptor inhibitor epigallocatechin-3-gallate protects INS-1E β-cell line against acute dioxin toxicity. Chemosphere 2013, 93, 1447-1455. [CrossRef] [PubMed]
-
(2013)
Chemosphere
, vol.93
, pp. 1447-1455
-
-
Martino, L.1
Masini, M.2
Novelli, M.3
Giacopelli, D.4
Beffy, P.5
Masiello, P.6
de Tata, V.7
-
105
-
-
84965154636
-
Oxytocin protects against stress-induced cell death in murine pancreatic β-cells
-
[CrossRef] [PubMed]
-
Watanabe, S.; Wei, F.Y.; Matsunaga, T.; Matsunaga, N.; Kaitsuka, T.; Tomizawa, K. Oxytocin protects against stress-induced cell death in murine pancreatic β-cells. Sci. Rep. 2016, 6, 25185. [CrossRef] [PubMed]
-
(2016)
Sci. Rep
, vol.6
, pp. 25185
-
-
Watanabe, S.1
Wei, F.Y.2
Matsunaga, T.3
Matsunaga, N.4
Kaitsuka, T.5
Tomizawa, K.6
-
106
-
-
84978174650
-
The p21-activated kinase (PAK1) is involved in diet-induced _ cell mass expansion and survival in mice and human islets
-
[CrossRef] [PubMed]
-
Ahn, M.; Yoder, S.M.; Wang, Z.; Oh, E.; Ramalingam, L.; Tunduguru, R.; Thurmond, D.C. The p21-activated kinase (PAK1) is involved in diet-induced _ cell mass expansion and survival in mice and human islets. Diabetologia 2016. in press. [CrossRef] [PubMed]
-
Diabetologia 2016
-
-
Ahn, M.1
Yoder, S.M.2
Wang, Z.3
Oh, E.4
Ramalingam, L.5
Tunduguru, R.6
Thurmond, D.C.7
-
107
-
-
52449084933
-
AMPK activator, AICAR, inhibits palmitate-induced apoptosis in osteoblast
-
[CrossRef] [PubMed]
-
Kim, J.E.; Ahn, M.W.; Baek, S.H.; Lee, I.K.; Kim, Y.W.; Kim, J.Y.; Dan, J.M.; Park, S.Y. AMPK activator, AICAR, inhibits palmitate-induced apoptosis in osteoblast. Bone 2008, 43, 394-404. [CrossRef] [PubMed]
-
(2008)
Bone
, vol.43
, pp. 394-404
-
-
Kim, J.E.1
Ahn, M.W.2
Baek, S.H.3
Lee, I.K.4
Kim, Y.W.5
Kim, J.Y.6
Dan, J.M.7
Park, S.Y.8
-
108
-
-
84899442293
-
FFAs-ROS-ERK/P38 pathway plays a key role in adipocyte lipotoxicity on osteoblasts in co-culture
-
[CrossRef] [PubMed]
-
Dong, X.; Bi, L.; He, S.; Meng, G.; Wei, B.; Jia, S.; Liu, J. FFAs-ROS-ERK/P38 pathway plays a key role in adipocyte lipotoxicity on osteoblasts in co-culture. Biochimie 2014, 101, 123-131. [CrossRef] [PubMed]
-
(2014)
Biochimie
, vol.101
, pp. 123-131
-
-
Dong, X.1
Bi, L.2
He, S.3
Meng, G.4
Wei, B.5
Jia, S.6
Liu, J.7
-
109
-
-
84908365772
-
Free fatty acid receptor 2, a candidate target for type 1 diabetes, induces cell apoptosis through ERK signaling
-
[CrossRef] [PubMed]
-
Shi, G.; Sun, C.; Gu, W.; Yang, M.; Zhang, X.; Zhai, N.; Lu, Y.; Zhang, Z.; Shou, P.; Zhang, Z.; Ning, G. Free fatty acid receptor 2, a candidate target for type 1 diabetes, induces cell apoptosis through ERK signaling. J. Mol. Endocrinol. 2014, 53, 367-380. [CrossRef] [PubMed]
-
(2014)
J. Mol. Endocrinol
, vol.53
, pp. 367-380
-
-
Shi, G.1
Sun, C.2
Gu, W.3
Yang, M.4
Zhang, X.5
Zhai, N.6
Lu, Y.7
Zhang, Z.8
Shou, P.9
Zhang, Z.10
Ning, G.11
-
110
-
-
1542328927
-
Structure, regulation and function of PKB/AKT—A major therapeutic target
-
[CrossRef] [PubMed]
-
Hanada, M.; Feng, J.; Hemmings, B.A. Structure, regulation and function of PKB/AKT—A major therapeutic target. Biochim. Biophys. Acta 2004, 1697, 3-16. [CrossRef] [PubMed]
-
(2004)
Biochim. Biophys. Acta
, vol.1697
, pp. 3-16
-
-
Hanada, M.1
Feng, J.2
Hemmings, B.A.3
-
111
-
-
84867265786
-
Role of AKT/mTORC1 pathway in pancreatic β-cell proliferation
-
Morales, B.M.; de Plata, A.C. Role of AKT/mTORC1 pathway in pancreatic β-cell proliferation. Colomb. Med. 2012, 43, 235-243.
-
(2012)
Colomb. Med
, vol.43
, pp. 235-243
-
-
Morales, B.M.1
de Plata, A.C.2
-
112
-
-
33646107369
-
VEGF receptor signalling—In control of vascular function
-
[CrossRef] [PubMed]
-
Olsson, A.K.; Dimberg, A.; Kreuger, J.; Claesson-Welsh, L. VEGF receptor signalling—In control of vascular function. Nat. Rev. Mol. Cell Biol. 2006, 7, 359-371. [CrossRef] [PubMed]
-
(2006)
Nat. Rev. Mol. Cell Biol
, vol.7
, pp. 359-371
-
-
Olsson, A.K.1
Dimberg, A.2
Kreuger, J.3
Claesson-Welsh, L.4
-
113
-
-
20444491588
-
Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic B cell survival is dependent upon phosphatidylinositol3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor FoxO1, and down-regulation of bax expression
-
[PubMed]
-
Kim, S.-J.; Winter, K.; Nian, C.; Tsuneoka, M.; Koda, Y.; McIntosh, C.H.S. Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic B cell survival is dependent upon phosphatidylinositol3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor FoxO1, and down-regulation of bax expression. J. Biol. Chem. 2005, 280, 22297-22307. [PubMed]
-
(2005)
J. Biol. Chem
, vol.280
, pp. 22297-22307
-
-
Kim, S.-J.1
Winter, K.2
Nian, C.3
Tsuneoka, M.4
Koda, Y.5
McIntosh, C.6
-
114
-
-
1842333237
-
Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
-
[CrossRef] [PubMed]
-
Del Peso, L.; Gonzalez-Garcia, M.; Page, C.; Herrera, R.; Nunez, G. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 1997, 278, 687-689. [CrossRef] [PubMed]
-
(1997)
Science
, vol.278
, pp. 687-689
-
-
Del Peso, L.1
Gonzalez-Garcia, M.2
Page, C.3
Herrera, R.4
Nunez, G.5
-
115
-
-
0033517189
-
NF-κB activation by tumour necrosis factor requires the Akt serine-threonine kinase
-
[CrossRef] [PubMed]
-
Ozes, O.N.; Mayo, L.D.; Gustin, J.A.; Pfeffer, S.R.; Pfeffer, L.M.; Donner, D.B. NF-κB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 1999, 401, 82-85. [CrossRef] [PubMed]
-
(1999)
Nature
, vol.401
, pp. 82-85
-
-
Ozes, O.N.1
Mayo, L.D.2
Gustin, J.A.3
Pfeffer, S.R.4
Pfeffer, L.M.5
Donner, D.B.6
-
116
-
-
77955081067
-
UPR-mediated TRIB3 expression correlates with reduced AKT phosphorylation and inability of interleukin 6 to overcome palmitate-induced apoptosis in RINm5F cells
-
[CrossRef] [PubMed]
-
Nicoletti-Carvalho, J.E.; Nogueira, T.C.; Gorjão, R.; Bromati, C.R.; Yamanaka, T.S.; Boschero, A.C.; Velloso, L.A.; Curi, R.; Anhê, G.F.; Bordin, S. UPR-mediated TRIB3 expression correlates with reduced AKT phosphorylation and inability of interleukin 6 to overcome palmitate-induced apoptosis in RINm5F cells. J. Endocrinol. 2010, 206, 183-193. [CrossRef] [PubMed]
-
(2010)
J. Endocrinol
, vol.206
, pp. 183-193
-
-
Nicoletti-Carvalho, J.E.1
Nogueira, T.C.2
Gorjão, R.3
Bromati, C.R.4
Yamanaka, T.S.5
Boschero, A.C.6
Velloso, L.A.7
Curi, R.8
Anhê, G.F.9
Bordin, S.10
-
117
-
-
84871706304
-
LRP16 gene protects mouse insulinoma MIN6 cells against fatty acid-induced apoptosis through Akt/FoxO1 signaling
-
[PubMed]
-
Li, X.J.; Guo, Q.H.; Wang, X.; Xue, B.; Sun, L.Q.; Meng, Q.T.; Lu, J.M.; Mu, Y.M. LRP16 gene protects mouse insulinoma MIN6 cells against fatty acid-induced apoptosis through Akt/FoxO1 signaling. Chin. Med. J. 2012, 125, 1695-1702. [PubMed]
-
(2012)
Chin. Med. J
, vol.125
, pp. 1695-1702
-
-
Li, X.J.1
Guo, Q.H.2
Wang, X.3
Xue, B.4
Sun, L.Q.5
Meng, Q.T.6
Lu, J.M.7
Mu, Y.M.8
-
118
-
-
84907422947
-
Protective action of liraglutide in β cells under lipotoxic stress via PI3K/Akt/FoxO1 pathway
-
[CrossRef] [PubMed]
-
Shao, S.; Nie, M.; Chen, C.; Chen, X.; Zhang, M.; Yuan, G.; Yu, X.; Yang, Y. Protective action of liraglutide in β cells under lipotoxic stress via PI3K/Akt/FoxO1 pathway. J. Cell. Biochem. 2014, 115, 1166-1175. [CrossRef] [PubMed]
-
(2014)
J. Cell. Biochem
, vol.115
, pp. 1166-1175
-
-
Shao, S.1
Nie, M.2
Chen, C.3
Chen, X.4
Zhang, M.5
Yuan, G.6
Yu, X.7
Yang, Y.8
-
119
-
-
84942551235
-
Curcumin attenuates palmitate-induced apoptosis in MIN6 pancreatic β-cells through PI3K/Akt/FoxO1 and mitochondrial survival pathways
-
[CrossRef] [PubMed]
-
Hao, F.; Kang, J.; Cao, Y.; Fan, S.; Yang, H.; An, Y.; Pan, Y.; Tie, L.; Li, X. Curcumin attenuates palmitate-induced apoptosis in MIN6 pancreatic β-cells through PI3K/Akt/FoxO1 and mitochondrial survival pathways. Apoptosis 2015, 20, 1420-1432. [CrossRef] [PubMed]
-
(2015)
Apoptosis
, vol.20
, pp. 1420-1432
-
-
Hao, F.1
Kang, J.2
Cao, Y.3
Fan, S.4
Yang, H.5
An, Y.6
Pan, Y.7
Tie, L.8
Li, X.9
-
120
-
-
77953506788
-
ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy
-
[CrossRef] [PubMed]
-
Qin, L.; Wang, Z.; Tao, L.; Wang, Y. ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy. Autophagy 2010, 6, 239-247. [CrossRef] [PubMed]
-
(2010)
Autophagy
, vol.6
, pp. 239-247
-
-
Qin, L.1
Wang, Z.2
Tao, L.3
Wang, Y.4
-
121
-
-
79953146630
-
Selective abrogation of BiP/GRP78 blunts activation of NF-κB through the ATF6 branch of the UPR: Involvement of C/EBPβ and mTOR-dependent dephosphorylation of Akt
-
[CrossRef] [PubMed]
-
Nakajima, S.; Hiramatsu, N.; Hayakawa, K.; Saito, Y.; Kato, H.; Huang, T.; Yao, J.; Paton, A.W.; Paton, J.C.; Kitamura, M. Selective abrogation of BiP/GRP78 blunts activation of NF-κB through the ATF6 branch of the UPR: Involvement of C/EBPβ and mTOR-dependent dephosphorylation of Akt. Mol. Cell. Biol. 2011, 31, 1710-1718. [CrossRef] [PubMed]
-
(2011)
Mol. Cell. Biol
, vol.31
, pp. 1710-1718
-
-
Nakajima, S.1
Hiramatsu, N.2
Hayakawa, K.3
Saito, Y.4
Kato, H.5
Huang, T.6
Yao, J.7
Paton, A.W.8
Paton, J.C.9
Kitamura, M.10
-
122
-
-
0034781057
-
Regulation of pancreatic β-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha
-
[CrossRef] [PubMed]
-
Tuttle, R.L.; Gill, N.S.; Pugh, W.; Lee, J.P.; Koeberlein, B.; Furth, E.E.; Polonsky, K.S.; Naji, A.; Birnbaum, M.J. Regulation of pancreatic β-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha. Nat. Med. 2001, 7, 1133-1137. [CrossRef] [PubMed]
-
(2001)
Nat. Med
, vol.7
, pp. 1133-1137
-
-
Tuttle, R.L.1
Gill, N.S.2
Pugh, W.3
Lee, J.P.4
Koeberlein, B.5
Furth, E.E.6
Polonsky, K.S.7
Naji, A.8
Birnbaum, M.J.9
-
123
-
-
84939627589
-
Docosahexaenoic acid induces cell death in human non-small cell lung cancer cells by repressing mTOR via AMPK activation and PI3K/Akt inhibition
-
[CrossRef] [PubMed]
-
Kim, N.; Jeong, S.; Jing, K.; Shin, S.; Kim, S.; Heo, J.Y.; Kweon, G.R.; Park, S.K.; Wu, T.; Park, J.I. et al. Docosahexaenoic acid induces cell death in human non-small cell lung cancer cells by repressing mTOR via AMPK activation and PI3K/Akt inhibition. BioMed Res. Int. 2015, 2015, 239764. [CrossRef] [PubMed]
-
Biomed Res. Int. 2015
, pp. 2015
-
-
Kim, N.1
Jeong, S.2
Jing, K.3
Shin, S.4
Kim, S.5
Heo, J.Y.6
Kweon, G.R.7
Park, S.K.8
Wu, T.9
Park, J.I.10
-
124
-
-
84929497376
-
G-CSF protects human brain vascular endothelial cells injury induced by high glucose, free fatty acids and hypoxia through MAPK and Akt signaling
-
Su, J.; Zhou, H.; Tao, Y.; Guo, J.; Guo, Z.; Zhang, S.; Zhang, Y.; Huang, Y.; Tang, Y.; Dong, Q. et al. G-CSF protects human brain vascular endothelial cells injury induced by high glucose, free fatty acids and hypoxia through MAPK and Akt signaling. PLoS ONE 2015, 10, e0120707.
-
(2015)
Plos ONE
, vol.10
-
-
Su, J.1
Zhou, H.2
Tao, Y.3
Guo, J.4
Guo, Z.5
Zhang, S.6
Zhang, Y.7
Huang, Y.8
Tang, Y.9
Dong, Q.10
|