The p21-activated kinase (PAK1) is involved in diet-induced beta cell mass expansion and survival in mice and human islets

Diabetologia

Volumn 59, Issue 10, 2016, Pages 2145-2155

  Ahn, Miwon ^a   Yoder, Stephanie M ^b   Wang, Zhanxiang ^b   Oh, Eunjin ^a   Ramalingam, Latha ^b   Tunduguru, Ragadeepthi ^a,b   Thurmond, Debbie C ^a,b  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Beta cell mass; Diet induced obesity; Insulin secretion; PAK1; Prediabetes; Type 2 diabetes

Indexed keywords

CASPASE 3; GLUCOSE; INDUCIBLE NITRIC OXIDE SYNTHASE; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; P21 ACTIVATED KINASE 1; PALMITIC ACID; PROTEIN BCL 2; GLUCOSE BLOOD LEVEL; P21 ACTIVATED KINASE;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BODY WEIGHT; CELL CULTURE; CELL DEATH; CELL DIVISION; CELL EXPANSION; CELL STRESS; CELL SURVIVAL; CONTROLLED STUDY; DIET; DISEASE PREDISPOSITION; FOOD INTAKE; GENE OVEREXPRESSION; GLUCOLIPOTOXICITY; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; HUMAN; HUMAN CELL; HYPERGLYCEMIA; INSULIN DEFICIENCY; INSULIN RESISTANCE; INSULIN RESPONSE; LIPOTOXICITY; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WILD TYPE; ANIMAL; C57BL MOUSE; CELL LINE; CELL PROLIFERATION; CONFOCAL MICROSCOPY; ENZYMOLOGY; GENETICS; IMMUNOBLOTTING; IN VITRO STUDY; KNOCKOUT MOUSE; METABOLISM; PANCREAS ISLET; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY;

ANIMALS; BLOOD GLUCOSE; CELL DEATH; CELL LINE; CELL PROLIFERATION; DIABETES MELLITUS, TYPE 2; GLUCOSE INTOLERANCE; HUMANS; HYPERGLYCEMIA; IMMUNOBLOTTING; IN VITRO TECHNIQUES; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; P21-ACTIVATED KINASES; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 84978174650     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-016-4042-0     Document Type: Article

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