메뉴 건너뛰기




Volumn 27, Issue 5, 2011, Pages 525-538

Inhibitory effect of unsaturated fatty acids on saturated fatty acid-induced apoptosis in human pancreatic β-cells: Activation of caspases and ER stress induction

Author keywords

Apoptosis; Caspases; Endo plasmic reticulum stress; Fatty acids; cell

Indexed keywords

CASPASE 2; CASPASE 6; CASPASE 7; CASPASE 8; CASPASE 9; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYTOCHROME C; FAS LIGAND; FAS RECEPTOR; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; MESSENGER RNA; OLEIC ACID; P53 INDUCED PROTEIN WITH DEATH DOMAIN PROTEIN; PALMITIC ACID; PALMITOLEIC ACID; PROTEIN; REACTIVE OXYGEN METABOLITE; RECEPTOR; SATURATED FATTY ACID; STEARIC ACID; UNCLASSIFIED DRUG; UNSATURATED FATTY ACID; X BOX BINDING PROTEIN 1;

EID: 79959402078     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000329954     Document Type: Article
Times cited : (51)

References (64)
  • 1
    • 0036163156 scopus 로고    scopus 로고
    • Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients
    • DOI 10.1007/s125-002-8248-z
    • Sakuraba H, Mizukami H, Yagihashi N, Wada R, Hanyu C, Yagihashi S: Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients. Diabetologia 2002;45:85-96. (Pubitemid 34118546)
    • (2002) Diabetologia , vol.45 , Issue.1 , pp. 85-96
    • Sakuraba, H.1    Mizukami, H.2    Yagihashi, N.3    Wada, R.4    Hanyu, C.5    Yagihashi, S.6
  • 4
    • 53849103951 scopus 로고    scopus 로고
    • The cytoprotective actions of long-chain mono-unsaturated fatty acids in pancreatic beta-cells
    • Morgan NG, Dhayal S, Diakogiannaki E, Welters HJ: The cytoprotective actions of long-chain mono-unsaturated fatty acids in pancreatic beta-cells. Biochem Soc Trans 2008;36:905-908.
    • (2008) Biochem Soc Trans , vol.36 , pp. 905-908
    • Morgan, N.G.1    Dhayal, S.2    Diakogiannaki, E.3    Welters, H.J.4
  • 5
    • 0035156817 scopus 로고    scopus 로고
    • Distinct effects of saturated and monounsaturated fatty acids on β-cell turnover and function
    • Maedler K, Spinas GA, Dyntar D, Moritz W, Kaiser N, Donath MY: Distinct effects of saturated and monounsaturated fatty acids on cell turnover and function. Diabetes 2001;50:69-76. (Pubitemid 32047983)
    • (2001) Diabetes , vol.50 , Issue.1 , pp. 69-76
    • Maedler, K.1    Spinas, G.A.2    Dyntar, D.3    Moritz, W.4    Kaiser, N.5    Donath, M.Y.6
  • 7
    • 0345354674 scopus 로고    scopus 로고
    • Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic β-cell turnover and function
    • DOI 10.2337/diabetes.52.3.726
    • Maedler K, Oberholzer J, Bucher P, Spinas GA, Donath MY: Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic cell turnover and function. Diabetes 2003;52:726-733. (Pubitemid 36323580)
    • (2003) Diabetes , vol.52 , Issue.3 , pp. 726-733
    • Maedler, K.1    Oberholzer, J.2    Bucher, P.3    Spinas, G.A.4    Donath, M.Y.5
  • 8
    • 40849099994 scopus 로고    scopus 로고
    • Comparison of the effect of individual saturated and unsaturated fatty acids on cell growth and death induction in the human pancreatic cell line NES2Y
    • Furstova, V, Kopska T, James RF, Kovar J: Comparison of the effect of individual saturated and unsaturated fatty acids on cell growth and death induction in the human pancreatic cell line NES2Y. Life Sci 2008;82:684-691.
    • (2008) Life Sci , vol.82 , pp. 684-691
    • Furstova, V.1    Kopska, T.2    James, R.F.3    Kovar, J.4
  • 9
    • 0037382424 scopus 로고    scopus 로고
    • Protein kinase C δ activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells
    • DOI 10.2337/diabetes.52.4.991
    • Eitel K, Staiger H, Rieger J, Mischak H, Brandhorst H, Brendel MD, Bretzel RG, Haring HU, Kellerer M: Protein kinase C delta activation and translocation to the nucleus are required for fatty acidinduced apoptosis of insulin-secreting cells. Diabetes 2003;52:991-997. (Pubitemid 36384269)
    • (2003) Diabetes , vol.52 , Issue.4 , pp. 991-997
    • Eitel, K.1    Staiger, H.2    Rieger, J.3    Mischak, H.4    Brandhorst, H.5    Brendel, M.D.6    Bretzel, R.G.7    Haring, H.-U.8    Kellerer, M.9
  • 11
    • 1542284737 scopus 로고    scopus 로고
    • Adiponectin counteracts cytokine- and fatty acid-induced apoptosis in the pancreatic beta-cell line INS-1
    • DOI 10.1007/s00125-003-1293-3
    • Rakatzi I, Mueller H, Ritzeler O, Tennagels N, Eckel J: Adiponectin counteracts cytokine-and fatty acidinduced apoptosis in the pancreatic betacell line INS-1. Diabetologia 2004;47:249-258. (Pubitemid 38315361)
    • (2004) Diabetologia , vol.47 , Issue.2 , pp. 249-258
    • Rakatzi, I.1    Mueller, H.2    Ritzeler, O.3    Tennagels, N.4    Eckel, J.5
  • 12
    • 33746911197 scopus 로고    scopus 로고
    • Sequential activation of caspases and synergistic β-cell cytotoxicity by palmitate and anti-Fas antibodies
    • DOI 10.1016/j.lfs.2006.03.048, PII S0024320506003274
    • Hirota N, Otabe S, Nakayama H, Yuan X, Yamada K: Sequential activation of caspases and synergistic cell cytotoxicity by palmitate and anti-Fas antibodies. Life Sci 2006;79:1312-1316. (Pubitemid 44188799)
    • (2006) Life Sciences , vol.79 , Issue.13 , pp. 1312-1316
    • Hirota, N.1    Otabe, S.2    Nakayama, H.3    Yuan, X.4    Yamada, K.5
  • 14
    • 42149111577 scopus 로고    scopus 로고
    • Structural requirements for the cytoprotective actions of mono-unsaturated fatty acids in the pancreatic β-cell line, BRIN-BD11
    • DOI 10.1038/bjp.2008.43, PII BJP200843
    • Dhayal S, Welters HJ, Morgan NG: Structural requirements for the cytoprotective actions of monounsaturated fatty acids in the pancreatic beta-cell line, BRIN-BD11. Br J Pharmacol 2008;153:1718-1727. (Pubitemid 351536000)
    • (2008) British Journal of Pharmacology , vol.153 , Issue.8 , pp. 1718-1727
    • Dhayal, S.1    Welters, H.J.2    Morgan, N.G.3
  • 16
    • 0037230114 scopus 로고    scopus 로고
    • Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the β-cell line INS-1
    • DOI 10.1210/en.2001-211282
    • Maestre I, Jordan J, Calvo S, Reig JA, Cena V, Soria B, Prentki M, Roche E: Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the cell line INS-1. Endocrinology 2003;144:335-345. (Pubitemid 36076123)
    • (2003) Endocrinology , vol.144 , Issue.1 , pp. 335-345
    • Maestre, I.1    Jordan, J.2    Calvo, S.3    Reig, J.A.4    Cena, V.5    Soria, B.6    Prentki, M.7    Roche, E.8
  • 17
    • 0037147215 scopus 로고    scopus 로고
    • Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic β-cells (INS-1)
    • DOI 10.1074/jbc.M208756200
    • Wrede CE, Dickson LM, Lingohr MK, Briaud I, Rhodes CJ: Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1). J Biol Chem 2002;277:49676-49684. (Pubitemid 36014411)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.51 , pp. 49676-49684
    • Wrede, C.E.1    Dickson, L.M.2    Lingohr, M.K.3    Briaud, I.4    Rhodes, C.J.5
  • 19
    • 2442453730 scopus 로고    scopus 로고
    • The PIDDosome, a Protein Complex Implicated in Activation of Caspase-2 in Response to Genotoxic Stress
    • DOI 10.1126/science.1095432
    • Tinel A, Tschopp J: The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress. Science 2004;304:843-846. (Pubitemid 38620177)
    • (2004) Science , vol.304 , Issue.5672 , pp. 843-846
    • Tinel, A.1    Tschopp, J.2
  • 20
    • 0035430782 scopus 로고    scopus 로고
    • Inverse Relationship between Cytotoxicity of Free Fatty Acids in Pancreatic Islet Cells and Cellular Triglyceride Accumulation
    • Cnop M, Hannaert JC, Hoorens A, Eizirik DL, Pipeleers DG: Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation. Diabetes 2001;50:1771-1777. (Pubitemid 33641595)
    • (2001) Diabetes , vol.50 , Issue.8 , pp. 1771-1777
    • Cnop, M.1    Hannaert, J.C.2    Hoorens, A.3    Eizirik, D.L.4    Pipeleers, D.G.5
  • 22
    • 4344716950 scopus 로고    scopus 로고
    • Fatty acid protection from palmitic acid-induced apoptosis is lost following PI3-kinase inhibition
    • DOI 10.1023/B:APPT.0000038039.82506.0c
    • Beeharry N, Chambers JA, Green IC: Fatty acid protection from palmitic acidinduced apoptosis is lost following PI3-kinase inhibition. Apoptosis 2004;9:599-607. (Pubitemid 39158636)
    • (2004) Apoptosis , vol.9 , Issue.5 , pp. 599-607
    • Beeharry, N.1    Chambers, J.A.2    Green, I.C.3
  • 23
    • 1342286820 scopus 로고    scopus 로고
    • Mono-unsaturated fatty acids protect against β-cell apoptosis induced by saturated fatty acids, serum withdrawal or cytokine exposure
    • DOI 10.1016/S0014-5793(04)00079-1
    • Welters HJ, Tadayyon M, Scarpello JH, Smith SA, Morgan NG: Monounsaturated fatty acids protect against cell apoptosis induced by saturated fatty acids, serum withdrawal or cytokine exposure. FEBS Lett 2004;560:103-108. (Pubitemid 38264301)
    • (2004) FEBS Letters , vol.560 , Issue.1-3 , pp. 103-108
    • Welters, H.J.1    Tadayyon, M.2    Scarpello, J.H.B.3    Smith, S.A.4    Morgan, N.G.5
  • 24
    • 33745854213 scopus 로고    scopus 로고
    • Differential protective effects of palmitoleic acid and cAMP on caspase activation and cell viability in pancreatic β-cells exposed to palmitate
    • DOI 10.1007/s10495-006-7450-7
    • Welters HJ, Diakogiannaki E, Mordue JM, Tadayyon M, Smith SA, Morgan NG: Differential protective effects of palmitoleic acid and cAMP on caspase activation and cell viability in pancreatic cells exposed to palmitate. Apoptosis 2006;11:1231-1238. (Pubitemid 44035970)
    • (2006) Apoptosis , vol.11 , Issue.7 , pp. 1231-1238
    • Welters, H.J.1    Diakogiannaki, E.2    Mordue, J.M.3    Tadayyon, M.4    Smith, S.A.5    Morgan, N.G.6
  • 25
    • 33745116619 scopus 로고    scopus 로고
    • Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic β-cell apoptosis
    • DOI 10.1210/en.2005-1494
    • Karaskov E, Scott C, Zhang L, Teodoro T, Ravazzola M, Volchuk A: Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis. Endocrinology 2006;147:3398-3407. (Pubitemid 43901131)
    • (2006) Endocrinology , vol.147 , Issue.7 , pp. 3398-3407
    • Karaskov, E.1    Scott, C.2    Zhang, L.3    Teodoro, T.4    Ravazzola, M.5    Volchuk, A.6
  • 27
    • 44949214679 scopus 로고    scopus 로고
    • Differential regulation of the endoplasmic reticulum stress response in pancreatic β-cells exposed to long-chain saturated and monounsaturated fatty acids
    • DOI 10.1677/JOE-08-0041
    • Diakogiannaki E, Welters HJ, Morgan NG: Differential regulation of the endoplasmic reticulum stress response in pancreatic beta-cells exposed to longchain saturated and monounsaturated fatty acids. J Endocrinol 2008;197:553-563. (Pubitemid 351803959)
    • (2008) Journal of Endocrinology , vol.197 , Issue.3 , pp. 553-563
    • Diakogiannaki, E.1    Welters, H.J.2    Morgan, N.G.3
  • 28
    • 53849086177 scopus 로고    scopus 로고
    • Differential regulation of the ER stress response by long-chain fatty acids in the pancreatic beta-cell
    • Diakogiannaki E, Morgan NG: Differential regulation of the ER stress response by long-chain fatty acids in the pancreatic beta-cell. Biochem Soc Trans 2008;36:959-962.
    • (2008) Biochem Soc Trans , vol.36 , pp. 959-962
    • Diakogiannaki, E.1    Morgan, N.G.2
  • 29
    • 0030858390 scopus 로고    scopus 로고
    • Impaired expression of transcription factor IUF1 in a pancreatic β-cell line derived from a patient with persistent hyperinsulinaemic hypoglycaemia of infancy (nesidioblastosis)
    • DOI 10.1016/S0014-5793(97)00874-0, PII S0014579397008740
    • Macfarlane WM, Cragg H, Docherty HM, Read ML, James RF, Aynsley-Green A, Docherty K: Impaired expression of transcription factor IUF1 in a pancreatic beta-cell line derived from a patient with persistent hyperinsulinaemic hypoglycaemia of infancy (nesidioblastosis). FEBS Lett 1997;413:304-308. (Pubitemid 27353289)
    • (1997) FEBS Letters , vol.413 , Issue.2 , pp. 304-308
    • MacFarlane, W.M.1    Cragg, H.2    Docherty, H.M.3    Read, M.L.4    James, R.F.L.5    Aynsley-Green, A.6    Docherty, K.7
  • 31
    • 0035801843 scopus 로고    scopus 로고
    • Additive stimulatory effect of extracellular calcium and potassium on non-transferrin ferric iron uptake by HeLa and K562 cells
    • DOI 10.1016/S0005-2736(01)00367-4, PII S0005273601003674
    • Musilkova J, Kovar J: Additive stimulatory effect of extracellular calcium and potassium on non-transferrin ferric iron uptake by HeLa and K562 cells. Biochim Biophys Acta 2001;1514:117-126. (Pubitemid 32769933)
    • (2001) Biochimica et Biophysica Acta - Biomembranes , vol.1514 , Issue.1 , pp. 117-126
    • Musilkova, J.1    Kovar, J.2
  • 32
    • 0024322560 scopus 로고
    • Growth-stimulating effect of transferrin on a hybridoma cell line: Relation to transferrin iron-transporting function
    • DOI 10.1016/0014-4827(89)90241-3
    • Kovar J, Franek F: Growth-stimulating effect of transferrin on a hybridoma cell line: relation to transferrin irontransporting function. Exp Cell Res 1989;182:358-369. (Pubitemid 19154057)
    • (1989) Experimental Cell Research , vol.182 , Issue.2 , pp. 358-369
    • Kovar, J.1    Franek, F.2
  • 33
    • 18044363070 scopus 로고    scopus 로고
    • Iron deprivation induces apoptosis via mitochondrial changes related to Bax translocation
    • DOI 10.1007/s10495-005-0812-8
    • Koc M, Nad'ova Z, Truksa J, Ehrlichova M, Kovar J: Iron deprivation induces apoptosis via mitochondrial changes related to Bax translocation. Apoptosis 2005;10:381-393. (Pubitemid 40603491)
    • (2005) Apoptosis , vol.10 , Issue.2 , pp. 381-393
    • Koc, M.1    Nad'ova, Z.2    Truksa, J.3    Ehrlichova, M.4    Kovar, J.5
  • 35
    • 0022186670 scopus 로고
    • Measurement of protein using bicinchoninic acid
    • DOI 10.1016/0003-2697(85)90442-7
    • Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto EK, Goeke NM, Olson BJ, Klenk DC: Measurement of protein using bicinchoninic acid. Anal Biochem 1985;150:76-85. (Pubitemid 16258399)
    • (1985) Analytical Biochemistry , vol.150 , Issue.1 , pp. 76-85
    • Smith, P.K.1    Krohn, R.I.2    Hermanson, G.T.3
  • 36
    • 27944468179 scopus 로고    scopus 로고
    • Cell death induced by taxanes in breast cancer cells: Cytochrome c is released in resistant but not in sensitive cells
    • Ehrlichova M, Koc M, Truksa J, Nadova Z, Vaclavikova R, Kovar J: Cell death induced by taxanes in breast cancer cells: cytochrome C is released in resistant but not in sensitive cells. Anticancer Res 2005;25:4215-4224. (Pubitemid 41665207)
    • (2005) Anticancer Research , vol.25 , Issue.6 B , pp. 4215-4224
    • Ehrlichova, M.1    Koc, M.2    Truksa, J.3    Naldova, Z.4    Vaclavikova, R.5    Kovarr, J.6
  • 38
    • 77955698519 scopus 로고    scopus 로고
    • Resveratrol-induced cytotoxicity in human Burkitt́s lymphoma cells is coupled to the unfolded protein response
    • Yan Y, Gao YY, Liu BQ, Niu XF, Zhuang Y, Wang HQ: Resveratrol-induced cytotoxicity in human Burkitt́s lymphoma cells is coupled to the unfolded protein response. BMC Cancer 2010;10:445-454.
    • (2010) BMC Cancer , vol.10 , pp. 445-454
    • Yan, Y.1    Gao, Y.Y.2    Liu, B.Q.3    Niu, X.F.4    Zhuang, Y.5    Wang, H.Q.6
  • 39
    • 58249136810 scopus 로고    scopus 로고
    • Differing expression of genes involved in non-transferrin iron transport across plasma membrane in various cell types under iron deficiency and excess
    • Balusikova K, Neubauerova J, Dostalikova-Cimburova M, Horak J, Kovar J: Differing expression of genes involved in non-transferrin iron transport across plasma membrane in various cell types under iron deficiency and excess. Mol Cell Biochemistry 2009;321:123-133.
    • (2009) Mol Cell Biochemistry , vol.321 , pp. 123-133
    • Balusikova, K.1    Neubauerova, J.2    Dostalikova-Cimburova, M.3    Horak, J.4    Kovar, J.5
  • 40
    • 0035718040 scopus 로고    scopus 로고
    • Quantitative determination of plasma C8-C26 total fatty acids for the biochemical diagnosis of nutritional and metabolic disorders
    • DOI 10.1006/mgme.2001.3170
    • Lagerstedt SA, Hinrichs DR, Batt SM, Magera MJ, Rinaldo P, McConnell JP: Quantitative determination of plasma c8-c26 total fatty acids for the biochemical diagnosis of nutritional and metabolic disorders. Mol Genet Metab 2001;73:38-45. (Pubitemid 34177622)
    • (2001) Molecular Genetics and Metabolism , vol.73 , Issue.1 , pp. 38-45
    • Lagerstedt, S.A.1    Hinrichs, D.R.2    Batt, S.M.3    Magera, M.J.4    Rinaldo, P.5    McConnell, J.P.6
  • 42
    • 33846219997 scopus 로고    scopus 로고
    • Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-κB pathway
    • DOI 10.1038/sj.emboj.7601473, PII 7601473
    • Tinel A, Janssens S, Lippens S, Cuenin S, Logette E, Jaccard B, Quadroni M, Tschopp J: Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway. EMBO J 2007;26:197-208. (Pubitemid 46094711)
    • (2007) EMBO Journal , vol.26 , Issue.1 , pp. 197-208
    • Tinel, A.1    Janssens, S.2    Lippens, S.3    Cuenin, S.4    Logette, E.5    Jaccard, B.6    Quadroni, M.7    Tschopp, J.8
  • 43
    • 0033782015 scopus 로고    scopus 로고
    • Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
    • Bertolotti A, Zhang Y, Hendershot LM, Harding HP, Ron D: Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat Cell Biol 2000;2:326-332.
    • (2000) Nat Cell Biol , vol.2 , pp. 326-332
    • Bertolotti, A.1    Zhang, Y.2    Hendershot, L.M.3    Harding, H.P.4    Ron, D.5
  • 44
    • 1842843855 scopus 로고    scopus 로고
    • Roles of CHOP/GADD153 in endoplasmic reticulum stress
    • DOI 10.1038/sj.cdd.4401373
    • Oyadomari S, Mori M: Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ 2004;11:381-389. (Pubitemid 38489416)
    • (2004) Cell Death and Differentiation , vol.11 , Issue.4 , pp. 381-389
    • Oyadomari, S.1    Mori, M.2
  • 45
    • 39149104320 scopus 로고    scopus 로고
    • The role for endoplasmic reticulum stress in diabetes mellitus
    • DOI 10.1210/er.2007-0015
    • Eizirik DL, Cardozo AK, Cnop M: The role for endoplasmic reticulum stress in diabetes mellitus. Endocr Rev 2008;29:42-61. (Pubitemid 351252746)
    • (2008) Endocrine Reviews , vol.29 , Issue.1 , pp. 42-61
    • Eizirik, D.L.1    Cardozo, A.K.2    Cnop, M.3
  • 46
    • 34547888676 scopus 로고    scopus 로고
    • Mechanisms involved in the cytotoxic and cytoprotective actions of saturated versus monounsaturated long-chain fatty acids in pancreatic β-cells
    • DOI 10.1677/JOE-07-0082
    • Diakogiannaki E, Dhayal S, Childs CE, Calder PC, Welters HJ, Morgan NG: Mechanisms involved in the cytotoxic and cytoprotective actions of saturated versus monounsaturated long-chain fatty acids in pancreatic beta-cells. J Endocrinol 2007;194:283-291. (Pubitemid 47249667)
    • (2007) Journal of Endocrinology , vol.194 , Issue.2 , pp. 283-291
    • Diakogiannaki, E.1    Dhayal, S.2    Childs, C.E.3    Calder, P.C.4    Welters, H.J.5    Morgan, N.G.6
  • 48
    • 0035816553 scopus 로고    scopus 로고
    • Apaf-1/cytochrome c-independent and Smacdependent induction of apoptosis in multiple myeloma (MM) cells
    • Chauhan D, Hideshima T, Rosen S, Reed JC, Kharbanda S, Anderson KC: Apaf-1/cytochrome c-independent and Smacdependent induction of apoptosis in multiple myeloma (MM) cells. J Biol Chem 2001;276:24453-24456.
    • (2001) J Biol Chem , vol.276 , pp. 24453-24456
    • Chauhan, D.1    Hideshima, T.2    Rosen, S.3    Reed, J.C.4    Kharbanda, S.5    Anderson, K.C.6
  • 49
    • 9144226235 scopus 로고    scopus 로고
    • Cephalostatin 1 Selectively Triggers the Release of Smac/DIABLO and Subsequent Apoptosis That Is Characterized by an Increased Density of the Mitochondrial Matrix
    • Dirsch, VM, Muller IM, Eichhorst ST, Pettit GR, Kamano Y, Inoue M, Xu JP, Ichihara Y, Wanner G, Vollmar AM: Cephalostatin 1 selectively triggers the release of Smac/DIABLO and subsequent apoptosis that is characterized by an increased density of the mitochondrial matrix. Cancer Res 2003;63:8869-8876. (Pubitemid 38064067)
    • (2003) Cancer Research , vol.63 , Issue.24 , pp. 8869-8876
    • Dirsch, V.M.1    Muller, I.M.2    Eichhorst, S.T.3    Pettit, G.R.4    Kamano, Y.5    Inoue, M.6    Xu, J.-P.7    Ichihara, Y.8    Wanner, G.9    Vollmar, A.M.10
  • 59
    • 77749246118 scopus 로고    scopus 로고
    • Enhanced signaling downstream of ribonucleic Acid-activated protein kinase-like endoplasmic reticulum kinase potentiates lipotoxic endoplasmic reticulum stress in human islets
    • Ladriere L, Igoillo-Esteve M, Cunha DA, Brion JP, Bugliani M, Marchetti P, Eizirik DL, Cnop M: Enhanced signaling downstream of ribonucleic Acid-activated protein kinase-like endoplasmic reticulum kinase potentiates lipotoxic endoplasmic reticulum stress in human islets. J Clin Endocrinol Metab 2010;95:1442-1449.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 1442-1449
    • Ladriere, L.1    Igoillo-Esteve, M.2    Cunha, D.A.3    Brion, J.P.4    Bugliani, M.5    Marchetti, P.6    Eizirik, D.L.7    Cnop, M.8
  • 60
    • 73249116246 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 agonists protect pancreatic cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB
    • Cunha DA, Ladriere L, Ortis F, Igoillo-Esteve M, Gurzov EN, Lupi R, Marchetti P, Eizirik DL, Cnop M: Glucagon-like peptide-1 agonists protect pancreatic cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB. Diabetes 2009;58:2851-2862.
    • (2009) Diabetes , vol.58 , pp. 2851-2862
    • Cunha, D.A.1    Ladriere, L.2    Ortis, F.3    Igoillo-Esteve, M.4    Gurzov, E.N.5    Lupi, R.6    Marchetti, P.7    Eizirik, D.L.8    Cnop, M.9
  • 61
    • 25844454854 scopus 로고    scopus 로고
    • Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic β-cells from lipoapoptosis
    • DOI 10.2337/diabetes.54.10.2917
    • Busch AK, Gurisik E, Cordery DV, Sudlow M, Denyer GS, Laybutt DR, Hughes WE, Biden TJ: Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic beta-cells from lipoapoptosis. Diabetes 2005;54:2917-2924. (Pubitemid 41401087)
    • (2005) Diabetes , vol.54 , Issue.10 , pp. 2917-2924
    • Busch, A.K.1    Gurisik, E.2    Cordery, D.V.3    Sudlow, M.4    Denyer, G.S.5    Ross Laybutt, D.6    Hughes, W.E.7    Biden, T.J.8
  • 63
    • 33845497181 scopus 로고    scopus 로고
    • Inflammatory caspases and inflammasomes: Master switches of inflammation
    • DOI 10.1038/sj.cdd.4402038, PII 4402038
    • Martinon F, Tschopp J: Inflammatory caspases and inflammasomes: master switches of inflammation. Cell Death Differ 2007;14:10-22. (Pubitemid 44911890)
    • (2007) Cell Death and Differentiation , vol.14 , Issue.1 , pp. 10-22
    • Martinon, F.1    Tschopp, J.2
  • 64
    • 33745242294 scopus 로고    scopus 로고
    • Involvement of caspase-2 and caspase-9 in endoplasmic reticulum stress-induced apoptosis: A role for the IAPs
    • DOI 10.1016/j.yexcr.2006.03.027, PII S0014482706001364
    • Cheung HH, Lynn Kelly N, Liston P, Korneluk RG: Involvement of caspase-2 and caspase-9 in endoplasmic reticulum stress-induced apoptosis: a role for the IAPs. Exp Cell Res 2006;312:2347-2357. (Pubitemid 43928950)
    • (2006) Experimental Cell Research , vol.312 , Issue.12 , pp. 2347-2357
    • Cheung, H.H.1    Lynn Kelly, N.2    Liston, P.3    Korneluk, R.G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.