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Volumn 34, Issue 1, 2010, Pages 75-80

Compound K protects MIN6N8 pancreatic β-cells against palmitate-induced apoptosis through modulating SAPK/JNK activation

Author keywords

C Jun N terminal kinase (JNK); Compound K; MIN6N8 cell; Palmitate induced apoptosis; Stress activated protein kinase (SAPK)

Indexed keywords

20 O BETA DEXTRO GLUCOPYRANOSYL 20 PROTOPANAXADIOL; FATTY ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PALMITIC ACID; PROTOPANAXADIOL; STRESS ACTIVATED PROTEIN KINASE; TETRAZOLIUM; UNCLASSIFIED DRUG; 20 O BETA D GLUCOPYRANOSYL PROTOPANAXADIOL; 20-O-BETA-D-GLUCOPYRANOSYL-PROTOPANAXADIOL; ANTIDIURETIC AGENT; GINSENOSIDE; PALMITIC ACID DERIVATIVE;

EID: 77951929835     PISSN: 10656995     EISSN: 10958355     Source Type: Journal    
DOI: 10.1042/CBI20090020     Document Type: Article
Times cited : (18)

References (49)
  • 1
    • 85009708837 scopus 로고    scopus 로고
    • Appearance of compound K a major metabolite of ginsenoside Rb1 by intestinal bacteria, in rat plasma after oral administration: measurement of compound K by enzyme immunoassay
    • Akao T, Kanaoka M, Kobashi K. Appearance of compound K a major metabolite of ginsenoside Rb1 by intestinal bacteria, in rat plasma after oral administration: measurement of compound K by enzyme immunoassay. Biol Pharm Bull 1998a;21:245-9.
    • (1998) Biol Pharm Bull , vol.21 , pp. 245-249
    • Akao, T.1    Kanaoka, M.2    Kobashi, K.3
  • 2
    • 0031736410 scopus 로고    scopus 로고
    • Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng
    • Akao T, Kida H, Kanaoka M, Hattori M, Kobashi K. Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng. J Pharmacokinet Phar 1998b;50:1155-60.
    • (1998) J Pharmacokinet Phar , vol.50 , pp. 1155-1160
    • Akao, T.1    Kida, H.2    Kanaoka, M.3    Hattori, M.4    Kobashi, K.5
  • 3
    • 0030757751 scopus 로고    scopus 로고
    • Morphological and biochemical characterization and analysis of apoptosis
    • Allen RT, Hunter WJ, Agrawal DW. Morphological and biochemical characterization and analysis of apoptosis. J Pharmacol Toxicol 1997;37:21-8.
    • (1997) J Pharmacol Toxicol , vol.37 , pp. 21-28
    • Allen, R.T.1    Hunter, W.J.2    Agrawal, D.W.3
  • 4
    • 0344549853 scopus 로고    scopus 로고
    • Ginseng pharmacology: multiple constituents and multiple actions
    • Attele AS, Wu JA, Yuan CS. Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol 1999;58:1685-93.
    • (1999) Biochem Pharmacol , vol.58 , pp. 1685-1693
    • Attele, A.S.1    Wu, J.A.2    Yuan, C.S.3
  • 5
    • 0036266324 scopus 로고    scopus 로고
    • Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component
    • Attele AS, Zhou YP, Xie JT, Wu JA, Zhang L, Dey L et al. Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component. Diabetes 2002;51:1851-8.
    • (2002) Diabetes , vol.51 , pp. 1851-1858
    • Attele, A.S.1    Zhou, Y.P.2    Xie, J.T.3    Wu, J.A.4    Zhang, L.5    Dey, L.6
  • 6
    • 0034536269 scopus 로고    scopus 로고
    • Constitutive β-glucosidase hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria
    • Bae EA, Park SY, Kim DH. Constitutive β-glucosidase hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria. Biol Pharm Bull 2000;23:1481-5.
    • (2000) Biol Pharm Bull , vol.23 , pp. 1481-1485
    • Bae, E.A.1    Park, S.Y.2    Kim, D.H.3
  • 7
    • 0036594246 scopus 로고    scopus 로고
    • Metabolism of ginsenoside Rc by human intestinal bacteria and its related antiallergic activity
    • Bae EA, Choo MK, Park EK, Park SY, Shin HY, Kim DH. Metabolism of ginsenoside Rc by human intestinal bacteria and its related antiallergic activity. Biol Pharm Bull 2002;25:743-7.
    • (2002) Biol Pharm Bull , vol.25 , pp. 743-747
    • Bae, E.A.1    Choo, M.K.2    Park, E.K.3    Park, S.Y.4    Shin, H.Y.5    Kim, D.H.6
  • 9
    • 0037219411 scopus 로고    scopus 로고
    • Butler PC. β-Cell deficit and increased β-cell apoptosis in humans with type 2 diabetes
    • Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. β-Cell deficit and increased β-cell apoptosis in humans with type 2 diabetes. Diabetes 2003;52:102-10.
    • (2003) Diabetes , vol.52 , pp. 102-110
    • Butler, A.E.1    Janson, J.2    Bonner-Weir, S.3    Ritzel, R.4    Rizza, R.A.5
  • 10
    • 27744444744 scopus 로고    scopus 로고
    • Transformation of ginsenosides Rb2 and Rc from Panax ginseng by food microorganisms
    • Chi H, Kim DH, Ji GE. Transformation of ginsenosides Rb2 and Rc from Panax ginseng by food microorganisms. Biol Pharm Bull 2005;28:2102-5.
    • (2005) Biol Pharm Bull , vol.28 , pp. 2102-2105
    • Chi, H.1    Kim, D.H.2    Ji, G.E.3
  • 12
    • 0038163804 scopus 로고    scopus 로고
    • Antiallergic activity of ginseng and its ginsenosides
    • Choo MK, Park EK, Han MJ, Kim D-H. Antiallergic activity of ginseng and its ginsenosides. Planta Med 2003;69:518-22.
    • (2003) Planta Med , vol.69 , pp. 518-522
    • Choo, M.K.1    Park, E.K.2    Han, M.J.3    Kim, D.-H.4
  • 13
    • 0041336976 scopus 로고    scopus 로고
    • Antihyperglycemic effects of ginseng: comparison between root and berry
    • Dey L, Xie JT, Wang A, Wu J, Maleckar SA, Yuan CS. Antihyperglycemic effects of ginseng: comparison between root and berry. Phytomedicine 2003;10:600-5.
    • (2003) Phytomedicine , vol.10 , pp. 600-605
    • Dey, L.1    Xie, J.T.2    Wang, A.3    Wu, J.4    Maleckar, S.A.5    Yuan, C.S.6
  • 14
    • 2342502747 scopus 로고    scopus 로고
    • Superoxide, nitric oxide, peroxynitrite and cytokine combinations all cause functional impairment and morphological changes in rat islets of langerhans and insulin-secreting cell lines but dictate cell death by different mechanism
    • Di Matteo MA, Loweth AC, Thomas S, Mabley JG, Morgan NG, Thorpe JR, Green IC. Superoxide, nitric oxide, peroxynitrite and cytokine combinations all cause functional impairment and morphological changes in rat islets of langerhans and insulin-secreting cell lines but dictate cell death by different mechanism. Apoptosis 1997;2:164-77.
    • (1997) Apoptosis , vol.2 , pp. 164-177
    • Di Matteo, M.A.1    Loweth, A.C.2    Thomas, S.3    Mabley, J.G.4    Morgan, N.G.5    Thorpe, J.R.6    Green, I.C.7
  • 15
    • 33749244427 scopus 로고    scopus 로고
    • Lipotoxicity versus adipotoxicity: the deleterious effects of adipose tissue on β-cells in the pathogenesis of type 2 diabetes
    • Eldor R, Raz I. Lipotoxicity versus adipotoxicity: the deleterious effects of adipose tissue on β-cells in the pathogenesis of type 2 diabetes. Diabetes Res Clin Pract 2006;74S:S3-8.
    • (2006) Diabetes Res Clin Pract , vol.74 S
    • Eldor, R.1    Raz, I.2
  • 16
    • 0032850020 scopus 로고    scopus 로고
    • Brown Z. p38 MAPK signaling cascades in inflammatory disease
    • Herlaar E, Brown Z. p38 MAPK signaling cascades in inflammatory disease. Mol Med Today 1999;5:439-47.
    • (1999) Mol Med Today , vol.5 , pp. 439-447
    • Herlaar, E.1
  • 17
    • 29844443744 scopus 로고    scopus 로고
    • Ginsenoside 20(S)-protopanaxatriol (PPT) activities peroxisome proliferators-activated receptor γ (PPARγ) in 3T3-L1 adipocytes
    • Han KL, Jung MH, Sohn JH, Hwang JK. Ginsenoside 20(S)-protopanaxatriol (PPT) activities peroxisome proliferators-activated receptor γ (PPARγ) in 3T3-L1 adipocytes. Biol Pharm Bull 2006;29:110-3.
    • (2006) Biol Pharm Bull , vol.29 , pp. 110-113
    • Han, K.L.1    Jung, M.H.2    Sohn, J.H.3    Hwang, J.K.4
  • 18
    • 0029840531 scopus 로고    scopus 로고
    • Main ginseng saponin metabolites formed by intestinal bacteria
    • Hasegawa H, Sung JH, Matsumiya S, Uchiyama M. Main ginseng saponin metabolites formed by intestinal bacteria. Planta Med 1996;62:453-7.
    • (1996) Planta Med , vol.62 , pp. 453-457
    • Hasegawa, H.1    Sung, J.H.2    Matsumiya, S.3    Uchiyama, M.4
  • 19
    • 0030864673 scopus 로고    scopus 로고
    • Role of human intestinal Prevotella oris in hydrolyzing ginseng saponins
    • Hasegawa H, Sung JH, Benno Y. Role of human intestinal Prevotella oris in hydrolyzing ginseng saponins. Planta Med 1997;63:436-40.
    • (1997) Planta Med , vol.63 , pp. 436-440
    • Hasegawa, H.1    Sung, J.H.2    Benno, Y.3
  • 20
    • 0003646552 scopus 로고    scopus 로고
    • Herbs with multiple actions
    • Boca Raton, FL: CRC Press
    • Huang KC. Herbs with multiple actions. In: The Pharmacology of Chinese Herbs. Boca Raton, FL: CRC Press; 1999.
    • (1999) The Pharmacology of Chinese Herbs
    • Huang, K.C.1
  • 21
    • 0025077096 scopus 로고
    • Studies on absorption, distribution, excretion and metabolism of ginseng saponins V. The decomposition products of ginsenoside Rb2 in the large intestine of rats
    • Karikura M, Miyase T, Tanizawa H, Takino Y, Taniyama T, Hayashi T. Studies on absorption, distribution, excretion and metabolism of ginseng saponins. V. The decomposition products of ginsenoside Rb2 in the large intestine of rats. Chem Pharm Bull 1990;38:2859-3286.
    • (1990) Chem Pharm Bull , vol.38 , pp. 2859-3286
    • Karikura, M.1    Miyase, T.2    Tanizawa, H.3    Takino, Y.4    Taniyama, T.5    Hayashi, T.6
  • 22
    • 0025981610 scopus 로고
    • Studies on absorption, distribution, excretion and metabolism of ginseng saponins, VI. The decomposition products of ginsenoside Rb2 in the stomach of rats
    • Karikura M, Miyase T, Tanizawa H, Taniyama T, Takino Y. Studies on absorption, distribution, excretion and metabolism of ginseng saponins. VI. The decomposition products of ginsenoside Rb2 in the stomach of rats. Chem Pharm Bull 1991a;39:400-4.
    • (1991) Chem Pharm Bull , vol.39 , pp. 400-404
    • Karikura, M.1    Miyase, T.2    Tanizawa, H.3    Taniyama, T.4    Takino, Y.5
  • 23
    • 0025946582 scopus 로고
    • Studies on absorption, distribution, excretion and metabolism of ginseng saponins VII. Comparison of the decomposition modes of ginsenoside-Rb1 and -Rb2 in the digestive tract of rats
    • Karikura M, Miyase T, Tanizawa H, Taniyama T, Takino Y. Studies on absorption, distribution, excretion and metabolism of ginseng saponins. VII. Comparison of the decomposition modes of ginsenoside-Rb1 and -Rb2 in the digestive tract of rats. Chem Pharm Bull 1991b;39:2357-61.
    • (1991) Chem Pharm Bull , vol.39 , pp. 2357-2361
    • Karikura, M.1    Miyase, T.2    Tanizawa, H.3    Taniyama, T.4    Takino, Y.5
  • 24
    • 24344453811 scopus 로고    scopus 로고
    • Synergistic activation of JNK/SAPK induced by TNF-α and IFN-γ: apoptosis of pancreatic β-cells via the p53 and ROS pathway
    • Kim WH, Lee JW, Gao B, Jung MH. Synergistic activation of JNK/SAPK induced by TNF-α and IFN-γ: apoptosis of pancreatic β-cells via the p53 and ROS pathway. Cell Signalling 2005;17:1516-32.
    • (2005) Cell Signalling , vol.17 , pp. 1516-1532
    • Kim, W.H.1    Lee, J.W.2    Gao, B.3    Jung, M.H.4
  • 25
    • 0029888125 scopus 로고    scopus 로고
    • Overexpression of HER2 modulate BCL-2, BCL-XL and tamoxifen-induced apoptosis in human MCF-7 breast cancer cells
    • Kumar R, Mandal M, Lipton A, Harvey H, Thompson CB. Overexpression of HER2 modulate BCL-2, BCL-XL and tamoxifen-induced apoptosis in human MCF-7 breast cancer cells. Clin Cancer Res 1996;2:1215-9.
    • (1996) Clin Cancer Res , vol.2 , pp. 1215-1219
    • Kumar, R.1    Mandal, M.2    Lipton, A.3    Harvey, H.4    Thompson, C.B.5
  • 26
    • 28444472055 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase is essential for interleukin-1-induced and nuclear factor kB-mediated gene expression in insulin-producting INS-1E cells
    • Larsen L, Storling J, Darville M, Eizirik DL, Bonny C, Billestrup N, Mandrup-Poulsen T. Extracellular signal-regulated kinase is essential for interleukin-1-induced and nuclear factor kB-mediated gene expression in insulin-producting INS-1E cells. Diabetologia 2005;48:2582-90.
    • (2005) Diabetologia , vol.48 , pp. 2582-2590
    • Larsen, L.1    Storling, J.2    Darville, M.3    Eizirik, D.L.4    Bonny, C.5    Billestrup, N.6    Mandrup-Poulsen, T.7
  • 28
    • 0043026915 scopus 로고    scopus 로고
    • β-Cell apoptosis in the pathogenesis of human type 2 diabetes mellitus
    • Leonardi O, Mints G, Hussain MA. β-Cell apoptosis in the pathogenesis of human type 2 diabetes mellitus. Eur J Endocrinol 2003;149:99-102.
    • (2003) Eur J Endocrinol , vol.149 , pp. 99-102
    • Leonardi, O.1    Mints, G.2    Hussain, M.A.3
  • 29
    • 0030941458 scopus 로고    scopus 로고
    • P53, the cellular gatekeeper for growth and division
    • Levine AJ. P53, the cellular gatekeeper for growth and division. Cell 1997;88:323-31.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 30
    • 63049115697 scopus 로고    scopus 로고
    • Phycocyanin protects INS-1E pancreatic β-cells against human islet amyloid polypeptide-induced apoptosis through attenuating oxidative stress and modulating JNK and p38 mitogen-activated protein kinase pathways
    • Li X-L, Xu G, Chen T, Wong Y-S, Zhao H-L, Fan R-R et al. Phycocyanin protects INS-1E pancreatic β-cells against human islet amyloid polypeptide-induced apoptosis through attenuating oxidative stress and modulating JNK and p38 mitogen-activated protein kinase pathways. Intern J Biochem Cell Biol 2009;41:1526-35.
    • (2009) Intern J Biochem Cell Biol , vol.41 , pp. 1526-1535
    • Li, X.-L.1    Xu, G.2    Chen, T.3    Wong, Y.-S.4    Zhao, H.-L.5    Fan, R.-R.6
  • 31
    • 0036315888 scopus 로고    scopus 로고
    • Prolonged exposure to free fatty acids has cytostatic and proapoptotic effects on human pancreatic islets: evidence that β-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated
    • Lupi R, Dotta F, Marselli L, Del Guerra S, Masini M, Santagelo C et al. Prolonged exposure to free fatty acids has cytostatic and proapoptotic effects on human pancreatic islets: evidence that β-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated. Diabetes 2002;51:1437-42.
    • (2002) Diabetes , vol.51 , pp. 1437-1442
    • Lupi, R.1    Dotta, F.2    Marselli, L.3    Del Guerra, S.4    Masini, M.5    Santagelo, C.6
  • 32
    • 0035156817 scopus 로고    scopus 로고
    • Distinct effects of saturated and monounsaturated fatty acids on β-cell turnover and function
    • Maedler K, Spinas GA, Dyntar D, Moritz W, Kaiser N, Donath MY. Distinct effects of saturated and monounsaturated fatty acids on β-cell turnover and function. Diabetes 2001;50:69-76.
    • (2001) Diabetes , vol.50 , pp. 69-76
    • Maedler, K.1    Spinas, G.A.2    Dyntar, D.3    Moritz, W.4    Kaiser, N.5    Donath, M.Y.6
  • 33
    • 0345354674 scopus 로고    scopus 로고
    • Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic β-cell turnover and function
    • Maedler K, Oberholzer J, Bucher P, Spinas GA, Donath MY. Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic β-cell turnover and function. Diabetes 2003;52:726-33.
    • (2003) Diabetes , vol.52 , pp. 726-733
    • Maedler, K.1    Oberholzer, J.2    Bucher, P.3    Spinas, G.A.4    Donath, M.Y.5
  • 34
    • 0442305381 scopus 로고    scopus 로고
    • Apoptotic signal transduction pathways in diabetes
    • Mandrup-Poulsen T. Apoptotic signal transduction pathways in diabetes. Biochem Pharmacol 2003;66:1433-40.
    • (2003) Biochem Pharmacol , vol.66 , pp. 1433-1440
    • Mandrup-Poulsen, T.1
  • 35
    • 42449126643 scopus 로고    scopus 로고
    • Inhibition of Foxo 1 protects pancreatic islet β-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis
    • Martinez SC, Tanabe K, Cras-Meneur C, Abumrad NA, Bernal-Mizrachi E, Permutt MA. Inhibition of Foxo 1 protects pancreatic islet β-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis. Diabetes 2008;57:846-59.
    • (2008) Diabetes , vol.57 , pp. 846-859
    • Martinez, S.C.1    Tanabe, K.2    Cras-Meneur, C.3    Abumrad, N.A.4    Bernal-Mizrachi, E.5    Permutt, M.A.6
  • 37
    • 21144444049 scopus 로고    scopus 로고
    • Inhibitory effect of ginsenoside Rb1 and compound K on NO and prostaglandin E2 biosynthesis of RAW 264, 7 cells induced by lipopolysaccharide
    • Park EK, Shin YW, Lee HU, Kim SS, Lee YC, Lee BY, Kim DH. Inhibitory effect of ginsenoside Rb1 and compound K on NO and prostaglandin E2 biosynthesis of RAW 264.7 cells induced by lipopolysaccharide. Biol Pharm Bull 2005;28(4):652-6.
    • (2005) Biol Pharm Bull , vol.28 , Issue.4 , pp. 652-656
    • Park, E.K.1    Shin, Y.W.2    Lee, H.U.3    Kim, S.S.4    Lee, Y.C.5    Lee, B.Y.6    Kim, D.H.7
  • 38
    • 34248597065 scopus 로고    scopus 로고
    • Differential regulation and properties of MAPKs
    • Raman M, Chen W, Cobb MH. Differential regulation and properties of MAPKs. Oncogene 2007;26:3100-12.
    • (2007) Oncogene , vol.26 , pp. 3100-3112
    • Raman, M.1    Chen, W.2    Cobb, M.H.3
  • 39
    • 12344323484 scopus 로고    scopus 로고
    • Type 2 diabetes: a matter of β-cell life and death?
    • Rhodes CJ. Type 2 diabetes: a matter of β-cell life and death? Science 2005;307:380-4.
    • (2005) Science , vol.307 , pp. 380-384
    • Rhodes, C.J.1
  • 40
    • 12244284221 scopus 로고    scopus 로고
    • Amylininduced cytotoxicity is associated with activation of caspase-3 and MAP kinases
    • Rumora L, Hadzija M, Barisic K, Maysinger D, Grubiic TZ. Amylininduced cytotoxicity is associated with activation of caspase-3 and MAP kinases. Biol Chem 2002;383:1751-8.
    • (2002) Biol Chem , vol.383 , pp. 1751-1758
    • Rumora, L.1    Hadzija, M.2    Barisic, K.3    Maysinger, D.4    Grubiic, T.Z.5
  • 42
    • 33644862368 scopus 로고    scopus 로고
    • JNK signaling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species
    • Shen IM, Liu Z. JNK signaling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species. Free Radical Biol Med 2006;40:928-39.
    • (2006) Free Radical Biol Med , vol.40 , pp. 928-939
    • Shen, I.M.1    Liu, Z.2
  • 43
    • 78651125802 scopus 로고
    • Studies on the constituents of Japanese and Chinese crude drugs. XI. Panaxadiol, a sapogenin of ginseng roots
    • Shibata S, Fujita M, Itokawa H, Tanaka O. Studies on the constituents of Japanese and Chinese crude drugs. XI. Panaxadiol, a sapogenin of ginseng roots. Chem Pharm Bull 1963;11:759-64.
    • (1963) Chem Pharm Bull , vol.11 , pp. 759-764
    • Shibata, S.1    Fujita, M.2    Itokawa, H.3    Tanaka, O.4
  • 44
    • 0029097005 scopus 로고
    • Ginseng therapy in noninsulindependent diabetic patients
    • Sotaniemi EA, Haapakoski E, Rautio A. Ginseng therapy in noninsulindependent diabetic patients. Diabetes Care 1995;18:1373-5.
    • (1995) Diabetes Care , vol.18 , pp. 1373-1375
    • Sotaniemi, E.A.1    Haapakoski, E.2    Rautio, A.3
  • 45
    • 0033514956 scopus 로고    scopus 로고
    • Regulation of fatty acid homeostasis in cells: novel role of leptin
    • Unger RH, Zhou YT, Orci L. Regulation of fatty acid homeostasis in cells: novel role of leptin. Proc Natl Acad Sci USA 1999;96:2327-32.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 2327-2332
    • Unger, R.H.1    Zhou, Y.T.2    Orci, L.3
  • 46
    • 0037147215 scopus 로고    scopus 로고
    • Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic β-cells (INS-1)
    • Wrede CE, Dickson LM, Lingohr MK, Briaud I, Rhodes C. Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic β-cells (INS-1). J Biol Chem 2002;277:49676-84.
    • (2002) J Biol Chem , vol.277 , pp. 49676-49684
    • Wrede, C.E.1    Dickson, L.M.2    Lingohr, M.K.3    Briaud, I.4    Rhodes, C.5
  • 47
    • 0042668497 scopus 로고    scopus 로고
    • Systematic review of herbs and dietary supplements for glycemic control in diabetes
    • Yeh GY, Eisenberg DM, Kaptchuk TJ, Phillips RS. Systematic review of herbs and dietary supplements for glycemic control in diabetes. Diabetes Care 2003;26:1277-94.
    • (2003) Diabetes Care , vol.26 , pp. 1277-1294
    • Yeh, G.Y.1    Eisenberg, D.M.2    Kaptchuk, T.J.3    Phillips, R.S.4
  • 48
    • 0029162631 scopus 로고
    • Expression of intercellular adhesion molecule 1 on pancreatic β-cell destruction by cytotoxic T-cells in murine autoimmune diabetes
    • Yagi N, Yokono K, Amano K, Nagata M, Tsukamoto K, Hasegawa Y et al. Expression of intercellular adhesion molecule 1 on pancreatic β-cell destruction by cytotoxic T-cells in murine autoimmune diabetes. Diabetes 1995;44:744-52.
    • (1995) Diabetes , vol.44 , pp. 744-752
    • Yagi, N.1    Yokono, K.2    Amano, K.3    Nagata, M.4    Tsukamoto, K.5    Hasegawa, Y.6
  • 49
    • 0346101742 scopus 로고    scopus 로고
    • Fibrilogenic amylin evokes islet β-cell apoptosis through linked activation of a cascade and JNK1
    • Zhang S, Liu J, Dragunow M, Cooper GJ. Fibrilogenic amylin evokes islet β-cell apoptosis through linked activation of a cascade and JNK1. J Biol Chem 2003;278:52810-9.
    • (2003) J Biol Chem , vol.278 , pp. 52810-52819
    • Zhang, S.1    Liu, J.2    Dragunow, M.3    Cooper, G.J.4


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