Involvement of Per-Arnt-sim kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic β-cells

Diabetes

Volumn 58, Issue 9, 2009, Pages 2048-2058

  Fontés, Ghislaine ^a,b   Semache, Meriem ^a   Hagman, Derek K ^a,b   Tremblay, Caroline ^a   Shah, Ramila ^c   Rhodes, Christopher J ^c   Rutter, Jared ^d   Poitout, Vincent ^a,b  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c University of Utah School of Medicine ^*  (United States)

^d UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN BETA; CERAMIDE; GLUCOSE; INSULIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PALMITIC ACID; PER ARNT SIM KINASE; PHOSPHOTRANSFERASE; PROTEIN KINASE B; TRANSCRIPTION FACTOR MAFA; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE; GENE EXPRESSION; GENE OVEREXPRESSION; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREATIC DUODENAL HOMEOBOX 1 GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL LINE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCARIC ACID; HUMANS; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MAP KINASE KINASE 1; MAP KINASE KINASE 2; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PALMITATES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RNA PRECURSORS; RNA, MESSENGER; SPHINGOSINE;

EID: 70349109268     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db08-0579     Document Type: Article

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