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Volumn 206, Issue 2, 2010, Pages 183-193

UPR-mediated TRIB3 expression correlates with reduced AKT phosphorylation and inability of interleukin 6 to overcome palmitate-induced apoptosis in RINm5F cells

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6; PALMITIC ACID; PROTEIN KINASE B; X BOX BINDING PROTEIN 1; CASPASE 3; PALMITIC ACID DERIVATIVE; PROTEIN KINASE; STAT3 PROTEIN; STAT3 PROTEIN, RAT; TRIB3 PROTEIN, RAT;

EID: 77955081067     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1677/JOE-09-0356     Document Type: Article
Times cited : (26)

References (48)
  • 5
    • 33746190686 scopus 로고    scopus 로고
    • Fatty acid-induced toxicity and neutral lipid accumulation in insulin-producing RINm5F cells
    • DOI 10.1016/j.tiv.2006.02.007, PII S088723330600035X
    • Azevedo-Martins AK, Monteiro AP, Lima CL, Lenzen S & Curi R 2006 Fatty acid-induced toxicity and neutral lipid accumulation in insulin-producing RINm5F cells. Toxicology In Vitro 20 1106-1113. (Pubitemid 44088590)
    • (2006) Toxicology in Vitro , vol.20 , Issue.7 , pp. 1106-1113
    • Azevedo-Martins, A.K.1    Monteiro, A.P.2    Lima, C.L.3    Lenzen, S.4    Curi, R.5
  • 6
    • 4344716950 scopus 로고    scopus 로고
    • Fatty acid protection from palmitic acid-induced apoptosis is lost following PI3-kinase inhibition
    • DOI 10.1023/B:APPT.0000038039.82506.0c
    • Beeharry N, Chambers JA & Green IC 2004 Fatty acid protection from palmitic acid-induced apoptosis is lost following PI3-kinase inhibition. Apoptosis 9 599-607. (Pubitemid 39158636)
    • (2004) Apoptosis , vol.9 , Issue.5 , pp. 599-607
    • Beeharry, N.1    Chambers, J.A.2    Green, I.C.3
  • 7
    • 0035862989 scopus 로고    scopus 로고
    • Endotoxin-mediated delayed islet graft function is associated with increased intra-islet cytokine production and islet cell apoptosis
    • Berney T, Damaris Molano R, Cattan P, Pileggi A, Vizzardelli C, Oliver R, Ricordi C & Inverardi L 2001 Endotoxin-mediated delayed islet graft function is associated with increased intra-islet cytokine production and islet cell apoptosis. Transplantation 71 125-132. (Pubitemid 32105789)
    • (2001) Transplantation , vol.71 , Issue.1 , pp. 125-132
    • Berney, T.1    Molano, R.D.2    Cattan, P.3    Pileggi, A.4    Vizzardelli, C.5    Oliver, R.6    Ricordi, C.7    Inverardi, L.8
  • 8
    • 0028828451 scopus 로고
    • Ionic mechanisms involved in the regulation of insulin secretion by muscarinic agonists
    • Bordin S, Boschero AC, Carneiro EM & Atwater I 1995 Ionic mechanisms involved in the regulation of insulin secretion by muscarinic agonists. Journal of Membrane Biology 148 177-184.
    • (1995) Journal of Membrane Biology , vol.148 , pp. 177-184
    • Bordin, S.1    Boschero, A.C.2    Carneiro, E.M.3    Atwater, I.4
  • 9
    • 34948813565 scopus 로고    scopus 로고
    • Leptin decreases apoptosis and alters BCL-2:Bax ratio in clonal rodent pancreatic beta-cells
    • Brown JEP & Dunmore SJ 2007 Leptin decreases apoptosis and alters BCL-2:Bax ratio in clonal rodent pancreatic beta-cells. Diabetes/Metabolism Research and Reviews 23 497-502.
    • (2007) Diabetes/Metabolism Research and Reviews , vol.23 , pp. 497-502
    • Brown, J.E.P.1    Dunmore, S.J.2
  • 11
    • 33644749322 scopus 로고    scopus 로고
    • Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: Many differences, few similarities
    • Cnop M, Welsh N, Jonas JC, Jörns A, Lenzen S & Eizirik DL 2005 Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities. Diabetes 54 S97-S107.
    • (2005) Diabetes , vol.54
    • Cnop, M.1    Welsh, N.2    Jonas, J.C.3    Jörns, A.4    Lenzen, S.5    Eizirik, D.L.6
  • 13
    • 44949214679 scopus 로고    scopus 로고
    • Differential regulation of the endoplasmic reticulum stress response in pancreatic β-cells exposed to long-chain saturated and monounsaturated fatty acids
    • DOI 10.1677/JOE-08-0041
    • Diakogiannaki E, Welters HJ & Morgan NG 2008 Differential regulation of the endoplasmic reticulum stress response in pancreatic b-cells exposed to long-chain saturated and monounsaturated fatty acids. Journal of Endocrinology 197 553-563. (Pubitemid 351803959)
    • (2008) Journal of Endocrinology , vol.197 , Issue.3 , pp. 553-563
    • Diakogiannaki, E.1    Welters, H.J.2    Morgan, N.G.3
  • 14
    • 0028568369 scopus 로고
    • Local production of human IL-6 promotes insulitis but retards the onset of insulin-dependent diabetes mellitus in non-obese diabetic mice
    • DiCosmo BF, Picarella D & Flavell RA 1994 Local production of human IL-6 promotes insulitis but retards the onset of insulin-dependent diabetes mellitus in non-obese diabetic mice. International Immunology 6 1829-1837.
    • (1994) International Immunology , vol.6 , pp. 1829-1837
    • DiCosmo, B.F.1    Picarella, D.2    Flavell, R.A.3
  • 16
    • 0038242819 scopus 로고    scopus 로고
    • TRB3: A tribbles homolog that inhibits Akt/PKB activation by insulin in liver
    • DOI 10.1126/science.1079817
    • Du K, Herzig S, Kulkarni RN & Montminy M 2003 TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science 300 1574-1577. (Pubitemid 36682889)
    • (2003) Science , vol.300 , Issue.5625 , pp. 1574-1577
    • Du, K.1    Herzig, S.2    Kulkarni, R.N.3    Montminy, M.4
  • 17
    • 35148833815 scopus 로고    scopus 로고
    • Regulation of β-cell mass and function by the Akt/protein kinase B signalling pathway
    • DOI 10.1111/j.1463-1326.2007.00783.x
    • Elghazi L, Rachdi L, Weiss AJ, Cras-Méneur C & Bernal-Mizrachi E 2007 Regulation of beta-cell mass and function by the Akt/protein kinase B signalling pathway. Diabetes, Obesity & Metabolism 9 147-157. (Pubitemid 47543137)
    • (2007) Diabetes, Obesity and Metabolism , vol.9 , Issue.SUPPL. 2 , pp. 147-157
    • Elghazi, L.1    Rachdi, L.2    Weiss, A.J.3    Cras-Meneur, C.4    Bernal-Mizrachi, E.5
  • 19
    • 37249073840 scopus 로고    scopus 로고
    • Role of interleukin-6 signalling in glucose and lipid metabolism
    • DOI 10.1111/j.1748-1716.2007.01779.x
    • Glund S & Krook A 2008 Role of interleukin-6 signalling in glucose and lipid metabolism. Acta Physiologica 192 37-48. (Pubitemid 350265360)
    • (2008) Acta Physiologica , vol.192 , Issue.1 , pp. 37-48
    • Glund, S.1    Krook, A.2
  • 21
    • 0033511647 scopus 로고    scopus 로고
    • How are free fatty acids transported in membranes? Is it by proteins or by free diffusion through the lipids?
    • Hamilton JA & Kamp F 1999 How are free fatty acids transported in membranes? Is it by proteins or by free diffusion through the lipids? Diabetes 48 2255-2269.
    • (1999) Diabetes , vol.48 , pp. 2255-2269
    • Hamilton, J.A.1    Kamp, F.2
  • 22
    • 0036895383 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and the development of diabetes: A review
    • Harding HP & Ron D 2002 Endoplasmic reticulum stress and the development of diabetes: a review. Diabetes 51 S455-S461. (Pubitemid 35403430)
    • (2002) Diabetes , vol.51 , Issue.SUPPL. 3
    • Harding, H.P.1    Ron, D.2
  • 24
    • 2442715069 scopus 로고    scopus 로고
    • Interleukin-6 activates phosphoinositol-3′ kinase in multiple myeloma tumor cells by signaling through RAS-dependent and, separately, through p85-dependent pathways
    • Hsu JH, Shi Y, Frost P, Yan H, Hoang B, Sharma S, Gera J & Lichtenstein A 2004 Interleukin-6 activates phosphoinositol-3′ kinase in multiple myeloma tumor cells by signaling through RAS-dependent and, separately, through p85-dependent pathways. Oncogene 23 3368-3375.
    • (2004) Oncogene , vol.23 , pp. 3368-3375
    • Hsu, J.H.1    Shi, Y.2    Frost, P.3    Yan, H.4    Hoang, B.5    Sharma, S.6    Gera, J.7    Lichtenstein, A.8
  • 26
    • 33745116619 scopus 로고    scopus 로고
    • Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic β-cell apoptosis
    • DOI 10.1210/en.2005-1494
    • Karaskov E, Scott C, Zhang L, Teodoro T, Ravazzola M & Volchuk A 2006 Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis. Endocrinology 147 3398-3407. (Pubitemid 43901131)
    • (2006) Endocrinology , vol.147 , Issue.7 , pp. 3398-3407
    • Karaskov, E.1    Scott, C.2    Zhang, L.3    Teodoro, T.4    Ravazzola, M.5    Volchuk, A.6
  • 27
    • 9244231766 scopus 로고    scopus 로고
    • Free fatty acids and cytokines induce pancreatic β-cell apoptosis by different mechanisms: Role of nuclear factor-κB and endoplasmic reticulum stress
    • DOI 10.1210/en.2004-0478
    • Kharroubi I, Ladriere L, Cardozo AK, Dogusan Z, Cnop M & Eizirik DL 2004 Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress. Endocrinology 145 5087-5096. (Pubitemid 39551129)
    • (2004) Endocrinology , vol.145 , Issue.11 , pp. 5087-5096
    • Kharroubi, I.1    Ladriere, L.2    Cardozo, A.K.3    Dogusan, Z.4    Cnop, M.5    Eizirik, D.L.6
  • 28
    • 20444491588 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic beta-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and down-regulation of bax expression
    • Kim SJ, Winter K, Nian C, Tsuneoka M, Koda Y & McIntosh CH 2005 Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic beta-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and down-regulation of bax expression. Journal of Biological Chemistry 280 22297-22307.
    • (2005) Journal of Biological Chemistry , vol.280 , pp. 22297-22307
    • Kim, S.J.1    Winter, K.2    Nian, C.3    Tsuneoka, M.4    Koda, Y.5    McIntosh, C.H.6
  • 29
    • 0035854780 scopus 로고    scopus 로고
    • Interleukin-6 protects against Fas-mediated death by establishing a critical level of anti-apoptotic hepatic proteins FLIP, Bcl-2, and Bcl-xL
    • Kovalovich K, Li W, DeAngelis R, Greenbaum LE, Ciliberto G & Taub R 2001 Interleukin-6 protects against Fas-mediated death by establishing a critical level of anti-apoptotic hepatic proteins FLIP, Bcl-2, and Bcl-xL. Journal of Biological Chemistry 276 26605-26613.
    • (2001) Journal of Biological Chemistry , vol.276 , pp. 26605-26613
    • Kovalovich, K.1    Li, W.2    DeAngelis, R.3    Greenbaum, L.E.4    Ciliberto, G.5    Taub, R.6
  • 30
    • 33644755633 scopus 로고    scopus 로고
    • Interleukin-6 and diabetes: The good, the bad, or the indifferent?
    • Kristiansen OP & Mandrup-Poulsen P 2005 Interleukin-6 and diabetes: the good, the bad, or the indifferent? Diabetes 54 S114-S124.
    • (2005) Diabetes , vol.54
    • Kristiansen, O.P.1    Mandrup-Poulsen, P.2
  • 32
    • 0035710746 scopus 로고    scopus 로고
    • -δδCT method
    • DOI 10.1006/meth.2001.1262
    • Livak KJ & Schmittgen TD 2001 Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25 402-408. (Pubitemid 34164012)
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 33
    • 42449126643 scopus 로고    scopus 로고
    • Inhibition of Foxo1 protects pancreatic islet beta-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis
    • Martinez SC, Tanabe K, Cras-Méneur C, Abumrad NA, Bernal-Mizrachi E & Permutt MA 2008 Inhibition of Foxo1 protects pancreatic islet beta-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis. Diabetes 57 846-859.
    • (2008) Diabetes , vol.57 , pp. 846-859
    • Martinez, S.C.1    Tanabe, K.2    Cras-Méneur, C.3    Abumrad, N.A.4    Bernal-Mizrachi, E.5    Permutt, M.A.6
  • 34
    • 0035144493 scopus 로고    scopus 로고
    • Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl-2 and perturbing the cellular redox state
    • McCullough KD, Martindale JL, Klotz LO, Aw TY & Holbrook NJ 2001 Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl-2 and perturbing the cellular redox state. Molecular and Cellular Biology 21 1249-1259.
    • (2001) Molecular and Cellular Biology , vol.21 , pp. 1249-1259
    • McCullough, K.D.1    Martindale, J.L.2    Klotz, L.O.3    Aw, T.Y.4    Holbrook, N.J.5
  • 36
    • 17144417669 scopus 로고    scopus 로고
    • TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death
    • DOI 10.1038/sj.emboj.7600596
    • Ohoka N, Yoshii S, Hattori T, Onozaki K & Hayashi H 2005 TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death. EMBO Journal 24 1243-1255. (Pubitemid 40516607)
    • (2005) EMBO Journal , vol.24 , Issue.6 , pp. 1243-1255
    • Ohoka, N.1    Yoshii, S.2    Hattori, T.3    Onozaki, K.4    Hayashi, H.5
  • 38
    • 34047235220 scopus 로고    scopus 로고
    • Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells
    • DOI 10.2337/db06-1253
    • Pirot P, Ortis F, Cnop M, Ma Y, Hendershot LM, Eizirik DL & Cardozo AK 2007 Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells. Diabetes 56 1069-1077. (Pubitemid 46540305)
    • (2007) Diabetes , vol.56 , Issue.4 , pp. 1069-1077
    • Pirot, P.1    Ortis, F.2    Cnop, M.3    Ma, Y.4    Hendershot, L.M.5    Eizirik, D.L.6    Cardozo, A.K.7
  • 40
    • 34250899722 scopus 로고    scopus 로고
    • Signal integration in the endoplasmic reticulum unfolded protein response
    • DOI 10.1038/nrm2199, PII NRM2199
    • Ron D & Walter P 2007 Signal integration in the endoplasmic reticulum unfolded protein response. Nature Reviews. Molecular Cell Biology 8 519-529. (Pubitemid 46985379)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.7 , pp. 519-529
    • Ron, D.1    Walter, P.2
  • 41
    • 0025159212 scopus 로고
    • Interleukin-6 affects insulin secretion and glucose metabolism of rat pancreatic islets in vitro
    • Sandler S, Bendtzen K, Eizirik DL & Welsh M 1990 Interleukin-6 affects insulin secretion and glucose metabolism of rat pancreatic islets in vitro. Endocrinology 126 1288-1294. (Pubitemid 20079554)
    • (1990) Endocrinology , vol.126 , Issue.2 , pp. 1288-1294
    • Sandler, S.1    Bendtzen, K.2    Eizirik, D.L.3    Welsh, M.4
  • 42
    • 0032478314 scopus 로고    scopus 로고
    • Fatty acid-induced beta cell apoptosis: A link between obesity and diabetes
    • Shimabukuro M, Zhou YT, Levi M & Unger RH 1998 Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes. PNAS 95 2498-2502.
    • (1998) PNAS , vol.95 , pp. 2498-2502
    • Shimabukuro, M.1    Zhou, Y.T.2    Levi, M.3    Unger, R.H.4
  • 43
    • 55849096988 scopus 로고    scopus 로고
    • Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes
    • Song B, Scheuner D, Ron D, Pennathur S & Kaufman RJ 2008 Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes. Journal of Clinical Investigation 118 3378-3389.
    • (2008) Journal of Clinical Investigation , vol.118 , pp. 3378-3389
    • Song, B.1    Scheuner, D.2    Ron, D.3    Pennathur, S.4    Kaufman, R.J.5
  • 44
    • 42449154297 scopus 로고    scopus 로고
    • Interaction between pro-inflammatory and anti-inflammatory cytokines in insulin-producing cells
    • DOI 10.1677/JOE-07-0638
    • Souza KL, Gurgul-Convey E, Elsner M & Lenzen S 2008 Interaction between pro-inflammatory and anti-inflammatory cytokines in insulin-producing cells. Journal of Endocrinology 197 139-150. (Pubitemid 351566933)
    • (2008) Journal of Endocrinology , vol.197 , Issue.1 , pp. 139-150
    • Souza, K.L.A.1    Gurgul-Convey, E.2    Elsner, M.3    Lenzen, S.4
  • 45
    • 0141644356 scopus 로고    scopus 로고
    • Effect of arachidonic acid on proliferation, cytokines production and pleiotropic genes expression in Jurkat cells - A comparison with oleic acid
    • Verlengia R, Gorjão R, Kanunfre CC, Bordin S, de Lima TM & Curi R 2003 Effect of arachidonic acid on proliferation, cytokines production and pleiotropic genes expression in Jurkat cells - a comparison with oleic acid. Life Sciences 73 2939-2951.
    • (2003) Life Sciences , vol.73 , pp. 2939-2951
    • Verlengia, R.1    Gorjão, R.2    Kanunfre, C.C.3    Bordin, S.4    De Lima, T.M.5    Curi, R.6
  • 46
    • 26244456414 scopus 로고    scopus 로고
    • ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicity
    • Wang H, Kouri G & Wollheim CB 2005 ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicity. Journal of Cell Science 118 3905-3915.
    • (2005) Journal of Cell Science , vol.118 , pp. 3905-3915
    • Wang, H.1    Kouri, G.2    Wollheim, C.B.3


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