Exendin-4 protects pancreatic beta cells from palmitate-induced apoptosis by interfering with GPR40 and the MKK4/7 stress kinase signalling pathway

Diabetologia

Volumn 56, Issue 11, 2013, Pages 2456-2466

  Natalicchio, Annalisa ^a   Labarbuta, Rossella ^a   Tortosa, Federica ^a   Biondi, Giuseppina ^a   Marrano, Nicola ^a   Peschechera, Alessandro ^a   Carchia, Emanuele ^b   Orlando, Maura Roberta ^a   Leonardini, Anna ^a   Cignarelli, Angelo ^a   Marchetti, Piero ^c   Perrini, Sebastio ^a   Laviola, Luigi ^a   Giorgino, Francesco ^a  

^a UNIVERSITY OF BARI   (Italy)

^b Grande Ospedale Metropolitano   (Italy)

^c UNIVERSITY HOSPITAL OF PISA   (Italy)

Author keywords

Beta cell apoptosis; Exendin 4; G protein coupled receptor 40; JNK; p38 MAPK; Palmitate

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; EXENDIN 4; G PROTEIN COUPLED RECEPTOR 40; GLUCAGON; INSULIN; ISLET BRAIN 1; KT 5720; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE P38; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PALMITIC ACID; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; INHIBITION KINETICS; INSULIN RELEASE; MOUSE; NONHUMAN; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CELL LINE; CELLS, CULTURED; HUMANS; IMMUNOBLOTTING; INSULIN-SECRETING CELLS; MAP KINASE KINASE 4; MAP KINASE KINASE 7; MICE; PALMITATES; PEPTIDES; RATS; RECEPTORS, G-PROTEIN-COUPLED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; VENOMS;

EID: 84885856271     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-013-3028-4     Document Type: Article

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