Inhibition of protein kinase C δ protects rat INS-1 cells against interleukin-1β and streptozotocin-induced apoptosis

Diabetes

Volumn 51, Issue 2, 2002, Pages 317-324

  Carpenter, Lee ^a   Cordery, Damien ^a   Biden, Trevor J ^a,b  

^a ST VINCENT S HOSPITAL   (Australia)

^b GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; DNA FRAGMENT; FREE RADICAL; INTERLEUKIN 1BETA; LIPOCORTIN 5; NITRIC OXIDE SYNTHASE; PROTEIN KINASE C DELTA; STREPTOZOCIN;

ADENOVIRUS; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; ENZYME ACTIVATION; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION SYSTEM; IMMUNOHISTOCHEMISTRY; INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

EID: 0036061642     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.51.2.317     Document Type: Article

References (49)

1. The role of interleukin-1 in the pathogenesis of IDDM
2. Cytokines and nitric oxide in islet inflammation and diabetes
3. Cytokines and their roles in pancreatic islet β-cell destruction and insulin-dependent diabetes mellitus
4. Apoptosis and the pathogenesis of IDDM: A question of life and death
5. Beta cell destruction in the development of autoimmune diabetes in the non-obese diabetic (NOD) mouse
6. A protein kinase C isozyme, nPKCε, is involved in the activation of NF-kappa B by 12-O-tetradecanoylphorbol-13-acetate (TPA) in rat 3Y1 fibroblasts
7. Protein kinase C-α modulates lipopolysaccharide-induced functions in a murine macrophage cell line
8. Antisense oligonucleotides targeting protein kinase C-α, -β I, or -δ but not -ε inhibit lipopolysaccharide-induced nitric oxide synthase expression in RAW 264.7 macrophages: Involvement of a nuclear factor kappa B-dependent mechanism
9. Activation of I kappa B kinase β by protein kinase C isoforms
10. Involvement of protein kinase C-γ in IL-1β-induced cyclooxygenase-2 expression in human pulmonary epithelial cells
11. The extended protein kinase C superfamily
12. Protein kinase C δ activation by interleukin-1β stabilizes inducible nitric-oxide synthase mRNA in pancreatic β-cells
13. Interleukin-1 β-induced nitric oxide production activates apoptosis in pancreatic RINm 5F cells
14. Apoptotic cell death triggered by nitric oxide in pancreatic β-cells
15. Proteolytic activation of protein kinase C δ by an ICE-like protease in apoptotic cells
16. Activation of protein kinase CΔ in human myeloid leukemia cells treated with 1-β-D-arabinofuranosylcytosine
17. Proteolytic activation of protein kinase C δ by an ICE/CED 3-like protease induces characteristics of apoptosis
18. Activation of pkc-alpha downstream from caspases during apoptosis induced by 7-hydroxystaurosporine or the topoisomerase inhibitors, camptothecin and etoposide, in human myeloid leukemia hl 60 cells
19. Protein kinase C δ is activated by caspase-dependent proteolysis during ultraviolet radiation-induced apoptosis of human keratinocytes
20. Protein kinase C δ is essential for etoposide-induced apoptosis in salivary gland acinar cells
21. Spontaneous neutrophil apoptosis involves caspase 3-mediated activation of protein kinase C-δ
22. Caspase-mediated proteolysis and activation of protein kinase C δ plays a central role in neutrophil apoptosis
23. Inactivation of DNA-dependent protein kinase by protein kinase C δ: Implications for apoptosis
24. Cleavage of ζPKC but not λιPKC by caspase-3 during UV-induced apoptosis
25. Caspases: Enemies within
26. Mammalian caspases: Structure, activation, substrates, and functions during apoptosis
27. Suicidal tendencies: Apoptotic cell death by caspase family proteinases
28. The biochenustry of apoptosis
29. Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase C δ
30. Apoptosis: The importance of being eaten
31. A point mutation at the putative ATP-binding site of protein kinase C α abolishes the kinase activity and renders it down-regulation-insensitive. A molecular link between autophosphorylation and down-regulation
32. Ras-dependent signal transduction is indispensable but not sufficient for the activation of AP1/Jun by PKC δ
33. Protein kinase C-τ isoenzyme selective stimulation of the transcription factor complex AP-1 in T lymphocytes
34. Characterization of a protein kinase C-δ (PKC-δ) ATP binding mutant. An inactive enzyme that competitively inhibits wild type PKC-δ enzymatic activity
35. Involvement of caspase 3-activated DNase in internucleosomal DNA cleavage induced by diverse apoptotic stimuli
36. PKCδ is required for mitochondrial-dependent apoptosis in salivary epithelial cells
37. Specificity and mechanism of action of some commonly used protein kinase inhibitors
38. Molecular cloning and characterization of human caspase-activated DNase
39. Caspase-3 is the primary activator of apoptotic DNA fragmentation via DNA fragmentation factor-45/inhibitor of caspase-activated DNase inactivation
40. Initiation of DNA fragmentation during apoptosis induces phosphorylation of H 2AX histone at serine 139
41. Expression and partial characterization of rat protein kinase C-delta and protein kinase C-ζ in insect cells using recombinant baculovirus
42. Nitric oxide generation during cellular metabolization of the diabetogenic N-methyl-N-nitroso-urea streptozotozin contributes to islet cell DNA damage
43. Biochemical evidence for nitric oxide formation from streptozotocin in isolated pancreatic islets
44. Site-specific DNA methylation and apoptosis: Induction by diabetogenic streptozotocin
45. NO induces a cGMP-independent release of cytochrome c from mitochondria which precedes caspase 3 activation in insulin producing RINm5F cells
46. Cytokines induce both necrosis and apoptosis via a common Bcl-2-inhibitable pathway in rat insulin-producing cells
47. Tumor necrosis factor-α-activated cell death pathways in NIT-1 insulinoma cells and primary pancreatic β cells
48. Protein kinase C δ targets mitochondria, alters mitochondrial membrane potential, and induces apoptosis in normal and neoplastic keratinocytes when overexpressed by an adenoviral vector
49. Mitochondria and apoptosis