Curcumin attenuates palmitate-induced apoptosis in MIN6 pancreatic β-cells through PI3K/Akt/FoxO1 and mitochondrial survival pathways

Apoptosis

Volumn 20, Issue 11, 2015, Pages 1420-1432

  Hao, Feng ^a   Kang, Jinsen ^a   Cao, Yajun ^a   Fan, Shengjun ^a   Yang, Haopeng ^a   An, Yu ^a   Pan, Yan ^a   Tie, Lu ^a   Li, Xuejun ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Apoptosis; Curcumin; FoxO1; Lipotoxicity; Palmitate; Cells

Indexed keywords

CASPASE 3; CASPASE 9; COPPER ZINC SUPEROXIDE DISMUTASE; CURCUMIN; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE REDUCTASE; LIPID PEROXIDE; MANGANESE SUPEROXIDE DISMUTASE; PALMITIC ACID; PHOSPHATIDYLINOSITOL 3 KINASE; PROCASPASE 3; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR FOXO; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, MOUSE; PALMITIC ACID DERIVATIVE;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL PROTECTION; CELL SURVIVAL; CELL VIABILITY; CHROMATIN CONDENSATION; CONTROLLED STUDY; ENZYME ACTIVATION; INSULIN RELEASE; LIPOTOXICITY; MEMBRANE DEPOLARIZATION; MIN6 CELL LINE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; ANIMAL; CYTOLOGY; DRUG EFFECTS; GENETICS; HUMAN; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CURCUMIN; DIABETES MELLITUS, TYPE 2; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INSULIN-SECRETING CELLS; MICE; MITOCHONDRIA; PALMITATES; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84942551235     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-015-1150-0     Document Type: Article

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