Signal transduction by protein kinase C in mammalian cells

Clinical and Experimental Pharmacology and Physiology

Volumn 25, Issue 12, 1998, Pages 974-985

  Kanashiro, Celia A ^a   Khalil, Raouf A ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

Carcinogenesis; Cell proliferation; Phorbol esters; Protein kinase C; Signal transduction

Indexed keywords

PROTEIN KINASE C;

ANIMAL CELL; CELL DIFFERENTIATION; CELL GROWTH; ENZYME ACTIVATION; ENZYME ACTIVITY; GROWTH REGULATION; NONHUMAN; PROTEIN PHOSPHORYLATION; SHORT SURVEY; SIGNAL TRANSDUCTION;

EID: 0032421728     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1681.1998.tb02170.x     Document Type: Short Survey

References (89)

1. Berridge MJ, Irvine RF. Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature 1984; 312: 315-25.
2. Nishizuka Y. Intracellular signaling by hydrolysis of phospholipids and activation of PKC. Science 1992; 258: 607-14.
3. Kaibuchi K, Takai M, Sawamura M, Hoshijima M, Fujikura T, Nishizuka Y. Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation. J. Biol. Chem. 1983; 258: 6701-4.
4. Newton AC. Protein kinase C. Structure, function and regulation. J. Biol. Chem. 1995; 270: 28495-8.
5. 2+, phorbol esters, and ATP. J. Biol. Chem. 1985; 260: 15718-22.
6. Takai Y, Kishimoto A, Iwasa Y, Kawahara Y. Mon T, Nishizuka Y. Calcium-dependent activation of a multifunctional protein kinase by membrane phospholipids. J. Biol. Chem. 1979; 254: 3692-5.
7. Ohanian V, Ohanian J, Shaw L. Scarth S. Parker PJ, Heagerty AM. Identification of protein kinase C isoforms in rat mesenteric small arteries and their possible role in agonist-induced contraction. Circ. Res. 1996; 78: 806-12.
8. i threshold for translocation of the α-protein kinase C isoform. Am. J. Physiol. 1994; 266: C1544-51.
9. Kohout TA, Rogers TB. Use of a PCR-based method to characterize protein kinase C isoform expression in cardiac cells. Am. J. Physiol. 1993; 264: C1350-9.
10. Goodnight J, Mischak H, Kolch W, Mushinski F. Immunocytochemical localization of eight protein kinase C isozymes overexpressed in NIH 3T3 fibroblasts. J. Biol. Chem. 1995; 270: 9991-10001.
11. Li W, Zhang J, Bottaro DP, Pierce JH. Identification of serine 643 of protein kinase C-delta as an important autophosphorylation site for its enzymatic activity. J. Biol. Chem. 1996; 272: 24550-5.
12. Hempel A, Maasch C, Heintze U et al. High glucose concentrations increase endothelial cell permeability via activation of protein kinase C. Circ. Res. 1997; 81: 363-71.
13. Khalil RA, Morgan KG. Imaging of protein kinase C distribution and translocation in living vascular smooth muscle cells. Circ. Res. 1991; 69: 1626-31.
14. lizuka K, Somlyo AP, Somlyo AV. Permeability of receptor coupled, permeabilized smooth muscle to high molecular weight (IgG) proteins. Biophys. J. 1994; 66: A409.
15. 2+-independent isoforms of protein kinase C differentially translocate in smooth muscle. Am. J. Physiol. 1992; 263: C714-19.
16. Coussens L, Parker PJ, Rhee L et al. Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways. Science 1986; 233: 859-66.
17. 2 zinc fingers. Science 1991; 253: 1367-93.
18. Ohno S, Konno Y, Akita Y, Yano A, Suzuki K. A point mutation at the putative ATP-binding site of protein kinase Ca abolishes the kinase activity and renders it down-regulation-insensitive. J. Biol. Chem. 1990; 265: 6296-300.
19. Parker PJ, Coussens L, Totty N et al. The complete primary structure of protein kinase C: The major phorbol ester receptor. Science 1986; 233: 853-9.
20. Ono Y, Fujii T, Ogita K, Kikkawa U, Igarashi K, Nishizuka Y. Protein kinase Cδ subspecies from rat brain: Its structure, expression, and properties. Proc. Natl Acad. Sci. USA 1989; 86: 3099-103.
21. Schaap D, Parker PJ, Bristol A, Kriz R, Knopf J. Unique substrate specificity and regulatory properties of PKC-epsilon: A rationale for diversity. FEBS Lett. 1989; 243: 351-7.
22. Osada S, Mizuno K, Saido TC, Suzuki K, Kuroki T, Ohno S. A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle. Mol. Cell Biol. 1992; 12: 3930-8.
23. Bacher N, Zisman Y, Berent E, Livneh E. Isolation and characterization of PKC-L, a new member of the protein kinase C-related gene family specifically expressed in lung, skin, and heart. Mol. Cell Biol. 1991; 11: 126-33.
24. Orr JW, Keranen LM, Newton AC. Reversible exposure of the pseudosubstrate domain of protein kinase C by phosphatidylserine and diacylglycerol. J. Biol. Chem. 1992; 267: 15263-6.
25. Makowske M, Rosen OM. Complete activation of protein kinase C by an antipeptide antibody directed against the pseudosubstrate prototope. J. Biol. Chem. 1989; 264: 16155-9.
26. House C, Kemp BE. Protein kinase C contains a pseudosubstrate prototope in its regulatory domain. Science 1987; 238: 1726-8.
27. Dekker LV, McIntyre P, Parker PJ. Mutagenesis of the regulatory domain of rat protein kinase C-η: A molecular basis for restricted histone kinase activity. J. Biol. Chem. 1993; 268: 19498-504.
28. Wang JKT, Walaas SI, Sihra TS, Aderem A, Greengard P. Phosphorylation and associated translocation of the 87 kDa protein, a major protein kinase C substrate, in isolated nerve terminals. Proc. Natl Acad. Sci. USA 1989; 86: 2253-6.
29. Hartwig JH, Thelen M, Rosen A, Janmey PA, Nairn AC, Aderem A. MARCKS is an aetin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin. Nature 1992; 356: 618-22.
30. Katada T, Gilman AG, Watanabe Y, Bauer S, Jakobs KH. Protein kinase C phosphorylates the inhibitory guanine-nucleotide-binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylatecyclase. Eur. J. Biochem. 1985; 151: 431-7.
31. Sibley DR, Nambi P, Peter JR, Lefkowitz RJ. Phorbol diesters promote β-adrenergic receptor phosphorylation and adenylate cyclase desensitization in duck erythrocytes. Biochem. Biophys. Res. Commun. 1984; 121: 973-9.
32. Limas CJ. Phosphorylation of cardiac sarcoplasmic reticulum by a calcium-activated, phospholipid-dependenl protein kinase. Biochem. Biophys. Res. Commun. 1980; 96: 1378-83.
33. + exchange. J. Biol. Chem. 1984; 259: 7056-60.
34. Inagaki M, Hisayuki Y, Itoh T, Kanmura Y, Kuriyama H, Hidaka H. Purified rabbit brain kinase C relaxes skinned vascular smooth muscle and phosphorylates myosin light chain. Arch. Biochem. Biophys. 1987; 254: 136-41.
35. Singer HA. Phorbol ester-induced stress and myosin light chain phosphorylation in swine medial smooth muscle. J. Pharmacol. Exp. Ther. 1990; 252: 1068-74.
36. Schwienbacher C, Jockusch BM, Rudiger M. Intramolecular interactions regulate serine/threonine phosphorylation of vinculin. FEBS Lett. 1996; 384: 71-4.
37. Mino T, Yuasa U, Naka M, Tanaka T. Phosphorylation of calponin mediated by protein kinase C in association with contraction in porcine coronary artery. Biochem. Biophys. Res. Commun. 1995; 208: 397-404.
38. O'Brian CA, Ward NE. Biology of protein kinase family. Cancer Metastasis Rev. 1989; 8: 199-214.
39. Leibersperger H, Gschwendt M, Gernold M, Marks F. Immunological demonstration of a calcium-unresponsive protein kinase C of the δ-type in different species and murine tissues. Predominance in epidermis. J. Biol. Chem. 1991; 266: 14778-84.
40. 2+, phospholipid-dependent protein kinase associated with plasma membrane. Nature 1983; 301: 621-3.
41. Hyat SL, Klauck T, Jaken S. Protein kinase C is localized in focal contacts of normal but not transformed fibroblasts. Mol. Carcinogen. 1990; 3: 45-53.
42. Kose A, Saito N, Ito H, Kikkawa U, Nishizuka Y, Tanaka C. Electron microscopic localization of type 1 protein kinase C in rat Purkinje cells. J. Neurosci. 1988; 8: 4262-8.
43. Leventhal PS, Bertics PJ. Activation of protein kinase C by selective binding of arginine-rich polypeptides. J. Biol. Chem. 1993; 268: 13906-13.
44. Ron D, Mochly-Rosen D. Agonists and antagonists of protein kinase C function, derived from its binding proteins. J. Biol. Chem. 1994; 269: 21 395-8.
45. Housey GM, Johnson MD, Hsiao WLW et al. Overproduction of protein kinase C causes disordered growth control in rat fibroblasts. Cell 1988; 52: 343-54.
46. Bazzi MD, Nelseusten GL. Protein kinase C interaction with calcium: A phospholipid-dependent process. Biochemistry 1990; 29: 7624-30.
47. Nishizuka Y. Protein kinase C and lipid signaling for sustained cellular responses. FASEB J. 1995; 9: 484-96.
48. Szallasi Z, Smith CB, Pettit GR, Blumnerg PM. Differential regulation of protein kinase C isozymes by bryostalin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts. J. Biol. Chem. 1994; 269: 2118-24.
49. Edwards AS, Newton AC. Phosphorylation at conserved carboxyl-terminal hydrophobic motif regulates the catalytic and regulatory domains of protein kinase C. J. Biol. Chem. 1997; 272: 18 382-90.
50. Keranen LM, Dutil EM, Newton AC. Protein kinase C is regulated in vivo by three functionally distinct phosphorylations. Curr. Biol. 1995; 5: 1394-403.
51. Reynolds NJ, McCombie SW, Shankar BB, Bishop WR, Fisher GJ. SCH 47112, a novel staurosporine derivative, inhibits 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and epidermal hyperplasia in hairless mouse skin. Arch. Dermatol. Res. 1997; 289: 540-6.
52. Herbert JM, Augereau JM, Gleye J, Maffrand JP. Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem. Biophys. Res. Commun. 1990; 172; 993-9.
53. Hidaka H, Hagiwara M. Pharmacology of the isoquinoline sulfonamide protein kinase C inhibitors. Trends Pharmacol. Sci. 1987; 8: 162-4.
54. Huang YT, Kuo ML, Liu JY, Huang SY, Lin JK. Inhibitions of protein kinase C and proto-oncogene expressions in NIH 3T3 cells by apigenin. Eur. J. Cancer 1996; 32A: 146-51.
55. Kobayashi K, Nakano H, Morimoto M, Tamaoki T. Calphostin C (UCN-102SC), a novel microbial compound, is a highly potent and specific-inhibitor of protein kinase C. Biochem. Biophys. Res. Commun. 1989; 159: 548-53.
56. Hannun YA, Loomiser Jr MAH, Bell RM. Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets. J. Biol. Chem. 1986; 261: 12604-9.
57. Schuller HM, Orloff M, Reznik GK. Inhibition of protein kinase C-dependent cell proliferation of human lung cancer cell lines by the dehydropyridine dexniguldipine. J. Cancer Res. Clin. Oncol. 1994; 120: 354-8.
58. Eicholtz T, de Bont DB, Widt J, Liskamp RMJ, Ploegh HL. A myristoylated pseudosubstrate peptide, a novel protein kinase C inhibitor. J. Biol. Chem. 1993; 268: 1982-6.
59. Martiny-Baron G, Kazanietz MG et al. Selective inhibition of protein kinase C isozymes by the indocarbazole Gö6976. J. Biol. Chem. 1993; 268: 9194-7.
60. Gekeler V, Boer R. Uberall F et al. Effects of the selective bisindolymaleimide protein kinase C inhibitor GH 109203X on P-glycoprotein-mediated multidrug resistance. Br. J. Cancer 1996; 74: 897-905.
61. Clement S, Tasinato A, Boscoboinik D, Azzi A. The effect of α-tocoferol on the synthesis, phosphorylation and activity of protein kinase C in smooth muscle cells after phorhol 12-myristate 13-acetate. Eur. J. Biochem. 1997; 246: 745-9.
62. Liou YM, Morgan KG. Redistribution of protein kinase C isoforms in association with vascular hypertrophy of rat aorta. Am. J. Physiol. 1994; 267: C980-9.
63. Manni A, Buckwalter E, Etindi R et al. Induction of a less aggressive-breast cancer phenotype by protein kinase C-alpha and -beta overexpression. Cell Growth Differ. 1996; 7: 1187-98.
64. Perletti GP, Folini M, Lin HC, Mischak H, Piccinim F, Tashjian Jr AH. Overexpression of protein kinase C epsilon is oncogenic in rat colonic epithelial cells. Oncogene 1996; 12: 847-54.
65. Mischak H, Goodnight J, Kolch W et al. Overexpression of protein kinase C-δ and -∈ in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity. J. Biol. Chem. 1993; 268: 6090-6.
66. Powell CT, Gschwend JE, Fair WR, Brittis NJ, Stec D, Huryk R. Overexpression of protein kinase C-zeta (PKC-zeta) inhibits invasive and metastatic abilities of Dunning R-3327 MAT-LyLu rat prostate cancer cells. Cancer Res. 1996; 56: 4137-41.
67. Farese RV, Standaert ML, Ishizuka T et al. Antisense DNA downregulates protein kinase C isozymes (beta and alpha) and insulin-stimulated 2-deoxyglucose uptake in rat adipocytes. Antisense Res. Dev. 1991; 1: 35-42.
68. Ishii H, Jirousek MR, Daisuke K et al. Amelioration of vascular dysfunction in diabetes rats by an oral PKC β inhibitor. Science 1996; 272: 728-31.
69. Malmberg AB, Chen C, Tonegawa S, Basbaum A. Preserved acute pain and reduced neuropathic pain in mice lacking PKC gamma. Science 1997; 278: 279-83.
70. Rudd CE, Trevillyan JM, Dasgupta JD. The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes, Proc. Natl Acad. Sci. USA 1988; 85: 5190-4.
71. Kosaka Y, Ogita K, Ase K, Nomura H, Kikkawa U, Nishizuka Y. The heterogeneity of protein kinase C in various rat tissues. Biochem. Biophys. Res. Commun. 1988; 151: 973-81.
72. Gschwendt M, Leibersperger H, Rincke G, Marks F. Immunological demonstration of ∈PKC. FEBS Lett. 1991; 290: 115-18.
73. Secrest RJ, Lucailes VL, Mendelsohn LG, Cohen ML. Protein kinase C translocation in rat stomach fundus: Effects of serotonin, carbamylcholine and phorbol dibutyrate. J. Pharmacol Exp. Ther. 1991; 256: 103-9.
74. Chardonnens D, Lang U, Rossier MF, Capponi AM, Valloton MB. Inhibitory and stimulatory effects of phorbol-ester on vasopressin-induced cellular responses in cultured rat aortic cells. J. Biol. Chem. 1990; 265: 10451-7.
75. Watanabe M, HachiyaT, Hagiwara M, Hidaka H. Identification of type III protein kinase C in bovine aortic tissue. Arch. Biochem. Biophys. 1989; 273: 165-9.
76. Haller H, Quass P, Lindschau C, Luft FC, Distler A. Platelet-derived growth factor and angiotensin II induce different spatial distribution of protein kinase C-α and -β in vascular smooth muscle cells. Hypertension 1994; 23: 848-52.
77. Knight DE, Baker PF. The phorbol ester TPA increases the affinity of exocytosis for calcium in 'leaky' adrenal medullary cells. FEBS Lett. 1983; 160: 98-100.
78. Kojima I, Lippes H, Kojima K, Rasmussen H. Aldosterone secretion: Effect of phorhol ester and A23187. Biochem. Biophys. Res. Commun. 1983; 116: 555-62.
79. Hubinont CJ, Best L, Sener A, Malaisse WJ. Activation of protein kinase C by a tumor-promoting phorbol ester in pancreatic islets. FEBS Lett. 1984; 170: 247-53.
80. - lates rat growth hormone (GH) release through different pathways from that of human pancreatic GH-releasing factor. Endocrinology 1985; 116: 728-33.
81. Brown EM, Redgrave J, Thatcher J. Effect of the phorbol ester TPA on PTH secretion. FEBS Lett. 1984; 175: 72-5.
82. Merrit JE, Rubin RP. Pancreatic amylase secretion and cytoplasmic free calcium. Biochem. J. 1985; 230: 151-9.
83. Anderson NG, Hanson PJ. Involvement of calcium-sensitive phospholipid-dependent protein kinase in control of acid secretion by isolated rat parietal cells. Biochem. J. 1985; 232: 609-11.
84. Publicover SJ. Stimulation of spontaneous transmitter release by the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate, an activator of protein kinase C. Brain Res. 1985; 333: 185-7.
85. Rasmussen H, Forder J, Kojima I, Scriabine A. TPA-induced contraction of isolated rabbit vascular smooth muscle. Biochem. Biophys. Res. Commun. 1984; 122: 776-84.
86. Rink TJ, Sanchez A, Hallam TJ. Diacylglycerol and phorbol ester stimulate secretion without raising cytoplasmic free calcium in human platelets. Nature 1983; 305: 317-19.
87. Mobley A, Tai HH. Synergistic stimulation of thromboxane biosynthesis. Biochem. Biophys. Res. Commun. 1985; 130: 717-23.
88. White JR, Huang CK, Hill JM, Naccache PH, Becker E, Sha'afi RI. Effect of phorbol 12-myristate 13-acetate and its analogue 4α-phorbol 12,13-didecanoate on protein phosphorylation and lysosomal enzyme release in rabbit neutrophils. J. Biol. Chem. 1984; 259: 8605-11.
89. Sagi-Eisenberg R, Lieman H, Pecht I. Protein kinase C regulation of the receptor-coupled calcium signal in histamine-secreting rat basophilic leukaemia cells. Nature 1985; 313: 59-60.