-
1
-
-
0028342686
-
Mechanisms of fatty acid-induced inhibition of glucose uptake
-
Boden G, Chen X, Ruiz J, White JV & Rossetti L 1994 Mechanisms of fatty acid-induced inhibition of glucose uptake. Journal of Clinical Investigation 93 2438-2446.
-
(1994)
Journal of Clinical Investigation
, vol.93
, pp. 2438-2446
-
-
Boden, G.1
Chen, X.2
Ruiz, J.3
White, J.V.4
Rossetti, L.5
-
2
-
-
13644256191
-
A selective inhibitor of eIF2α dephosphorylation protects cells from ER stress
-
Boyce M, Bryant KF, Jousse C, Long K, Harding HP, Scheuner D, Kaufman RJ, Ma D, Coen DM, Ron D et al. 2005 A selective inhibitor of eIF2α dephosphorylation protects cells from ER stress. Science 307 935-939.
-
(2005)
Science
, vol.307
, pp. 935-939
-
-
Boyce, M.1
Bryant, K.F.2
Jousse, C.3
Long, K.4
Harding, H.P.5
Scheuner, D.6
Kaufman, R.J.7
Ma, D.8
Coen, D.M.9
Ron, D.10
-
3
-
-
0034005968
-
Prolonged elevation of plasma free fatty acids impairs pancreatic γ-cell function in obese nondiabetic humans but not in individuals with type 2 diabetes
-
Carpentier A, Mittelman SD, Bergman RN, Giacca A & Lewis GF 2000 Prolonged elevation of plasma free fatty acids impairs pancreatic γ-cell function in obese nondiabetic humans but not in individuals with type 2 diabetes. Diabetes 49 399-408.
-
(2000)
Diabetes
, vol.49
, pp. 399-408
-
-
Carpentier, A.1
Mittelman, S.D.2
Bergman, R.N.3
Giacca, A.4
Lewis, G.F.5
-
4
-
-
0035430782
-
Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation
-
Cnop M, Hannaert JC, Hoorens A, Eizirik DL & Pipeleers DG 2001 Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation. Diabetes 50 1771-1777.
-
(2001)
Diabetes
, vol.50
, pp. 1771-1777
-
-
Cnop, M.1
Hannaert, J.C.2
Hoorens, A.3
Eizirik, D.L.4
Pipeleers, D.G.5
-
5
-
-
33947510911
-
Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic β-cell dysfunction and apoptosis
-
Coop M, Ladriere L, Hekerman P, Ortis F, Cardozo AK, Dogusan Z, Flamez D, Boyce M, Yuan J & Eizirik DL 2007 Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic β-cell dysfunction and apoptosis. Journal of Biological Chemistry 282 3989-3997.
-
(2007)
Journal of Biological Chemistry
, vol.282
, pp. 3989-3997
-
-
Coop, M.1
Ladriere, L.2
Hekerman, P.3
Ortis, F.4
Cardozo, A.K.5
Dogusan, Z.6
Flamez, D.7
Boyce, M.8
Yuan, J.9
Eizirik, D.L.10
-
6
-
-
42149111577
-
Structural requirements for the cytoprorective actions of mono-unsaturated fatty acids in the pancreatic β-cell line, BRIN-BD11
-
In press
-
Dhayal S, Welters H & Morgan NG 2008 Structural requirements for the cytoprorective actions of mono-unsaturated fatty acids in the pancreatic β-cell line, BRIN-BD11. British Journal of Pharmacology. In press.
-
(2008)
British Journal of Pharmacology
-
-
Dhayal, S.1
Welters, H.2
Morgan, N.G.3
-
7
-
-
34547888676
-
Mechanisms involved in the cytotoxic and cytoprotective actions of saturated versus monounsaturated long-chain fatty acids in pancreatic β-cells
-
Diakogiannaki E, Dhayal S, Childs CE, Calder PC, Welters HJ & Morgan NG 2007 Mechanisms involved in the cytotoxic and cytoprotective actions of saturated versus monounsaturated long-chain fatty acids in pancreatic β-cells. Journal of Endocrinology 194 283-291.
-
(2007)
Journal of Endocrinology
, vol.194
, pp. 283-291
-
-
Diakogiannaki, E.1
Dhayal, S.2
Childs, C.E.3
Calder, P.C.4
Welters, H.J.5
Morgan, N.G.6
-
8
-
-
0036260126
-
The composition of dietary fat directly influences glucose-stimulated insulin secretion in rats
-
Dobbins RL, Szczepaniak LS, Mybill J, Tamura Y, Uchino H, Giacca A & McGarry JD 2002 The composition of dietary fat directly influences glucose-stimulated insulin secretion in rats. Diabetes 51 1825-1833.
-
(2002)
Diabetes
, vol.51
, pp. 1825-1833
-
-
Dobbins, R.L.1
Szczepaniak, L.S.2
Mybill, J.3
Tamura, Y.4
Uchino, H.5
Giacca, A.6
McGarry, J.D.7
-
9
-
-
39149104320
-
The role for endoplasmic reticulum stress in diabetes mellitus
-
Eizirik DL, Cardozo AK & Cnop M 2008 The role for endoplasmic reticulum stress in diabetes mellitus. Endocrine Reviews 29 42-61.
-
(2008)
Endocrine Reviews
, vol.29
, pp. 42-61
-
-
Eizirik, D.L.1
Cardozo, A.K.2
Cnop, M.3
-
10
-
-
0000847623
-
Non-esterified fatty acids in the blood of obese and lean subjects
-
Gordon ES 1960 Non-esterified fatty acids in the blood of obese and lean subjects American Journal of Clinical Nutrition 8 740-747.
-
(1960)
American Journal of Clinical Nutrition
, vol.8
, pp. 740-747
-
-
Gordon, E.S.1
-
11
-
-
0037211642
-
Pleiotropic effects of fatty acids on pancreatic β-cells
-
Haber EP, Ximenes HM, Procopio J, Carvalho CR, Curi R & Carpinelli AR 2003 Pleiotropic effects of fatty acids on pancreatic β-cells. Journal of Cellular Physiology 194 1-12.
-
(2003)
Journal of Cellular Physiology
, vol.194
, pp. 1-12
-
-
Haber, E.P.1
Ximenes, H.M.2
Procopio, J.3
Carvalho, C.R.4
Curi, R.5
Carpinelli, A.R.6
-
12
-
-
0036895383
-
Endoplasmic reticulum stress and the development of diabetes: A review
-
Harding HP & Ron D 2002 Endoplasmic reticulum stress and the development of diabetes: a review. Diabetes 51 S455-S461.
-
(2002)
Diabetes
, vol.51
-
-
Harding, H.P.1
Ron, D.2
-
13
-
-
34547638958
-
High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated β-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes
-
Huang CJ, Lin CY, Haataja L, Gurlo T, Butler AE, Rizza RA & Butler PC 2007 High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated β-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes. Diabetes 56 2016-2027.
-
(2007)
Diabetes
, vol.56
, pp. 2016-2027
-
-
Huang, C.J.1
Lin, C.Y.2
Haataja, L.3
Gurlo, T.4
Butler, A.E.5
Rizza, R.A.6
Butler, P.C.7
-
14
-
-
33745116619
-
Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis
-
Karaskov E, Scott C, Zhang L, Teodoro T, Ravazzola M & Volchuk A 2006 Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis. Endocrinology 147 3398-3407.
-
(2006)
Endocrinology
, vol.147
, pp. 3398-3407
-
-
Karaskov, E.1
Scott, C.2
Zhang, L.3
Teodoro, T.4
Ravazzola, M.5
Volchuk, A.6
-
15
-
-
9244231766
-
Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by diffierent mechanisms: Role of nuclear factor-kappaB and endoplasmic reticulum stress
-
Kharroubi I, Ladriere L, Cardozo AK, Dogusan Z, Cnop M & Eizirik DL 2004 Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by diffierent mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress. Endocrinology 145 5087-5096.
-
(2004)
Endocrinology
, vol.145
, pp. 5087-5096
-
-
Kharroubi, I.1
Ladriere, L.2
Cardozo, A.K.3
Dogusan, Z.4
Cnop, M.5
Eizirik, D.L.6
-
17
-
-
33847677975
-
Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes
-
Laybutt DR, Preston AM, Akerfeldt MC, Kench JG, Busch AK, Biankin AV & Biden TJ 2007 Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes. Diabetologia 50 752-763.
-
(2007)
Diabetologia
, vol.50
, pp. 752-763
-
-
Laybutt, D.R.1
Preston, A.M.2
Akerfeldt, M.C.3
Kench, J.G.4
Busch, A.K.5
Biankin, A.V.6
Biden, T.J.7
-
18
-
-
0345354674
-
Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic β-cell turnover and function
-
Maedler K, Oberholzer J, Bucher P, Spinas GA & Donath MY 2003 Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic β-cell turnover and function. Diabetes 52 726-733.
-
(2003)
Diabetes
, vol.52
, pp. 726-733
-
-
Maedler, K.1
Oberholzer, J.2
Bucher, P.3
Spinas, G.A.4
Donath, M.Y.5
-
19
-
-
35848963392
-
The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients
-
Marchetti P, Bugliam M, Lupi R, Marselli L, Masini M, Boggi U, Filipponi F, Weir GC, Eizirik DL & Cnop M 2007 The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients. Diabetologia 30 2486-2494.
-
(2007)
Diabetologia
, vol.30
, pp. 2486-2494
-
-
Marchetti, P.1
Bugliam, M.2
Lupi, R.3
Marselli, L.4
Masini, M.5
Boggi, U.6
Filipponi, F.7
Weir, G.C.8
Eizirik, D.L.9
Cnop, M.10
-
20
-
-
33846267745
-
Life and death decisions of the pancreatic β-cell: The role of fatty acids
-
Newsholme F, Keane D, Welters HJ & Morgan NG 2007 Life and death decisions of the pancreatic β-cell: the role of fatty acids. Clinical Science 112 27-42.
-
(2007)
Clinical Science
, vol.112
, pp. 27-42
-
-
Newsholme, F.1
Keane, D.2
Welters, H.J.3
Morgan, N.G.4
-
21
-
-
36649027086
-
Free fatty acid-induced reduction in glucose-stimulated insulin secretion: Evidence for a role of oxidative stress in vitro and in vivo
-
Oprescu AI, Bikopoulos G, Naassan A, Allister EM, Tang C, Park E, Uchino H, Lewis GE Fantus IG, Rozakis-Adcock M et al. 2007 Free fatty acid-induced reduction in glucose-stimulated insulin secretion: evidence for a role of oxidative stress in vitro and in vivo. Diabetes 56 2927-2937.
-
(2007)
Diabetes
, vol.56
, pp. 2927-2937
-
-
Oprescu, A.I.1
Bikopoulos, G.2
Naassan, A.3
Allister, E.M.4
Tang, C.5
Park, E.6
Uchino, H.7
Lewis, G.E.8
Fantus, I.G.9
Rozakis-Adcock, M.10
-
22
-
-
1842843855
-
Roles of CHOP/GADD153 in endoplasmic reticulum stress
-
Cyadomari S & Mori M 2004 Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death and Diferentiation 11381-389.
-
(2004)
Cell Death and Diferentiation
, pp. 11381-11389
-
-
Cyadomari, S.1
Mori, M.2
-
23
-
-
0036797785
-
Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: Possible role of oxidative stress
-
Piro S, Anello M, Di Pietro C, Lizzio MN, Patane G, Rabuazzo AM, Vigneri R, Purrello M & Purrello F 2002 Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress. Metabolism 51 1340-1347.
-
(2002)
Metabolism
, vol.51
, pp. 1340-1347
-
-
Piro, S.1
Anello, M.2
Di Pietro, C.3
Lizzio, M.N.4
Patane, G.5
Rabuazzo, A.M.6
Vigneri, R.7
Purrello, M.8
Purrello, F.9
-
24
-
-
43549108142
-
Glucolipotoxicity: Fuel excess and β-cell dysfunction
-
In press
-
Poitout V & Robertson RP 2008 Glucolipotoxicity: fuel excess and β-cell dysfunction. Endocrine Reviews. In press.
-
(2008)
Endocrine Reviews
-
-
Poitout, V.1
Robertson, R.P.2
-
25
-
-
0036856008
-
Translational control in the endoplasmic reticulumn stress response
-
Ron D 2002 Translational control in the endoplasmic reticulumn stress response. Journal of Clinical Investigation 110 1383-1388.
-
(2002)
Journal of Clinical Investigation
, vol.110
, pp. 1383-1388
-
-
Ron, D.1
-
26
-
-
34250899722
-
-
Ron D & Walter P 2007 Signal integration in the endoplasmic reticulum unfolded protein response. Nature Review. Molecular and Cellular Biology 8 519-529.
-
Ron D & Walter P 2007 Signal integration in the endoplasmic reticulum unfolded protein response. Nature Review. Molecular and Cellular Biology 8 519-529.
-
-
-
-
28
-
-
36849073683
-
Fasting nonesterified fatty acid profiles in childhood and their relationship with adiposity, insulin sensitivity, and lipid levels
-
Sabin MA, De Hora M, Holly JM, Hunt LP, Ford AL, Williams SR, Baker JS, Retallick CJ, Crowne EC & Shield JP 2007 Fasting nonesterified fatty acid profiles in childhood and their relationship with adiposity, insulin sensitivity, and lipid levels. Pediatrics 120 e1426-e1433.
-
(2007)
Pediatrics
, vol.120
-
-
Sabin, M.A.1
De Hora, M.2
Holly, J.M.3
Hunt, L.P.4
Ford, A.L.5
Williams, S.R.6
Baker, J.S.7
Retallick, C.J.8
Crowne, E.C.9
Shield, J.P.10
-
29
-
-
0032478314
-
Fatty acid-induced beta cell apoptosis: A link between obesity and diabetes
-
Shnnabukuro M, Zhou YT, Levi M & Unger RH 1998 Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes. PNAS 95 2498-2502.
-
(1998)
PNAS
, vol.95
, pp. 2498-2502
-
-
Shnnabukuro, M.1
Zhou, Y.T.2
Levi, M.3
Unger, R.H.4
-
30
-
-
0029888870
-
Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat
-
Stein DT, Esser V, Stevenson BE, Lane KE, Whiteside JH, Daniels MB, Chen S & McGarry JD 1996 Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat. Journal of Clinical Investigation 97 2728-2735.
-
(1996)
Journal of Clinical Investigation
, vol.97
, pp. 2728-2735
-
-
Stein, D.T.1
Esser, V.2
Stevenson, B.E.3
Lane, K.E.4
Whiteside, J.H.5
Daniels, M.B.6
Chen, S.7
McGarry, J.D.8
-
32
-
-
0029151863
-
Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications
-
Unger RH 1995 Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications. Diabetes 44 863-870.
-
(1995)
Diabetes
, vol.44
, pp. 863-870
-
-
Unger, R.H.1
-
34
-
-
1342286820
-
Mono-unsaturated fatty acids protect against β-cell apoptosis induced by saturated fatty acids, serum withdrawal or cytokine exposure
-
Welters HJ, Tadayyon M, Scarpello JH, Smith SA & Morgan NG 2004 Mono-unsaturated fatty acids protect against β-cell apoptosis induced by saturated fatty acids, serum withdrawal or cytokine exposure. FEBS Letters 560 103-108.
-
(2004)
FEBS Letters
, vol.560
, pp. 103-108
-
-
Welters, H.J.1
Tadayyon, M.2
Scarpello, J.H.3
Smith, S.A.4
Morgan, N.G.5
-
35
-
-
33745854213
-
Differential protective effects of palmitoleic acid and cAMP on caspase activation and cell viability in pancreatic β-cells exposed to palmitate
-
Welters HJ, Diakogiannaki E, Mordue JM, Tadayyon M, Smith SA & Morgan NG 2006 Differential protective effects of palmitoleic acid and cAMP on caspase activation and cell viability in pancreatic β-cells exposed to palmitate. Apoptosis 11 1231-1238.
-
(2006)
Apoptosis
, vol.11
, pp. 1231-1238
-
-
Welters, H.J.1
Diakogiannaki, E.2
Mordue, J.M.3
Tadayyon, M.4
Smith, S.A.5
Morgan, N.G.6
-
36
-
-
33750448469
-
GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic rericulum stress
-
Yusta B, Baggio LL, Estall JL, Koehler JA, Holland DP, Li H, Pipeleers D, Ling Z & Drucker DJ 2006 GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic rericulum stress. Cell Metabolism 4 391-406.
-
(2006)
Cell Metabolism
, vol.4
, pp. 391-406
-
-
Yusta, B.1
Baggio, L.L.2
Estall, J.L.3
Koehler, J.A.4
Holland, D.P.5
Li, H.6
Pipeleers, D.7
Ling, Z.8
Drucker, D.J.9
-
37
-
-
0028268936
-
Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle
-
Zhou YP & Grill VE 1994 Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. Journal of Clinical Investigation 93 870-876.
-
(1994)
Journal of Clinical Investigation
, vol.93
, pp. 870-876
-
-
Zhou, Y.P.1
Grill, V.E.2
|