-
1
-
-
0033770540
-
Life and death of the pancreatic beta cells
-
Bonner-Weir S. Life and death of the pancreatic beta cells. Trends Endocrinol Metab. 2000:375-8.
-
(2000)
Trends Endocrinol Metab.
, pp. 375-378
-
-
Bonner-Weir, S.1
-
2
-
-
2342510386
-
Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation
-
Dor Y, Brown J, Martinez OI, Melton DA. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429. 2004:41-6.
-
(2004)
Nature 429.
, pp. 41-46
-
-
Dor, Y.1
Brown, J.2
Martinez, O.I.3
Melton, D.A.4
-
3
-
-
24144473869
-
Very slow turnover of beta-cells in aged adult mice
-
Teta M, Long SY, Wartschow LM, Rankin MM, Kushner JA. Very slow turnover of beta-cells in aged adult mice. Diabetes. 2005:2557-67.
-
(2005)
Diabetes.
, pp. 2557-2567
-
-
Teta, M.1
Long, S.Y.2
Wartschow, L.M.3
Rankin, M.M.4
Kushner, J.A.5
-
4
-
-
3242656480
-
Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: A role for protein kinase B in the Akt
-
Dickson LM, Rhodes CJ. Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt? Am J Physiol Endocrinol Metab. 2004:E192-8.
-
(2004)
Am J Physiol Endocrinol Metab.
-
-
Dickson, L.M.1
Rhodes, C.J.2
-
5
-
-
0032567937
-
Disruption of IRS-2 causes type 2 diabetes in mice
-
Withers DJ, Gutierrez JS, Towery H, Burks DJ, Ren JM, Previs S, et al. Disruption of IRS-2 causes type 2 diabetes in mice. Nature. 1998;391(6670):900-4.
-
(1998)
Nature.
, vol.391
, Issue.6670
, pp. 900-904
-
-
Withers, D.J.1
Gutierrez, J.S.2
Towery, H.3
Burks, D.J.4
Ren, J.M.5
Previs, S.6
-
6
-
-
33644836361
-
Emerging role of protein kinase B/Akt signaling in pancreatic beta-cell mass and function
-
Elghazi L, Balcazar N, Bernal-Mizrachi E. Emerging role of protein kinase B/Akt signaling in pancreatic beta-cell mass and function. Int J Biochem Cell Biol. 2006:157-63.
-
(2006)
Int J Biochem Cell Biol.
, pp. 157-163
-
-
Elghazi, L.1
Balcazar, N.2
Bernal-Mizrachi, E.3
-
7
-
-
0035210374
-
Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia
-
Bernal-Mizrachi E, Wen W, Stahlhut S, Welling CM, Permutt MA. Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia. J Clin Invest. 2001;108(11):1631-8.
-
(2001)
J Clin Invest.
, vol.108
, Issue.11
, pp. 1631-1638
-
-
Bernal-Mizrachi, E.1
Wen, W.2
Stahlhut, S.3
Welling, C.M.4
Permutt, M.A.5
-
8
-
-
9644270397
-
Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells
-
Bernal-Mizrachi E, Fatrai S, Johnson JD, Ohsugi M, Otani K, Han Z, et al. Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells. J Clin Invest. 2004;114(7):928-36.
-
(2004)
J Clin Invest.
, vol.114
, Issue.7
, pp. 928-936
-
-
Bernal-Mizrachi, E.1
Fatrai, S.2
Johnson, J.D.3
Ohsugi, M.4
Otani, K.5
Han, Z.6
-
9
-
-
0032937751
-
Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia
-
Rane SG, Dubus P, Mettus RV, Galbreath EJ, Boden G, Reddy EP, et al. Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia. Nat Genet. 1999;22(1):44-52.
-
(1999)
Nat Genet.
, vol.22
, Issue.1
, pp. 44-52
-
-
Rane, S.G.1
Dubus, P.2
Mettus, R.V.3
Galbreath, E.J.4
Boden, G.5
Reddy, E.P.6
-
10
-
-
17644387563
-
Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth
-
Kushner JA, Ciemerych MA, Sicinska E, Wartschow LM, Teta M, Long SY, et al. Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth. Mol Cell Biol. 2005:3752-62.
-
(2005)
Mol Cell Biol.
, pp. 3752-3762
-
-
Kushner, J.A.1
Ciemerych, M.A.2
Sicinska, E.3
Wartschow, L.M.4
Teta, M.5
Long, S.Y.6
-
11
-
-
0032533225
-
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization
-
Diehl JA, Cheng M, Roussel MF, Sherr CJ. Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev. 1998;12(22):3499-511.
-
(1998)
Genes Dev.
, vol.12
, Issue.22
, pp. 3499-3511
-
-
Diehl, J.A.1
Cheng, M.2
Roussel, M.F.3
Sherr, C.J.4
-
12
-
-
6344240450
-
P38SAPK2 phosphorylates cyclin D3 at Thr-283 and targets it for proteasomal degradation
-
Casanovas O, Jaumot M, Paules AB, Agell N, Bachs O. P38SAPK2 phosphorylates cyclin D3 at Thr-283 and targets it for proteasomal degradation. Oncogene. 2004:7537-44.
-
(2004)
Oncogene.
, pp. 7537-7544
-
-
Casanovas, O.1
Jaumot, M.2
Paules, A.B.3
Agell, N.4
Bachs, O.5
-
13
-
-
35348826054
-
Glycogen synthase kinase-3beta and p38 phosphorylate cyclin D2 on Thr280 to trigger its ubiquitin/proteasome-dependent degradation in hematopoietic cells
-
Kida A, Kakihana K, Kotani S, Kurosu T, Miura O. Glycogen synthase kinase-3beta and p38 phosphorylate cyclin D2 on Thr280 to trigger its ubiquitin/proteasome-dependent degradation in hematopoietic cells. Oncogene 2007:6630-40.
-
(2007)
Oncogene
, pp. 6630-6640
-
-
Kida, A.1
Kakihana, K.2
Kotani, S.3
Kurosu, T.4
Miura, O.5
-
14
-
-
33644754585
-
Akt induces beta-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity
-
Fatrai S, Elghazi L, Balcazar N, Cras-Meneur C, Krits I, Kiyokawa H, et al. Akt induces beta-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity. Diabetes. 2006:318-25.
-
(2006)
Diabetes.
, pp. 318-325
-
-
Fatrai, S.1
Elghazi, L.2
Balcazar, N.3
Cras-Meneur, C.4
Krits, I.5
Kiyokawa, H.6
-
15
-
-
0037352170
-
Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: A target for cancer chemotherapy
-
Chang F, Lee JT, Navolanic PM, Steelman LS, Shelton JG, Blalock WL, et al. Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy. Leukemia. 2003:590-603.
-
(2003)
Leukemia.
, pp. 590-603
-
-
Chang, F.1
Lee, J.T.2
Navolanic, P.M.3
Steelman, L.S.4
Shelton, J.G.5
Blalock, W.L.6
-
16
-
-
20044380925
-
Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice
-
Uchida T, Nakamura T, Hashimoto N, Matsuda T, Kotani K, Sakaue H, et al. Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice. Nat Med. 2005:175-82.
-
(2005)
Nat Med.
, pp. 175-182
-
-
Uchida, T.1
Nakamura, T.2
Hashimoto, N.3
Matsuda, T.4
Kotani, K.5
Sakaue, H.6
-
17
-
-
33845530379
-
Differential effects of p27 in regulation of beta-cell mass during development, neonatal period, and adult life
-
Rachdi L, Balcazar N, Elghazi L, Barker DJ, Krits I, Kiyokawa H, et al. Differential effects of p27 in regulation of beta-cell mass during development, neonatal period, and adult life. Diabetes. 2006:3520-8.
-
(2006)
Diabetes.
, pp. 3520-3528
-
-
Rachdi, L.1
Balcazar, N.2
Elghazi, L.3
Barker, D.J.4
Krits, I.5
Kiyokawa, H.6
-
18
-
-
0025776523
-
Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
-
Heitman J, Movva NR, Hall MN. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science. 1991;253(5022):905-9.
-
(1991)
Science.
, vol.253
, Issue.5022
, pp. 905-909
-
-
Heitman, J.1
Movva, N.R.2
Hall, M.N.3
-
19
-
-
0037015269
-
TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation
-
Long X, Spycher C, Han ZS, Rose AM, Muller F, Avruch J. TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation. Curr Biol. 2002:1448-61.
-
(2002)
Curr Biol.
, pp. 1448-1461
-
-
Long, X.1
Spycher, C.2
Han, Z.S.3
Rose, A.M.4
Muller, F.5
Avruch, J.6
-
20
-
-
0034729905
-
Genetic control of size in Drosophila
-
Oldham S, Bohni R, Stocker H, Brogiolo W, Hafen E. Genetic control of size in Drosophila. Philos Trans R Soc Lond B Biol Sci. 2000;355(1399):945-52.
-
(2000)
Philos Trans R Soc Lond B Biol Sci.
, vol.355
, Issue.1399
, pp. 945-952
-
-
Oldham, S.1
Bohni, R.2
Stocker, H.3
Brogiolo, W.4
Hafen, E.5
-
21
-
-
0028239893
-
RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
-
Sabatini DM, Erdjument-Bromage H, Lui M, Tempst P, Snyder SH. RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell. 1994:35-43.
-
(1994)
Cell.
, pp. 35-43
-
-
Sabatini, D.M.1
Erdjument-Bromage, H.2
Lui, M.3
Tempst, P.4
Snyder, S.H.5
-
22
-
-
3342895823
-
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
-
Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, et al. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol. 2004:1296-302.
-
(2004)
Curr Biol.
, pp. 1296-1302
-
-
Sarbassov, D.D.1
Ali, S.M.2
Kim, D.H.3
Guertin, D.A.4
Latek, R.R.5
Erdjument-Bromage, H.6
-
23
-
-
0037178781
-
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
-
Hara K, Maruki Y, Long X, Yoshino K, Oshiro N, Hidayat S, et al. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell. 2002:177-89.
-
(2002)
Cell.
, pp. 177-189
-
-
Hara, K.1
Maruki, Y.2
Long, X.3
Yoshino, K.4
Oshiro, N.5
Hidayat, S.6
-
24
-
-
0037178786
-
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
-
Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR, Erdjument-Bromage H, et al. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell. 2002:163-75.
-
(2002)
Cell.
, pp. 163-175
-
-
Kim, D.H.1
Sarbassov, D.D.2
Ali, S.M.3
King, J.E.4
Latek, R.R.5
Erdjument-Bromage, H.6
-
25
-
-
67349241955
-
DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival
-
Peterson TR, Laplante M, Thoreen CC, Sancak Y, Kang SA, Kuehl WM, et al. DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell. 2009:873-86.
-
(2009)
Cell.
, pp. 873-886
-
-
Peterson, T.R.1
Laplante, M.2
Thoreen, C.C.3
Sancak, Y.4
Kang, S.A.5
Kuehl, W.M.6
-
26
-
-
70449900928
-
TOR complex 2: A signaling pathway of its own
-
Cybulski N, Hall MN. TOR complex 2: a signaling pathway of its own. Trends Biochem Sci. 2009:620-7.
-
(2009)
Trends Biochem Sci.
, pp. 620-627
-
-
Cybulski, N.1
Hall, M.N.2
-
28
-
-
33646023695
-
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
-
Sarbassov DD, Ali SM, Sengupta S, Sheen JH, Hsu PP, Bagley AF, et al. Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol Cell. 2006:159-68.
-
(2006)
Mol Cell.
, pp. 159-168
-
-
Sarbassov, D.D.1
Ali, S.M.2
Sengupta, S.3
Sheen, J.H.4
Hsu, P.P.5
Bagley, A.F.6
-
29
-
-
0043127125
-
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
-
Inoki K, Li Y, Xu T, Guan KL. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev. 2003:1829-34.
-
(2003)
Genes Dev.
, pp. 1829-1834
-
-
Inoki, K.1
Li, Y.2
Xu, T.3
Guan, K.L.4
-
30
-
-
18044381192
-
Rheb binds and regulates the mTOR kinase
-
Long X, Lin Y, Ortiz-Vega S, Yonezawa K, Avruch J. Rheb binds and regulates the mTOR kinase. Curr Biol. 2005:702-13.
-
(2005)
Curr Biol.
, pp. 702-713
-
-
Long, X.1
Lin, Y.2
Ortiz-Vega, S.3
Yonezawa, K.4
Avruch, J.5
-
31
-
-
33847397874
-
Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40
-
Vander Haar E, Lee SI, Bandhakavi S, Griffin TJ, Kim DH. Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40. Nat Cell Biol. 2007:316-23.
-
(2007)
Nat Cell Biol.
, pp. 316-323
-
-
Vander Haar, E.1
Lee, S.I.2
Bandhakavi, S.3
Griffin, T.J.4
Kim, D.H.5
-
32
-
-
4043171462
-
Upstream and downstream of mTOR
-
Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev. 2004:1926-45.
-
(2004)
Genes Dev.
, pp. 1926-1945
-
-
Hay, N.1
Sonenberg, N.2
-
33
-
-
0034312315
-
Regulation of cellular growth by the Drosophila target of rapamycin dTOR
-
Zhang H, Stallock JP, Ng JC, Reinhard C, Neufeld TP. Regulation of cellular growth by the Drosophila target of rapamycin dTOR. Genes Dev. 2000;14(21):2712-24.
-
(2000)
Genes Dev.
, vol.14
, Issue.21
, pp. 2712-2724
-
-
Zhang, H.1
Stallock, J.P.2
Ng, J.C.3
Reinhard, C.4
Neufeld, T.P.5
-
34
-
-
0036440779
-
Regulation of mammalian translation factors by nutrients
-
Proud CG. Regulation of mammalian translation factors by nutrients. Eur J Biochem. 2002:5338-49.
-
(2002)
Eur J Biochem.
, pp. 5338-5349
-
-
Proud, C.G.1
-
35
-
-
26444575415
-
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase
-
Nobukuni T, Joaquin M, Roccio M, Dann SG, Kim SY, Gulati P, et al. Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. Proc Natl Acad Sci. 2005:14238-43.
-
(2005)
Proc Natl Acad Sci.
, pp. 14238-14243
-
-
Nobukuni, T.1
Joaquin, M.2
Roccio, M.3
Dann, S.G.4
Kim, S.Y.5
Gulati, P.6
-
36
-
-
0035798097
-
Mammalian TOR: A homeostatic ATP sensor
-
Dennis PB, Jaeschke A, Saitoh M, Fowler B, Kozma SC, Thomas G. Mammalian TOR: a homeostatic ATP sensor. Science. 2001:1102-5.
-
(2001)
Science.
, pp. 1102-1105
-
-
Dennis, P.B.1
Jaeschke, A.2
Saitoh, M.3
Fowler, B.4
Kozma, S.C.5
Thomas, G.6
-
37
-
-
0037025356
-
AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling
-
Bolster DR, Crozier SJ, Kimball SR, Jefferson LS. AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling. J Biol Chem. 2002:23977-80.
-
(2002)
J Biol Chem.
, pp. 23977-23980
-
-
Bolster, D.R.1
Crozier, S.J.2
Kimball, S.R.3
Jefferson, L.S.4
-
39
-
-
25444524850
-
Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity
-
Hahn-Windgassen A, Nogueira V, Chen CC, Skeen JE, Sonenberg N, Hay N. Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity. J Biol Chem. 2005:32081-9.
-
(2005)
J Biol Chem.
, pp. 32081-32089
-
-
Hahn-Windgassen, A.1
Nogueira, V.2
Chen, C.C.3
Skeen, J.E.4
Sonenberg, N.5
Hay, N.6
-
40
-
-
0036320205
-
Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake
-
Edinger AL, Thompson CB. Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake. Mol Biol Cell. 2002;13(7):2276-88.
-
(2002)
Mol Biol Cell.
, vol.13
, Issue.7
, pp. 2276-2288
-
-
Edinger, A.L.1
Thompson, C.B.2
-
41
-
-
0042031047
-
A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets
-
Arsham AM, Howell JJ, Simon MC. A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets. J Biol Chem. 2003:29655-60.
-
(2003)
J Biol Chem.
, pp. 29655-29660
-
-
Arsham, A.M.1
Howell, J.J.2
Simon, M.C.3
-
42
-
-
0030915898
-
Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k
-
Jefferies HB, Fumagalli S, Dennis PB, Reinhard C, Pearson RB, Thomas G. Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k. EMBO J. 1997;16(12):3693-704.
-
(1997)
EMBO J.
, vol.16
, Issue.12
, pp. 3693-3704
-
-
Jefferies, H.B.1
Fumagalli, S.2
Dennis, P.B.3
Reinhard, C.4
Pearson, R.B.5
Thomas, G.6
-
44
-
-
11144356304
-
S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway
-
Pende M, Um SH, Mieulet V, Sticker M, Goss VL, Mestan J, et al. S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway. Mol Cell Biol. 2004;24(8):3112-24.
-
(2004)
Mol Cell Biol.
, vol.24
, Issue.8
, pp. 3112-3124
-
-
Pende, M.1
Um, S.H.2
Mieulet, V.3
Sticker, M.4
Goss, V.L.5
Mestan, J.6
-
45
-
-
0032538890
-
Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase
-
Shima H, Pende M, Chen Y, Fumagalli S, Thomas G, Kozma SC. Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase. EMBO J. 1998;17(22):6649-59.
-
(1998)
EMBO J.
, vol.17
, Issue.22
, pp. 6649-6659
-
-
Shima, H.1
Pende, M.2
Chen, Y.3
Fumagalli, S.4
Thomas, G.5
Kozma, S.C.6
-
46
-
-
0032843917
-
Drosophila S6 kinase: A regulator of cell size
-
Montagne J, Stewart MJ, Stocker H, Hafen E, Kozma SC, Thomas G. Drosophila S6 kinase: a regulator of cell size. Science. 1999:2126-9.
-
(1999)
Science.
, pp. 2126-2129
-
-
Montagne, J.1
Stewart, M.J.2
Stocker, H.3
Hafen, E.4
Kozma, S.C.5
Thomas, G.6
-
47
-
-
0028197298
-
Dominant negative mutants of mammalian translation initiation factor eIF-4A define a critical role for eIF-4F in cap-dependent and cap-independent initiation of translation
-
Pause A, Methot N, Svitkin Y, Merrick WC, Sonenberg N. Dominant negative mutants of mammalian translation initiation factor eIF-4A define a critical role for eIF-4F in cap-dependent and cap-independent initiation of translation. EMBO J. 1994;13(5):1205-15.
-
(1994)
EMBO J.
, vol.13
, Issue.5
, pp. 1205-1215
-
-
Pause, A.1
Methot, N.2
Svitkin, Y.3
Merrick, W.C.4
Sonenberg, N.5
-
48
-
-
0037097863
-
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
-
Fingar DC, Salama S, Tsou C, Harlow E, Blenis J. Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev. 2002;16(12):1472-87.
-
(2002)
Genes Dev.
, vol.16
, Issue.12
, pp. 1472-1487
-
-
Fingar, D.C.1
Salama, S.2
Tsou, C.3
Harlow, E.4
Blenis, J.5
-
49
-
-
0026583874
-
The mRNA 5' cap-binding protein, eIF-4E, cooperates with v-myc or E1A in the transformation of primary rodent fibroblasts
-
Lazaris-Karatzas A, Sonenberg N. The mRNA 5' cap-binding protein, eIF-4E, cooperates with v-myc or E1A in the transformation of primary rodent fibroblasts. Mol Cell Biol. 1992;12(3):1234-8.
-
(1992)
Mol Cell Biol.
, vol.12
, Issue.3
, pp. 1234-1238
-
-
Lazaris-Karatzas, A.1
Sonenberg, N.2
-
50
-
-
0034976004
-
The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila
-
Miron M, Verdu J, Lachance PE, Birnbaum MJ, Lasko PF, Sonenberg N. The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila. Nat Cell Biol. 2001:596-601.
-
(2001)
Nat Cell Biol.
, pp. 596-601
-
-
Miron, M.1
Verdu, J.2
Lachance, P.E.3
Birnbaum, M.J.4
Lasko, P.F.5
Sonenberg, N.6
-
51
-
-
33645638812
-
Glucose-stimulated DNA synthesis through mammalian target of rapamycin (mTOR) is regulated by KATP channels: Effects on cell cycle progression in rodent islets
-
Kwon G, Marshall CA, Liu H, Pappan KL, Remedi MS, Mc-Daniel ML. Glucose-stimulated DNA synthesis through mammalian target of rapamycin (mTOR) is regulated by KATP channels: effects on cell cycle progression in rodent islets. J Biol Chem. 2006:3261-7.
-
(2006)
J Biol Chem.
, pp. 3261-3267
-
-
Kwon, G.1
Marshall, C.A.2
Liu, H.3
Pappan, K.L.4
Remedi, M.S.5
Mc-Daniel, M.L.6
-
52
-
-
34249850161
-
The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells
-
Gleason CE, Lu D, Witters LA, Newgard CB, Birnbaum MJ. The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells. J Biol Chem. 2007:10341-51.
-
(2007)
J Biol Chem.
, pp. 10341-10351
-
-
Gleason, C.E.1
Lu, D.2
Witters, L.A.3
Newgard, C.B.4
Birnbaum, M.J.5
-
53
-
-
24944464482
-
Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis
-
Ruvinsky I, Sharon N, Lerer T, Cohen H, Stolovich-Rain M, Nir T, et al. Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis. Genes Dev. 2005:2199-211.
-
(2005)
Genes Dev.
, pp. 2199-2211
-
-
Ruvinsky, I.1
Sharon, N.2
Lerer, T.3
Cohen, H.4
Stolovich-Rain, M.5
Nir, T.6
-
54
-
-
48249146208
-
Disruption of Tsc2 in pancreatic beta cells induces beta cell mass expansion and improved glucose tolerance in a TORC1-dependent manner
-
Rachdi L, Balcazar N, Osorio-Duque F, Elghazi L, Weiss A, Gould A, et al. Disruption of Tsc2 in pancreatic beta cells induces beta cell mass expansion and improved glucose tolerance in a TORC1-dependent manner. Proc Natl Acad Sci. 2008:9250-5.
-
(2008)
Proc Natl Acad Sci.
, pp. 9250-9255
-
-
Rachdi, L.1
Balcazar, N.2
Osorio-Duque, F.3
Elghazi, L.4
Weiss, A.5
Gould, A.6
-
55
-
-
33947180978
-
Generation of a conditional disruption of the Tsc2 gene
-
Hernandez O, Way S, McKenna J, 3rd, Gambello MJ. Generation of a conditional disruption of the Tsc2 gene. Genesis. 2007;45(2):101-6.
-
(2007)
Genesis.
, vol.45
, Issue.2
, pp. 101-106
-
-
Hernandez, O.1
Way, S.2
McKenna, I.I.J.3
Gambello, M.J.4
-
56
-
-
70350449081
-
Critical roles for the TSC-mTOR pathway in betacell function
-
Mori H, Inoki K, Opland D, Munzberg H, Villanueva EC, Faouzi M, et al. Critical roles for the TSC-mTOR pathway in betacell function. Am J Physiol Endocrinol Metab. 2009:E1013-22.
-
(2009)
Am J Physiol Endocrinol Metab.
-
-
Mori, H.1
Inoki, K.2
Opland, D.3
Munzberg, H.4
Villanueva, E.C.5
Faouzi, M.6
-
57
-
-
65549130128
-
mTORC1 activation regulates beta-cell mass and proliferation by modulation of cyclin D2 synthesis and stability
-
Balcazar N, Sathyamurthy A, Elghazi L, Gould A, Weiss A, Shiojima I, et al. mTORC1 activation regulates beta-cell mass and proliferation by modulation of cyclin D2 synthesis and stability. J Biol Chem. 2009:7832-42.
-
(2009)
J Biol Chem.
, pp. 7832-7842
-
-
Balcazar, N.1
Sathyamurthy, A.2
Elghazi, L.3
Gould, A.4
Weiss, A.5
Shiojima, I.6
-
58
-
-
42449104351
-
mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes
-
Fraenkel M, Ketzinel-Gilad M, Ariav Y, Pappo O, Karaca M, Castel J, et al. mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes. Diabetes. 2008:945-57.
-
(2008)
Diabetes.
, pp. 945-957
-
-
Fraenkel, M.1
Ketzinel-Gilad, M.2
Ariav, Y.3
Pappo, O.4
Karaca, M.5
Castel, J.6
-
59
-
-
33750583959
-
Sirolimus is associated with reduced islet engraftment and impaired beta-cell function
-
Zhang N, Su D, Qu S, Tse T, Bottino R, Balamurugan AN, et al. Sirolimus is associated with reduced islet engraftment and impaired beta-cell function. Diabetes. 2006:2429-36.
-
(2006)
Diabetes.
, pp. 2429-2436
-
-
Zhang, N.1
Su, D.2
Qu, S.3
Tse, T.4
Bottino, R.5
Balamurugan, A.N.6
-
60
-
-
77957579650
-
Decreased IRS signaling impairs beta-cell cycle progression and survival in transgenic mice overexpressing S6K in beta-cells
-
Elghazi L, Balcazar N, Blandino-Rosano M, Cras-Meneur C, Fatrai S, Gould AP, et al. Decreased IRS signaling impairs beta-cell cycle progression and survival in transgenic mice overexpressing S6K in beta-cells. Diabetes. 2010:2390-9.
-
(2010)
Diabetes.
, pp. 2390-2399
-
-
Elghazi, L.1
Balcazar, N.2
Blandino-Rosano, M.3
Cras-Meneur, C.4
Fatrai, S.5
Gould, A.P.6
|