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Volumn 7, Issue 7, 2016, Pages

Therapeutic targeting of telomerase

Author keywords

Aging; Atherosclerosis; Cancer; Gene therapy; Immunotherapy; Personalized medicine; Regenerative medicine; Senescence; Telomerase; Telomeres

Indexed keywords

ANTINEOPLASTIC AGENT; OLIGONUCLEOTIDE INHIBITOR DERIVATIVE; PLANT MEDICINAL PRODUCT; SMALL MOLECULE TELOMERASE INHIBITOR DERIVATIVE; TELOMERASE; UNCLASSIFIED DRUG;

EID: 84979300215     PISSN: None     EISSN: 20734425     Source Type: Journal    
DOI: 10.3390/genes7070039     Document Type: Review
Times cited : (110)

References (257)
  • 1
    • 69849112228 scopus 로고    scopus 로고
    • Interrelationships among HDL metabolism, aging, and atherosclerosis
    • [CrossRef] [PubMed]
    • Walter, M. Interrelationships among HDL metabolism, aging, and atherosclerosis. Arterioscler Thromb. Vasc. Biol. 2009, 29, 1244-1250. [CrossRef] [PubMed]
    • (2009) Arterioscler Thromb. Vasc. Biol , vol.29 , pp. 1244-1250
    • Walter, M.1
  • 2
    • 84876912049 scopus 로고    scopus 로고
    • The roles of senescence and telomere shortening in cardiovascular disease
    • [CrossRef] [PubMed]
    • Fyhrquist, F, Saijonmaa, O, Strandberg, T. The roles of senescence and telomere shortening in cardiovascular disease. Nat. Rev. Cardiol. 2013, 10, 274-283. [CrossRef] [PubMed]
    • (2013) Nat. Rev. Cardiol , vol.10 , pp. 274-283
    • Fyhrquist, F.1    Saijonmaa, O.2    Strandberg, T.3
  • 3
    • 84971432531 scopus 로고    scopus 로고
    • What telomeres say about activity and health: A rapid review
    • [CrossRef] [PubMed]
    • To-Miles, F.Y.L, Backman, C.L. What telomeres say about activity and health: A rapid review. Can. J. Occup. Ther. 2016. [CrossRef] [PubMed]
    • (2016) Can. J. Occup. Ther
    • To-Miles, F.1    Backman, C.L.2
  • 4
    • 79951795555 scopus 로고    scopus 로고
    • Healthy aging and disease: Role for telomere biology?
    • [CrossRef] [PubMed]
    • Zhu, H, Blecher, M, van der Harst, P. Healthy aging and disease: Role for telomere biology? Clin. Sci. 2011, 120, 427-440. [CrossRef] [PubMed]
    • (2011) Clin. Sci , vol.120 , pp. 427-440
    • Zhu, H.1    Blecher, M.2    Van Der Harst, P.3
  • 5
    • 84864809893 scopus 로고    scopus 로고
    • Telomerase gene therapy: A novel approach to combat aging
    • [CrossRef] [PubMed]
    • Boccardi, V, Herbig, U. Telomerase gene therapy: A novel approach to combat aging. EMBO Mol. Med. 2012. [CrossRef] [PubMed]
    • (2012) EMBO Mol. Med
    • Boccardi, V.1    Herbig, U.2
  • 6
    • 58849150874 scopus 로고    scopus 로고
    • The telosome/shelterin complex and its functions
    • [CrossRef] [PubMed]
    • Xin, H, Liu, D, Songyang, Z. The telosome/shelterin complex and its functions. Genome Biol. 2008. [CrossRef] [PubMed]
    • (2008) Genome Biol
    • Xin, H.1    Liu, D.2    Songyang, Z.3
  • 7
    • 24944460598 scopus 로고    scopus 로고
    • Shelterin: The protein complex that shapes and safeguards human telomeres
    • [CrossRef] [PubMed]
    • De Lange, T. Shelterin: The protein complex that shapes and safeguards human telomeres. Genes Dev. 2005, 19, 2100-2110. [CrossRef] [PubMed]
    • (2005) Genes Dev , vol.19 , pp. 2100-2110
    • De Lange, T.1
  • 8
    • 74049111326 scopus 로고    scopus 로고
    • Telomeres and telomerase in cancer
    • [CrossRef] [PubMed]
    • Artandi, S.E, DePinho, R.A. Telomeres and telomerase in cancer. Carcinogenesis 2010, 31, 9-18. [CrossRef] [PubMed]
    • (2010) Carcinogenesis , vol.31 , pp. 9-18
    • Artandi, S.E.1    Depinho, R.A.2
  • 11
    • 84938086280 scopus 로고    scopus 로고
    • The short and long telomere syndromes: Paired paradigms for molecular medicine
    • [CrossRef] [PubMed]
    • Stanley, S.E, Armanios, M. The short and long telomere syndromes: Paired paradigms for molecular medicine. Curr. Opin. Gen. Dev. 2015, 33, 1-9. [CrossRef] [PubMed]
    • (2015) Curr. Opin. Gen. Dev , vol.33 , pp. 1-9
    • Stanley, S.E.1    Armanios, M.2
  • 13
    • 77954210220 scopus 로고    scopus 로고
    • An updated overview on Wnt signaling pathways: A prelude for more
    • [CrossRef] [PubMed]
    • Rao, T.P, Kuhl, M. An updated overview on Wnt signaling pathways: A prelude for more. Circ. Res. 2010, 106, 1798-1806. [CrossRef] [PubMed]
    • (2010) Circ. Res. , vol.106 , pp. 1798-1806
    • Rao, T.P.1    Kuhl, M.2
  • 14
    • 0036629255 scopus 로고    scopus 로고
    • Oxidative stress shortens telomeres
    • [CrossRef]
    • Von Zglinicki, T. Oxidative stress shortens telomeres. Trends Biochem. Sci. 2001, 27, 339-344. [CrossRef]
    • (2001) Trends Biochem. Sci , vol.27 , pp. 339-344
    • Von Zglinicki, T.1
  • 15
    • 84979274339 scopus 로고    scopus 로고
    • Telomerase therapy to reserve cardiovascular senescence
    • [CrossRef] [PubMed]
    • Nazari-Shafti, T.Z, Cooke, J.P. Telomerase therapy to reserve cardiovascular senescence. Methodist Debakey Cardiovasc. J. 2015, 11, 172-175. [CrossRef] [PubMed]
    • (2015) Methodist Debakey Cardiovasc. J , vol.11 , pp. 172-175
    • Nazari-Shafti, T.Z.1    Cooke, J.P.2
  • 16
    • 84945456411 scopus 로고    scopus 로고
    • Tissue formation and tissue engineering through host cell recruitment or a potential injectable cell-based biocomposite with replicative potential: Molecular mechanisms controlling cellular senescence and the involvement of controlled transient telomerase activation therapies
    • Babizhayev, M.A, Yegorov, Y.E. Tissue formation and tissue engineering through host cell recruitment or a potential injectable cell-based biocomposite with replicative potential: Molecular mechanisms controlling cellular senescence and the involvement of controlled transient telomerase activation therapies. J. Biomed. Mater. Res. Part A 2015, 103A, 3993-4023.
    • (2015) J. Biomed. Mater. Res. Part A , vol.103A , pp. 3993-4023
    • Babizhayev, M.A.1    Yegorov, Y.E.2
  • 17
    • 0034672243 scopus 로고    scopus 로고
    • Interferon α down-regulates telomerase reverse transcriptase and telomerase activity in human malignant and nonmalignant hematopoietic cells
    • [PubMed]
    • Xu, D, Erickson, S, Szeps, M, Gruber, A, Sangfelt, O, Einhorn, S, Pisa, P, Grandér, D. Interferon α down-regulates telomerase reverse transcriptase and telomerase activity in human malignant and nonmalignant hematopoietic cells. Blood 2000, 96, 4313-4318. [PubMed]
    • (2000) Blood , vol.96 , pp. 4313-4318
    • Xu, D.1    Erickson, S.2    Szeps, M.3    Gruber, A.4    Sangfelt, O.5    Einhorn, S.6    Pisa, P.7    Grandér, D.8
  • 18
    • 32544457689 scopus 로고    scopus 로고
    • Menopause modifies the association of leukocyte telomere length with insulin resistance and inflammation
    • [CrossRef] [PubMed]
    • Aviv, A, Valdes, A, Gardner, J.P, Swaminathan, R, Kimura, M, Spector, T.D. Menopause modifies the association of leukocyte telomere length with insulin resistance and inflammation. J. Clin. Endocrinol. Metab. 2006, 91, 635-640. [CrossRef] [PubMed]
    • (2006) J. Clin. Endocrinol. Metab , vol.91 , pp. 635-640
    • Aviv, A.1    Valdes, A.2    Gardner, J.P.3    Swaminathan, R.4    Kimura, M.5    Spector, T.D.6
  • 20
    • 84951776090 scopus 로고    scopus 로고
    • Telomerase activity and its association with psychological stress, mental disorders, lifestyle factors and interventions: A systematic review
    • [CrossRef] [PubMed]
    • Deng, W, Cheung, S.T, Tsao, S.W, Wang, X.M, Tiwari, A.F. Telomerase activity and its association with psychological stress, mental disorders, lifestyle factors and interventions: A systematic review. Psychoneuroendocrinology 2016, 64, 150-163. [CrossRef] [PubMed]
    • (2016) Psychoneuroendocrinology , vol.64 , pp. 150-163
    • Deng, W.1    Cheung, S.T.2    Tsao, S.W.3    Wang, X.M.4    Tiwari, A.F.5
  • 21
    • 84952683678 scopus 로고    scopus 로고
    • Systematic review of the association between chronic social stress and telomere length: A life course perspective
    • [CrossRef] [PubMed]
    • Oliveira, B.S, Zunzunegui, M.V, Quinlan, J, Fahmi, H, Tu, M.T, Guerra, R.O. Systematic review of the association between chronic social stress and telomere length: A life course perspective. Ageing Res. Rev. 2016, 26, 37-52. [CrossRef] [PubMed]
    • (2016) Ageing Res. Rev , vol.26 , pp. 37-52
    • Oliveira, B.S.1    Zunzunegui, M.V.2    Quinlan, J.3    Fahmi, H.4    Tu, M.T.5    Guerra, R.O.6
  • 24
    • 11144268164 scopus 로고    scopus 로고
    • Significant Role for p16INK4a in p53-Independent Telomere-Directed Senescence
    • [CrossRef] [PubMed]
    • Jacobs, J.J.L, de Lange, T. Significant Role for p16INK4a in p53-Independent Telomere-Directed Senescence. Curr. Biol. 2004, 14, 2302-2308. [CrossRef] [PubMed]
    • (2004) Curr. Biol , vol.14 , pp. 2302-2308
    • Jacobs, J.1    De Lange, T.2
  • 25
    • 84890602703 scopus 로고    scopus 로고
    • Loss of Telomere Protection: Consequences and Opportunities
    • [CrossRef] [PubMed]
    • Jacobs, J.J.L. Loss of Telomere Protection: Consequences and Opportunities. Front. Oncol. 2013. [CrossRef] [PubMed]
    • (2013) Front. Oncol
    • Jacobs, J.J.L.1
  • 26
    • 0037224923 scopus 로고    scopus 로고
    • Telomere-based crisis: Functional differences between telomerase activation and ALT in tumor progression
    • [CrossRef] [PubMed]
    • Chang, S, Khoo, C.M, Naylor, M.L, Maser, R.S, DePinho, R.A. Telomere-based crisis: Functional differences between telomerase activation and ALT in tumor progression. Genes Dev. 2003, 17, 88-100. [CrossRef] [PubMed]
    • (2003) Genes Dev , vol.17 , pp. 88-100
    • Chang, S.1    Khoo, C.M.2    Naylor, M.L.3    Maser, R.S.4    Depinho, R.A.5
  • 27
    • 84863116250 scopus 로고    scopus 로고
    • Antitelomerase Therapy Provokes ALT and Mitochondrial Adaptive Mechanisms in Cancer
    • [CrossRef] [PubMed]
    • Hu, J, Hwang, S.S, Liesa, M, Gan, B, Sahin, E, Jaskelioff, M, Ding, Z, Ying, H, Boutin, A.T, Zhang, H, et al. Antitelomerase Therapy Provokes ALT and Mitochondrial Adaptive Mechanisms in Cancer. Cell 2012, 148, 651-663. [CrossRef] [PubMed]
    • (2012) Cell , vol.148 , pp. 651-663
    • Hu, J.1    Hwang, S.S.2    Liesa, M.3    Gan, B.4    Sahin, E.5    Jaskelioff, M.6    Ding, Z.7    Ying, H.8    Boutin, A.T.9    Zhang, H.10
  • 28
    • 84927633829 scopus 로고    scopus 로고
    • Assembly of telomeric chromatin to create ALTernative endings
    • [CrossRef] [PubMed]
    • O’Sullivan, R, Almouzni, G. Assembly of telomeric chromatin to create ALTernative endings. Trends Cell Biol. 2014, 24, 675-685. [CrossRef] [PubMed]
    • (2014) Trends Cell Biol , vol.24 , pp. 675-685
    • O’Sullivan, R.1    Almouzni, G.2
  • 32
    • 84954565622 scopus 로고    scopus 로고
    • Telomere biology: Rationale for diagnostics and therapeutics in cancer
    • Rousseau, P, Autexier, C. Telomere biology: Rationale for diagnostics and therapeutics in cancer. RNA Biol. 2016, 12, 1078-1082.
    • (2016) RNA Biol , vol.12 , pp. 1078-1082
    • Rousseau, P.1    Autexier, C.2
  • 33
    • 84950976296 scopus 로고    scopus 로고
    • New surprises from an old favourite: The emergence of telomerase as a key player in the regulation of cancer stemness
    • [CrossRef] [PubMed]
    • Teralı, K, Yilmazer, A. New surprises from an old favourite: The emergence of telomerase as a key player in the regulation of cancer stemness. Biochimie 2016, 121, 170-178. [CrossRef] [PubMed]
    • (2016) Biochimie , vol.121 , pp. 170-178
    • Teralı, K.1    Yilmazer, A.2
  • 34
    • 0030892905 scopus 로고    scopus 로고
    • Amplification, increased dosage and in situ expression of the telomerase RNA gene in human cancer
    • [CrossRef] [PubMed]
    • Soder, A.I, Hoare, S.F, Muir, S, Going, J.J, Parkinson, E.K, Keith, W.N. Amplification, increased dosage and in situ expression of the telomerase RNA gene in human cancer. Oncogene 1997, 14, 1013-1021. [CrossRef] [PubMed]
    • (1997) Oncogene , vol.14 , pp. 1013-1021
    • Soder, A.I.1    Hoare, S.F.2    Muir, S.3    Going, J.J.4    Parkinson, E.K.5    Keith, W.N.6
  • 35
    • 33846703426 scopus 로고    scopus 로고
    • Hallmarks of telomeres in ageing research
    • [CrossRef] [PubMed]
    • Shay, J.W, Wright, W.E. Hallmarks of telomeres in ageing research. J. Pathol. 2007, 211, 114-123. [CrossRef] [PubMed]
    • (2007) J. Pathol. , vol.211 , pp. 114-123
    • Shay, J.W.1    Wright, W.E.2
  • 36
    • 77950265945 scopus 로고    scopus 로고
    • Linking functional decline of telomeres, mitochondria and stem cells during ageing
    • [CrossRef] [PubMed]
    • Sahin, E, Depinho, R.A. Linking functional decline of telomeres, mitochondria and stem cells during ageing. Nature 2010, 464, 520-528. [CrossRef] [PubMed]
    • (2010) Nature , vol.464 , pp. 520-528
    • Sahin, E.1    Depinho, R.A.2
  • 37
    • 32244447211 scopus 로고    scopus 로고
    • Use of telomerase to create bioengineered tissues
    • [CrossRef] [PubMed]
    • Shay, J.W, Wright, W.E. Use of telomerase to create bioengineered tissues. Ann. N. Y. Acad. Sci. 2005, 1057, 479-491. [CrossRef] [PubMed]
    • (2005) Ann. N. Y. Acad. Sci , vol.1057 , pp. 479-491
    • Shay, J.W.1    Wright, W.E.2
  • 39
    • 0037071386 scopus 로고    scopus 로고
    • Replicative senescence of hematiopoietic stem cells during serial transplantation: Does telomere shortening play a role?
    • [CrossRef] [PubMed]
    • Allsopp, R.C, Weissman, I.L. Replicative senescence of hematiopoietic stem cells during serial transplantation: Does telomere shortening play a role? Oncogene 2002, 21, 3270-3273. [CrossRef] [PubMed]
    • (2002) Oncogene , vol.21 , pp. 3270-3273
    • Allsopp, R.C.1    Weissman, I.L.2
  • 41
    • 24744436980 scopus 로고    scopus 로고
    • Lack of telomerase gene expression in alternative lengthening of telomere cells is associated with chromatin remodeling of the hTR and hTERT gene promoters
    • [PubMed]
    • Atkinson, S.P, Hoare, S.F, Glasspool, R.M, Keith, W.N. Lack of telomerase gene expression in alternative lengthening of telomere cells is associated with chromatin remodeling of the hTR and hTERT gene promoters. Cancer Res. 2005, 65, 7585-7590. [PubMed]
    • (2005) Cancer Res. , vol.65 , pp. 7585-7590
    • Atkinson, S.P.1    Hoare, S.F.2    Glasspool, R.M.3    Keith, W.N.4
  • 42
    • 33749018683 scopus 로고    scopus 로고
    • Telomerase promoter reprogramming and interaction with general transcription factors in the human mesenchymal stem cell
    • Serenicki, N, Hoare, S.F, Kassem, M, Atkinson, S.P, Keith, W.N. Telomerase promoter reprogramming and interaction with general transcription factors in the human mesenchymal stem cell. Regen. Med. 2006, 1, 125-131.
    • (2006) Regen. Med , vol.1 , pp. 125-131
    • Serenicki, N.1    Hoare, S.F.2    Kassem, M.3    Atkinson, S.P.4    Keith, W.N.5
  • 44
    • 0035871710 scopus 로고    scopus 로고
    • Cutting edge: Telomerase activation in human T lymphocytes does not require increase in telomerase reverse transcriptase (hTERT) protein but is associated with hTERT phosphorylation and nuclear translocation
    • [CrossRef] [PubMed]
    • Liu, K, Hodes, R.J, Weng, N. Cutting edge: Telomerase activation in human T lymphocytes does not require increase in telomerase reverse transcriptase (hTERT) protein but is associated with hTERT phosphorylation and nuclear translocation. J. Immunol. 2001, 166, 4826-4830. [CrossRef] [PubMed]
    • (2001) J. Immunol , vol.166 , pp. 4826-4830
    • Liu, K.1    Hodes, R.J.2    Weng, N.3
  • 45
    • 36749079827 scopus 로고    scopus 로고
    • Pharmacological intervention strategies for affecting telomerase activity: Future prospects to treat cancer and degenerative disease
    • [CrossRef] [PubMed]
    • Tarkanyi, I, Aradi, J. Pharmacological intervention strategies for affecting telomerase activity: Future prospects to treat cancer and degenerative disease. Biochemie 2008, 90, 156-172. [CrossRef] [PubMed]
    • (2008) Biochemie , vol.90 , pp. 156-172
    • Tarkanyi, I.1    Aradi, J.2
  • 46
    • 2342426512 scopus 로고    scopus 로고
    • Multiple levels of telomerase regulation
    • [CrossRef] [PubMed]
    • Stewart, S.A. Multiple levels of telomerase regulation. Mol. Interv. 2002, 2, 481-483. [CrossRef] [PubMed]
    • (2002) Mol. Interv , vol.2 , pp. 481-483
    • Stewart, S.A.1
  • 49
    • 0032485416 scopus 로고    scopus 로고
    • Telomerase activity is restored in human cells by ectopic expression of hTERT (HEST2), the catalytic subunit of telomerase
    • [CrossRef] [PubMed]
    • Counter, C.M, Meyerson, M, Eaton, E.N, Ellisen, L.W, Caddle, S.D, Haber, D.A, Weinberg, R.A. Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase. Oncogene 1998, 16, 1217-1222. [CrossRef] [PubMed]
    • (1998) Oncogene , vol.16 , pp. 1217-1222
    • Counter, C.M.1    Meyerson, M.2    Eaton, E.N.3    Ellisen, L.W.4    Caddle, S.D.5    Haber, D.A.6    Weinberg, R.A.7
  • 50
    • 0032567967 scopus 로고    scopus 로고
    • Benchimol, S. Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span
    • [CrossRef]
    • Vaziri, H, Benchimol, S. Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr. Biol. 1998, 8, 279-282. [CrossRef]
    • (1998) Curr. Biol , vol.8 , pp. 279-282
    • Vaziri, H.1
  • 51
    • 0032923742 scopus 로고    scopus 로고
    • Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype
    • [CrossRef] [PubMed]
    • Jiang, X.R, Jimenez, G, Chang, E, Frolkis, M, Kusler, B, Sage, M, Beeche, M, Bodnar, A.G, Wahl, G.M, Tlsty, T.D, et al. Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype. Nat. Genet. 1999, 21, 111-114. [CrossRef] [PubMed]
    • (1999) Nat. Genet , vol.21 , pp. 111-114
    • Jiang, X.R.1    Jimenez, G.2    Chang, E.3    Frolkis, M.4    Kusler, B.5    Sage, M.6    Beeche, M.7    Bodnar, A.G.8    Wahl, G.M.9    Tlsty, T.D.10
  • 53
    • 0034255633 scopus 로고    scopus 로고
    • Telomerase expression restores dermal integrity to in vitro-aged fibroblasts in a reconstituted skin model
    • [CrossRef] [PubMed]
    • Funk, W.D, Wang, C.K, Shelton, D.N, Harley, C.B, Pagon, G.D, Hoeffler, W.K. Telomerase expression restores dermal integrity to in vitro-aged fibroblasts in a reconstituted skin model. Exp. Cell Res. 2000, 258, 270-278. [CrossRef] [PubMed]
    • (2000) Exp. Cell Res , vol.258 , pp. 270-278
    • Funk, W.D.1    Wang, C.K.2    Shelton, D.N.3    Harley, C.B.4    Pagon, G.D.5    Hoeffler, W.K.6
  • 55
    • 56449100020 scopus 로고    scopus 로고
    • Cleavage of MCM2 licensing protein fosters senescence in human keratinocytes
    • [CrossRef] [PubMed]
    • Harada, H, Nakagawa, H, Takaoka, M, Lee, J, Herlyn, M, Diehl, J.A, Rustgi, A.K. Cleavage of MCM2 licensing protein fosters senescence in human keratinocytes. Cell Cycle 2008, 7, 3534-3538. [CrossRef] [PubMed]
    • (2008) Cell Cycle , vol.7 , pp. 3534-3538
    • Harada, H.1    Nakagawa, H.2    Takaoka, M.3    Lee, J.4    Herlyn, M.5    Diehl, J.A.6    Rustgi, A.K.7
  • 57
    • 0035964313 scopus 로고    scopus 로고
    • Telomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survival
    • [CrossRef] [PubMed]
    • Oh, H, Taffet, G.E, Youker, K.A, Entman, M.L, Overbeek, P.A, Michael, L.H, Schneider, M.D. Telomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survival. Proc. Natl. Acad. Sci. USA 2001, 98, 10308-10313. [CrossRef] [PubMed]
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 10308-10313
    • Oh, H.1    Taffet, G.E.2    Youker, K.A.3    Entman, M.L.4    Overbeek, P.A.5    Michael, L.H.6    Schneider, M.D.7
  • 58
    • 0142105972 scopus 로고    scopus 로고
    • Telomerase alone extends the replicative life span of human skeletal muscle cells without compromising genomic stability
    • [CrossRef] [PubMed]
    • Wootton, M, Steeghs, K, Watt, D, Munro, J, Gordon, K, Ireland, H, Morrison, V, Behan, W, Parkinson, E.K. Telomerase alone extends the replicative life span of human skeletal muscle cells without compromising genomic stability. Hum. Gene Ther. 2003, 14, 1473-1487. [CrossRef] [PubMed]
    • (2003) Hum. Gene Ther , vol.14 , pp. 1473-1487
    • Wootton, M.1    Steeghs, K.2    Watt, D.3    Munro, J.4    Gordon, K.5    Ireland, H.6    Morrison, V.7    Behan, W.8    Parkinson, E.K.9
  • 60
    • 0038576704 scopus 로고    scopus 로고
    • And retinal vascular endothelial cells with extended life span established by ectopic expression of telomerase
    • [CrossRef] [PubMed]
    • Gu, X, Zhang, J, Brann, D.W, Yu, F.S. Brain and retinal vascular endothelial cells with extended life span established by ectopic expression of telomerase. Invest. Ophthalmol. Vis. Sci. 2003, 44, 3219-3225. [CrossRef] [PubMed]
    • (2003) Invest. Ophthalmol. Vis. Sci , vol.44 , pp. 3219-3225
    • Gu, X.1    Zhang, J.2    Brann, D.W.3    Yu, B.4
  • 63
    • 0035984715 scopus 로고    scopus 로고
    • Bone formation by human postnatal bone marrow stromal stem cells is enhanced by telomerase expression
    • [CrossRef] [PubMed]
    • Shi, S, Gronthos, S, Chen, S, Reddi, A, Counter, C.M, Robey, P.G, Wang, C.Y. Bone formation by human postnatal bone marrow stromal stem cells is enhanced by telomerase expression. Nat. Biotechnol. 2002, 20, 587-591. [CrossRef] [PubMed]
    • (2002) Nat. Biotechnol , vol.20 , pp. 587-591
    • Shi, S.1    Gronthos, S.2    Chen, S.3    Reddi, A.4    Counter, C.M.5    Robey, P.G.6    Wang, C.Y.7
  • 64
    • 0035984714 scopus 로고    scopus 로고
    • Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells
    • [CrossRef] [PubMed]
    • Simonsen, J.L, Rosada, C, Serakinci, N, Justesen, J, Stenderup, K, Rattan, S.I, Jensen, T.G, Kassem, M. Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells. Nat. Biotechnol. 2002, 20, 592-596. [CrossRef] [PubMed]
    • (2002) Nat. Biotechnol , vol.20 , pp. 592-596
    • Simonsen, J.L.1    Rosada, C.2    Serakinci, N.3    Justesen, J.4    Stenderup, K.5    Rattan, S.I.6    Jensen, T.G.7    Kassem, M.8
  • 65
    • 0038424780 scopus 로고    scopus 로고
    • Telomerase accelerates osteogenesis of bone marrow stromal stem cells by upregulation of CBFA1, osterix, and osteocalcin
    • [CrossRef] [PubMed]
    • Gronthos, S, Chen, S, Wang, C.Y, Robey, P.G, Shi, S. Telomerase accelerates osteogenesis of bone marrow stromal stem cells by upregulation of CBFA1, osterix, and osteocalcin. J. Bone Miner Res. 2003, 18, 716-722. [CrossRef] [PubMed]
    • (2003) J. Bone Miner Res , vol.18 , pp. 716-722
    • Gronthos, S.1    Chen, S.2    Wang, C.Y.3    Robey, P.G.4    Shi, S.5
  • 66
    • 0037438385 scopus 로고    scopus 로고
    • Ex vivo expansion of human umbilical cord hematopoietic progenitor cells using a coculture system with human telomerase catalytic subunit (HTERT)-transfected human stromal cells
    • [CrossRef] [PubMed]
    • Kawano, Y, Kobune, M, Yamaguchi, M, Nakamura, K, Ito, Y, Sasaki, K, Takahashi, S, Nakamura, T, Chiba, H, Sato, T, et al. Ex vivo expansion of human umbilical cord hematopoietic progenitor cells using a coculture system with human telomerase catalytic subunit (hTERT)-transfected human stromal cells. Blood 2003, 101, 532-540. [CrossRef] [PubMed]
    • (2003) Blood , vol.101 , pp. 532-540
    • Kawano, Y.1    Kobune, M.2    Yamaguchi, M.3    Nakamura, K.4    Ito, Y.5    Sasaki, K.6    Takahashi, S.7    Nakamura, T.8    Chiba, H.9    Sato, T.10
  • 68
    • 0034925471 scopus 로고    scopus 로고
    • Kimura, T. Reconstituting telomerase activity using the telomerase catalytic subunit prevents the telomere shorting and replicative senescence in human osteoblasts
    • [CrossRef] [PubMed]
    • Yudoh, K, Matsuno, H, Nakazawa, F, Katayama, R, Kimura, T. Reconstituting telomerase activity using the telomerase catalytic subunit prevents the telomere shorting and replicative senescence in human osteoblasts. J. Bone Miner Res. 2001, 16, 1453-1464. [CrossRef] [PubMed]
    • (2001) J. Bone Miner Res , vol.16 , pp. 1453-1464
    • Yudoh, K.1    Matsuno, H.2    Nakazawa, F.3    Katayama, R.4
  • 69
    • 2942718540 scopus 로고    scopus 로고
    • Telomerized presenescent osteoblasts prevent bone mass loss in vivo
    • [CrossRef] [PubMed]
    • Yudoh, K, Nishioka, K. Telomerized presenescent osteoblasts prevent bone mass loss in vivo. Gene Ther. 2004, 11, 909-915. [CrossRef] [PubMed]
    • (2004) Gene Ther , vol.11 , pp. 909-915
    • Yudoh, K.1    Nishioka, K.2
  • 70
    • 0037205438 scopus 로고    scopus 로고
    • Odontoblast cells immortalized by telomerase produce mineralized dentin-like tissue both in vitro and in vivo
    • [CrossRef] [PubMed]
    • Hao, J, Narayanan, K, Ramachandran, A, He, G, Almushayt, A, Evans, C, George, A. Odontoblast cells immortalized by telomerase produce mineralized dentin-like tissue both in vitro and in vivo. J. Biol. Chem. 2002, 277, 19976-19981. [CrossRef] [PubMed]
    • (2002) J. Biol. Chem. , vol.277 , pp. 19976-19981
    • Hao, J.1    Narayanan, K.2    Ramachandran, A.3    He, G.4    Almushayt, A.5    Evans, C.6    George, A.7
  • 71
    • 0038819110 scopus 로고    scopus 로고
    • Ectopic hTERT expression extends the life span of human CD4 helper and regulatory T-cell clones and confers resistance to oxidative stress-induced apoptosis
    • [CrossRef] [PubMed]
    • Luiten, R.M, Pene, J, Yssel, H, Spits, H. Ectopic hTERT expression extends the life span of human CD4 helper and regulatory T-cell clones and confers resistance to oxidative stress-induced apoptosis. Blood 2003, 101, 4512-4519. [CrossRef] [PubMed]
    • (2003) Blood , vol.101 , pp. 4512-4519
    • Luiten, R.M.1    Pene, J.2    Yssel, H.3    Spits, H.4
  • 72
    • 0041666341 scopus 로고    scopus 로고
    • Telomerized human multipotent mesenchymal cells can differentiate into hematopoietic and cobblestone area-supporting cells
    • [CrossRef]
    • Kobune, M, Kawano, Y, Ito, Y, Chiba, H, Nakamura, K, Tsuda, H, Sasaki, K, Dehari, H, Uchida, H, Honmou, O. Telomerized human multipotent mesenchymal cells can differentiate into hematopoietic and cobblestone area-supporting cells. Exp. Hematol. 2003, 31, 715-722. [CrossRef]
    • (2003) Exp. Hematol , vol.31 , pp. 715-722
    • Kobune, M.1    Kawano, Y.2    Ito, Y.3    Chiba, H.4    Nakamura, K.5    Tsuda, H.6    Sasaki, K.7    Dehari, H.8    Uchida, H.9    Honmou, O.10
  • 74
    • 0036130252 scopus 로고    scopus 로고
    • Immortal activated human hepatic stellate cells generated by ectopic telomerase expression
    • [CrossRef] [PubMed]
    • Schnabl, B, Choi, Y.H, Olsen, J.C, Hagedorn, C.H, Brenner, D.A. Immortal activated human hepatic stellate cells generated by ectopic telomerase expression. Lab. Invest. 2002, 82, 323-333. [CrossRef] [PubMed]
    • (2002) Lab. Invest , vol.82 , pp. 323-333
    • Schnabl, B.1    Choi, Y.H.2    Olsen, J.C.3    Hagedorn, C.H.4    Brenner, D.A.5
  • 77
    • 84908587479 scopus 로고    scopus 로고
    • Bone marrow failure and the telomeropathies
    • [CrossRef] [PubMed]
    • Townsley, D.M, Dumitriu, B, Young, N.S. Bone marrow failure and the telomeropathies. Blood 2014, 124, 2775-2783. [CrossRef] [PubMed]
    • (2014) Blood , vol.124 , pp. 2775-2783
    • Townsley, D.M.1    Dumitriu, B.2    Young, N.S.3
  • 78
    • 0033986708 scopus 로고    scopus 로고
    • The use of telomerized cells for tissue engineering
    • [CrossRef] [PubMed]
    • Shay, J.W, Wright, W.E. The use of telomerized cells for tissue engineering. Nat. Biotechnol. 2000, 18, 22-23. [CrossRef] [PubMed]
    • (2000) Nat. Biotechnol. , vol.18 , pp. 22-23
    • Shay, J.W.1    Wright, W.E.2
  • 79
    • 4143133239 scopus 로고    scopus 로고
    • Telomere Maintenance in Clinical Medicine
    • [CrossRef] [PubMed]
    • Ulaner, G.A. Telomere Maintenance in Clinical Medicine. Am. J. Med. 2004, 117, 262-269. [CrossRef] [PubMed]
    • (2004) Am. J. Med , vol.117 , pp. 262-269
    • Ulaner, G.A.1
  • 80
    • 84982187297 scopus 로고    scopus 로고
    • Telomerase gene therapy rescues telomere length, bone marrow aplasia, and survival in mice with aplastic anemia
    • [CrossRef] [PubMed]
    • Bär, C, Povedano, J.M, Serrano, R, Benitez-Buelga, C, Popkes, M, Formentini, I, Bobadilla, M, Bosch, F, Blasco, M.A. Telomerase gene therapy rescues telomere length, bone marrow aplasia, and survival in mice with aplastic anemia. Blood 2016, 127, 1770-1779. [CrossRef] [PubMed]
    • (2016) Blood , vol.127 , pp. 1770-1779
    • Bär, C.1    Povedano, J.M.2    Serrano, R.3    Benitez-Buelga, C.4    Popkes, M.5    Formentini, I.6    Bobadilla, M.7    Bosch, F.8    Blasco, M.A.9
  • 81
    • 84961970570 scopus 로고    scopus 로고
    • Telomeres, NAFLD and Chronic Liver Disease
    • [CrossRef] [PubMed]
    • Donati, B, Valenti, L. Telomeres, NAFLD and Chronic Liver Disease. Int. J. Mol. Sci. 2016. [CrossRef] [PubMed]
    • (2016) Int. J. Mol. Sci
    • Donati, B.1    Valenti, L.2
  • 82
    • 84903834247 scopus 로고    scopus 로고
    • Telomeres in lung diseases
    • [PubMed]
    • Calado, R.T. Telomeres in lung diseases. Prog. Mol. Biol. Transl. Sci. 2014, 125, 173-183. [PubMed]
    • (2014) Prog. Mol. Biol. Transl. Sci , vol.125 , pp. 173-183
    • Calado, R.T.1
  • 83
    • 84864191875 scopus 로고    scopus 로고
    • Cell senescence: A challenge in cartilage engineering and regeneration
    • [CrossRef] [PubMed]
    • Li, J, Pei, M. Cell senescence: A challenge in cartilage engineering and regeneration. Tissue Eng. Part B Rev. 2012, 18, 270-287. [CrossRef] [PubMed]
    • (2012) Tissue Eng. Part B Rev , vol.18 , pp. 270-287
    • Li, J.1    Pei, M.2
  • 84
    • 77956642205 scopus 로고    scopus 로고
    • Telomere attrition in lens epithelial cells—A target for N-acetylcarnosine therapy. Front
    • [CrossRef]
    • Babizhayev, M.A, Yegorov, Y.E. Telomere attrition in lens epithelial cells—A target for N-acetylcarnosine therapy. Front. Biosci. 2010, 15, 934-956. [CrossRef]
    • (2010) Biosci , vol.15 , pp. 934-956
    • Babizhayev, M.A.1    Yegorov, Y.E.2
  • 85
    • 70349962909 scopus 로고    scopus 로고
    • Rejuvenating the immune system in rheumatoid arthritis
    • [CrossRef] [PubMed]
    • Weyand, C.M, Fujii, H, Shao, L, Goronzy, J.J. Rejuvenating the immune system in rheumatoid arthritis. Nat. Rev. Rheumatol. 2009, 5, 583-588. [CrossRef] [PubMed]
    • (2009) Nat. Rev. Rheumatol , vol.5 , pp. 583-588
    • Weyand, C.M.1    Fujii, H.2    Shao, L.3    Goronzy, J.J.4
  • 86
    • 0033989539 scopus 로고    scopus 로고
    • Formation of functional tissue from transplanted adrenocortical cells expressing telomerase reverse transcriptase
    • [PubMed]
    • Thomas, M, Yang, L, Hornsby, P.J. Formation of functional tissue from transplanted adrenocortical cells expressing telomerase reverse transcriptase. Nat. Biotechnol. 2000, 18, 39-42. [PubMed]
    • (2000) Nat. Biotechnol , vol.18 , pp. 39-42
    • Thomas, M.1    Yang, L.2    Hornsby, P.J.3
  • 88
    • 84864017351 scopus 로고    scopus 로고
    • Role of CD8 T Cell Replicative Senescence in Human Aging and in HIV-mediated Immunosenescence
    • [PubMed]
    • Dock, J.N, Effros, R.B. Role of CD8 T Cell Replicative Senescence in Human Aging and in HIV-mediated Immunosenescence. Aging Dis. 2011, 2, 382-397. [PubMed]
    • (2011) Aging Dis , vol.2 , pp. 382-397
    • Dock, J.N.1    Effros, R.B.2
  • 89
    • 78650973371 scopus 로고    scopus 로고
    • A natural product telomerase activator as part of a health maintenance program
    • [CrossRef] [PubMed]
    • Harley, C.B, Liu, W, Blasco, M, Vera, E, Andrews, W.H, Briggs, L.A, Raffaele, J.M. A natural product telomerase activator as part of a health maintenance program. Rejuven. Res. 2011, 14, 45-56. [CrossRef] [PubMed]
    • (2011) Rejuven. Res , vol.14 , pp. 45-56
    • Harley, C.B.1    Liu, W.2    Blasco, M.3    Vera, E.4    Rews, W.H.5    Briggs, L.A.6    Raffaele, J.M.7
  • 90
    • 79960322707 scopus 로고    scopus 로고
    • The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence
    • [CrossRef] [PubMed]
    • Bernardes de Jesus, B, Schneeberger, K, Vera, E, Tejera, A, Harley, C.B, Blasco, M.A. The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence. Aging Cell 2011, 10, 604-621. [CrossRef] [PubMed]
    • (2011) Aging Cell , vol.10 , pp. 604-621
    • Bernardes De Jesus, B.1    Schneeberger, K.2    Vera, E.3    Tejera, A.4    Harley, C.B.5    Blasco, M.A.6
  • 91
    • 84957110417 scopus 로고    scopus 로고
    • Evaluation of an oral telomerase activator for early age-related macular degeneration—A pilot study
    • [CrossRef] [PubMed]
    • Dow, C.T, Harley, C.B. Evaluation of an oral telomerase activator for early age-related macular degeneration—A pilot study. Clin. Ophthalmol. 2016, 10, 243-249. [CrossRef] [PubMed]
    • (2016) Clin. Ophthalmol , vol.10 , pp. 243-249
    • Dow, C.T.1    Harley, C.B.2
  • 92
    • 84886018077 scopus 로고    scopus 로고
    • Natural product telomerase activator as part of a health maintenance program: Metabolic and cardiovascular response
    • [CrossRef] [PubMed]
    • Harley, C.B, Liu, W, Flom, P.L, Raffaele, J.M. A natural product telomerase activator as part of a health maintenance program: Metabolic and cardiovascular response. Rejuven. Res. 2013, 16, 386-395. [CrossRef] [PubMed]
    • (2013) Rejuven. Res. , vol.16 , pp. 386-395
    • Harley, C.B.1    Liu, W.2    Flom, P.L.3    Raffaele, J.4
  • 93
    • 85007129468 scopus 로고    scopus 로고
    • A Natural Product Telomerase Activator Lengthens Telomeres in Humans: A Randomized, Double Blind, and Placebo Controlled Study
    • [CrossRef] [PubMed]
    • Salvador, L, Singaravelu, G, Harley, C.B, Flom, P, Suram, A, Raffaele, J.M. A Natural Product Telomerase Activator Lengthens Telomeres in Humans: A Randomized, Double Blind, and Placebo Controlled Study. Rejuven. Res. 2016. [CrossRef] [PubMed]
    • (2016) Rejuven. Res
    • Salvador, L.1    Singaravelu, G.2    Harley, C.B.3    Flom, P.4    Suram, A.5    Raffaele, J.M.6
  • 94
    • 42049085145 scopus 로고    scopus 로고
    • Immortalization of epithelial progenitor cells mediated by resveratrol
    • [CrossRef] [PubMed]
    • Pearce, V.P, Sherrell, J, Lou, Z, Kopelovich, L, Wright, W.E, Shay, J.W. Immortalization of epithelial progenitor cells mediated by resveratrol. Oncogene 2008, 27, 2365-2374. [CrossRef] [PubMed]
    • (2008) Oncogene , vol.27 , pp. 2365-2374
    • Pearce, V.P.1    Sherrell, J.2    Lou, Z.3    Kopelovich, L.4    Wright, W.E.5    Shay, J.W.6
  • 95
    • 52949093112 scopus 로고    scopus 로고
    • Resveratrol reduces endothelial progenitor cells senescence through augmentation of telomerase activity by vAkt-dependent mechanisms
    • [CrossRef] [PubMed]
    • Xia, L, Wang, X.X, Hu, X.S, Guo, X.G, Shang, Y.P, Chen, H.J, Zeng, C.L, Zhang, F.R, Chen, J.Z. Resveratrol reduces endothelial progenitor cells senescence through augmentation of telomerase activity by vAkt-dependent mechanisms. Br. J. Pharmacol. 2008, 155, 387-394. [CrossRef] [PubMed]
    • (2008) Br. J. Pharmacol , vol.155 , pp. 387-394
    • Xia, L.1    Wang, X.X.2    Hu, X.S.3    Guo, X.G.4    Shang, Y.P.5    Chen, H.J.6    Zeng, C.L.7    Zhang, F.R.8    Chen, J.Z.9
  • 96
    • 84855183935 scopus 로고    scopus 로고
    • Pharmaceutical regulation of telomerase and its clinical potential
    • [CrossRef] [PubMed]
    • Sprouse, A.A, Steding, C.E, Herbert, B.-S. Pharmaceutical regulation of telomerase and its clinical potential. J. Cell. Mol. Med. 2012, 16, 1-7. [CrossRef] [PubMed]
    • (2012) J. Cell. Mol. Med. , vol.16 , pp. 1-7
    • Sprouse, A.A.1    Steding, C.E.2    Herbert, B.-S.3
  • 97
    • 84859383206 scopus 로고    scopus 로고
    • Novel telomerase-increasing compound in mouse brain delays the onset of amyotrophic lateral sclerosis
    • [CrossRef] [PubMed]
    • Eitan, E, Tichon, A, Gazit, A, Gitler, D, Slavin, S, Priel, E. Novel telomerase-increasing compound in mouse brain delays the onset of amyotrophic lateral sclerosis. EMBO Mol. Med. 2012, 4, 313-329. [CrossRef] [PubMed]
    • (2012) EMBO Mol. Med , vol.4 , pp. 313-329
    • Eitan, E.1    Tichon, A.2    Gazit, A.3    Gitler, D.4    Slavin, S.5    Priel, E.6
  • 98
    • 84902353894 scopus 로고    scopus 로고
    • NGF and TERT co-transfected BMSCs improve the restoration of cognitive impairment in vascular dementia rats
    • [CrossRef] [PubMed]
    • Wang, F, Chang, G, Geng, X. NGF and TERT co-transfected BMSCs improve the restoration of cognitive impairment in vascular dementia rats. PLoS ONE 2014, 9, e98774. [CrossRef] [PubMed]
    • (2014) Plos ONE , vol.9
    • Wang, F.1    Chang, G.2    Geng, X.3
  • 99
    • 1842611977 scopus 로고    scopus 로고
    • Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells
    • [CrossRef] [PubMed]
    • Haendeler, J, Hoffman, J, Diehl, J.F, Vasa, M, Spyridopoulos, I, Zeiher, A.M, Dimmeler, S. Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells. Circ. Res. 2004, 94, 768-775. [CrossRef] [PubMed]
    • (2004) Circ. Res , vol.94 , pp. 768-775
    • Haendeler, J.1    Hoffman, J.2    Diehl, J.F.3    Vasa, M.4    Spyridopoulos, I.5    Zeiher, A.M.6    Dimmeler, S.7
  • 100
    • 35048863077 scopus 로고    scopus 로고
    • Age-dependent telomere-shortening is repressed by phosphorylated alpha-tocopherol together with cellular longevity and intracellular oxidative-stress reduction in human brain microvascular endotheliocytes
    • [CrossRef] [PubMed]
    • Tanaka, Y, Moritoh, Y, Miva, N. Age-dependent telomere-shortening is repressed by phosphorylated alpha-tocopherol together with cellular longevity and intracellular oxidative-stress reduction in human brain microvascular endotheliocytes. J. Cell Biochem. 2007, 102, 689-703. [CrossRef] [PubMed]
    • (2007) J. Cell Biochem. , vol.102 , pp. 689-703
    • Tanaka, Y.1    Moritoh, Y.2    Miva, N.3
  • 102
    • 33846049673 scopus 로고    scopus 로고
    • Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: A nested case-control study
    • [CrossRef]
    • Brouilette, S.W, Moore, J.S, McMahon, A.D, Thompson, J.R, Ford, I, Shepherd, J, Packard, C.J, Samani, N.J. Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: A nested case-control study. Lancet 2007, 369, 107-114. [CrossRef]
    • (2007) Lancet , vol.369 , pp. 107-114
    • Brouilette, S.W.1    Moore, J.S.2    McMahon, A.D.3    Thompson, J.R.4    Ford, I.5    Shepherd, J.6    Packard, C.J.7    Samani, N.J.8
  • 103
    • 8544236989 scopus 로고    scopus 로고
    • Statins enhance migratory capacity by upregulation of the telomere repeat binding factor TRF2 in endothelial progenitor cells
    • [CrossRef] [PubMed]
    • Spyridopoulos, I, Haendeler, J, Urbich, C, Brummendorf, T.H, Oh, H, Schneider, M.D, Zeiher, A.M, Dimmeler, S. Statins enhance migratory capacity by upregulation of the telomere repeat binding factor TRF2 in endothelial progenitor cells. Circulation 2004, 110, 3136-3142. [CrossRef] [PubMed]
    • (2004) Circulation , vol.110 , pp. 3136-3142
    • Spyridopoulos, I.1    Haendeler, J.2    Urbich, C.3    Brummendorf, T.H.4    Oh, H.5    Schneider, M.D.6    Zeiher, A.M.7    Dimmeler, S.8
  • 104
    • 33847218666 scopus 로고    scopus 로고
    • Ginkgo Biloba extract reduces endothelial progenitor-cell senescence trough augmentation of telomerase activity
    • [CrossRef] [PubMed]
    • Dong, X.X, Hui, Y.J, Xiang, W.X, Rong, Z.F, Jian, S, Zhu, C.J. Ginkgo Biloba extract reduces endothelial progenitor-cell senescence trough augmentation of telomerase activity. J. Cardiovasc. Pharmacol. 2007, 49, 111-115. [CrossRef] [PubMed]
    • (2007) J. Cardiovasc. Pharmacol. , vol.49 , pp. 111-115
    • Dong, X.X.1    Hui, Y.J.2    Xiang, W.X.3    Rong, Z.F.4    Jian, S.5    Zhu, C.J.6
  • 105
    • 33750592790 scopus 로고    scopus 로고
    • Recent advances on the significance of stem cells in tissue regeneration and cancer therapies
    • [CrossRef] [PubMed]
    • Mimeault, M, Batra, S.K. Recent advances on the significance of stem cells in tissue regeneration and cancer therapies. Stem Cells 2006, 24, 2319-2345. [CrossRef] [PubMed]
    • (2006) Stem Cells , vol.24 , pp. 2319-2345
    • Mimeault, M.1    Batra, S.K.2
  • 107
    • 38349150596 scopus 로고    scopus 로고
    • In vivo perfusion of human skin substitutes with microvessels formed by adult circulating endothelial progenitor cells
    • [PubMed]
    • Kung, E.F, Wang, F, Schechner, J.S. In vivo perfusion of human skin substitutes with microvessels formed by adult circulating endothelial progenitor cells. Dermatol. Surg. 2008, 34, 137-146. [PubMed]
    • (2008) Dermatol. Surg , vol.34 , pp. 137-146
    • Kung, E.F.1    Wang, F.2    Schechner, J.S.3
  • 108
    • 50449100799 scopus 로고    scopus 로고
    • Therapeutic potential of stem cells in skin repair and regeneration
    • [CrossRef]
    • Zhang, C.P, Fu, X.B. Therapeutic potential of stem cells in skin repair and regeneration. Chin. J. Traumatol. 2008, 11, 209-221. [CrossRef]
    • (2008) Chin. J. Traumatol. , vol.11 , pp. 209-221
    • Zhang, C.P.1    Fu, X.B.2
  • 109
    • 53149087075 scopus 로고    scopus 로고
    • Adipose-derived stem cells and their secretory factors as a promising therapy for skin aging
    • [PubMed]
    • Park, B.S, Jang, K.A, Sung, J.H, Park, J.S, Kwon, Y.H, Kim, K.J, Kim, W.S. Adipose-derived stem cells and their secretory factors as a promising therapy for skin aging. Dermatol. Surg. 2008, 34, 1323-1326. [PubMed]
    • (2008) Dermatol. Surg , vol.34 , pp. 1323-1326
    • Park, B.S.1    Jang, K.A.2    Sung, J.H.3    Park, J.S.4    Kwon, Y.H.5    Kim, K.J.6    Kim, W.S.7
  • 110
    • 58849124929 scopus 로고    scopus 로고
    • A review of gene and stem cell therapy in cutaneous wound healing
    • [CrossRef] [PubMed]
    • Branski, L.K, Gauglitz, G.G, Herndon, D.N, Jeschke, M.G. A review of gene and stem cell therapy in cutaneous wound healing. Burns 2008, 35, 171-180. [CrossRef] [PubMed]
    • (2008) Burns , vol.35 , pp. 171-180
    • Branski, L.K.1    Gauglitz, G.G.2    Herndon, D.N.3    Jeschke, M.G.4
  • 111
    • 66249106736 scopus 로고    scopus 로고
    • IGFBP-2 Contributes to the proliferation of less proliferative cells in forming skin equivalents
    • [CrossRef] [PubMed]
    • Kim, D.S, Cho, H.J, Yang, S.K, Shin, J.W, Huh, C.H, Park, K.C. IGFBP-2 Contributes to the proliferation of less proliferative cells in forming skin equivalents. Tissue Eng. Part A 2009, 15, 1075-1080. [CrossRef] [PubMed]
    • (2009) Tissue Eng. Part A , vol.15 , pp. 1075-1080
    • Kim, D.S.1    Cho, H.J.2    Yang, S.K.3    Shin, J.W.4    Huh, C.H.5    Park, K.C.6
  • 112
    • 35548999281 scopus 로고    scopus 로고
    • Telomerase reverses epidermal hair follicle stem cell defects and loss of longterm survival associated with critically short telomeres
    • [CrossRef] [PubMed]
    • Siegl-Cachedenier, I, Flores, I, Klatt, P, Blasco, M.A. Telomerase reverses epidermal hair follicle stem cell defects and loss of longterm survival associated with critically short telomeres. J. Cell Biol. 2007, 179, 277-290. [CrossRef] [PubMed]
    • (2007) J. Cell Biol , vol.179 , pp. 277-290
    • Siegl-Cachedenier, I.1    Flores, I.2    Klatt, P.3    Blasco, M.A.4
  • 113
    • 34548133667 scopus 로고    scopus 로고
    • Bone marrow-derived stem cells in wound healing
    • [CrossRef] [PubMed]
    • Wu, Y, Wang, J, Scott, P.G, Tredget, E.E. Bone marrow-derived stem cells in wound healing: A review. Wound Repair Regen. 2007, 15, S18-S26. [CrossRef] [PubMed]
    • (2007) A Review. Wound Repair Regen. , vol.15 , pp. S18-S26
    • Wu, Y.1    Wang, J.2    Scott, P.G.3    Tredget, E.E.4
  • 114
    • 84855432882 scopus 로고    scopus 로고
    • The use of polyethylenimine-DNA to topically deliver hTERT to promote hair growth
    • [CrossRef] [PubMed]
    • Jan, H.M, Wei, M.F, Peng, C.L, Lin, S.J, Lai, P.S, Shieh, M.J. The use of polyethylenimine-DNA to topically deliver hTERT to promote hair growth. Gene Ther. 2012, 19, 86-93. [CrossRef] [PubMed]
    • (2012) Gene Ther , vol.19 , pp. 86-93
    • Jan, H.M.1    Wei, M.F.2    Peng, C.L.3    Lin, S.J.4    Lai, P.S.5    Shieh, M.J.6
  • 115
    • 84900463505 scopus 로고    scopus 로고
    • Novel in vitro culture condition improves the stemness of human dermal stem/progenitor cells
    • [CrossRef] [PubMed]
    • Shim, J.H, Lee, T.R, Shin, D.W. Novel in vitro culture condition improves the stemness of human dermal stem/progenitor cells. Mol. Cells 2013, 36, 556-563. [CrossRef] [PubMed]
    • (2013) Mol. Cells , vol.36 , pp. 556-563
    • Shim, J.H.1    Lee, T.R.2    Shin, D.W.3
  • 116
    • 84948682335 scopus 로고    scopus 로고
    • Telomere length is not related to established cardiovascular risk factors but does correlate with red and white blood cell counts in a German blood donor population
    • [CrossRef] [PubMed]
    • Neuner, B, Lenfers, A, Kelsch, R, Jäger, K, Brüggmann, N, van der Harst, P, Walter, M. Telomere length is not related to established cardiovascular risk factors but does correlate with red and white blood cell counts in a German blood donor population. PLoS ONE 2015, 10, e0139308. [CrossRef] [PubMed]
    • (2015) Plos ONE , vol.10
    • Neuner, B.1    Lenfers, A.2    Kelsch, R.3    Jäger, K.4    Brüggmann, N.5    Van Der Harst, P.6    Walter, M.7
  • 117
    • 2442705193 scopus 로고    scopus 로고
    • The establishment of telomerase-immortalized Tangier disease cell lines indicates the existence of an apolipoprotein A-I-inducible but ABCA1-independent cholesterol efflux pathway
    • [CrossRef] [PubMed]
    • Walter, M, Forsyth, N.R, Wright, W, Shay, J.W, Roth, M.G. The establishment of telomerase-immortalized Tangier disease cell lines indicates the existence of an apolipoprotein A-I-inducible but ABCA1-independent cholesterol efflux pathway. J. Biol. Chem. 2004, 279, 20866-20873. [CrossRef] [PubMed]
    • (2004) J. Biol. Chem , vol.279 , pp. 20866-20873
    • Walter, M.1    Forsyth, N.R.2    Wright, W.3    Shay, J.W.4    Roth, M.G.5
  • 118
    • 84891380201 scopus 로고    scopus 로고
    • Characterization of cholesterol homeostasis in telomerase-immortalized Tangier disease fibroblasts reveals marked phenotype variability
    • [CrossRef] [PubMed]
    • Kannenberg, F, Gorzelniak, K, Jäger, K, Fobker, M, Rust, S, Repa, J, Roth, M, Björkhem, I, Walter, M. Characterization of cholesterol homeostasis in telomerase-immortalized Tangier disease fibroblasts reveals marked phenotype variability. J. Biol. Chem. 2013, 288, 36936-36947. [CrossRef] [PubMed]
    • (2013) J. Biol. Chem , vol.288 , pp. 36936-36947
    • Kannenberg, F.1    Gorzelniak, K.2    Jäger, K.3    Fobker, M.4    Rust, S.5    Repa, J.6    Roth, M.7    Björkhem, I.8    Walter, M.9
  • 119
    • 84870318459 scopus 로고    scopus 로고
    • Telomeres and tissue engineering: The potential roles of TERT in VEGF-mediated angiogenesis
    • [CrossRef] [PubMed]
    • Hartwig, F.P, Nedel, F, Collares, T.V, Tarquinio, S.B, Nör, J.E, Demarco, F.F. Telomeres and tissue engineering: The potential roles of TERT in VEGF-mediated angiogenesis. Stem Cell Rev. 2012, 8, 1275-1281. [CrossRef] [PubMed]
    • (2012) Stem Cell Rev , vol.8 , pp. 1275-1281
    • Hartwig, F.P.1    Nedel, F.2    Collares, T.V.3    Tarquinio, S.B.4    Nör, J.E.5    Demarco, F.F.6
  • 120
    • 0035955754 scopus 로고    scopus 로고
    • ENOS Activity Is Reduced in Senescent Human Endothelial Cells Preservation by hTERT Immortalization
    • [CrossRef] [PubMed]
    • Matsushita, H, Chang, E, Glassford, A.J, Cooke, J.P, Chiu, C.P, Tsao, P.S. eNOS Activity Is Reduced in Senescent Human Endothelial Cells Preservation by hTERT Immortalization. Circ. Res. 2001, 89, 793-798. [CrossRef] [PubMed]
    • (2001) Circ. Res , vol.89 , pp. 793-798
    • Matsushita, H.1    Chang, E.2    Glassford, A.J.3    Cooke, J.P.4    Chiu, C.P.5    Tsao, P.S.6
  • 121
    • 80052173228 scopus 로고    scopus 로고
    • Hippocampal telomerase is involved in the modulation of depressive behaviors
    • [CrossRef] [PubMed]
    • Zhou, Q.G, Hu, Y, Wu, D.L, Zhu, L.J, Chen, C, Jin, X, Luo, C.X, Wu, H.Y, Zhang, J, Zhu, D.Y. Hippocampal telomerase is involved in the modulation of depressive behaviors. J. Neurosci. 2011, 31, 12258-12269. [CrossRef] [PubMed]
    • (2011) J. Neurosci , vol.31 , pp. 12258-12269
    • Zhou, Q.G.1    Hu, Y.2    Wu, D.L.3    Zhu, L.J.4    Chen, C.5    Jin, X.6    Luo, C.X.7    Wu, H.Y.8    Zhang, J.9    Zhu, D.Y.10
  • 124
    • 84930230942 scopus 로고    scopus 로고
    • Telomerase dysregulation in the hippocampus of a rat model of depression. Normalization by lithium
    • [CrossRef] [PubMed]
    • Wei, Y.B, Backlund, L, Wegener, G, Mathé, A.A, Lavebratt, C. Telomerase dysregulation in the hippocampus of a rat model of depression. Normalization by lithium. Int. J. Neuropsychopharmacol. 2015. [CrossRef] [PubMed]
    • (2015) Int. J. Neuropsychopharmacol
    • Wei, Y.B.1    Backlund, L.2    Wegener, G.3    Mathé, A.A.4    Lavebratt, C.5
  • 126
    • 43749121593 scopus 로고    scopus 로고
    • Short telomeres in patients with chronic schizophrenia who show a poor response to treatment
    • [PubMed]
    • Yu, W.Y, Chang, H.W, Lin, C.H, Cho, C.L. Short telomeres in patients with chronic schizophrenia who show a poor response to treatment. J. Psychiatry Neurosci. 2008, 33, 244-247. [PubMed]
    • (2008) J. Psychiatry Neurosci , vol.33 , pp. 244-247
    • Yu, W.Y.1    Chang, H.W.2    Lin, C.H.3    Cho, C.L.4
  • 128
    • 0034762873 scopus 로고    scopus 로고
    • Regulation of adult neurogenesis by psychotropic drugs and stress
    • [PubMed]
    • Duman, R.S, Malberg, J, Nakagawa, S. Regulation of adult neurogenesis by psychotropic drugs and stress. J. Pharmacol. Exp. Ther. 2001, 299, 401-407. [PubMed]
    • (2001) J. Pharmacol. Exp. Ther. , vol.299 , pp. 401-407
    • Duman, R.S.1    Malberg, J.2    Nakagawa, S.3
  • 130
    • 84855493135 scopus 로고    scopus 로고
    • It all comes together at the ends: Telomerase structure, function, and biogenesis
    • [CrossRef] [PubMed]
    • Podlevsky, J.D, Chen, J.J. It all comes together at the ends: Telomerase structure, function, and biogenesis. Mutat. Res. 2012, 730, 3-11. [CrossRef] [PubMed]
    • (2012) Mutat. Res. , vol.730 , pp. 3-11
    • Podlevsky, J.D.1    Chen, J.J.2
  • 132
    • 0029867408 scopus 로고    scopus 로고
    • Inhibition of human telomerase activity by peptide nucleic acids
    • [CrossRef] [PubMed]
    • Norton, J.C, Piatyszek, M.A, Wright, W.E, Shay, J.W, Corey, D.R. Inhibition of human telomerase activity by peptide nucleic acids. Nat. Biotechnol. 1996, 14, 615-619. [CrossRef] [PubMed]
    • (1996) Nat. Biotechnol , vol.14 , pp. 615-619
    • Norton, J.C.1    Piatyszek, M.A.2    Wright, W.E.3    Shay, J.W.4    Corey, D.R.5
  • 134
    • 0032578525 scopus 로고
    • Inhibition of human telomerase by 2’-O-methyl-RNA
    • [CrossRef]
    • Pitts, A.E, Corey, D.R. Inhibition of human telomerase by 2’-O-methyl-RNA. Proc. Natl. Acad. Sci. USA 1988, 95, 11549-11554. [CrossRef]
    • (1988) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 11549-11554
    • Pitts, A.E.1    Corey, D.R.2
  • 135
    • 0033455559 scopus 로고    scopus 로고
    • Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death
    • [CrossRef] [PubMed]
    • Herbert, B, Pitts, A.E, Baker, S.I, Hamilton, S.E, Wright, W.E, Shay, J.W, Corey, D.R. Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death. Proc. Natl. Acad. Sci. USA 1999, 96, 14276-14281. [CrossRef] [PubMed]
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 14276-14281
    • Herbert, B.1    Pitts, A.E.2    Baker, S.I.3    Hamilton, S.E.4    Wright, W.E.5    Shay, J.W.6    Corey, D.R.7
  • 136
    • 0037148329 scopus 로고    scopus 로고
    • Telomerase inhibition, oligonucleotides, and clinical trials
    • [CrossRef] [PubMed]
    • Corey, D.R. Telomerase inhibition, oligonucleotides, and clinical trials. Oncogene 2002, 21, 631-637. [CrossRef] [PubMed]
    • (2002) Oncogene , vol.21 , pp. 631-637
    • Corey, D.R.1
  • 138
    • 39749163359 scopus 로고    scopus 로고
    • Telomerase and cancer therapeutics
    • [CrossRef] [PubMed]
    • Harley, C.B. Telomerase and cancer therapeutics. Nat. Rev. Cancer 2008, 8, 167-179. [CrossRef] [PubMed]
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 167-179
    • Harley, C.B.1
  • 139
    • 74949143829 scopus 로고    scopus 로고
    • The telomerase antagonist, imetelstat, efficiently targets glioblastoma tumor-initiating cells leading to decreased proliferation and tumor growth
    • [CrossRef] [PubMed]
    • Marian, C.O, Cho, S.K, McEllin, B.M, Maher, E.A, Hatanpaa, K.J, Madden, C.J, Mickey, B.E, Wright, W.E, Shay, J.W, Bachoo, R.M. The telomerase antagonist, imetelstat, efficiently targets glioblastoma tumor-initiating cells leading to decreased proliferation and tumor growth. Clin. Cancer Res. 2010, 16, 154-163. [CrossRef] [PubMed]
    • (2010) Clin. Cancer Res , vol.16 , pp. 154-163
    • Marian, C.O.1    Cho, S.K.2    McEllin, B.M.3    Maher, E.A.4    Hatanpaa, K.J.5    Madden, C.J.6    Mickey, B.E.7    Wright, W.E.8    Shay, J.W.9    Bachoo, R.M.10
  • 140
    • 0033566694 scopus 로고    scopus 로고
    • FJ5002: A potent telomerase inhibitor identified by exploiting the disease-oriented screening program with COMPARE analysis
    • [PubMed]
    • Naasani, I, Seimiya, H, Yamori, T, Tsuruo, T. FJ5002: A potent telomerase inhibitor identified by exploiting the disease-oriented screening program with COMPARE analysis. Cancer Res. 1999, 59, 4004-4011. [PubMed]
    • (1999) Cancer Res , vol.59 , pp. 4004-4011
    • Naasani, I.1    Seimiya, H.2    Yamori, T.3    Tsuruo, T.4
  • 144
    • 84875423336 scopus 로고    scopus 로고
    • Yeast chemical genetic screen identifies inhibitors of human telomerase
    • [CrossRef] [PubMed]
    • Wong, L.H, Unciti-Broceta, A, Spitzer, M, White, R, Tyers, M, Harrington, L. A yeast chemical genetic screen identifies inhibitors of human telomerase. Chem. Biol. 2013, 20, 333-340. [CrossRef] [PubMed]
    • (2013) Chem. Biol , vol.20 , pp. 333-340
    • Wong, L.H.1    Unciti-Broceta, A.2    Spitzer, M.3    White, R.4    Tyers, M.5    Harrington, L.A.6
  • 145
    • 78649348967 scopus 로고    scopus 로고
    • Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress
    • [CrossRef] [PubMed]
    • Sengupta, S, Peterson, T.R, Sabatini, D.M. Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol. Cell 2010, 40, 310-322. [CrossRef] [PubMed]
    • (2010) Mol. Cell , vol.40 , pp. 310-322
    • Sengupta, S.1    Peterson, T.R.2    Sabatini, D.M.3
  • 146
    • 38049112379 scopus 로고    scopus 로고
    • Coupled down-regulation of mTOR and telomerase activity during fluorouracil-induced apoptosis of hepatocarcinoma cells
    • [CrossRef] [PubMed]
    • Bu, X, Jia, F, Wang, W, Guo, X, Wu, M, Wei, L. Coupled down-regulation of mTOR and telomerase activity during fluorouracil-induced apoptosis of hepatocarcinoma cells. BMC Cancer 2007. [CrossRef] [PubMed]
    • (2007) BMC Cancer
    • Bu, X.1    Jia, F.2    Wang, W.3    Guo, X.4    Wu, M.5    Wei, L.6
  • 147
    • 84868194994 scopus 로고    scopus 로고
    • The isoprenoid perillyl alcohol inhibits telomerase activity in prostate cancer cells
    • [CrossRef] [PubMed]
    • Sundin, T, Peffley, D.M, Gauthier, D, Hentosh, P. The isoprenoid perillyl alcohol inhibits telomerase activity in prostate cancer cells. Biochimie 2012, 94, 2639-2648. [CrossRef] [PubMed]
    • (2012) Biochimie , vol.94 , pp. 2639-2648
    • Sundin, T.1    Peffley, D.M.2    Gauthier, D.3    Hentosh, P.4
  • 148
    • 84873056486 scopus 로고    scopus 로고
    • Disruption of an hTERT-mTOR-RAPTOR protein complex by a phytochemical perillyl alcohol and rapamycin
    • [CrossRef] [PubMed]
    • Sundin, T, Peffley, D.M, Hentosh, P. Disruption of an hTERT-mTOR-RAPTOR protein complex by a phytochemical perillyl alcohol and rapamycin. Mol. Cell Biochem. 2013, 375, 97-104. [CrossRef] [PubMed]
    • (2013) Mol. Cell Biochem , vol.375 , pp. 97-104
    • Sundin, T.1    Peffley, D.M.2    Hentosh, P.3
  • 149
    • 75349112400 scopus 로고    scopus 로고
    • Telomerase in cancer immunotherapy
    • [CrossRef] [PubMed]
    • Liu, J.P, Chen, W, Schwarer, A.P, Li, H. Telomerase in cancer immunotherapy. Biochim. Biophys. Acta 2010, 1805, 35-42. [CrossRef] [PubMed]
    • (2010) Biochim. Biophys. Acta , vol.1805 , pp. 35-42
    • Liu, J.P.1    Chen, W.2    Schwarer, A.P.3    Li, H.4
  • 151
    • 85010276089 scopus 로고    scopus 로고
    • A second chance for telomerase reverse transcriptase in anticancer immunotherapy
    • [CrossRef] [PubMed]
    • Zanetti, M. A second chance for telomerase reverse transcriptase in anticancer immunotherapy. Nat. Rev. Clin. Oncol. 2016. [CrossRef] [PubMed]
    • (2016) Nat. Rev. Clin. Oncol
    • Zanetti, M.1
  • 152
    • 0038066552 scopus 로고    scopus 로고
    • Immunological and clinical responses in metastatic renal cancer patients vaccinated with tumor RNA-transfected dendritic cells
    • [PubMed]
    • Su, Z, Dannull, J, Heiser, A, Yancey, D, Pruitt, S, Madden, J, Coleman, D, Niedzwiecki, D, Gilboa, E, Vieweg, J. Immunological and clinical responses in metastatic renal cancer patients vaccinated with tumor RNA-transfected dendritic cells. Cancer Res. 2003, 63, 2127-2133. [PubMed]
    • (2003) Cancer Res , vol.63 , pp. 2127-2133
    • Su, Z.1    Dannull, J.2    Heiser, A.3    Yancey, D.4    Pruitt, S.5    Madden, J.6    Coleman, D.7    Niedzwiecki, D.8    Gilboa, E.9    Vieweg, J.10
  • 153
    • 3242690518 scopus 로고    scopus 로고
    • Immunization of patients with the hTERT: 540-548 peptide induces peptide-reactive T lymphocytes that do not recognize tumors endogenously expressing telomerase
    • [CrossRef] [PubMed]
    • Parkhurst, M.R, Riley, J.P, Igarashi, T, Li, Y, Robbins, P.F, Rosenberg, S.A. Immunization of patients with the hTERT: 540-548 peptide induces peptide-reactive T lymphocytes that do not recognize tumors endogenously expressing telomerase. Clin. Cancer Res. 2004, 10, 4688-4698. [CrossRef] [PubMed]
    • (2004) Clin. Cancer Res , vol.10 , pp. 4688-4698
    • Parkhurst, M.R.1    Riley, J.P.2    Igarashi, T.3    Li, Y.4    Robbins, P.F.5    Rosenberg, S.A.6
  • 155
    • 20144364773 scopus 로고    scopus 로고
    • Telomerase mRNA-transfected dendritic cells stimulate antigen-specific CD8+ and CD4+ T cell responses in patients with metastatic prostate cancer
    • [CrossRef] [PubMed]
    • Su, Z, Dannull, J, Yang, B.K, Dahm, P, Coleman, D, Yancey, D, Sichi, S, Niedzwiecki, D, Boczkowski, D, Gilboa, E, et al. Telomerase mRNA-transfected dendritic cells stimulate antigen-specific CD8+ and CD4+ T cell responses in patients with metastatic prostate cancer. J. Immunol. 2005, 174, 3798-3807. [CrossRef] [PubMed]
    • (2005) J. Immunol , vol.174 , pp. 3798-3807
    • Su, Z.1    Dannull, J.2    Yang, B.K.3    Dahm, P.4    Coleman, D.5    Yancey, D.6    Sichi, S.7    Niedzwiecki, D.8    Boczkowski, D.9    Gilboa, E.10
  • 156
    • 34047143340 scopus 로고    scopus 로고
    • Telomerase immunity from bench to bedside: Round one
    • [CrossRef] [PubMed]
    • Cortez-Gonzalez, X, Zanetti, M. Telomerase immunity from bench to bedside: Round one. J. Transl. Med. 2007. [CrossRef] [PubMed]
    • (2007) J. Transl. Med
    • Cortez-Gonzalez, X.1    Zanetti, M.2
  • 163
    • 79960329487 scopus 로고    scopus 로고
    • Telomerase peptide vaccination combined with temozolomide: A clinical trial in stage IV melanoma patients
    • [CrossRef] [PubMed]
    • Kyte, J.A, Gaudernack, G, Dueland, S, Trachsel, S, Julsrud, L, Aamdal, S. Telomerase peptide vaccination combined with temozolomide: A clinical trial in stage IV melanoma patients. Clin. Cancer Res. 2011, 17, 4568-4580. [CrossRef] [PubMed]
    • (2011) Clin. Cancer Res. , vol.17 , pp. 4568-4580
    • Kyte, J.A.1    Gaudernack, G.2    Dueland, S.3    Trachsel, S.4    Julsrud, L.5    Aamdal, S.6
  • 164
    • 78751699860 scopus 로고    scopus 로고
    • Combination immunotherapy using adoptive T-cell transfer and tumor antigen vaccination on the basis of hTERT and survivin after ASCT for myeloma
    • [CrossRef] [PubMed]
    • Rapoport, A.P, Aqui, N.A, Stadtmauer, E.A, Vogl, D.T, Fang, H.B, Cai, L, Janofsky, S, Chew, A, Storek, J, Akpek, G, et al. Combination immunotherapy using adoptive T-cell transfer and tumor antigen vaccination on the basis of hTERT and survivin after ASCT for myeloma. Blood 2011, 117, 788-797. [CrossRef] [PubMed]
    • (2011) Blood , vol.117 , pp. 788-797
    • Rapoport, A.P.1    Aqui, N.A.2    Stadtmauer, E.A.3    Vogl, D.T.4    Fang, H.B.5    Cai, L.6    Janofsky, S.7    Chew, A.8    Storek, J.9    Akpek, G.10
  • 167
    • 84904392184 scopus 로고    scopus 로고
    • Telomerase (GV1001) vaccination together with gemcitabine in advanced pancreatic cancer patients
    • [CrossRef] [PubMed]
    • Staff, C, Mozaffari, F, Frodin, J.E, Mellstedt, H, Liljefors, M. Telomerase (GV1001) vaccination together with gemcitabine in advanced pancreatic cancer patients. Int. J. Oncol. 2014, 45, 1293-1303. [CrossRef] [PubMed]
    • (2014) Int. J. Oncol , vol.45 , pp. 1293-1303
    • Staff, C.1    Mozaffari, F.2    Frodin, J.E.3    Mellstedt, H.4    Liljefors, M.5
  • 168
    • 84862127178 scopus 로고    scopus 로고
    • Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation of mouse cells
    • [CrossRef] [PubMed]
    • Davoli, T, de Lange, T. Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation of mouse cells. Cancer Cell 2012, 21, 765-776. [CrossRef] [PubMed]
    • (2012) Cancer Cell , vol.21 , pp. 765-776
    • Davoli, T.1    De Lange, T.2
  • 169
    • 77953963578 scopus 로고    scopus 로고
    • A phase II open label trial evaluating safety and efficacy of a telomerase peptide vaccination in patients with advanced hepatocellular carcinoma
    • [CrossRef] [PubMed]
    • Greten, T.F, Forner, A, Korangy, F, N'Kontchou, G, Barget, N, Ayuso, C, Ormandy, L.A, Manns, M.P, Beaugrand, M, Bruix, J. A phase II open label trial evaluating safety and efficacy of a telomerase peptide vaccination in patients with advanced hepatocellular carcinoma. BMC Cancer 2010. [CrossRef] [PubMed]
    • (2010) BMC Cancer
    • Greten, T.F.1    Forner, A.2    Korangy, F.3    N'kontchou, G.4    Barget, N.5    Ayuso, C.6    Ormandy, L.A.7    Manns, M.P.8    Beaugrand, M.9    Bruix, J.10
  • 170
    • 80455140226 scopus 로고    scopus 로고
    • Telomerase peptide vaccination in NSCLC: A phase II trial in stage III patients vaccinated after chemoradiotherapy and an 8-year update on a phase I/II trial
    • [CrossRef] [PubMed]
    • Brunsvig, P.F, Kyte, J.A, Kersten, C, Sundstrøm, S, Møller, M, Nyakas, M, Hansen, G.L, Gaudernack, G, Aamdal, S. Telomerase peptide vaccination in NSCLC: A phase II trial in stage III patients vaccinated after chemoradiotherapy and an 8-year update on a phase I/II trial. Clin. Cancer Res. 2001, 17, 6847-6857. [CrossRef] [PubMed]
    • (2001) Clin. Cancer Res , vol.17 , pp. 6847-6857
    • Brunsvig, P.F.1    Kyte, J.A.2    Kersten, C.3    Sundstrøm, S.4    Møller, M.5    Nyakas, M.6    Hansen, G.L.7    Gaudernack, G.8    Aamdal, S.9
  • 171
    • 84867552067 scopus 로고    scopus 로고
    • Metastatic melanoma patients treated with dendritic cell vaccination, interleukin-2 and metronomic cyclophosphamide: Results from a phase II trial
    • [CrossRef] [PubMed]
    • Ellebaek, E, Engell-Noerregaard, L, Iversen, T.Z, Froesig, T.M, Munir, S, Hadrup, S.R, Andersen, M.H, Svane, I.M. Metastatic melanoma patients treated with dendritic cell vaccination, interleukin-2 and metronomic cyclophosphamide: Results from a phase II trial. Cancer Immunol. Immunother. 2012, 61, 1791-1804. [CrossRef] [PubMed]
    • (2012) Cancer Immunol. Immunother. , vol.61 , pp. 1791-1804
    • Ellebaek, E.1    Engell-Noerregaard, L.2    Iversen, T.Z.3    Froesig, T.M.4    Munir, S.5    Hadrup, S.R.6    Ersen, M.H.7    Svane, I.M.8
  • 172
    • 84856324806 scopus 로고    scopus 로고
    • Clinical outcome of patients with various advanced cancer types vaccinated with an optimized cryptic human telomerase reverse transcriptase (TERT) peptide: Results of an expanded phase II study
    • [CrossRef] [PubMed]
    • Kotsakis, A, Vetsika, E.K, Christou, S, Hatzidaki, D, Vardakis, N, Aggouraki, D, Konsolakis, G, Georgoulias, V, Christophyllakis, C, Cordopatis, P, et al. Clinical outcome of patients with various advanced cancer types vaccinated with an optimized cryptic human telomerase reverse transcriptase (TERT) peptide: Results of an expanded phase II study. Ann. Oncol. 2012, 23, 442-449. [CrossRef] [PubMed]
    • (2012) Ann. Oncol , vol.23 , pp. 442-449
    • Kotsakis, A.1    Vetsika, E.K.2    Christou, S.3    Hatzidaki, D.4    Vardakis, N.5    Aggouraki, D.6    Konsolakis, G.7    Georgoulias, V.8    Christophyllakis, C.9    Cordopatis, P.10
  • 173
    • 84903527674 scopus 로고    scopus 로고
    • Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac): An open-label, randomised, phase 3 trial
    • [CrossRef]
    • Middleton, G, Silcocks, P, Cox, T, Valle, J, Wadsley, J, Propper, D, Coxon, F, Ross, P, Madhusudan, S, Roques, T, et al. Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac): An open-label, randomised, phase 3 trial. Lancet Oncol. 2014, 15, 829-840. [CrossRef]
    • (2014) Lancet Oncol , vol.15 , pp. 829-840
    • Middleton, G.1    Silcocks, P.2    Cox, T.3    Valle, J.4    Wadsley, J.5    Propper, D.6    Coxon, F.7    Ross, P.8    Madhusudan, S.9    Roques, T.10
  • 175
    • 76349086193 scopus 로고    scopus 로고
    • A phase I study of telomerase-specific replication competent oncolytic adenovirus (Telomelysin) for various solid tumours
    • [CrossRef] [PubMed]
    • Nemunaitis, J, Tong, A.W, Nemunaitis, M, Senzer, N, Phadke, A.P, Bedell, C, Adams, N, Zhang, Y.A, Maples, P.B, Chen, S, et al. A phase I study of telomerase-specific replication competent oncolytic adenovirus (telomelysin) for various solid tumours. Mol. Ther. 2010, 18, 429-434. [CrossRef] [PubMed]
    • (2010) Mol. Ther , vol.18 , pp. 429-434
    • Nemunaitis, J.1    Tong, A.W.2    Nemunaitis, M.3    Senzer, N.4    Phadke, A.P.5    Bedell, C.6    Adams, N.7    Zhang, Y.A.8    Maples, P.B.9    Chen, S.10
  • 176
    • 20444452034 scopus 로고    scopus 로고
    • Drug insight: Cancer cell immortality-telomerase as a target for novel cancer gene therapies
    • [CrossRef] [PubMed]
    • Keith, W.N, Bilsland, A, Hardie, M, Evans, T.R. Drug insight: Cancer cell immortality-telomerase as a target for novel cancer gene therapies. Nat. Clin. Pract. Oncol. 2004, 1, 88-96. [CrossRef] [PubMed]
    • (2004) Nat. Clin. Pract. Oncol , vol.1 , pp. 88-96
    • Keith, W.N.1    Bilsland, A.2    Hardie, M.3    Evans, T.R.4
  • 177
    • 84964819271 scopus 로고    scopus 로고
    • Functional and mechanistic analysis of telomerase: An antitumor drug target
    • [CrossRef] [PubMed]
    • Chen, Y, Zhang, Y. Functional and mechanistic analysis of telomerase: An antitumor drug target. Pharmacol. Ther. 2016, 163, 24-47. [CrossRef] [PubMed]
    • (2016) Pharmacol. Ther , vol.163 , pp. 24-47
    • Chen, Y.1    Zhang, Y.2
  • 178
    • 0141829813 scopus 로고    scopus 로고
    • Effects of allicin on both telomerase activity and apoptosis in gastric cancer SGC-7901 cells
    • [CrossRef] [PubMed]
    • Sun, L, Wang, X. Effects of allicin on both telomerase activity and apoptosis in gastric cancer SGC-7901 cells. World J. Gastroenterol. 2003, 9, 1930-1934. [CrossRef] [PubMed]
    • (2003) World J. Gastroenterol , vol.9 , pp. 1930-1934
    • Sun, L.1    Wang, X.2
  • 179
    • 33646492469 scopus 로고    scopus 로고
    • Inhibition of telomerase activity and induction of apoptosis by curcumin in K-562 cells
    • [CrossRef] [PubMed]
    • Chakraborty, S, Ghosh, U, Bhattacharyya, N.P, Bhattacharya, R.K, Roy, M. Inhibition of telomerase activity and induction of apoptosis by curcumin in K-562 cells. Mutat. Res. 2006, 596, 81-90. [CrossRef] [PubMed]
    • (2006) Mutat. Res , vol.596 , pp. 81-90
    • Chakraborty, S.1    Ghosh, U.2    Bhattacharyya, N.P.3    Bhattacharya, R.K.4    Roy, M.5
  • 180
    • 38649088961 scopus 로고    scopus 로고
    • Antiproliferative effects of the major tea polyphenol, (-)-epigallocatechin gallate and retinoic acid in cervical adenocarcinoma
    • [CrossRef] [PubMed]
    • Yokoyama, M, Noguchi, M, Nakao, Y, Ysunaga, M, Yamasaki, F, Iwasaka, T. Antiproliferative effects of the major tea polyphenol, (-)-epigallocatechin gallate and retinoic acid in cervical adenocarcinoma. Gynecol Oncol. 2008, 108, 326-331. [CrossRef] [PubMed]
    • (2008) Gynecol Oncol , vol.108 , pp. 326-331
    • Yokoyama, M.1    Noguchi, M.2    Nakao, Y.3    Ysunaga, M.4    Yamasaki, F.5    Iwasaka, T.6
  • 181
    • 0037044179 scopus 로고    scopus 로고
    • Curcumin inhibits telomerase activity through human telomerase reverse transcritpase in MCF-7 breast cancer cell line
    • [CrossRef]
    • Ramachandran, C, Fonseca, H.B, Jhabvala, P, Escalon, E.A, Melnick, S.J. Curcumin inhibits telomerase activity through human telomerase reverse transcritpase in MCF-7 breast cancer cell line. Cancer Lett. 2002, 184, 1-6. [CrossRef]
    • (2002) Cancer Lett , vol.184 , pp. 1-6
    • Ramachandran, C.1    Fonseca, H.B.2    Jhabvala, P.3    Escalon, E.A.4    Melnick, S.J.5
  • 182
    • 77952882851 scopus 로고    scopus 로고
    • N-acetyl cysteine mitigates curcumin-mediated telomerase inhibition through rescuing of Sp1 reduction in A549 cells
    • [CrossRef] [PubMed]
    • Hsin, I.L, Sheu, G.T, Chen, H.H, Chiu, L.Y, Wang, H.D, Chan, H.W, Hsu, C.P, Ko, J.L. N-acetyl cysteine mitigates curcumin-mediated telomerase inhibition through rescuing of Sp1 reduction in A549 cells. Mutat. Res. 2010, 688, 72-77. [CrossRef] [PubMed]
    • (2010) Mutat. Res , vol.688 , pp. 72-77
    • Hsin, I.L.1    Sheu, G.T.2    Chen, H.H.3    Chiu, L.Y.4    Wang, H.D.5    Chan, H.W.6    Hsu, C.P.7    Ko, J.L.8
  • 183
    • 77249158324 scopus 로고    scopus 로고
    • Curcumin inhibits nuclear localization of telomerase by dissociating the Hsp90 co-chaperone p23 from hTERT
    • [CrossRef] [PubMed]
    • Lee, J.H, Chung, I.K. Curcumin inhibits nuclear localization of telomerase by dissociating the Hsp90 co-chaperone p23 from hTERT. Cancer Lett. 2010, 290, 76-86. [CrossRef] [PubMed]
    • (2010) Cancer Lett , vol.290 , pp. 76-86
    • Lee, J.H.1    Chung, I.K.2
  • 184
    • 64249171413 scopus 로고    scopus 로고
    • Molecular mechanism of curcumin induced cytotoxicity in human cervical carcinoma cells
    • [CrossRef] [PubMed]
    • Singh, M, Singh, N. Molecular mechanism of curcumin induced cytotoxicity in human cervical carcinoma cells. Mol. Cell Biochem. 2009, 325, 107-119. [CrossRef] [PubMed]
    • (2009) Mol. Cell Biochem , vol.325 , pp. 107-119
    • Singh, M.1    Singh, N.2
  • 185
    • 33947414787 scopus 로고    scopus 로고
    • Curcumin-induced apoptosis in human leukemia cell HL-60 is associated with inhibition of telomerase activity
    • [CrossRef] [PubMed]
    • Mukherjee Nee Chakraborty, S, Ghosh, U, Bhattacharyya, N.P, Bhattacharya, R.K, Dey, S, Roy, M. Curcumin-induced apoptosis in human leukemia cell HL-60 is associated with inhibition of telomerase activity. Mol. Cell Biochem. 2007, 297, 31-39. [CrossRef] [PubMed]
    • (2007) Mol. Cell Biochem , vol.297 , pp. 31-39
    • Mukherjee Nee Chakraborty, S.1    Ghosh, U.2    Bhattacharyya, N.P.3    Bhattacharya, R.K.4    Dey, S.5    Roy, M.6
  • 186
    • 38649100332 scopus 로고    scopus 로고
    • Epigenetic and genetic mechanisms contribute to telomerase inhibition by EGCG
    • [CrossRef] [PubMed]
    • Berletch, J.B, Liu, C, Love, W.K, Andrews, L.G, Katiyar, S.K, Tollefsbol, T.O. Epigenetic and genetic mechanisms contribute to telomerase inhibition by EGCG. J. Cell Biochem. 2008, 103, 509-519. [CrossRef] [PubMed]
    • (2008) J. Cell Biochem , vol.103 , pp. 509-519
    • Berletch, J.B.1    Liu, C.2    Love, W.K.3    Rews, L.G.4    Katiyar, S.K.5    Tollefsbol, T.O.6
  • 187
    • 67449084948 scopus 로고    scopus 로고
    • Genistein depletes telomerase activity through cross-talk between genetic and epigenetic mechanisms
    • [CrossRef] [PubMed]
    • Li, Y, Liu, L, Andrews, L.G, Tollefsbol, T.O. Genistein depletes telomerase activity through cross-talk between genetic and epigenetic mechanisms. Int. J. Cancer 2009, 125, 286-296. [CrossRef] [PubMed]
    • (2009) Int. J. Cancer , vol.125 , pp. 286-296
    • Li, Y.1    Liu, L.2    Rews, L.G.3    Tollefsbol, T.O.4
  • 188
    • 80051520893 scopus 로고    scopus 로고
    • Novel prodrug of epigallocatechin-3-gallate: Differential epigenetic hTERT repression in human breast cancer cells
    • [CrossRef] [PubMed]
    • Meeran, S.M, Patel, S.N, Chan, T.H, Tollefsbol, T.O. A novel prodrug of epigallocatechin-3-gallate: Differential epigenetic hTERT repression in human breast cancer cells. Cancer Prev. Res. (Phila) 2011, 4, 1243-1254. [CrossRef] [PubMed]
    • (2011) Cancer Prev. Res. (Phila) , vol.4 , pp. 1243-1254
    • Meeran, S.M.1    Patel, S.N.2    Chan, T.H.3    Tollefsbol, T.4
  • 189
    • 77954032493 scopus 로고    scopus 로고
    • Sulforaphane decreases viability and telomerase activity in hepatocellular carcinoma Hep3B cells through the reactive oxygen species-dependent pathway
    • [CrossRef] [PubMed]
    • Moon, D.O, Kang, S.H, Kim, K.C, Kim, M.O, Choi, Y.H, Kim, G.Y. Sulforaphane decreases viability and telomerase activity in hepatocellular carcinoma Hep3B cells through the reactive oxygen species-dependent pathway. Cancer Lett. 2010, 295, 260-266. [CrossRef] [PubMed]
    • (2010) Cancer Lett , vol.295 , pp. 260-266
    • Moon, D.O.1    Kang, S.H.2    Kim, K.C.3    Kim, M.O.4    Choi, Y.H.5    Kim, G.Y.6
  • 190
    • 5444270872 scopus 로고    scopus 로고
    • EGCG down-regulates telomerase in human breast carcinoma MCF-7 cells, leading to suppression of cell viability and induction of apoptosis
    • [CrossRef] [PubMed]
    • Mittal, A, Pate, M.S, Wylie, R.C, Tollefsbol, T.O, Katiyar, S.K. EGCG down-regulates telomerase in human breast carcinoma MCF-7 cells, leading to suppression of cell viability and induction of apoptosis. Int. J. Oncol. 2004, 24, 703-710. [CrossRef] [PubMed]
    • (2004) Int. J. Oncol. , vol.24 , pp. 703-710
    • Mittal, A.1    Pate, M.S.2    Wylie, R.C.3    Tollefsbol, T.O.4    Katiyar, S.K.5
  • 191
    • 84863109868 scopus 로고    scopus 로고
    • Second-generation tyrosine kinase inhibitors reduce telomerase activity in K562 cells
    • [CrossRef] [PubMed]
    • Shapira, S, Granot, G, Mor-Tzuntz, R, Raanani, P, Uziel, O, Lahav, M, Shpilberg, O. Second-generation tyrosine kinase inhibitors reduce telomerase activity in K562 cells. Cancer Lett. 2012, 323, 223-231. [CrossRef] [PubMed]
    • (2012) Cancer Lett , vol.323 , pp. 223-231
    • Shapira, S.1    Granot, G.2    Mor-Tzuntz, R.3    Raanani, P.4    Uziel, O.5    Lahav, M.6    Shpilberg, O.7
  • 192
    • 71549161721 scopus 로고    scopus 로고
    • Effect of imatinib on the signal transduction cascade regulating telomerase activity in K562 (BCR-ABL-positive) cells sensitive and resistant to imatinib
    • [CrossRef] [PubMed]
    • Mor-Tzuntz, R, Uziel, O, Shpilberg, O, Lahav, J, Raanani, P, Bakhanashvili, M, Rabizadeh, E, Zimra, Y, Lahav, M, Granot, G. Effect of imatinib on the signal transduction cascade regulating telomerase activity in K562 (BCR-ABL-positive) cells sensitive and resistant to imatinib. Exp. Hematol. 2010, 8, 27-37. [CrossRef] [PubMed]
    • (2010) Exp. Hematol , vol.8 , pp. 27-37
    • Mor-Tzuntz, R.1    Uziel, O.2    Shpilberg, O.3    Lahav, J.4    Raanani, P.5    Bakhanashvili, M.6    Rabizadeh, E.7    Zimra, Y.8    Lahav, M.9    Granot, G.10
  • 193
    • 70450185876 scopus 로고    scopus 로고
    • Gefitinib induces apoptosis and decreases telomerase activity in MDA-MB-231 human breast cancer cells
    • [CrossRef] [PubMed]
    • Moon, D.O, Kim, M.O, Heo, M.S, Lee, J.D, Choi, Y.H, Kim, G.Y. Gefitinib induces apoptosis and decreases telomerase activity in MDA-MB-231 human breast cancer cells. Arch. Pharm. Res. 2009, 32, 1351-1360. [CrossRef] [PubMed]
    • (2009) Arch. Pharm. Res , vol.32 , pp. 1351-1360
    • Moon, D.O.1    Kim, M.O.2    Heo, M.S.3    Lee, J.D.4    Choi, Y.H.5    Kim, G.Y.6
  • 194
    • 84919799270 scopus 로고    scopus 로고
    • Arsenic trioxide suppresses transcription of hTERT through down-regulation ofmultiple transcription factors in HL-60 leukemia cells
    • [CrossRef] [PubMed]
    • Zhang, Y, Sun, M, Shi, W, Yang, Q, Chen, C, Wang, Z, Zhou, X. Arsenic trioxide suppresses transcription of hTERT through down-regulation ofmultiple transcription factors in HL-60 leukemia cells. Toxicol. Lett. 2015, 232, 481-489. [CrossRef] [PubMed]
    • (2015) Toxicol. Lett , vol.232 , pp. 481-489
    • Zhang, Y.1    Sun, M.2    Shi, W.3    Yang, Q.4    Chen, C.5    Wang, Z.6    Zhou, X.7
  • 195
    • 84924973690 scopus 로고    scopus 로고
    • The DNA methylation inhibitor induces telomere dysfunction and apoptosis of leukemia cells that is attenuated by telomerase over-expression
    • [CrossRef] [PubMed]
    • Zhang, X, Li, B, de Jonge, N, Bjorkholm, M, Xu, D. The DNA methylation inhibitor induces telomere dysfunction and apoptosis of leukemia cells that is attenuated by telomerase over-expression. Oncotarget 2015, 6, 4888-4900. [CrossRef] [PubMed]
    • (2015) Oncotarget , vol.6 , pp. 4888-4900
    • Zhang, X.1    Li, B.2    De Jonge, N.3    Bjorkholm, M.4    Xu, D.5
  • 196
    • 0141730399 scopus 로고    scopus 로고
    • Inhibition of telomerase activity in malignant glioma cells correlates with their sensitivity to temozolomide
    • [CrossRef] [PubMed]
    • Kanzawa, T, Germano, I.M, Kondo, Y, Ito, H, Kyo, S, Kondo, S. Inhibition of telomerase activity in malignant glioma cells correlates with their sensitivity to temozolomide. Br. J. Cancer 2003, 89, 922-929. [CrossRef] [PubMed]
    • (2003) Br. J. Cancer , vol.89 , pp. 922-929
    • Kanzawa, T.1    Germano, I.M.2    Kondo, Y.3    Ito, H.4    Kyo, S.5    Kondo, S.6
  • 197
    • 84925495930 scopus 로고    scopus 로고
    • Pharmacodynamics of telomerase inhibition and telomere shortening by noncytotoxic suramin
    • [CrossRef] [PubMed]
    • Gan, Y, Lu, J, Yeung, B.Z, Cottage, C.T, Wientjes, M.G, Au, J.L. Pharmacodynamics of telomerase inhibition and telomere shortening by noncytotoxic suramin. AAPS J. 2015, 17, 268-276. [CrossRef] [PubMed]
    • (2015) AAPS J , vol.17 , pp. 268-276
    • Gan, Y.1    Lu, J.2    Yeung, B.Z.3    Cottage, C.T.4    Wientjes, M.G.5    Au, J.L.6
  • 198
    • 33644833354 scopus 로고    scopus 로고
    • Inhibition of human telomerase reverse transcriptase by nonsteroidal antiinflammatory drugs in colon carcinoma
    • [CrossRef] [PubMed]
    • He, H, Xia, H.H, Wang, J.D, Gu, Q, Lin, M.C, Zou, B, Lam, S.K, Chan, A.O, Yuen, M.F, Kung, H.F, et al. Inhibition of human telomerase reverse transcriptase by nonsteroidal antiinflammatory drugs in colon carcinoma. Cancer 2006, 106, 1243-1249. [CrossRef] [PubMed]
    • (2006) Cancer , vol.106 , pp. 1243-1249
    • He, H.1    Xia, H.H.2    Wang, J.D.3    Gu, Q.4    Lin, M.C.5    Zou, B.6    Lam, S.K.7    Chan, A.O.8    Yuen, M.F.9    Kung, H.F.10
  • 199
    • 84904605103 scopus 로고    scopus 로고
    • Antiproliferative effects of celecoxib in Hep-2 cells through telomerase inhibition and induction of apoptosis
    • [CrossRef] [PubMed]
    • Zhao, Y.-Q, Feng, H.-W, Jia, T, Chen, X.-M, Zhang, H, Xu, A.-T, Zhang, H.L, Fan, X.-L. Antiproliferative effects of celecoxib in Hep-2 cells through telomerase inhibition and induction of apoptosis. Asian Pac. J. Cancer Prev. 2014, 15, 4919-4923. [CrossRef] [PubMed]
    • (2014) Asian Pac. J. Cancer Prev , vol.15 , pp. 4919-4923
    • Zhao, Y.-Q.1    Feng, H.-W.2    Jia, T.3    Chen, X.-M.4    Zhang, H.5    Xu, A.-T.6    Zhang, H.L.7    Fan, X.-L.8
  • 200
    • 84979266188 scopus 로고    scopus 로고
    • Troglitazone suppresses telomerase activity independently of PPARgamma in estrogen-receptor negative breast cancer cells
    • [CrossRef]
    • Rashid-Kolvear, F, Taboski, M.A, Nguyen, J, Wang, D.Y, Harrington, L.A, Done, S.J. Troglitazone suppresses telomerase activity independently of PPARgamma in estrogen-receptor negative breast cancer cells. BMC Cancer 2011. [CrossRef]
    • (2011) BMC Cancer
    • Rashid-Kolvear, F.1    Taboski, M.A.2    Nguyen, J.3    Wang, D.Y.4    Harrington, L.A.5    Done, S.J.6
  • 202
    • 80053207760 scopus 로고    scopus 로고
    • Vorinostat, SAHA, represses telomerase activity via epigenetic regulation of telomerase reverse transcriptase in non-small cell lung cancer cells
    • [CrossRef] [PubMed]
    • Li, C.T, Hsiao, Y.M, Wu, T.C, Lin, Y.W, Yeh, K.T, Ko, J.L. Vorinostat, SAHA, represses telomerase activity via epigenetic regulation of telomerase reverse transcriptase in non-small cell lung cancer cells. J. Cell Biochem. 2011, 112, 3044-3053. [CrossRef] [PubMed]
    • (2011) J. Cell Biochem , vol.112 , pp. 3044-3053
    • Li, C.T.1    Hsiao, Y.M.2    Wu, T.C.3    Lin, Y.W.4    Yeh, K.T.5    Ko, J.L.6
  • 203
    • 41549098401 scopus 로고    scopus 로고
    • Antiproliferative effect of rapamycin on human T-cell leukemia cell line Jurkat by cell cycle arrest and telomerase inhibition
    • [CrossRef] [PubMed]
    • Zhao, Y.M, Zhou, Q, Xu, Y, Lai, X.Y, Huang, H. Antiproliferative effect of rapamycin on human T-cell leukemia cell line Jurkat by cell cycle arrest and telomerase inhibition. Acta Pharmacol. Sin. 2008, 29, 481-488. [CrossRef] [PubMed]
    • (2008) Acta Pharmacol. Sin , vol.29 , pp. 481-488
    • Zhao, Y.M.1    Zhou, Q.2    Xu, Y.3    Lai, X.Y.4    Huang, H.5
  • 204
    • 22844452668 scopus 로고    scopus 로고
    • Growth inhibition of A549 human lung carcinoma cells by beta-lapachone through induction of apoptosis and inhibition of telomerase activity
    • [PubMed]
    • Woo, H.J, Choi, Y.H. Growth inhibition of A549 human lung carcinoma cells by beta-lapachone through induction of apoptosis and inhibition of telomerase activity. Int. J. Oncol. 2005, 26, 1017-1023. [PubMed]
    • (2005) Int. J. Oncol. , vol.26 , pp. 1017-1023
    • Woo, H.J.1    Choi, Y.H.2
  • 205
    • 0030993152 scopus 로고    scopus 로고
    • Inhibition of telomerase activity by cisplatin in human testicular cancer cells
    • [CrossRef]
    • Burger, A.M, Double, J.A, Newell, D.R. Inhibition of telomerase activity by cisplatin in human testicular cancer cells. Eur. J. Cancer 1997, 33, 638-644. [CrossRef]
    • (1997) Eur. J. Cancer , vol.33 , pp. 638-644
    • Burger, A.M.1    Double, J.A.2    Newell, D.R.3
  • 206
    • 0042913095 scopus 로고    scopus 로고
    • Melatonin inhibits telomerase activity in the MCF-7 tumor cell line both in vivo and in vitro
    • [CrossRef] [PubMed]
    • Leon-Blanco, M.M, Guerrero, J.M, Reiter, R.J, Calvo, J.R, Pozo, D. Melatonin inhibits telomerase activity in the MCF-7 tumor cell line both in vivo and in vitro. J. Pineal. Res. 2003, 35, 204-211. [CrossRef] [PubMed]
    • (2003) J. Pineal. Res. , vol.35 , pp. 204-211
    • Leon-Blanco, M.M.1    Guerrero, J.M.2    Reiter, R.J.3    Calvo, J.R.4    Pozo, D.5
  • 208
    • 3543017329 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibitor nimesulide suppresses telomerase activity by blocking Akt/PKB activation in gastric cancer cell line
    • [CrossRef] [PubMed]
    • Baoping, Y, Guoyong, H, Jieping, Y, Zongxue, R, Hesheng, L. Cyclooxygenase-2 inhibitor nimesulide suppresses telomerase activity by blocking Akt/PKB activation in gastric cancer cell line. Dig. Dis. Sci. 2004, 49, 948-953. [CrossRef] [PubMed]
    • (2004) Dig. Dis. Sci , vol.49 , pp. 948-953
    • Baoping, Y.1    Guoyong, H.2    Jieping, Y.3    Zongxue, R.4    Hesheng, L.5
  • 209
    • 84874742657 scopus 로고    scopus 로고
    • Antiproliferative effect of gold (I) compound auranofin through inhibition of STAT3 and telomerase activity in MDA-MB 231 human breast cancer cells
    • [CrossRef] [PubMed]
    • Kim, N.-H, Park, H.J, Oh, M.-K, Kim, I.-S. Antiproliferative effect of gold (I) compound auranofin through inhibition of STAT3 and telomerase activity in MDA-MB 231 human breast cancer cells. BMB Rep. 2013, 46, 59-64. [CrossRef] [PubMed]
    • (2013) BMB Rep , vol.46 , pp. 59-64
    • Kim, N.-H.1    Park, H.J.2    Oh, M.-K.3    Kim, I.-S.4
  • 211
    • 1542649544 scopus 로고    scopus 로고
    • Telomerase inhibition using azidothymidine in the HT-29 colon cancer cell line
    • [CrossRef] [PubMed]
    • Brown, T, Sigurdson, E, Rogatko, A, Broccoli, D. Telomerase inhibition using azidothymidine in the HT-29 colon cancer cell line. Ann. Surg. Oncol. 2003, 10, 910-915. [CrossRef] [PubMed]
    • (2003) Ann. Surg. Oncol , vol.10 , pp. 910-915
    • Brown, T.1    Sigurdson, E.2    Rogatko, A.3    Broccoli, D.4
  • 212
    • 0142151220 scopus 로고    scopus 로고
    • Antiproliferative effect of octreotide on gastric cancer cells mediated by inhibition of Akt/PKB and telomerase
    • [CrossRef] [PubMed]
    • Gao, S, Yu, B.P, Li, Y, Dong, W.G, Luo, H.S. Antiproliferative effect of octreotide on gastric cancer cells mediated by inhibition of Akt/PKB and telomerase. World J. Gastroenterol. 2003, 9, 2362-2365. [CrossRef] [PubMed]
    • (2003) World J. Gastroenterol , vol.9 , pp. 2362-2365
    • Gao, S.1    Yu, B.P.2    Li, Y.3    Dong, W.G.4    Luo, H.S.5
  • 213
    • 0030668587 scopus 로고    scopus 로고
    • New quinolones, ofloxacin and levofloxacin, inhibit telomerase activity in transitional cell carcinoma cell lines
    • [CrossRef]
    • Yamakuchi, M, Nakata, M, Kawahara, K, Kitajima, I, Maruyama, I. New quinolones, ofloxacin and levofloxacin, inhibit telomerase activity in transitional cell carcinoma cell lines. Cancer Lett. 1997, 119, 213-219. [CrossRef]
    • (1997) Cancer Lett , vol.119 , pp. 213-219
    • Yamakuchi, M.1    Nakata, M.2    Kawahara, K.3    Kitajima, I.4    Maruyama, I.5
  • 214
    • 84862912035 scopus 로고    scopus 로고
    • Recognize three different human telomeric G-quadruplex conformations by quinacrine
    • [CrossRef] [PubMed]
    • Sun, H, Xiang, J, Li, Q, Liu, Y, Li, L, Shang, Q, Xu, G, Tang, Y. Recognize three different human telomeric G-quadruplex conformations by quinacrine. Analyst 2012, 137, 862-867. [CrossRef] [PubMed]
    • (2012) Analyst , vol.137 , pp. 862-867
    • Sun, H.1    Xiang, J.2    Li, Q.3    Liu, Y.4    Li, L.5    Shang, Q.6    Xu, G.7    Tang, Y.8
  • 215
    • 84947785855 scopus 로고    scopus 로고
    • Bortezomibmediated down-regulation of telomerase and disruption of telomere homeostasis contributes to apoptosis of malignant cells
    • [PubMed]
    • Ci, X, Li, B, Ma, X, Kong, F, Zheng, C, Björkholm, M, Jia, J, Xu, D. Bortezomibmediated down-regulation of telomerase and disruption of telomere homeostasis contributes to apoptosis of malignant cells. Oncotarget 2015, 6, 38079-38092. [PubMed]
    • (2015) Oncotarget , vol.6 , pp. 38079-38092
    • Ci, X.1    Li, B.2    Ma, X.3    Kong, F.4    Zheng, C.5    Björkholm, M.6    Jia, J.7    Xu, D.8
  • 216
    • 84877131726 scopus 로고    scopus 로고
    • Gene expression levels of human shelterin complex and shelterin-associated factors regulated by the topoisomerase II inhibitors doxorubicin and etoposide in human cultured cells
    • [CrossRef] [PubMed]
    • Kato, M, Nakayama, M, Agata, M, Yoshida, K. Gene expression levels of human shelterin complex and shelterin-associated factors regulated by the topoisomerase II inhibitors doxorubicin and etoposide in human cultured cells. Tumour Biol. 2013, 34, 723-733. [CrossRef] [PubMed]
    • (2013) Tumour Biol , vol.34 , pp. 723-733
    • Kato, M.1    Nakayama, M.2    Agata, M.3    Yoshida, K.4
  • 217
    • 84855343604 scopus 로고    scopus 로고
    • Anthracyclines disrupt telomere maintenance by telomerase through inducing PinX1 ubiquitination and degradation
    • [CrossRef] [PubMed]
    • Zhang, B, Qian, D, Ma, H.H, Jin, R, Yang, P.X, Cai, M.Y, Liu, Y.H, Liao, Y.J, Deng, H.X, Mai, S.J, et al. Anthracyclines disrupt telomere maintenance by telomerase through inducing PinX1 ubiquitination and degradation. Oncogene 2012, 31, 1-12. [CrossRef] [PubMed]
    • (2012) Oncogene , vol.31 , pp. 1-12
    • Zhang, B.1    Qian, D.2    Ma, H.H.3    Jin, R.4    Yang, P.X.5    Cai, M.Y.6    Liu, Y.H.7    Liao, Y.J.8    Deng, H.X.9    Mai, S.J.10
  • 218
    • 35648999534 scopus 로고    scopus 로고
    • Recent advances on cancer stem/progenitor cell research: Therapeutic implications for overcoming resistance to the most aggressive cancers
    • [CrossRef] [PubMed]
    • Mimeault, M, Hauke, R, Mehta, P.P, Batra, S.K. Recent advances on cancer stem/progenitor cell research: Therapeutic implications for overcoming resistance to the most aggressive cancers. J. Mol. Cell Med. 2007, 11, 981-1011. [CrossRef] [PubMed]
    • (2007) J. Mol. Cell Med , vol.11 , pp. 981-1011
    • Mimeault, M.1    Hauke, R.2    Mehta, P.P.3    Batra, S.K.4
  • 219
    • 58149232517 scopus 로고    scopus 로고
    • Recent advances on the development of novel anti-cancer drugs targeting cancer stem/progenitor cells
    • [CrossRef]
    • Mimeault, M, Batra, S.K. Recent advances on the development of novel anti-cancer drugs targeting cancer stem/progenitor cells. Drug Dev. Res. 2008, 69, 415-430. [CrossRef]
    • (2008) Drug Dev. Res , vol.69 , pp. 415-430
    • Mimeault, M.1    Batra, S.K.2
  • 220
    • 35348872467 scopus 로고    scopus 로고
    • Novel Hedgehog pathway targets against basal cell carcinoma
    • [CrossRef] [PubMed]
    • Tang, J.Y, So, P.L, Epstein, E.H., Jr. Novel Hedgehog pathway targets against basal cell carcinoma. Toxicol. Appl. Pharmacol. 2006, 224, 257-264. [CrossRef] [PubMed]
    • (2006) Toxicol. Appl. Pharmacol , vol.224 , pp. 257-264
    • Tang, J.Y.1    So, P.L.2    Epstein, E.H.3
  • 221
    • 58149288674 scopus 로고    scopus 로고
    • UV-induced EGFR signal transactivation is dependent on proligand shedding by activated metalloproteases in skin cancer cell lines
    • [CrossRef] [PubMed]
    • Singh, B, Schneider, M, Knyazev, P, Ullrich, A. UV-induced EGFR signal transactivation is dependent on proligand shedding by activated metalloproteases in skin cancer cell lines. Int. J. Cancer 2009, 124, 531-539. [CrossRef] [PubMed]
    • (2009) Int. J. Cancer , vol.124 , pp. 531-539
    • Singh, B.1    Schneider, M.2    Knyazev, P.3    Ullrich, A.4
  • 222
    • 34347226348 scopus 로고    scopus 로고
    • Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways
    • [CrossRef] [PubMed]
    • Stecca, B, Mas, C, Clement, V, Zbinden, M, Correa, R, Piguet, V, Beermann, F, Ruiz, I, Altaba, A. Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways. Proc. Natl. Acad. Sci. USA 2007, 104, 5895-5900. [CrossRef] [PubMed]
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 5895-5900
    • Stecca, B.1    Mas, C.2    Clement, V.3    Zbinden, M.4    Correa, R.5    Piguet, V.6    Beermann, F.7    Ruiz, I.8    Altaba, A.9
  • 224
    • 47149112001 scopus 로고    scopus 로고
    • Telomere maintenance and human bone marrow failure
    • [CrossRef] [PubMed]
    • Calado, R.T, Young, N.S. Telomere maintenance and human bone marrow failure. Blood 2008, 111, 4446-4455. [CrossRef] [PubMed]
    • (2008) Blood , vol.111 , pp. 4446-4455
    • Calado, R.T.1    Young, N.S.2
  • 225
    • 41649085578 scopus 로고    scopus 로고
    • Upregulated ATM gene expression and activated DNA crosslink-induced damage response checkpoint in Fanconi anemia: Implications for carcinogenesis
    • [CrossRef] [PubMed]
    • Yamamoto, K, Nihrane, A, Aglipay, J, Sironi, J, Arkin, S, Lipton, J.M, Ouchi, T, Liu, J.M. Upregulated ATM gene expression and activated DNA crosslink-induced damage response checkpoint in Fanconi anemia: Implications for carcinogenesis. Mol. Med. 2008, 14, 167-174. [CrossRef] [PubMed]
    • (2008) Mol. Med , vol.14 , pp. 167-174
    • Yamamoto, K.1    Nihrane, A.2    Aglipay, J.3    Sironi, J.4    Arkin, S.5    Lipton, J.M.6    Ouchi, T.7    Liu, J.M.8
  • 226
    • 42049090788 scopus 로고    scopus 로고
    • Gone with the Wnt/Notch: Stem cells in laminopathies, progeria, and aging
    • [CrossRef] [PubMed]
    • Meshorer, E, Gruenbaum, Y. Gone with the Wnt/Notch: Stem cells in laminopathies, progeria, and aging. J. Cell Biol. 2008, 181, 9-13. [CrossRef] [PubMed]
    • (2008) J. Cell Biol , vol.181 , pp. 9-13
    • Meshorer, E.1    Gruenbaum, Y.2
  • 227
    • 43149124203 scopus 로고    scopus 로고
    • Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing
    • [CrossRef] [PubMed]
    • Scaffidi, P, Misteli, T. Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing. Nat. Cell Biol. 2008, 10, 452-459. [CrossRef] [PubMed]
    • (2008) Nat. Cell Biol , vol.10 , pp. 452-459
    • Scaffidi, P.1    Misteli, T.2
  • 228
    • 47749117475 scopus 로고    scopus 로고
    • Nucleotide excision repair and related human diseases
    • [PubMed]
    • Bergoglio, V, Magnaldo, T. Nucleotide excision repair and related human diseases. Genome Dyn. 2006, 1, 35-52. [PubMed]
    • (2006) Genome Dyn , vol.1 , pp. 35-52
    • Bergoglio, V.1    Magnaldo, T.2
  • 229
    • 68249131322 scopus 로고    scopus 로고
    • Genetic dissection of the mechanisms underlying telomereassociated diseases: Impact of the TRF2 telomeric protein on mouse epidermal stem cells
    • [CrossRef] [PubMed]
    • Stout, G.J, Blasco, M.A. Genetic dissection of the mechanisms underlying telomereassociated diseases: Impact of the TRF2 telomeric protein on mouse epidermal stem cells. Dis. Model Mech. 2009, 2, 139-156. [CrossRef] [PubMed]
    • (2009) Dis. Model Mech , vol.2 , pp. 139-156
    • Stout, G.J.1    Blasco, M.A.2
  • 230
    • 42149185640 scopus 로고    scopus 로고
    • Telomeres and aging
    • [CrossRef] [PubMed]
    • Aubert, G, Lansdorp, P.M. Telomeres and aging. Physiol. Rev. 2008, 88, 557-579. [CrossRef] [PubMed]
    • (2008) Physiol. Rev , vol.88 , pp. 557-579
    • Aubert, G.1    Lansdorp, P.M.2
  • 231
    • 18044373421 scopus 로고    scopus 로고
    • Dyskeratosis congenital—A disease of dysfunctional telomere maintenance
    • [CrossRef] [PubMed]
    • Mason, P.J, Wilson, D.B, Bessler, M. Dyskeratosis congenital—A disease of dysfunctional telomere maintenance. Curr. Mol. Med. 2005, 5, 159-170. [CrossRef] [PubMed]
    • (2005) Curr. Mol. Med , vol.5 , pp. 159-170
    • Mason, P.J.1    Wilson, D.B.2    Bessler, M.3
  • 232
    • 38049024575 scopus 로고    scopus 로고
    • The role of DNA damage repair in aging of adult stem cells
    • [CrossRef] [PubMed]
    • Kenyon, J, Gerson, S.L. The role of DNA damage repair in aging of adult stem cells. Nucleic Acids Res. 2007, 35, 7557-7565. [CrossRef] [PubMed]
    • (2007) Nucleic Acids Res , vol.35 , pp. 7557-7565
    • Kenyon, J.1    Gerson, S.L.2
  • 234
    • 51049112962 scopus 로고    scopus 로고
    • Defective transcription/repair factor IIH recruitment to specific UV lesions in trichothiodystrophy syndrome
    • [CrossRef] [PubMed]
    • Chigancas, V, Lima-Bessa, K.M, Stary, A, Menck, C.F, Sarasin, A. Defective transcription/repair factor IIH recruitment to specific UV lesions in trichothiodystrophy syndrome. Cancer Res. 2008, 68, 6074-6083. [CrossRef] [PubMed]
    • (2008) Cancer Res , vol.68 , pp. 6074-6083
    • Chigancas, V.1    Lima-Bessa, K.M.2    Stary, A.3    Menck, C.F.4    Sarasin, A.5
  • 235
    • 0242490106 scopus 로고    scopus 로고
    • Inhibition of the epidermal growth factor receptor suppresses telomerase activity in HSC-1 human cutaneous squamous cell carcinoma cells
    • [CrossRef] [PubMed]
    • Budiyanto, A, Bito, T, Kunisada, M, Ashida, M, Ichihashi, M, Ueda, M. Inhibition of the epidermal growth factor receptor suppresses telomerase activity in HSC-1 human cutaneous squamous cell carcinoma cells. J. Invest. Dermatol. 2003, 121, 1088-1094. [CrossRef] [PubMed]
    • (2003) J. Invest. Dermatol , vol.121 , pp. 1088-1094
    • Budiyanto, A.1    Bito, T.2    Kunisada, M.3    Ashida, M.4    Ichihashi, M.5    Ueda, M.6
  • 237
    • 33745962138 scopus 로고    scopus 로고
    • Therapeutic potential of resveratrol: The in vivo evidence
    • [CrossRef] [PubMed]
    • Baur, J.A, Sinclair, D.A. Therapeutic potential of resveratrol: The in vivo evidence. Nat. Rev. Drug Discov. 2006, 5, 493-506. [CrossRef] [PubMed]
    • (2006) Nat. Rev. Drug Discov , vol.5 , pp. 493-506
    • Baur, J.A.1    Sinclair, D.A.2
  • 239
    • 77955845914 scopus 로고    scopus 로고
    • Telomeres and telomerase in normal and cancer stem cells
    • [CrossRef] [PubMed]
    • Shay, J.W, Wright, W.E. Telomeres and telomerase in normal and cancer stem cells. FEBS Lett. 2010, 584, 3819-3825. [CrossRef] [PubMed]
    • (2010) FEBS Lett , vol.584 , pp. 3819-3825
    • Shay, J.W.1    Wright, W.E.2
  • 243
    • 33745712849 scopus 로고    scopus 로고
    • The power and the promise of oncogene-induced senescence markers
    • [CrossRef] [PubMed]
    • Collado, M, Serrano, M. The power and the promise of oncogene-induced senescence markers. Nat. Rev. Cancer 2006, 6, 472-476. [CrossRef] [PubMed]
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 472-476
    • Collado, M.1    Serrano, M.2
  • 244
  • 247
    • 0037086268 scopus 로고    scopus 로고
    • DNA damage is able to induce senescence in tumor cells in vitro and in vivo
    • [PubMed]
    • Te Poele, R.H, Okorokov, A.L, Jardine, L, Cummings, J, Joel, S.P. DNA damage is able to induce senescence in tumor cells in vitro and in vivo. Cancer Res. 2002, 62, 1876-1883. [PubMed]
    • (2002) Cancer Res , vol.62 , pp. 1876-1883
    • Te Poele, R.H.1    Okorokov, A.L.2    Jardine, L.3    Cummings, J.4    Joel, S.P.5
  • 248
    • 0034978564 scopus 로고    scopus 로고
    • Telomere dysfunction and evolution of intestinal carcinoma in mice and humans
    • [CrossRef] [PubMed]
    • Rudolph, K.L, Millard, M, Bosenberg, M.W, DePinho, R.A. Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nat. Genet. 2001, 28, 155-159. [CrossRef] [PubMed]
    • (2001) Nat. Genet , vol.28 , pp. 155-159
    • Rudolph, K.L.1    Millard, M.2    Bosenberg, M.W.3    Depinho, R.A.4
  • 249
    • 0033553516 scopus 로고    scopus 로고
    • P53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
    • [CrossRef]
    • Chin, L, Artandi, S.E, Shen, Q, Tam, A, Lee, S.-L, Gottlieb, G.J, Greider, C.W, DePinho, R.A. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell 1999, 97, 527-538. [CrossRef]
    • (1999) Cell , vol.97 , pp. 527-538
    • Chin, L.1    Artandi, S.E.2    Shen, Q.3    Tam, A.4    Lee, S.-L.5    Gottlieb, G.J.6    Greider, C.W.7    Depinho, R.A.8
  • 250
    • 0034632717 scopus 로고    scopus 로고
    • Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
    • [PubMed]
    • Artandi, S.E, Chang, S, Lee, S.L, Alson, S, Gottlieb, G.J, Chin, L, DePinho, R.A. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature 2000, 406, 641-645. [PubMed]
    • (2000) Nature , vol.406 , pp. 641-645
    • Artandi, S.E.1    Chang, S.2    Lee, S.L.3    Alson, S.4    Gottlieb, G.J.5    Chin, L.6    Depinho, R.A.7
  • 252
    • 0035252089 scopus 로고    scopus 로고
    • Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes
    • [CrossRef] [PubMed]
    • Romanov, S.R, Kozakiewicz, B.K, Holst, C.R, Stampfer, M.R, Haupt, L.M, Tlsty, T.D. Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes. Nature 2001, 409, 633-637. [CrossRef] [PubMed]
    • (2001) Nature , vol.409 , pp. 633-637
    • Romanov, S.R.1    Kozakiewicz, B.K.2    Holst, C.R.3    Stampfer, M.R.4    Haupt, L.M.5    Tlsty, T.D.6
  • 255
    • 22944488871 scopus 로고    scopus 로고
    • Telomeres and human disease: Ageing, cancer and beyond
    • [CrossRef] [PubMed]
    • Blasco, M.A. Telomeres and human disease: Ageing, cancer and beyond. Nat. Rev. Genet. 2005, 6, 611-622. [CrossRef] [PubMed]
    • (2005) Nat. Rev. Genet , vol.6 , pp. 611-622
    • Blasco, M.A.1
  • 256
    • 16444367180 scopus 로고    scopus 로고
    • Antagonistic effects of telomerase on cancer and aging in K5-mTert transgenic mice
    • [CrossRef] [PubMed]
    • Gonzalez-Suarez, E, Geserick, C, Flores, J.M, Blasco, M.A. Antagonistic effects of telomerase on cancer and aging in K5-mTert transgenic mice. Oncogene 2005, 24, 2256-2270. [CrossRef] [PubMed]
    • (2005) Oncogene , vol.24 , pp. 2256-2270
    • Gonzalez-Suarez, E.1    Geserick, C.2    Flores, J.M.3    Blasco, M.A.4
  • 257
    • 84864823834 scopus 로고    scopus 로고
    • Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer
    • [CrossRef] [PubMed]
    • Bernardes de Jesus, B, Vera, E, Schneeberger, K, Tejera, A.M, Ayuso, E, Bosch, F, Blasco, M.A. Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer. EMBO Mol. Med. 2012, 4, 691-704. [CrossRef] [PubMed]
    • (2012) EMBO Mol. Med , vol.4 , pp. 691-704
    • Bernardes De Jesus, B.1    Vera, E.2    Schneeberger, K.3    Tejera, A.M.4    Ayuso, E.5    Bosch, F.6    Blasco, M.A.7


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