-
1
-
-
0029096515
-
The RNA component of human telomerase
-
Feng, J., Funk, W. D., Wang, S-S., Weinrich, S. L., Avilion, A. A., Chiu, C-P., Adams, R. R., Chang, E., Yu, J., Le, S., West, M. D., Harley, C. B., Andrews, W. H., Greider, C. W., and Villeponteau, B. The RNA component of human telomerase. Science (Wash. DC), 269: 1236-1241, 1995.
-
(1995)
Science (Wash. DC)
, vol.269
, pp. 1236-1241
-
-
Feng, J.1
Funk, W.D.2
Wang, S.-S.3
Weinrich, S.L.4
Avilion, A.A.5
Chiu, C.-P.6
Adams, R.R.7
Chang, E.8
Yu, J.9
Le, S.10
West, M.D.11
Harley, C.B.12
Andrews, W.H.13
Greider, C.W.14
Villeponteau, B.15
-
2
-
-
0030819894
-
Telomerase catalytic subunit homologs from fission yeast and human
-
Nakamura, T. M., Morin, G. B., Chapman, K. B., Weinrich, S. L., Andrews, W. H., Lingner, J., Harley, C. B., and Cech, T. R. Telomerase catalytic subunit homologs from fission yeast and human. Science (Wash. DC), 277: 911-912, 1997.
-
(1997)
Science (Wash. DC)
, vol.277
, pp. 911-912
-
-
Nakamura, T.M.1
Morin, G.B.2
Chapman, K.B.3
Weinrich, S.L.4
Andrews, W.H.5
Lingner, J.6
Harley, C.B.7
Cech, T.R.8
-
3
-
-
0032566005
-
Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA
-
Kondo, S., Kondo, Y., Li, G., Silverman, R. H., and Cowell, J. K. Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA. Oncogene, 16: 3323-3330, 1998.
-
(1998)
Oncogene
, vol.16
, pp. 3323-3330
-
-
Kondo, S.1
Kondo, Y.2
Li, G.3
Silverman, R.H.4
Cowell, J.K.5
-
4
-
-
0035300424
-
Ribozyme cleavage of telomerase mRNA sensitizes breast epithelial cells to inhibitors of topoisomerase
-
Ludwig, A., Saretzki, G., Holm, P. S., Tiemann, F., Lorenz, M., Emrich, T., Harley, C. B., and von Zglinicki, T. Ribozyme cleavage of telomerase mRNA sensitizes breast epithelial cells to inhibitors of topoisomerase. Cancer Res., 61: 3053-3061, 2001.
-
(2001)
Cancer Res.
, vol.61
, pp. 3053-3061
-
-
Ludwig, A.1
Saretzki, G.2
Holm, P.S.3
Tiemann, F.4
Lorenz, M.5
Emrich, T.6
Harley, C.B.7
Von Zglinicki, T.8
-
5
-
-
0028564951
-
Specific association of human telomerase activity with immortal cells and cancer
-
Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., and Shay, J. W. Specific association of human telomerase activity with immortal cells and cancer. Science (Wash. DC), 266: 2011-2015, 1994.
-
(1994)
Science (Wash. DC)
, vol.266
, pp. 2011-2015
-
-
Kim, N.W.1
Piatyszek, M.A.2
Prowse, K.R.3
Harley, C.B.4
West, M.D.5
Ho, P.L.C.6
Coviello, G.M.7
Wright, W.E.8
Weinrich, S.L.9
Shay, J.W.10
-
6
-
-
0037148328
-
Telomerase is not an oncogene
-
Harley, C. B. Telomerase is not an oncogene. Oncogene, 21: 494-502, 2002.
-
(2002)
Oncogene
, vol.21
, pp. 494-502
-
-
Harley, C.B.1
-
7
-
-
0028262113
-
Telomerase activity in human ovarian carcinoma
-
Counter, C. M., Hirte, H. W., Bacchetti, S., and Harley, C. B. Telomerase activity in human ovarian carcinoma. Proc. Natl. Acad. Sci. USA, 91: 2900-2904, 1994.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 2900-2904
-
-
Counter, C.M.1
Hirte, H.W.2
Bacchetti, S.3
Harley, C.B.4
-
8
-
-
0037148334
-
Telomeres and telomerase in hematologic neoplasia
-
Ohyashiki, J. H., Sashida, G., Tauchi, T., and Ohyashiki, K. Telomeres and telomerase in hematologic neoplasia. Oncogene, 21: 680-687, 2002.
-
(2002)
Oncogene
, vol.21
, pp. 680-687
-
-
Ohyashiki, J.H.1
Sashida, G.2
Tauchi, T.3
Ohyashiki, K.4
-
9
-
-
0032547230
-
Telomerase inhibition, telomere shortening, and senescence of cancer cells by tea catechins
-
Naasani, I., Seimiya, H., and Tsuruo, T. Telomerase inhibition, telomere shortening, and senescence of cancer cells by tea catechins. Biochem. Biophys. Res. Comm, 249: 391-396, 1998.
-
(1998)
Biochem. Biophys. Res. Comm.
, vol.249
, pp. 391-396
-
-
Naasani, I.1
Seimiya, H.2
Tsuruo, T.3
-
10
-
-
4243937106
-
A highly selective telomerase inhibitor limiting human cancer cell proliferation
-
Damm, K., Hemmann, U., Garin-Chesa, P., Hauel, N., Kauffmann, I., Priepke, H., Niestroj, C., Daiber, C., Enenkel, B., and Guilliard, B. A highly selective telomerase inhibitor limiting human cancer cell proliferation. EMBO J., 20: 6958-6968, 2001.
-
(2001)
EMBO J.
, vol.20
, pp. 6958-6968
-
-
Damm, K.1
Hemmann, U.2
Garin-Chesa, P.3
Hauel, N.4
Kauffmann, I.5
Priepke, H.6
Niestroj, C.7
Daiber, C.8
Enenkel, B.9
Guilliard, B.10
-
11
-
-
0033566694
-
J.5002: A potent telomerase inhibitor identified by exploiting the disease-oriented screening program with COMPARE analysis
-
Naasani, I., Seimiya, H., Yamori, T., and Tsuruo, T. F. J.5002: a potent telomerase inhibitor identified by exploiting the disease-oriented screening program with COMPARE analysis. Cancer Res., 59: 4004-4011, 1999.
-
(1999)
Cancer Res.
, vol.59
, pp. 4004-4011
-
-
Naasani, I.1
Seimiya, H.2
Yamori, T.3
Tsuruo, T.F.4
-
12
-
-
0033566941
-
5, 6- Trans-16-ene-vitamin D3: A new class of potent inhibitors of proliferation of prostate, breast, and myeloid leukemic cells
-
Hisatake, J., Kubota, T., Hisatake, Y., Uskokovic, M., Tomoyasu, S., and Koeffler, H. P. 5, 6- trans-16-ene-vitamin D3: a new class of potent inhibitors of proliferation of prostate, breast, and myeloid leukemic cells. Cancer Res, 59: 4023-4029, 1999.
-
(1999)
Cancer Res.
, vol.59
, pp. 4023-4029
-
-
Hisatake, J.1
Kubota, T.2
Hisatake, Y.3
Uskokovic, M.4
Tomoyasu, S.5
Koeffler, H.P.6
-
13
-
-
0034018083
-
Structure-activity relationships among guanine-quadruplex telomerase inhibitors
-
Neidle, S., Harrison, R. J., Reszka, A. P., and Read, M. A. Structure-activity relationships among guanine-quadruplex telomerase inhibitors. Pharmacol. Ther., 85: 133-139, 2000.
-
(2000)
Pharmacol. Ther.
, vol.85
, pp. 133-139
-
-
Neidle, S.1
Harrison, R.J.2
Reszka, A.P.3
Read, M.A.4
-
14
-
-
0034064858
-
G-quadruplexes as targets for drug design
-
Hurley, L. H., Wheelhouse, R. T., Sun, D., Kerwin, S. M., Salazar, M., Fedoroff, O. Yu Han, F. X., Han, H., Izbicka, E., and Von Hoff, D. D. G-quadruplexes as targets for drug design. Pharmacol. Ther., 85: 141-158, 2000.
-
(2000)
Pharmacol. Ther.
, vol.85
, pp. 141-158
-
-
Hurley, L.H.1
Wheelhouse, R.T.2
Sun, D.3
Kerwin, S.M.4
Salazar, M.5
Fedoroff, O.6
Yu Han, F.X.7
Han, H.8
Izbicka, E.9
Von Hoff, D.D.10
-
15
-
-
0032828652
-
Inhibition of telomerase limits the growth of human cancer cells
-
Hahn, W. C., Stewart, S. A., Brooks, M. W., York, S. G., Eaton, E., Kurachi, A., Beijersbergen, R. L., Knoll, J. H. M., Meyerson, M., and Weinberg, R. A. Inhibition of telomerase limits the growth of human cancer cells. Nat. Med., 5: 1164-1170, 1999.
-
(1999)
Nat. Med.
, vol.5
, pp. 1164-1170
-
-
Hahn, W.C.1
Stewart, S.A.2
Brooks, M.W.3
York, S.G.4
Eaton, E.5
Kurachi, A.6
Beijersbergen, R.L.7
Knoll, J.H.M.8
Meyerson, M.9
Weinberg, R.A.10
-
16
-
-
0032551733
-
Inhibition of telomerase activity of melanoma cells in vitro by antisense oligonucleotides
-
Glukhov, A. I., Zimnik, O. V., Gordeev, S. A., and Severin, S. E. Inhibition of telomerase activity of melanoma cells in vitro by antisense oligonucleotides. Biochem. Biophys. Res. Comm., 248: 368-371, 1998.
-
(1998)
Biochem. Biophys. Res. Comm.
, vol.248
, pp. 368-371
-
-
Glukhov, A.I.1
Zimnik, O.V.2
Gordeev, S.A.3
Severin, S.E.4
-
17
-
-
0034662616
-
2-5A antisense telomerase RNA therapy for intracranial malignant gliomas
-
Mukai, S., Kondo, Y., Koga, S., Komata, T., Barna, B. P., and Kondo, S. 2-5A antisense telomerase RNA therapy for intracranial malignant gliomas. Cancer Res., 60: 4461-4467, 2000.
-
(2000)
Cancer Res.
, vol.60
, pp. 4461-4467
-
-
Mukai, S.1
Kondo, Y.2
Koga, S.3
Komata, T.4
Barna, B.P.5
Kondo, S.6
-
18
-
-
0029867408
-
Inhibition of human telomerase activity by peptide nucleic acids
-
Norton, J. C., Piatyszek, M. A., Wright, W. E., Shay, J. W., and Corey, D. R. Inhibition of human telomerase activity by peptide nucleic acids. Nat. Biotechnol., 14: 615-619, 1996.
-
(1996)
Nat. Biotechnol.
, vol.14
, pp. 615-619
-
-
Norton, J.C.1
Piatyszek, M.A.2
Wright, W.E.3
Shay, J.W.4
Corey, D.R.5
-
19
-
-
0033557230
-
Telomerase protein rather than its RNA is the target of phosphorothioate-modified oligonucleotides
-
Matthes, E., and Lehmann, C. Telomerase protein rather than its RNA is the target of phosphorothioate-modified oligonucleotides. Nucleic Acids Res., 27: 1152-1158, 1999.
-
(1999)
Nucleic Acids Res.
, vol.27
, pp. 1152-1158
-
-
Matthes, E.1
Lehmann, C.2
-
20
-
-
0032578525
-
Inhibition of human telomerase by 2′-O-methyl-RNA
-
Pitts, A. E., and Corey, D. R. Inhibition of human telomerase by 2′-O-methyl-RNA. Proc. Natl. Acad. Sci. USA, 95: 11549-11554, 1998.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 11549-11554
-
-
Pitts, A.E.1
Corey, D.R.2
-
21
-
-
0035870755
-
Inhibition of telomerase by 2′-O-(2-methoxyethyl) RNA oligomers: Effect of length, phosphorothioate substitution and time inside cells
-
Elayadi, A. N., Demieville, A., Wancewicz, E. V., Monia, B. P., and Corey, D. R. Inhibition of telomerase by 2′-O-(2-methoxyethyl) RNA oligomers: effect of length, phosphorothioate substitution and time inside cells. Nucleic Acids Res., 29: 1683-1689, 2001.
-
(2001)
Nucleic Acids Res.
, vol.29
, pp. 1683-1689
-
-
Elayadi, A.N.1
Demieville, A.2
Wancewicz, E.V.3
Monia, B.P.4
Corey, D.R.5
-
22
-
-
0031686224
-
Synthetic 2′-O-methyl-modified hammerhead ribozymes targeted to the RNA component of telomerase as sequence-specific inhibitors of telomerase activity
-
Wan, M. S. K., Fell, P. L., and Akhtar, S. Synthetic 2′-O-methyl-modified hammerhead ribozymes targeted to the RNA component of telomerase as sequence-specific inhibitors of telomerase activity. Antisense Nucleic Acid Drug Dev., 8: 309-317, 1998.
-
(1998)
Antisense Nucleic Acid Drug Dev.
, vol.8
, pp. 309-317
-
-
Wan, M.S.K.1
Fell, P.L.2
Akhtar, S.3
-
23
-
-
0035375098
-
Combination therapy of 2-5A antisense against telomerase RNA and cisplatin for malignant gliomas
-
Kondo, Y., Komata, T., and Kondo, S. Combination therapy of 2-5A antisense against telomerase RNA and cisplatin for malignant gliomas. Int. J. Oncol., 18: 1287-1292, 2001.
-
(2001)
Int. J. Oncol.
, vol.18
, pp. 1287-1292
-
-
Kondo, Y.1
Komata, T.2
Kondo, S.3
-
24
-
-
0033455559
-
Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death
-
Herbert, B-S., Pitts, A. E., Baker, S. I., Hamilton, S. E., Wright, W. E., Shay, J. W., and Corey, D. R. Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death. Proc. Natl. Acad. Sci. USA, 96: 14276-14281, 1999.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 14276-14281
-
-
Herbert, B.-S.1
Pitts, A.E.2
Baker, S.I.3
Hamilton, S.E.4
Wright, W.E.5
Shay, J.W.6
Corey, D.R.7
-
25
-
-
0034839552
-
Telomerase inhibitors-oligonucleotide phosphoramidates as potential therapeutic agents
-
Gryaznov, S., Pongracz, K., Matray, T., Schultz, R., Pruzan, R., Aimi, J., Chin, A., Harley, C., Shea-Herbert, B., Shay, J., Oshima, Y., Asai, A., and Amashita, Y. Telomerase inhibitors-oligonucleotide phosphoramidates as potential therapeutic agents. Nucleosides Nucleotides Nucleic Acids, 20: 401-410, 2001.
-
(2001)
Nucleosides Nucleotides Nucleic Acids
, vol.20
, pp. 401-410
-
-
Gryaznov, S.1
Pongracz, K.2
Matray, T.3
Schultz, R.4
Pruzan, R.5
Aimi, J.6
Chin, A.7
Harley, C.8
Shea-Herbert, B.9
Shay, J.10
Oshima, Y.11
Asai, A.12
Amashita, Y.13
-
26
-
-
0037148567
-
Oligonucleotide N3′→P5′ phosphoramidates as efficient telomerase inhibitors
-
Shea-Herbert, B., Pongracz, K., Shay, J., and Gryaznov, S. Oligonucleotide N3′→P5′ phosphoramidates as efficient telomerase inhibitors. Oncogene, 21: 638-642, 2002.
-
(2002)
Oncogene
, vol.21
, pp. 638-642
-
-
Shea-Herbert, B.1
Pongracz, K.2
Shay, J.3
Gryaznov, S.4
-
27
-
-
0029975255
-
Telomerase as a potential molecular target to study G-quartet phosphorothioates
-
Sharma, H. W., Hsiao, R., and Narayanan, R. Telomerase as a potential molecular target to study G-quartet phosphorothioates. Antisense Nucleic Acid Drug Dev., 6: 3-7, 1996.
-
(1996)
Antisense Nucleic Acid Drug Dev.
, vol.6
, pp. 3-7
-
-
Sharma, H.W.1
Hsiao, R.2
Narayanan, R.3
-
28
-
-
0032403229
-
Modified (PNA, 2′-O-methyl and phosphoramidate) anti-TAR antisense oligonucleotides as strong and specific inhibitors of in vitro HIV-1 reverse transcription
-
Boulme, F., Freund, F., Moreau, S., Nielsen, P., Gryaznov, S., Toulme, J-J., and Litvak, S. Modified (PNA, 2′-O-methyl and phosphoramidate) anti-TAR antisense oligonucleotides as strong and specific inhibitors of in vitro HIV-1 reverse transcription. Nucleic Acids Res., 26: 5492-5500, 1998.
-
(1998)
Nucleic Acids Res.
, vol.26
, pp. 5492-5500
-
-
Boulme, F.1
Freund, F.2
Moreau, S.3
Nielsen, P.4
Gryaznov, S.5
Toulme, J.-J.6
Litvak, S.7
-
29
-
-
0033595857
-
Oligonucleotide N3′→P5′ thio-phosphoramidates: Synthesis and properties
-
Pongracz, K., and Gryaznov, S. Oligonucleotide N3′→P5′ thio-phosphoramidates: synthesis and properties. Tetrahedron Lett., 40: 7661-7664, 1999.
-
(1999)
Tetrahedron Lett.
, vol.40
, pp. 7661-7664
-
-
Pongracz, K.1
Gryaznov, S.2
-
30
-
-
0031021880
-
An improved method for the synthesis of N3′→P5′ phosphoramidates oligonucleotides
-
McCurdy, S. N., Nelson, J. S., Hirschbein, B. L., and Fearon, K. L. An improved method for the synthesis of N3′→P5′ phosphoramidates oligonucleotides. Tetrahedron Lett. 38: 207-210, 1997.
-
(1997)
Tetrahedron Lett.
, vol.38
, pp. 207-210
-
-
McCurdy, S.N.1
Nelson, J.S.2
Hirschbein, B.L.3
Fearon, K.L.4
-
31
-
-
0037079670
-
Allosteric inhibitors of telomerase: Oligonucleotide N3′→P5′ phosphoramidates
-
Pruzan, R., Pongracz, K., Gietzen, K., Wallweber, G., and Gryaznov, S. Allosteric inhibitors of telomerase: oligonucleotide N3′→P5′ phosphoramidates. Nucleic Acids Res., 30: 559-568, 2002.
-
(2002)
Nucleic Acids Res.
, vol.30
, pp. 559-568
-
-
Pruzan, R.1
Pongracz, K.2
Gietzen, K.3
Wallweber, G.4
Gryaznov, S.5
-
32
-
-
0041393565
-
-
Substituted Indole Compounds and Methods of Their Use. United States Patent #6, 372, 742 B1 issued April 16, 2002
-
Chin, A. C., Tolman, R. L., Nguyen, M. Q., and Holcomb, R. Substituted Indole Compounds and Methods of Their Use. United States Patent #6, 372, 742 B1 issued April 16, 2002.
-
-
-
Chin, A.C.1
Tolman, R.L.2
Nguyen, M.Q.3
Holcomb, R.4
-
33
-
-
0026523228
-
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
-
Counter, C. M., Avilion, A. A., LeFeuvre, C. E., Stewart, N. G., Greider, C. W., Harley, C. B., and Bacchetti, S. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J., 5: 1921-1929, 1992.
-
(1992)
EMBO J.
, vol.5
, pp. 1921-1929
-
-
Counter, C.M.1
Avilion, A.A.2
LeFeuvre, C.E.3
Stewart, N.G.4
Greider, C.W.5
Harley, C.B.6
Bacchetti, S.7
-
34
-
-
0035796403
-
Human telomerase contains two cooperating telomerase RNA molecules
-
Wenz, C., Enenkel, B., Amacker, M., Kelleher, C., Damm, K., and Lingner, J. Human telomerase contains two cooperating telomerase RNA molecules. EMBO J. 20: 3526-3534, 2001.
-
(2001)
EMBO J.
, vol.20
, pp. 3526-3534
-
-
Wenz, C.1
Enenkel, B.2
Amacker, M.3
Kelleher, C.4
Damm, K.5
Lingner, J.6
-
35
-
-
0030872852
-
RNase H-independent antisense activity of oligonucleotide N3′-P5′ phosphoramidates
-
Heidenreich, O., Gryaznov, S., and Nerenberg, M. RNase H-independent antisense activity of oligonucleotide N3′-P5′ phosphoramidates. Nucleic Acids Res., 25: 776-780, 1997.
-
(1997)
Nucleic Acids Res.
, vol.25
, pp. 776-780
-
-
Heidenreich, O.1
Gryaznov, S.2
Nerenberg, M.3
-
36
-
-
0033525558
-
Longevity, stress response, and cancer in aging telomerase-deficient mice
-
Rudolph, K. L., Chang, S., Lee, H. W., Blasco, M., Goettlieb, G. J., Greider, C. W., and DePinho, R. A. Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell, 96: 701-712, 1999.
-
(1999)
Cell
, vol.96
, pp. 701-712
-
-
Rudolph, K.L.1
Chang, S.2
Lee, H.W.3
Blasco, M.4
Goettlieb, G.J.5
Greider, C.W.6
DePinho, R.A.7
-
37
-
-
0033199787
-
Novel potent strategy for gene delivery using a single peptide vector as a carrier
-
Morris, M. C., Chaloin, L., Mery, J., Hietz, F., and Divita, G. A. novel potent strategy for gene delivery using a single peptide vector as a carrier. Nucleic Acids Res., 27: 3510-3517, 1999.
-
(1999)
Nucleic Acids Res.
, vol.27
, pp. 3510-3517
-
-
Morris, M.C.1
Chaloin, L.2
Mery, J.3
Hietz, F.4
Divita, G.A.5
|