메뉴 건너뛰기




Volumn 121, Issue , 2016, Pages 170-178

New surprises from an old favourite: The emergence of telomerase as a key player in the regulation of cancer stemness

Author keywords

Cancer stemness; CSCs; Positive feedback loops; Targeted anticancer therapy; Telomerase; TERT

Indexed keywords

TELOMERASE; UNCLASSIFIED DRUG;

EID: 84950976296     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2015.12.001     Document Type: Review
Times cited : (18)

References (104)
  • 1
    • 84911477017 scopus 로고    scopus 로고
    • Extra-telomeric functions of human telomerase: Cancer, mitochondria and oxidative stress
    • G. Saretzki Extra-telomeric functions of human telomerase: cancer, mitochondria and oxidative stress Curr. Pharm. Des. 20 2014 6386 6403
    • (2014) Curr. Pharm. Des. , vol.20 , pp. 6386-6403
    • Saretzki, G.1
  • 3
    • 0031010342 scopus 로고    scopus 로고
    • A survey of telomerase activity in human cancer
    • J.W. Shay, and S. Bacchetti A survey of telomerase activity in human cancer Eur. J. Cancer 33 1997 787 791
    • (1997) Eur. J. Cancer , vol.33 , pp. 787-791
    • Shay, J.W.1    Bacchetti, S.2
  • 4
    • 84911485552 scopus 로고    scopus 로고
    • Telomere maintenance mechanisms in human cancer: Clinical implications
    • R.R. Reddel Telomere maintenance mechanisms in human cancer: clinical implications Curr. Pharm. Des. 20 2014 6361 6374
    • (2014) Curr. Pharm. Des. , vol.20 , pp. 6361-6374
    • Reddel, R.R.1
  • 5
    • 84896125494 scopus 로고    scopus 로고
    • Evolution of the cancer stem cell model
    • A. Kreso, and J.E. Dick Evolution of the cancer stem cell model Cell Stem Cell 14 2014 275 291
    • (2014) Cell Stem Cell , vol.14 , pp. 275-291
    • Kreso, A.1    Dick, J.E.2
  • 11
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • D. Bonnet, and J.E. Dick Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell Nat. Med. 3 1997 730 737
    • (1997) Nat. Med. , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 12
    • 0036090222 scopus 로고    scopus 로고
    • Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro
    • S.M. Graham, H.G. Jørgensen, E. Allan, C. Pearson, M.J. Alcorn, L. Richmond, and T.L. Holyoake Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro Blood 99 2002 319 325
    • (2002) Blood , vol.99 , pp. 319-325
    • Graham, S.M.1    Jørgensen, H.G.2    Allan, E.3    Pearson, C.4    Alcorn, M.J.5    Richmond, L.6    Holyoake, T.L.7
  • 18
    • 34249980343 scopus 로고    scopus 로고
    • Identification and characterization of tumorigenic liver cancer stem/progenitor cells
    • S. Ma, K.W. Chan, L. Hu, T.K. Lee, J.Y. Wo, I.O. Ng, B.J. Zheng, and X.Y. Guan Identification and characterization of tumorigenic liver cancer stem/progenitor cells Gastroenterology 132 2007 2542 2556
    • (2007) Gastroenterology , vol.132 , pp. 2542-2556
    • Ma, S.1    Chan, K.W.2    Hu, L.3    Lee, T.K.4    Wo, J.Y.5    Ng, I.O.6    Zheng, B.J.7    Guan, X.Y.8
  • 20
    • 33846100356 scopus 로고    scopus 로고
    • A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    • C.A. O'Brien, A. Pollett, S. Gallinger, and J.E. Dick A human colon cancer cell capable of initiating tumour growth in immunodeficient mice Nature 445 2007 106 110
    • (2007) Nature , vol.445 , pp. 106-110
    • O'Brien, C.A.1    Pollett, A.2    Gallinger, S.3    Dick, J.E.4
  • 24
  • 25
    • 28244472369 scopus 로고    scopus 로고
    • Prospective identification of tumorigenic prostate cancer stem cells
    • A.T. Collins, P.A. Berry, C. Hyde, M.J. Stower, and N.J. Maitland Prospective identification of tumorigenic prostate cancer stem cells Cancer Res. 65 2005 10946 10951
    • (2005) Cancer Res. , vol.65 , pp. 10946-10951
    • Collins, A.T.1    Berry, P.A.2    Hyde, C.3    Stower, M.J.4    Maitland, N.J.5
  • 29
    • 60949100188 scopus 로고    scopus 로고
    • Recent insights into the molecular mechanisms involved in aging and the malignant transformation of adult stem/progenitor cells and their therapeutic implications
    • M. Mimeault, and S.K. Batra Recent insights into the molecular mechanisms involved in aging and the malignant transformation of adult stem/progenitor cells and their therapeutic implications Ageing Res. Rev. 8 2009 94 112
    • (2009) Ageing Res. Rev. , vol.8 , pp. 94-112
    • Mimeault, M.1    Batra, S.K.2
  • 30
    • 0042386051 scopus 로고    scopus 로고
    • Telomere dysfunction and the initiation of genome instability
    • D.M. Feldser, J.A. Hackett, and C.W. Greider Telomere dysfunction and the initiation of genome instability Nat. Rev. Cancer 3 2003 623 627
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 623-627
    • Feldser, D.M.1    Hackett, J.A.2    Greider, C.W.3
  • 31
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • J.P. Thiery, H. Acloque, R.Y. Huang, and M.A. Nieto Epithelial-mesenchymal transitions in development and disease Cell. 139 2009 871 890
    • (2009) Cell. , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 32
    • 84885915873 scopus 로고    scopus 로고
    • Epithelial-mesenchymal plasticity in carcinoma metastasis
    • J.H. Tsai, and J. Yang Epithelial-mesenchymal plasticity in carcinoma metastasis Genes Dev. 27 2013 2192 2206
    • (2013) Genes Dev. , vol.27 , pp. 2192-2206
    • Tsai, J.H.1    Yang, J.2
  • 33
    • 84907022547 scopus 로고    scopus 로고
    • Metabostemness: A new cancer hallmark
    • J.A. Menendez, and T. Alarcón Metabostemness: a new cancer hallmark Front. Oncol. 4 2014 262
    • (2014) Front. Oncol. , vol.4 , pp. 262
    • Menendez, J.A.1    Alarcón, T.2
  • 34
    • 80054046029 scopus 로고    scopus 로고
    • Aerobic glycolysis: Meeting the metabolic requirements of cell proliferation
    • S.Y. Lunt, and M.G. Vander Heiden Aerobic glycolysis: meeting the metabolic requirements of cell proliferation Annu. Rev. Cell Dev. Biol. 27 2011 441 464
    • (2011) Annu. Rev. Cell Dev. Biol. , vol.27 , pp. 441-464
    • Lunt, S.Y.1    Vander Heiden, M.G.2
  • 35
    • 84886381428 scopus 로고    scopus 로고
    • The influence of pH and hypoxia on tumor metastasis
    • M. Abaza, and Y.A. Luqmani The influence of pH and hypoxia on tumor metastasis Expert Rev. Anticancer Ther. 13 2013 1229 1242
    • (2013) Expert Rev. Anticancer Ther. , vol.13 , pp. 1229-1242
    • Abaza, M.1    Luqmani, Y.A.2
  • 39
    • 84903768676 scopus 로고    scopus 로고
    • Tackling the cancer stem cells - What challenges do they pose?
    • D.R. Pattabiraman, and R.A. Weinberg Tackling the cancer stem cells - what challenges do they pose? Nat. Rev. Drug Discov. 13 2014 497 512
    • (2014) Nat. Rev. Drug Discov. , vol.13 , pp. 497-512
    • Pattabiraman, D.R.1    Weinberg, R.A.2
  • 40
    • 84906962169 scopus 로고    scopus 로고
    • Altered gene products involved in the malignant reprogramming of cancer stem/progenitor cells and multitargeted therapies
    • M. Mimeault, and S.K. Batra Altered gene products involved in the malignant reprogramming of cancer stem/progenitor cells and multitargeted therapies Mol. Asp. Med. 39 2014 3 32
    • (2014) Mol. Asp. Med. , vol.39 , pp. 3-32
    • Mimeault, M.1    Batra, S.K.2
  • 42
    • 84893645443 scopus 로고    scopus 로고
    • Molecular biomarkers of cancer stem/progenitor cells associated with progression, metastases, and treatment resistance of aggressive cancers
    • M. Mimeault, and S.K. Batra Molecular biomarkers of cancer stem/progenitor cells associated with progression, metastases, and treatment resistance of aggressive cancers Cancer Epidemiol. Biomark. Prev. 23 2014 234 254
    • (2014) Cancer Epidemiol. Biomark. Prev. , vol.23 , pp. 234-254
    • Mimeault, M.1    Batra, S.K.2
  • 43
    • 84925505862 scopus 로고    scopus 로고
    • The molecular mechanisms underlying the therapeutic resistance of cancer stem cells
    • J.K. Kim, H.Y. Jeon, and H. Kim The molecular mechanisms underlying the therapeutic resistance of cancer stem cells Arch. Pharm. Res. 38 2015 389 401
    • (2015) Arch. Pharm. Res. , vol.38 , pp. 389-401
    • Kim, J.K.1    Jeon, H.Y.2    Kim, H.3
  • 44
    • 84892671815 scopus 로고    scopus 로고
    • MicroRNAs regulate both epithelial-to-mesenchymal transition and cancer stem cells
    • P. Ceppi, and M.E. Peter MicroRNAs regulate both epithelial-to-mesenchymal transition and cancer stem cells Oncogene 33 2014 269 278
    • (2014) Oncogene , vol.33 , pp. 269-278
    • Ceppi, P.1    Peter, M.E.2
  • 45
    • 77956615870 scopus 로고    scopus 로고
    • Sizing the ends: Normal length of human telomeres
    • O. Samassekou, M. Gadji, R. Drouin, and J. Yan Sizing the ends: normal length of human telomeres Ann. Anat. 192 2010 284 291
    • (2010) Ann. Anat. , vol.192 , pp. 284-291
    • Samassekou, O.1    Gadji, M.2    Drouin, R.3    Yan, J.4
  • 46
    • 46249125488 scopus 로고    scopus 로고
    • How shelterin protects mammalian telomeres
    • W. Palm, and T. de Lange How shelterin protects mammalian telomeres Annu. Rev. Genet. 42 2008 301 334
    • (2008) Annu. Rev. Genet. , vol.42 , pp. 301-334
    • Palm, W.1    De Lange, T.2
  • 50
    • 77955845914 scopus 로고    scopus 로고
    • Telomeres and telomerase in normal and cancer stem cells
    • J.W. Shay, and W.E. Wright Telomeres and telomerase in normal and cancer stem cells FEBS Lett. 584 2010 3819 3825
    • (2010) FEBS Lett. , vol.584 , pp. 3819-3825
    • Shay, J.W.1    Wright, W.E.2
  • 51
    • 84905595327 scopus 로고    scopus 로고
    • Inventory of telomerase components in human cells reveals multiple subpopulations of hTR and hTERT
    • L. Xi, and T.R. Cech Inventory of telomerase components in human cells reveals multiple subpopulations of hTR and hTERT Nucleic Acids Res. 42 2014 8565 8577
    • (2014) Nucleic Acids Res. , vol.42 , pp. 8565-8577
    • Xi, L.1    Cech, T.R.2
  • 52
    • 0038056347 scopus 로고    scopus 로고
    • Telomerase modulates expression of growth-controlling genes and enhances cell proliferation
    • L.L. Smith, H.A. Coller, and J.M. Roberts Telomerase modulates expression of growth-controlling genes and enhances cell proliferation Nat. Cell Biol. 5 2003 474 479
    • (2003) Nat. Cell Biol. , vol.5 , pp. 474-479
    • Smith, L.L.1    Coller, H.A.2    Roberts, J.M.3
  • 53
    • 79959919116 scopus 로고    scopus 로고
    • Telomerase activity-independent function of TERT allows glioma cells to attain cancer stem cell characteristics by inducing EGFR expression
    • S. Beck, X. Jin, Y.W. Sohn, J.K. Kim, S.H. Kim, J. Yin, X. Pian, S.C. Kim, D.H. Nam, Y.J. Choi, and H. Kim Telomerase activity-independent function of TERT allows glioma cells to attain cancer stem cell characteristics by inducing EGFR expression Mol. Cells 31 2011 9 15
    • (2011) Mol. Cells , vol.31 , pp. 9-15
    • Beck, S.1    Jin, X.2    Sohn, Y.W.3    Kim, J.K.4    Kim, S.H.5    Yin, J.6    Pian, X.7    Kim, S.C.8    Nam, D.H.9    Choi, Y.J.10    Kim, H.11
  • 54
    • 0032537806 scopus 로고    scopus 로고
    • Telomerase activity in a specific cell subset co-expressing integrin beta1/EGFR but not p75NGFR/bcl2/integrin beta4 in normal human epithelial cells
    • C. Kunimura, K. Kikuchi, N. Ahmed, A. Shimizu, and S. Yasumoto Telomerase activity in a specific cell subset co-expressing integrin beta1/EGFR but not p75NGFR/bcl2/integrin beta4 in normal human epithelial cells Oncogene 17 1998 187 197
    • (1998) Oncogene , vol.17 , pp. 187-197
    • Kunimura, C.1    Kikuchi, K.2    Ahmed, N.3    Shimizu, A.4    Yasumoto, S.5
  • 58
    • 33746190649 scopus 로고    scopus 로고
    • Telomerase reverse transcriptase regulates the expression of a key cell cycle regulator, cyclin D1
    • S. Jagadeesh, and P.P. Banerjee Telomerase reverse transcriptase regulates the expression of a key cell cycle regulator, cyclin D1 Biochem. Biophys. Res. Commun. 347 2006 774 780
    • (2006) Biochem. Biophys. Res. Commun. , vol.347 , pp. 774-780
    • Jagadeesh, S.1    Banerjee, P.P.2
  • 59
    • 79954565935 scopus 로고    scopus 로고
    • Human telomerase reverse transcriptase regulates cyclin D1 and G1/S phase transition in laryngeal squamous carcinoma
    • J. Li, X. Huang, X. Xie, J. Wang, and M. Duan Human telomerase reverse transcriptase regulates cyclin D1 and G1/S phase transition in laryngeal squamous carcinoma Acta Otolaryngol. 131 2011 546 551
    • (2011) Acta Otolaryngol. , vol.131 , pp. 546-551
    • Li, J.1    Huang, X.2    Xie, X.3    Wang, J.4    Duan, M.5
  • 62
    • 84868674716 scopus 로고    scopus 로고
    • Alternatively spliced telomerase reverse transcriptase variants lacking telomerase activity stimulate cell proliferation
    • R. Hrdličková, J. Nehyba, and H.R. Bose Jr. Alternatively spliced telomerase reverse transcriptase variants lacking telomerase activity stimulate cell proliferation Mol. Cell Biol. 32 2012 4283 4296
    • (2012) Mol. Cell Biol. , vol.32 , pp. 4283-4296
    • Hrdličková, R.1    Nehyba, J.2    Bose, H.R.3
  • 64
    • 84891427530 scopus 로고    scopus 로고
    • An investigation of the effects of the core protein telomerase reverse transcriptase on Wnt signaling in breast cancer cells
    • I. Listerman, F.S. Gazzaniga, and E.H. Blackburn An investigation of the effects of the core protein telomerase reverse transcriptase on Wnt signaling in breast cancer cells Mol. Cell Biol. 34 2014 280 289
    • (2014) Mol. Cell Biol. , vol.34 , pp. 280-289
    • Listerman, I.1    Gazzaniga, F.S.2    Blackburn, E.H.3
  • 65
    • 79958053622 scopus 로고    scopus 로고
    • Phenotypes in mTERT+/- and mTERT-/- mice are due to short telomeres, not telomere-independent functions of telomerase reverse transcriptase
    • M.A. Strong, S.L. Vidal-Cardenas, B. Karim, H. Yu, N. Guo, and C.W. Greider Phenotypes in mTERT+/- and mTERT-/- mice are due to short telomeres, not telomere-independent functions of telomerase reverse transcriptase Mol. Cell Biol. 31 2011 2369 2379
    • (2011) Mol. Cell Biol. , vol.31 , pp. 2369-2379
    • Strong, M.A.1    Vidal-Cardenas, S.L.2    Karim, B.3    Yu, H.4    Guo, N.5    Greider, C.W.6
  • 68
    • 6344247581 scopus 로고    scopus 로고
    • Death receptor signaling regulatory function for telomerase: HTERT abolishes TRAIL-induced apoptosis, independently of telomere maintenance
    • C. Dudognon, F. Pendino, J. Hillion, A. Saumet, M. Lanotte, and E. Segal-Bendirdjian Death receptor signaling regulatory function for telomerase: hTERT abolishes TRAIL-induced apoptosis, independently of telomere maintenance Oncogene 23 2004 7469 7474
    • (2004) Oncogene , vol.23 , pp. 7469-7474
    • Dudognon, C.1    Pendino, F.2    Hillion, J.3    Saumet, A.4    Lanotte, M.5    Segal-Bendirdjian, E.6
  • 71
    • 0031006856 scopus 로고    scopus 로고
    • Bcl-2 modulates telomerase activity
    • M. Mandal, and R. Kumar Bcl-2 modulates telomerase activity J. Biol. Chem. 272 1997 14183 14187
    • (1997) J. Biol. Chem. , vol.272 , pp. 14183-14187
    • Mandal, M.1    Kumar, R.2
  • 72
    • 14844301658 scopus 로고    scopus 로고
    • HTERT antagonizes p53-induced apoptosis independently of telomerase activity
    • R. Rahman, L. Latonen, and K.G. Wiman hTERT antagonizes p53-induced apoptosis independently of telomerase activity Oncogene 24 2005 1320 1327
    • (2005) Oncogene , vol.24 , pp. 1320-1327
    • Rahman, R.1    Latonen, L.2    Wiman, K.G.3
  • 75
    • 84884232859 scopus 로고    scopus 로고
    • Pluripotency transcription factors and cancer stem cells: Small genes make a big difference
    • A. Liu, X. Yu, and S. Liu Pluripotency transcription factors and cancer stem cells: small genes make a big difference Chin. J. Cancer 32 2013 483 487
    • (2013) Chin. J. Cancer , vol.32 , pp. 483-487
    • Liu, A.1    Yu, X.2    Liu, S.3
  • 77
    • 84883743387 scopus 로고    scopus 로고
    • Telomerase reverse transcriptase promotes epithelial-mesenchymal transition and stem cell-like traits in cancer cells
    • Z. Liu, Q. Li, K. Li, L. Chen, W. Li, M. Hou, T. Liu, J. Yang, C. Lindvall, M. Bjorkholm, J. Jia, and D. Xu Telomerase reverse transcriptase promotes epithelial-mesenchymal transition and stem cell-like traits in cancer cells Oncogene 32 2013 4203 4213
    • (2013) Oncogene , vol.32 , pp. 4203-4213
    • Liu, Z.1    Li, Q.2    Li, K.3    Chen, L.4    Li, W.5    Hou, M.6    Liu, T.7    Yang, J.8    Lindvall, C.9    Bjorkholm, M.10    Jia, J.11    Xu, D.12
  • 78
    • 0035253472 scopus 로고    scopus 로고
    • Telomerase activity of cultured human pancreatic carcinoma cell lines correlates with their potential for migration and invasion
    • N. Sato, N. Maehara, K. Mizumoto, E. Nagai, T. Yasoshima, K. Hirata, and M. Tanaka Telomerase activity of cultured human pancreatic carcinoma cell lines correlates with their potential for migration and invasion Cancer 91 2001 496 504
    • (2001) Cancer , vol.91 , pp. 496-504
    • Sato, N.1    Maehara, N.2    Mizumoto, K.3    Nagai, E.4    Yasoshima, T.5    Hirata, K.6    Tanaka, M.7
  • 79
    • 0037183542 scopus 로고    scopus 로고
    • Constitutive human telomerase reverse transcriptase expression enhances regenerative properties of endothelial progenitor cells
    • S. Murasawa, J. Uevadot, M. Silver, J.M. Isner, D.W. Losordo, and T. Asahara Constitutive human telomerase reverse transcriptase expression enhances regenerative properties of endothelial progenitor cells Circulation 106 2002 1133 1139
    • (2002) Circulation , vol.106 , pp. 1133-1139
    • Murasawa, S.1    Uevadot, J.2    Silver, M.3    Isner, J.M.4    Losordo, D.W.5    Asahara, T.6
  • 80
    • 44449102571 scopus 로고    scopus 로고
    • Enhanced migration and CXCR4 over-expression in fibroblasts with telomerase reconstitution
    • Y. Qu, M. Mao, X. Li, L. Zhang, X. Huang, C. Yang, F. Zhao, Y. Xiong, and D. Mu Enhanced migration and CXCR4 over-expression in fibroblasts with telomerase reconstitution Mol. Cell Biochem. 313 2008 45 52
    • (2008) Mol. Cell Biochem. , vol.313 , pp. 45-52
    • Qu, Y.1    Mao, M.2    Li, X.3    Zhang, L.4    Huang, X.5    Yang, C.6    Zhao, F.7    Xiong, Y.8    Mu, D.9
  • 81
    • 84887041006 scopus 로고    scopus 로고
    • Human telomerase reverse transcriptase regulates MMP expression independently of telomerase activity via NF-kappaB-dependent transcription
    • D. Ding, P. Xi, J. Zhou, M. Wang, and Y.S. Cong Human telomerase reverse transcriptase regulates MMP expression independently of telomerase activity via NF-kappaB-dependent transcription FASEB J. 27 2013 4375 4383
    • (2013) FASEB J. , vol.27 , pp. 4375-4383
    • Ding, D.1    Xi, P.2    Zhou, J.3    Wang, M.4    Cong, Y.S.5
  • 83
    • 80053243106 scopus 로고    scopus 로고
    • MMP-9 silencing regulates hTERT expression via beta1 integrin-mediated FAK signaling and induces senescence in glioma xenograft cells
    • S. Ponnala, C. Chetty, K.K. Veeravalli, D.H. Dinh, J.D. Klopfenstein, and J.S. Rao MMP-9 silencing regulates hTERT expression via beta1 integrin-mediated FAK signaling and induces senescence in glioma xenograft cells Cell Signal 23 2011 2065 2075
    • (2011) Cell Signal , vol.23 , pp. 2065-2075
    • Ponnala, S.1    Chetty, C.2    Veeravalli, K.K.3    Dinh, D.H.4    Klopfenstein, J.D.5    Rao, J.S.6
  • 87
    • 84862638243 scopus 로고    scopus 로고
    • Antagonism of miR-21 reverses epithelial-mesenchymal transition and cancer stem cell phenotype through AKT/ERK1/2 inactivation by targeting PTEN
    • M. Han, M. Liu, Y. Wang, X. Chen, J. Xu, Y. Sun, L. Zhao, H. Qu, Y. Fan, and C. Wu Antagonism of miR-21 reverses epithelial-mesenchymal transition and cancer stem cell phenotype through AKT/ERK1/2 inactivation by targeting PTEN PLoS One 7 2012 e39520
    • (2012) PLoS One , vol.7
    • Han, M.1    Liu, M.2    Wang, Y.3    Chen, X.4    Xu, J.5    Sun, Y.6    Zhao, L.7    Qu, H.8    Fan, Y.9    Wu, C.10
  • 92
    • 78651386195 scopus 로고    scopus 로고
    • HTERT overexpression alleviates intracellular ROS production, improves mitochondrial function, and inhibits ROS-mediated apoptosis in cancer cells
    • I. Indran, P. Hande, and S. Pervaiz hTERT overexpression alleviates intracellular ROS production, improves mitochondrial function, and inhibits ROS-mediated apoptosis in cancer cells Cancer Res. 71 2011 266 276
    • (2011) Cancer Res. , vol.71 , pp. 266-276
    • Indran, I.1    Hande, P.2    Pervaiz, S.3
  • 93
  • 94
    • 84877748662 scopus 로고    scopus 로고
    • The major reverse transcriptase-incompetent splice variant of the human telomerase protein inhibits telomerase activity but protects from apoptosis
    • I. Listerman, J. Sun, F.S. Gazzaniga, J.L. Lukas, and E.H. Blackburn The major reverse transcriptase-incompetent splice variant of the human telomerase protein inhibits telomerase activity but protects from apoptosis Cancer Res. 73 2013 2817 2828
    • (2013) Cancer Res. , vol.73 , pp. 2817-2828
    • Listerman, I.1    Sun, J.2    Gazzaniga, F.S.3    Lukas, J.L.4    Blackburn, E.H.5
  • 96
    • 1842478446 scopus 로고    scopus 로고
    • Introduction of human telomerase reverse transcriptase to normal human fibroblasts enhances DNA repair capacity
    • K.H. Shin, M.K. Kang, E. Dicterow, A. Kameta, M.A. Baluda, and N.H. Park Introduction of human telomerase reverse transcriptase to normal human fibroblasts enhances DNA repair capacity Clin. Cancer Res. 10 2004 2551 2560
    • (2004) Clin. Cancer Res. , vol.10 , pp. 2551-2560
    • Shin, K.H.1    Kang, M.K.2    Dicterow, E.3    Kameta, A.4    Baluda, M.A.5    Park, N.H.6
  • 97
    • 84955169949 scopus 로고    scopus 로고
    • Telomerase reverse transcriptase expression protects transformed human cells against DNA-damaging agents, and increases tolerance to chromosomal instability
    • H.B. Fleisig, K.R. Hukezalie, C.A.H. Thompson, T.T.T. Au-Yeung, A.T. Ludlow, C.R. Xhao, and J.M.Y. Wong Telomerase reverse transcriptase expression protects transformed human cells against DNA-damaging agents, and increases tolerance to chromosomal instability Oncogene 2015 10.1038/onc.2015.75
    • (2015) Oncogene
    • Fleisig, H.B.1    Hukezalie, K.R.2    Thompson, C.A.H.3    Au-Yeung, T.T.T.4    Ludlow, A.T.5    Xhao, C.R.6    Wong, J.M.Y.7
  • 99
    • 67650601775 scopus 로고    scopus 로고
    • Telomerase reverse transcriptase activates the expression of vascular endothelial growth factor independent of telomerase activity
    • L. Zhou, D. Zheng, M. Wang, and Y.S. Cong Telomerase reverse transcriptase activates the expression of vascular endothelial growth factor independent of telomerase activity Biochem. Biophys. Res. Commun. 386 2009 739 743
    • (2009) Biochem. Biophys. Res. Commun. , vol.386 , pp. 739-743
    • Zhou, L.1    Zheng, D.2    Wang, M.3    Cong, Y.S.4
  • 101
    • 77954091914 scopus 로고    scopus 로고
    • Knockdown of hTERT by siRNA suppresses growth of Capan-2 human pancreatic cancer cell via the inhibition of expressions of Bcl-2 and COX-2
    • Y.Q. Zhong, Z.S. Xia, Y.R. Fu, and Z.H. Zhu Knockdown of hTERT by siRNA suppresses growth of Capan-2 human pancreatic cancer cell via the inhibition of expressions of Bcl-2 and COX-2 J. Dig. Dis. 11 2010 176 184
    • (2010) J. Dig. Dis. , vol.11 , pp. 176-184
    • Zhong, Y.Q.1    Xia, Z.S.2    Fu, Y.R.3    Zhu, Z.H.4
  • 104
    • 0034711223 scopus 로고    scopus 로고
    • NF-kappa B regulates transcription of the mouse telomerase catalytic subunit
    • L. Yin, A.K. Hubbard, and C. Giardina NF-kappa B regulates transcription of the mouse telomerase catalytic subunit J. Biol. Chem. 275 2000 36,671 5
    • (2000) J. Biol. Chem. , vol.275 , pp. 36671-36675
    • Yin, L.1    Hubbard, A.K.2    Giardina, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.