Chromosomal instability in ulcerative colitis is related to telomere shortening

Nature Genetics

Volumn 32, Issue 2, 2002, Pages 280-284

  O'Sullivan, Jacintha N ^a   Bronner, Mary P ^a   Brentnall, Teresa A ^a   Finley, Jennifer C ^a   Shen, Wen Tang ^a   Emerson, Scott ^a   Emond, Mary J ^a   Gollahon, Katherine A ^a   Moskovitz, Alexander H ^b   Crispin, David A ^a   Potter, John D ^c   Rabinovitch, Peter S ^a,c  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ANAPHASE; ARTICLE; CANCER RISK; CHROMOSOME ABERRATION; CLINICAL ARTICLE; COLORECTAL CARCINOMA; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GENETIC STABILITY; HUMAN; MALE; OXIDATIVE STRESS; PRIORITY JOURNAL; TELOMERE; ULCERATIVE COLITIS;

ADULT; AMIDES; CHROMOSOME ABERRATIONS; COLITIS, ULCERATIVE; FEMALE; FLUORESCEIN-5-ISOTHIOCYANATE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; ORGANOMETALLIC COMPOUNDS; PHOSPHORIC ACIDS; STROMAL CELLS; TELOMERE;

EID: 18644370262     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng989     Document Type: Article

References (29)

1. Ekbom, A., Helmick, C., Zack, M. & Adami, H.O. Ulcerative colitis and colorectal cancer. A population based study. N. Eng. J. Med. 323, 1228-1233 (1990).
2. Loeb, K.R. & Loeb, L.A. Genetic instability and the mutator phenotype: studies in ulcerative colitis. Am. J. Pathol. 154, 1621-1626 (1999).
3. von Zglinicki, T. Role of oxidative stress in telomere length regulation and replicative senescence. Ann. NYAcad. Sci. 908, 99-110 (2000).
4. Blackburn, E.H. Structure and function of telomeres. Nature 350, 569-573 (1991).
5. Hande, M.P., Samper, E., Lansdorp, R & Blasco, M.A. Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice. J. Cell. Biol. 144, 589-601 (1999).
6. Artandi, S.E. et al. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature406, 641-645 (2000).
7. deLange, T. in Telomeres (eds Blackburn, E., & Greider, C.) 265-293 (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1995).
8. Tisty, T.D. Genetic instability and its role in neoplasia. Curr. Top. Microbiol. Immunol. 221, 37-46 (1997).
9. McClintock, B. The stability of broken ends of chromosomes in Zea Mays. Genetics 26, 234-282 (1941).
10. Oexle, K. Telomere length distribution and Southern blot analysis. J. Theor. Biol. 190, 369-377 (1998).
11. Rufer, N., Dragowska, W., Thornbury, G., Roosnek, E. & Lansdorp, P.M. Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry. Nat. Biotechnol. 16, 743-747 (1998).
12. Lansdorp, RM. et al. Heterogeneity in telomere length of human chromosomes. Hum. Mol. Genet. 5, 685-691 (1996).
13. Gisselsson, D. et aL Abnormal nuclear shape in solid tumors reflects mitotic instability. Am. J. Pathol. 158, 199-206 (2001).
14. Gisselsson, D. et al. Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors. Proc. Natl Acad. Sci. USA 98, 12683-12688 (2001).
15. Rudolph, K.L., Millard, M., Bosenberg, M.W. & DePinho, R.A. Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nat. Genet. 28, 155-159 (2001).
16. Rabinovitch, P.S. et al. Pancolonic chromosomal instability precedes dysplasia and cancer in ulcerative colitis. Cancer Res. 59, 5148-5153 (1999).
17. Fouladi, B., Sabatier, L., Miller, D., Pottier, G. & Murnane, J.P. The relationship between spontaneous telomere loss and chromosomal instability in a human tumor cell line. Neoplasia 2, 540-554 (2000).
18. Hemann, M.T., Strong, M.A., Hao, L.Y. & Greider, C.W. The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell 107, 67-77 (2001).
19. Wright, W.W. & Shay, J.W. Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology. Nature Med. 6, 849-851 (2000).
20. Martens, U.M. et al. Short telomeres on human chromosome 17p. Nat. Genet. 18, 76-80 (1998).
21. n telomeric sequence in vertebrate chromosomes. Chromosoma 99, 3-10 (1990).
22. Day, J.P., Limoli, C.L. & Morgan, W.F. Recombination involving interstitial telomere repeat-like sequences promotes chromosomal instability in Chinese hamster cells. Carcinogenesis 19, 259-265 (1998).
23. Kilburn A.E., Shea, M.J., Sargent, R.G. & Wilson, J.H. Insertion of a telomere repeat sequence into a mammalian gene causes chromosome instability. Mol. Cell. Biol. 21, 126-135 (2001).
24. Brentnall, T.A. et aL Mutations in the p53 gene: an early marker of neoplastic progression in ulcerative colitis. Gastroenterology 2, 369-378 (1994).
25. Taylor, W.R. & Stark, G.R. Regulation of the G2/M transition by p53. Oncogene 20, 1803-1815 (2001).
26. Whitehead, C.M. & Salisbury, J.L. Regulation and regulatory activities of centrosomes. J. Cell Biochem. Suppl. 32-33, 192-199 (1999).
27. Chin, L. et al. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell 97, 527-538 (1999).
28. Rubin C.E. et al. DNA aneuploidy in colonic biopsies predicts future development of dysplasia in ulcerative colitis. Gastroenterology 103, 1611-1620 (1992).
29. Riddell, R.H. et al. Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications. Hum. Pathol. 11, 931-968 (1983).