Telomere length is not related to established cardiovascular risk factors but does correlate with red and white blood cell counts in a German blood donor population

PLoS ONE

Volumn 10, Issue 10, 2015, Pages

  Neuner, Bruno ^a   Lenfers, Anna ^b   Kelsch, Reinhard ^b   Jäger, Kathrin ^a   Brüggmann, Nina ^a   Van Der Harst, Pim ^c   Walter, Michael ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; BIOLOGICAL MARKER;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; BLOOD DONOR; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; ERYTHROCYTE; ERYTHROCYTE COUNT; FAMILY HISTORY; FEMALE; GERMAN (CITIZEN); HEMATOCRIT; HUMAN; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; RISK ASSESSMENT; SEX DIFFERENCE; SMOKING; TELOMERE; TELOMERE LENGTH; THROMBOCYTE; ADOLESCENT; AGING; GENETICS; LEUKOCYTE; METABOLISM; PROCEDURES; RISK FACTOR; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGING; BIOMARKERS; BLOOD DONORS; CARDIOVASCULAR DISEASES; CHOLESTEROL; ERYTHROCYTE COUNT; ERYTHROCYTES; FEMALE; HEMATOCRIT; HEMOGLOBINS; HUMANS; LEUKOCYTE COUNT; LEUKOCYTES; MALE; MIDDLE AGED; RISK FACTORS; TELOMERE; TRIGLYCERIDES; YOUNG ADULT;

EID: 84948682335     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0139308     Document Type: Article

References (36)

1. Samani NJ, vander Harst P. Biological ageing and cardiovascular disease. Heart 2008;94:537-9. doi: 10.1136/hrt.2007.136010 PMID: 18411343
2. Walter M. Interrelationships among HDL metabolism, aging, and atherosclerosis. ArteriosclerThromb Vasc Biol. 2009;29:1244-50. Review. doi: 10.1161/ATVBAHA.108.181438 PMID: 19667114
3. Ogami M, Ikura Y, Ohsawa M, Matsuo T, Kayo S, Yoshimi N, et al. Telomere shortening in human coronary artery diseases. ArteriosclerThromb Vasc Biol 2004;24:546-50. PMID: 14726417
4. Brouilette SW, Moore JS, McMahon AD, Thompson JR, Ford I, Shepherd J, et al. Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study. Lancet 2007;369:107-14. PMID: 17223473
5. Huzen J, Peeters W, de Boer RA, Moll FL, Wong LS, Codd V, et al. Circulating leukocyte and carotid atherosclerotic plaque telomere length: interrelation, association with plaque characteristics, and restenosis after endarterectomy. ArteriosclerThromb Vasc Biol. 2011;31:1219-25. doi: 10.1161/ATVBAHA.110.217158 PMID: 21372300
6. Fitzpatrick AL, Kronmal RA, Gardner JP, Psaty BM, Jenny NS, Tracy RP, et al. Leukocyte telomere length and cardiovascular disease in the cardiovascular health study. Am J Epidemiol 2007;165:14-21. PMID: 17043079
7. Okuda K, Khan MY, Skurnick J, Kimura M, Aviv H, Aviv A. Telomere attrition of the human abdominal aorta: relationships with age and atherosclerosis. Atherosclerosis 2000;152:391-8. PMID: 10998467
8. Wilson WR, Herbert KE, Mistry Y, Stevens SE, Patel HR, Hastings RA, et al. Blood leukocytetelomere DNA content predicts vascular telomere DNA content in humans with and without vascular disease. Eur Heart J 2008;29:2689-94. doi: 10.1093/eurheartj/ehn386 PMID: 18762552
9. Benetos A, Gardner JP, Zureik M, Labat C, Xiaobin L, Adamopoulos C, et al. Short telomeres are associated with increased carotid atherosclerosis in hypertensive subjects. Hypertension 2004;43:182-5. PMID: 14732735
10. Adaikalakoteswari A, Balasubramanyam M, Ravikumar R, Deepa R, Mohan V. Association of telomere shortening with impaired glucose tolerance and diabetic macroangiopathy. Atherosclerosis 2007;195:83-9. PMID: 17222848
11. van der Harst P, van der Steege G, de Boer RA, Voors AA, Hall AS, Mulder MJ, et al. Telomere length of circulating leukocytes is decreased in patients with chronic heart failure. J Am Coll Cardiol 2007;49:1459-64. PMID: 17397675
12. Demissie S, Levy D, Benjamin EJ, Cupples LA, Gardner JP, Herbert A, et al. Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study. Aging Cell 2006;5:325-30. PMID: 16913878
13. Valdes AM, Andrew T, Gardner JP, Kimura M, Oelsner E, Cherkas LF, et al. Obesity, cigarette smoking, and telomere length in women. Lancet 2005;366:662-4. PMID: 16112303
14. Gardner JP, Li S, Srinivasan SR, Chen W, Kimura M, Lu X, et al. Rise in insulin resistance is associated with escalated telomere attrition. Circulation 2005;111:2171-7. PMID: 15851602
15. Jeanclos E, Krolewski A, Skurnick J, Kimura M, Aviv H, Warram JH, et al. Shortened telomere length in white blood cells of patients with IDDM. Diabetes 1998;47:482-6. PMID: 9519758
16. Sampson MJ, Winterbone MS, Hughes JC, Dozio N, Hughes DA. Monocyte telomere shortening and oxidative DNA damage in type 2 diabetes. Diabetes Care 2006;29:283-9. PMID: 16443874
17. Morla M, Busquets X, Pons J, Sauleda J, MacNee W, Agusti AG. Telomere shortening in smokers with and without COPD. Eur Respir J 2006;27:525e8.
18. Bischoff C, Petersen HC, Graakjaer J, Andersen-Ranberg K, Vaupel JW, Bohr VA, et al. No association between telomere length and survival among the elderly and oldest old. Epidemiology 2006;17:190-4. PMID: 16477260
19. Martin-Ruiz CM, Gussekloo J, van Heemst D, von Zglinicki T, Westendorp RG. Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: a population-based study. Aging Cell 2005;4:287-90. PMID: 16300480
20. Bekaert S, De Meyer T, Rietzschel ER, De Buyzere ML, De Bacquer D, Langlois M, et al. Telomere length and cardiovascular risk factors in a middle-aged population free of overt cardiovascular disease. Aging Cell. 2007;6:639-47. PMID: 17874998
21. Cawthon RM. Telomere length measurement by a novel monochrome multiplex quantitative PCR method. Nucleic Acids Res. 2009;37:e21. doi: 10.1093/nar/gkn1027 PMID: 19129229
22. Cawthon RM, Smith KR, O'Brien E, Sivatchenko A, Kerber RA. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet. 2003;361:393-5. PMID: 12573379
23. Gardner M, Bann D, Wiley L, Cooper R, Hardy R, Nitsch D etal. Gender and telomere length: systematic review and meta-analysis. Exp Gerontol. 2014;51:15-27. doi: 10.1016/j.exger.2013.12.004 PMID: 24365661
24. Sanders JL, Newman AB. Telomere length in epidemiology: abiomarkerof aging, age-related disease, both, or neither? Epidemiol Rev. 2013;35:112-31. doi: 10.1093/epirev/mxs008 PMID: 23302541
25. Needham BL, Diez Roux AV, Bird CE, Bradley R, Fitzpatrick AL, Jacobs DR, et al. A test of biological and behavioral explanations for gender differences in telomere length: the multi-ethnic study of atherosclerosis. Biodemography Soc Biol. 2014;60:156-73 doi: 10.1080/19485565.2014.947471 PMID: 25343364
26. Goldeck D, Pawelec G, Norman K, Steinhagen-Thiessen E, Oettinger L, Haehnel K, Demuth I. No strong correlations between serum cytokine levels, CMV serostatus and hand-grip strength in older subjects in the Berlin BASE-II cohort. Biogerontology. 2015 Apr24. [Epub ahead of print] PMID: 25906063
27. Chang E, Harley CB (1995) Telomere length and replicative aging in human vascular tissues. ProcNatl Acad Sci U S A 92:11190-11194. PMID: 7479963
28. Matthews C, Gorenne I, Scott S, Figg N, Kirkpatrick P, Ritchie A, et al. Vascular smooth muscle cells undergo telomere-based senescence in human atherosclerosis: effects of telomerase and oxidative stress. Circ Res 2006;99:156-164 PMID: 16794190
29. Brouilette SW, Whittaker A, Stevens SE, van der Harst P, Goodall AH, Samani NJ. Telomere length is shorter in healthy offspring of subjects with coronary artery disease: support for the telomere hypothesis. Heart. 2008;94:422-5. doi: 10.1136/hrt.2007.139675 PMID: 18347373
30. De Meyer T, Van Daele CM, De Buyzere ML, Denil S, De Bacquer D, Segers P, et al. No shorter telomeres in subjects with a family history of cardiovascular disease in the Asklepios study. Arterioscler Thromb Vasc Biol. 2012;32:3076-81 doi: 10.1161/ATVBAHA.112.300341 PMID: 23087363
31. Wong LS, Huzen J, van der Harst P, de Boer RA, Codd V, Westenbrink BD, et al. Anaemia is associated with shorter leucocyte telomere length in patients with chronic heart failure. Eur J Heart Fail. 2010;12:348-53. doi: 10.1093/eurjhf/hfq007 PMID: 20335352
32. De Meyer T, De Buyzere ML, Langlois M, Rietzschel ER, Cassiman P, De Bacquer D, et al. Lower red blood cell counts in middle-aged subjects with shorter peripheral blood leukocyte telomere length. Aging Cell 2008;7:700-705.
33. Kozlitina J, Garcia CK. Red blood cell size is inversely associated with leukocyte telomere length in a large multi-ethnic population. PLoSOne. 2012;7;e51046. doi: 10.1371/journal.pone.0051046 PMID: 23226558
34. Gutmajster E, Witecka J, Wyskida M, Koscinska-Marczewska J, Szwed M, Owczarz M, et al. Telomere length in elderly Caucasians weakly correlates with blood cell counts. ScientificWorldJournal. 2013;2013:153608 doi: 10.1155/2013/153608 PMID: 24453794
35. Aulinas A, Ramírez MJ, Barahona MJ, Valassi E, Resmini E, Mato E, et al. Telomere length analysis in Cushing's syndrome. Eur J Endocrinol 2014;171:21-9. doi: 10.1530/EJE-14-0098 PMID: 24743394
36. Satoh H, Hiyama K, Takeda M, Awaya Y, Watanabe K, Ihara Y, et al. Telomere shortening in peripheral blood cells was related with aging but not with white blood cell count. Jpn J Hum Genet. 1996;41:413-7. PMID: 9088112