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Volumn 101, Issue 11, 2003, Pages 4512-4519

Ectopic hTERT expression extends the life span of human CD4+ helper and regulatory T-cell clones and confers resistance to oxidative stress-induced apoptosis

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYFLUORESCEIN DIACETATE SUCCINIMIDYL ESTER; CD4 ANTIGEN; PROTEIN BCL 2; RNA DIRECTED DNA POLYMERASE; TELOMERASE REVERSE TRANSCRIPTASE; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; TELOMERASE;

EID: 0038819110     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2002-07-2018     Document Type: Article
Times cited : (94)

References (33)
  • 1
    • 0030823184 scopus 로고    scopus 로고
    • Replicative senescence of T cells: Does the Hayflick Limit lead to immune exhaustion?
    • Efiros RB, Pawelec G. Replicative senescence of T cells: does the Hayflick Limit lead to immune exhaustion? Immunol Today. 1997;18:450-454.
    • (1997) Immunol Today , vol.18 , pp. 450-454
    • Efiros, R.B.1    Pawelec, G.2
  • 2
    • 0030297442 scopus 로고    scopus 로고
    • Decreased proliferative capacity and increased susceptibility to activation-induced cell death in late-passage human CD4+ TCR2+ cultured T cell clones
    • Pawelec G, Sansom D, Rehbein A, Adibzadeh M, Beckman I. Decreased proliferative capacity and increased susceptibility to activation-induced cell death in late-passage human CD4+ TCR2+ cultured T cell clones. Exp Gerontol. 1996;31:655-668.
    • (1996) Exp Gerontol , vol.31 , pp. 655-668
    • Pawelec, G.1    Sansom, D.2    Rehbein, A.3    Adibzadeh, M.4    Beckman, I.5
  • 3
    • 0028177371 scopus 로고
    • Long-term in vitro growth of human T cell clones: Can postmitotic "senescent' cell populations be defined?
    • Grubeck-Loebenstein B, Lechner H, Trieb K. Long-term in vitro growth of human T cell clones: can postmitotic "senescent' cell populations be defined? Int Arch Allergy Immunol. 1994;104:232-239.
    • (1994) Int Arch Allergy Immunol , vol.104 , pp. 232-239
    • Grubeck-Loebenstein, B.1    Lechner, H.2    Trieb, K.3
  • 4
    • 0025279931 scopus 로고
    • Telomeres shorten during ageing of human fibroblasts
    • Harley CB, Futcher AB, Grelder CW, Telomeres shorten during ageing of human fibroblasts. Nature. 1990;345:458-460.
    • (1990) Nature , vol.345 , pp. 458-460
    • Harley, C.B.1    Futcher, A.B.2    Grelder, C.W.3
  • 6
    • 0010045614 scopus 로고    scopus 로고
    • Extension of life-span by introduction of telomerase into normal human cells
    • Bodnar AG, Ouellette M, Frolkis M, et al. Extension of life-span by introduction of telomerase into normal human cells. Science. 1998;279:349-352.
    • (1998) Science , vol.279 , pp. 349-352
    • Bodnar, A.G.1    Ouellette, M.2    Frolkis, M.3
  • 7
    • 0032567967 scopus 로고    scopus 로고
    • Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span
    • Vaziri H, Benchimol S. Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr Biol. 1998;8:279-282.
    • (1998) Curr Biol , vol.8 , pp. 279-282
    • Vaziri, H.1    Benchimol, S.2
  • 8
    • 0000726641 scopus 로고    scopus 로고
    • Sequence-specific DNA cleavage by Fe2+-mediated fenton reactions has possible biological implications
    • Henle ES, Han Z, Tang N, Rai P, Luo Y, Linn S. Sequence-specific DNA cleavage by Fe2+-mediated fenton reactions has possible biological implications. J Biol Chem. 1999;274:962-971.
    • (1999) J Biol Chem , vol.274 , pp. 962-971
    • Henle, E.S.1    Han, Z.2    Tang, N.3    Rai, P.4    Luo, Y.5    Linn, S.6
  • 9
    • 0033954684 scopus 로고    scopus 로고
    • Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts
    • von Zglinicki T, Pilger R, Sitte N. Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts. Free Radic Biol Med. 2000;28:64-74.
    • (2000) Free Radic Biol Med , vol.28 , pp. 64-74
    • Von Zglinicki, T.1    Pilger, R.2    Sitte, N.3
  • 10
    • 0035910475 scopus 로고    scopus 로고
    • Expression of telomerase inhibits hydroxyl radical-induced apoptosis in normal telomerase negative human lung fibroblasts
    • Ren JG, Xia HL, Tian YM, Just T, Cal GP, Dai YR, Expression of telomerase inhibits hydroxyl radical-induced apoptosis in normal telomerase negative human lung fibroblasts. FEBS Lett. 2001;488:133-138.
    • (2001) FEBS Lett , vol.488 , pp. 133-138
    • Ren, J.G.1    Xia, H.L.2    Tian, Y.M.3    Just, T.4    Cal, G.P.5    Dai, Y.R.6
  • 11
    • 0030579071 scopus 로고    scopus 로고
    • Mechanism of telomerase induction during T cell activation
    • Bodnar AG, Kim NW, Effros RB, Chiu CP. Mechanism of telomerase induction during T cell activation. Exp Cell Res, 1996;228:58-64.
    • (1996) Exp Cell Res , vol.228 , pp. 58-64
    • Bodnar, A.G.1    Kim, N.W.2    Effros, R.B.3    Chiu, C.P.4
  • 12
    • 0031569378 scopus 로고    scopus 로고
    • Changes in telomerase activity and telomere length during human T lymphocyte senescence
    • Pan C, Xue BH, Ellis TM, Peace DJ, Diaz MO. Changes in telomerase activity and telomere length during human T lymphocyte senescence. Exp Cell Res. 1997;231:346-353.
    • (1997) Exp Cell Res , vol.231 , pp. 346-353
    • Pan, C.1    Xue, B.H.2    Ellis, T.M.3    Peace, D.J.4    Diaz, M.O.5
  • 13
    • 0031879115 scopus 로고    scopus 로고
    • Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry
    • Rufer N, Dragowska W, Thornbury G, Roosnek E, Lansdorp PM. Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry. Nat Biotechnol. 1998;16:743-747.
    • (1998) Nat Biotechnol , vol.16 , pp. 743-747
    • Rufer, N.1    Dragowska, W.2    Thornbury, G.3    Roosnek, E.4    Lansdorp, P.M.5
  • 14
    • 0027486732 scopus 로고
    • Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes
    • Vaziri H, Schachter F, Uchida I, et al. Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. Am J Hum Genet. 1993;52:661-667.
    • (1993) Am J Hum Genet , vol.52 , pp. 661-667
    • Vaziri, H.1    Schachter, F.2    Uchida, I.3
  • 15
    • 0033949149 scopus 로고    scopus 로고
    • In vivo reduction of telomere length in human antigenreactive memory T cells
    • Burns JB, Lobo ST, Bartholomew BD. In vivo reduction of telomere length in human antigenreactive memory T cells. Eur J Immunol. 2000;30:1894-1901.
    • (2000) Eur J Immunol , vol.30 , pp. 1894-1901
    • Burns, J.B.1    Lobo, S.T.2    Bartholomew, B.D.3
  • 16
    • 0012950854 scopus 로고    scopus 로고
    • Lineage-specific telomere shortening and unaltered capacity for telomerase expression in human T and B lymphocytes with age
    • Son NH, Murray S, Yanovski J, Hodes RJ, Weng N. Lineage-specific telomere shortening and unaltered capacity for telomerase expression in human T and B lymphocytes with age. J Immuno. 2000;165:1191-1196.
    • (2000) J Immuno , vol.165 , pp. 1191-1196
    • Son, N.H.1    Murray, S.2    Yanovski, J.3    Hodes, R.J.4    Weng, N.5
  • 17
    • 0034667771 scopus 로고    scopus 로고
    • Immortalization of human CDS+ T cell clones by ectopic expression of telomerase reverse transcriptase
    • Hooijberg E, Ruizendaal JJ, Snijders PJ, Kueter EW, Walboomers JM, Spits H. Immortalization of human CDS+ T cell clones by ectopic expression of telomerase reverse transcriptase. J Immunol. 2000;165:4239-4245.
    • (2000) J Immunol , vol.165 , pp. 4239-4245
    • Hooijberg, E.1    Ruizendaal, J.J.2    Snijders, P.J.3    Kueter, E.W.4    Walboomers, J.M.5    Spits, H.6
  • 18
    • 0029833422 scopus 로고    scopus 로고
    • Episomal vectors rapidly and stably produce high-titer recombinant retrovirus
    • Kinsella TM, Nolan GP. Episomal vectors rapidly and stably produce high-titer recombinant retrovirus. Hum Gene Ther. 1996;7:1405.
    • (1996) Hum Gene Ther , vol.7 , pp. 1405
    • Kinsella, T.M.1    Nolan, G.P.2
  • 19
    • 0034326634 scopus 로고    scopus 로고
    • Ectopic human telomerase catalytic subunit expression maintains telomere length but is not sufficient for CD8+ T lymphocyte immortalization
    • Migliaccio M, Amacker M, Just T, et al. Ectopic human telomerase catalytic subunit expression maintains telomere length but is not sufficient for CD8+ T lymphocyte immortalization. J Immunol. 2000;165:4978-4984.
    • (2000) J Immunol , vol.165 , pp. 4978-4984
    • Migliaccio, M.1    Amacker, M.2    Just, T.3
  • 20
    • 0028385758 scopus 로고
    • Versatile retroviral vectors for potential use in gene therapy
    • Hawley RG, Lieu FH, Fong AZ, Hawley TS. Versatile retroviral vectors for potential use in gene therapy. Gene Ther. 1994;1:136-138.
    • (1994) Gene Ther , vol.1 , pp. 136-138
    • Hawley, R.G.1    Lieu, F.H.2    Fong, A.Z.3    Hawley, T.S.4
  • 21
    • 0035720180 scopus 로고    scopus 로고
    • Phenotypic characterization of human CD4+ regulatory T cells obtained from cutaneous dinitrochlorobenzene-induced delayed type hypersensitivity reactions
    • Lecart S, Boulay V, Raison-Peyron N, et al. Phenotypic characterization of human CD4+ regulatory T cells obtained from cutaneous dinitrochlorobenzene-induced delayed type hypersensitivity reactions. J Invest Dermatol. 2001;117:318-325.
    • (2001) J Invest Dermatol , vol.117 , pp. 318-325
    • Lecart, S.1    Boulay, V.2    Raison-Peyron, N.3
  • 22
    • 0026571223 scopus 로고
    • T cell activation-inducing epitopes of the house dust mite allergen Der p I: Proliferation and lymphokine production patterns by Der p I-specific CD4+ T cell clones
    • Yssel H, Johnson KE, Schneider PV, et al. T cell activation-inducing epitopes of the house dust mite allergen Der p I: proliferation and lymphokine production patterns by Der p I-specific CD4+ T cell clones. J Immunol. 1992;148:738-745.
    • (1992) J Immunol , vol.148 , pp. 738-745
    • Yssel, H.1    Johnson, K.E.2    Schneider, P.V.3
  • 23
    • 0029839059 scopus 로고    scopus 로고
    • Differentiation and stability of T helper 1 and 2 cells derived from naive human neonatal CD4+ T cells, analyzed at the single-cell level
    • Sornasse T, Larenas PV, Davis KA, de Vries JE, Yssel H. Differentiation and stability of T helper 1 and 2 cells derived from naive human neonatal CD4+ T cells, analyzed at the single-cell level. J Exp Med. 1996;184:473-483.
    • (1996) J Exp Med , vol.184 , pp. 473-483
    • Sornasse, T.1    Larenas, P.V.2    Davis, K.A.3    De Vries, J.E.4    Yssel, H.5
  • 24
    • 0033542815 scopus 로고    scopus 로고
    • Enrichment of an antigen-specific T cell response by retrovirally transduced human dendritic cells
    • Heemskerk MH, Hooijberg E, Ruizendaal JJ, et al. Enrichment of an antigen-specific T cell response by retrovirally transduced human dendritic cells. Cell Immunol. 1999;195:10-17.
    • (1999) Cell Immunol , vol.195 , pp. 10-17
    • Heemskerk, M.H.1    Hooijberg, E.2    Ruizendaal, J.J.3
  • 25
    • 0021253159 scopus 로고
    • Serum-free medium for generation and propagation of functional human cytotoxic and helper T cell clones
    • Yssel H, De Vries JE, Koken M, Van Blitterswijk W, Spits H. Serum-free medium for generation and propagation of functional human cytotoxic and helper T cell clones. J Immunol Methods. 1984;72:219-227.
    • (1984) J Immunol Methods , vol.72 , pp. 219-227
    • Yssel, H.1    De Vries, J.E.2    Koken, M.3    Van Blitterswijk, W.4    Spits, H.5
  • 26
    • 0021015910 scopus 로고
    • Characterization of monoclonal antibodies against surface molecules associated with cytotoxic activity of natural and activated killer cells and clones CTL lines
    • Spits H, Keizer G, Borst J, Terhorst C, Hekman A, de Vries JE. Characterization of monoclonal antibodies against surface molecules associated with cytotoxic activity of natural and activated killer cells and clones CTL lines. Hybridoma. 1983;2:423-432.
    • (1983) Hybridoma , vol.2 , pp. 423-432
    • Spits, H.1    Keizer, G.2    Borst, J.3    Terhorst, C.4    Hekman, A.5    De Vries, J.E.6
  • 27
    • 0028262128 scopus 로고
    • Determination of lymphocyte division by flow cytometry
    • Lyons AB, Parish CR. Determination of lymphocyte division by flow cytometry. J Immunol Methods. 1994;171:131-137.
    • (1994) J Immunol Methods , vol.171 , pp. 131-137
    • Lyons, A.B.1    Parish, C.R.2
  • 28
    • 0029927422 scopus 로고    scopus 로고
    • The role of proteases during apoptosis
    • Patel T, Gores GJ, Kaufmann SH. The role of proteases during apoptosis. FASEB J. 1996;10:587-597.
    • (1996) FASEB J , vol.10 , pp. 587-597
    • Patel, T.1    Gores, G.J.2    Kaufmann, S.H.3
  • 29
    • 0037148328 scopus 로고    scopus 로고
    • Telomerase is not an oncogene
    • Harley CB. Telomerase is not an oncogene. Oncogene. 2002;21:494-502.
    • (2002) Oncogene , vol.21 , pp. 494-502
    • Harley, C.B.1
  • 30
    • 0033543760 scopus 로고    scopus 로고
    • Human endothelial cell life extension by telomerase expression
    • Yang J, Chang E, Cherry AM, et al. Human endothelial cell life extension by telomerase expression. J Biol Chem. 1999;274:26141-26148.
    • (1999) J Biol Chem , vol.274 , pp. 26141-26148
    • Yang, J.1    Chang, E.2    Cherry, A.M.3
  • 31
    • 0032923742 scopus 로고    scopus 로고
    • Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype
    • Jiang XR, Jimenez G, Chang E, et al. Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype. Nat Genet. 1999;21:111-114.
    • (1999) Nat Genet , vol.21 , pp. 111-114
    • Jiang, X.R.1    Jimenez, G.2    Chang, E.3
  • 32
    • 0032924343 scopus 로고    scopus 로고
    • Absence of cancer-associated changes in human fibroblasts immortalized with telomerase
    • Morales CP, Holt SE, Ouellette M, et al. Absence of cancer-associated changes in human fibroblasts immortalized with telomerase, Nat Genet. 1999;21:115-118.
    • (1999) Nat Genet , vol.21 , pp. 115-118
    • Morales, C.P.1    Holt, S.E.2    Ouellette, M.3
  • 33
    • 0035437179 scopus 로고    scopus 로고
    • Transfer of the human telomerase reverse transcriptase (TERT) gene into T lymphocytes results in extension of replicative potential
    • Rufer N, Migliaccio M, Antonchuk J, Humphries RK, Roosnek E, Lansdorp PM. Transfer of the human telomerase reverse transcriptase (TERT) gene into T lymphocytes results in extension of replicative potential. Blood. 2001;98:597-603.
    • (2001) Blood , vol.98 , pp. 597-603
    • Rufer, N.1    Migliaccio, M.2    Antonchuk, J.3    Humphries, R.K.4    Roosnek, E.5    Lansdorp, P.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.