Inhibition of telomerase activity and induction of apoptosis by curcumin in K-562 cells

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 596, Issue 1-2 SPEC. ISS., 2006, Pages 81-90

  Chakraborty, Sutapa ^a   Ghosh, Utpal ^b   Bhattacharyya, N P ^b   Bhattacharya, R K ^a   Roy, Madhumita ^a  

^a CHITTARANJAN NATIONAL CANCER INSTITUTE   (India)

^b SAHA INSTITUTE OF NUCLEAR PHYSICS   (India)

Author keywords

Apoptosis; Apoptotic index; Caspase; Curcumin; K 562; Telomerase

Indexed keywords

CASPASE 3; CASPASE 8; CURCUMIN; CYTOCHROME C; PROTEIN BAX; PROTEIN BCL 2; PROTEIN SUBUNIT; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE;

APOPTOSIS; ARTICLE; CELL NUCLEUS; CELL STRAIN K 562; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOSOL; DNA CONTENT; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME RELEASE; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; MITOCHONDRION; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; TELOMERIC REPEAT AMPLIFICATION PROTOCOL; UPREGULATION;

APOPTOSIS; CASPASES; CURCUMIN; CYTOCHROMES C; DNA-BINDING PROTEINS; FLOW CYTOMETRY; HUMANS; K562 CELLS; KINETICS; TELOMERASE;

CURCUMA LONGA;

EID: 33646492469     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2005.12.007     Document Type: Article

References (54)

1. Kim N.W., Piyatszek M.A., Prowse K.R., Harley C.B., West M.D., Ho P.L., Coviell G.M., Wright W.E., Weinrich S.L., and Shay J.W. Specific association of human telomerase activity with immortal cells and cancer. Science 266 (1994) 2011-2015
2. Holt S.E., and Shay J.W. Role of telomerase in cellular proliferation and cancer. J. Cellular Physiol. 180 (1999) 10-18
3. Parkinson E.K. Telomerase as a novel and potentially selective target for cancer chemotherapy. Ann. Med. 35 (2003) 466-475
4. Harley C.B., Futcher A.B., and Greider C.W. Telomeres shorten with aging. Nature 45 (1990) 458-460
5. Greider C.W. Telomerase activation- one-step on the road to cancer. Trends Genet. 15 (1999) 109-112
6. Shay J.W., and Bacchettti S. A survey of telomerase activity in human cancer. Eur. J. Cancer 33 (1997) 787-791
7. Piyatyszek M.A., Kim N.W., Weinrich S.L., Keiko H., Hiyama E., Wright W.E., and Shay J.W. Detection of telomerase activity in human cells and tumors by a telomeric repeat amplification protocol (TRAP). Meth. Cell Sci. 17 (1995) 1-15
8. Ramirez R., Carracedo J., Jimenez R., Canela A., Herrera E., Aljama P., and Blasco M.A. Massive telomere loss is an early event of DNA damaged-induced apoptosis. J. Biol. Chem. 278 (2003) 836-842
9. Herbert B., Pitts A.E., Baker S.I., Hamilton S.E., Wright W.E., Shay J.W., and Corey D.R. Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 14276-14281
10. Gao S., Yu B.P., Li Y., Dong W.G., and Luo H.S. Antiproliferative effect of octreotide on gastric cancer cells mediated by inhibition of Akt/PKB and telomerase. World J. Gastroenterol. 9 (2003) 2362-2365
11. Takahashi H., Amano R., Saneyoshi M., Maruyama T., and Yamaguchi T. Inhibition of vertebrate telomerases by the triphosphate derivatives of carbocyclic oxetanocin analogs. Nucl. Acid Res. Suppl. 3 (2003) 285-286
12. Mittal A., Pate M.S., Wylie R.C., Tollefsbol T.O., and Katiyar S.K. EGCG down-regulates telomerase in human breast carcinoma MCF-7 cells, leading to suppression of cell viability and induction of apoptosis. Int. J. Oncol. 24 (2004) 703-710
13. Naasani I., Seimiya H., and Tsuruo T. Telomerase inhibition, telomere shortening, and senescence of cancer cells by tea catechins. Biochem. Biophys. Res. Commun. 249 (1998) 391-396
14. Yokoyama M., Noguchi M., Nakao Y., Pater A., and Iwasaka T. The tea polyphenol, (-)-epigallocatechin gallate effects on growth, apoptosis, and telomerase activity in cervical cell lines. Gynecol. Oncol. 92 (2004) 197-204
15. Lyu S.Y., Choi S.H., and Park W.B. Korean mistletoe lectin-induced apoptosis in hepatocarcinoma cells is associated with inhibition of telomerase via mitochondrial controlled pathway independent of p53. Arch. Pharm. Res. 25 (2002) 93-101
16. Cheng Y.-L., Chang W.-L., Lee S.-C., Liu Y.-G., Lin H.-C., Chen C.-J., Yen C.-Y., Yu D.-S., Lin S.-Z., and Harn H.-J. Acetone extract of Bupleurum scorzonerifolium inhibits proliferation of A549 human lung cancer cells via inducing apoptosis and suppressing telomerase activity. Life Sci. 73 (2003) 2383-2394
17. Anto R.J., Kuttan G., DineshBabu K.V., Rajashekharan K.N., and Kuttan R. Antiinflammatory activity of natural and synthetic curcuminoids. Pharm. Pharmacol. Commun. 4 (1998) 103-106
18. Nagabhusan M., Amonkar A.J., and Bhide S.V. In vitro antimutagenicity of curcumin against environmental mutagens. Food. Chem. Toxicol. 25 (1987) 545-547
19. Azuine M.A., Kayal J.J., and Bhide S.V. Protective role of aqueous turmeric extract against mutagenicity of direct-acting carcinogens as well as benzo[a]pyrene induced genotoxicity and carcinogenicity. J. Cancer Res. Clin. Oncol. 118 (1992) 447-452
20. Soni K.B., Lahiri M., Chackradeo P., Bhide S.V., and Kuttan R. Protective effect of food additives on aflatoxin-induced mutagenicity and hepatocarcinogenicity. Cancer Lett. 115 (1997) 129-133
21. Mulky N., Amonkar A.J., and Bhide S.V. Antimutagenicity of curcumin and related compounds: the structural requirement for the antimutagenicity of curcumins. Indian Drugs 25 (1988) 1-3
22. Conney A.H., Lou Y.-R., Xie J.G., Osawa T., Newmark H.L., Liu Y., Chang R.L., and Huang M.T. Some perspectives on dietary inhibition of carcinogenesis: studies with curcumin and tea. Proc. Soc. Exp. Med. 216 (1997) 234-245
23. Rao C.V., Rivenson A., Simi B., and Reddy B.S. Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound. Cancer Res. 55 (1995) 259-266
24. Pereira M.A., Grubbs C.J., Barnes L.H., Li H., Olson G.R., Eto I., Juliana M., Whitaker L.M., Kelloff G.J., Steele V.E., and Lubet R.A. Effects of the phytochemicals, curcumin and quercetin, upon azoxymethane-induced colon cancer and 7,12-dimethylbenz[a]anthracene-induced mammary cancer in rats. Carcinogenesis 17 (1996) 1305-1311
25. Huang M.T., Lou Y.R., Xie J.G., Ma W., Lu Y.P., Yen P., Zhu B.T., Newmark H., and Ho C.T. Effect of dietary curcumin and dibenzoylmethane on formation of 7,12-dimethyl-benz[a]anthracene-induced mammary tumors and lymphomas/leukemias in Sencar mice. Carcinogenesis 19 (1998) 1697-1700
26. Ushida J., Sugie S., Kawabata A., Pham Q.V., Tanaka T., Fujii K., Takeuchi H., Ito Y., and Mori H. Chemopreventive effect of curcumin on N-nitrosomethylbenzylamine-induced oesophageal carcinogenesis in rats. Jpn. J Cancer. Res. 91 (2000) 893-898
27. Sreejayan N., and Rao M.N.A. Curcuminoids as potent inhibitors of lipid peroxidation. J. Pharm. Pharmacol. 46 (1994) 1013-1016
28. Subramanium M., Sreejayan N., Rao M.N., Devsagyam T.P., and Singh B.B. Diminution of singlet oxygen-induced DNA damage by curcumin and related antioxidants. Mutat. Res. 311 (1994) 249-255
29. Huang M.T., Lystz T., Ferraro T., Abidi T.F., Laskin J.D., and Conney J.H. Inhibitory effects of curcumin on in vitro lipoxygenase and cycloxygenase activities in mouse epidermis. Cancer Res. 51 (1991) 813-819
30. Jiang M.C., Yang-Yen H.F., Yen J.J., and Lin J.K. Curcumin induces apoptosis in immortalized NIH 3T3 and malignant cancer cell lines. Nutr. Cancer 26 (1996) 111-120
31. Kuo M.L., Huang T.S., and Lin J.K. Curcumin, an antioxidant and antitumor promoter induces apoptosis in human leukemia cells. Biochem. Biophys. Acta 1317 (1996) 95-100
32. Anto R.J., Mukhopadhyay A., Denning K., and Aggarwal B.B. Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl. Carcinogenesis 23 (2002) 143-150
33. Roy M., Chakraborty S., Siddiqi M., and Bhattacharya R.K. Induction of apoptosis in tumor cells by natural phenolic compounds. Asian Pacific J. Cancer Prev. 3 (2002) 61-67
34. Mehta K., Pantazis P., McQueen T., and Aggarwal B.B. Antiproliferative effect of curcumin (diferuloylmethane) against human breast tumor cell lines. Anticancer Drugs 8 (1997) 470-481
35. Marx J. Cell death studies yields cancer clues. Science 259 (1993) 760-761
36. Schulte-Herman R., Kraupp Grasle B., and Bursch W. Dose-response and threshold effects in cytotoxicity and apoptosis. Mutat. Res. 464 (2000) 13-18
37. Bursch W., Oberhammer F., and Schulte-Hermann R. Cell death by apoptosis and its protective role against disease. Trends Pharmacol. Sci. 13 (1992) 245-251
38. Taraphdar A.K., Roy M., and Bhattacharya R.K. Natural products as inducers of apoptosis: implication for cancer therapy and prevention. Curr. Sci. 80 (2001) 1387-1396
39. Lee L.S., Lee A., Nishikawa F., Furukawa K., Kasahara K., and Kim S.U. Effects of Selaginella tamariscina on in vitro tumor cell growth, p53 expression, G1 arrest and in vivo gastric cell proliferation. Cancer Lett. 144 (1999) 93-99
40. Ghosh U., Pandit B., and Bhattacharyya N.P. Induction of apoptosis by benzamide and its inhibition by aurin tricarboxylic acid (ATA) in Chinese hamster V79 cells. Mutat. Res. 554 (2004) 121-129
41. Martin S.J., Newmeyer D.D., Mathias S., Farschon D.M., Wang H.-G., Reed J.C., Kolesnick R.N., and Green D.R. Cell free reconstitution of Fas-, UV radiation and ceramide-induced apoptosis. EMBO J. 14 (1995) 5191-5200
42. Lowry O.H., Rosebrough A.L., Farr A.L., and Randell R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193 (1951) 265-275
43. 4, In Vitro (1998).
44. Boklan J., Nanjangud G., Mackenzie K.L., May C., Sadelain M., and Moore M.A. Limited proliferation and telomere dysfunction following telomerase inhibition in immortal murine fibriblasts. Cancer Res. 62 (2002) 2104-2114
45. Ramachandran C., Fonseca H.B., Jhabvala P., Escalon E.A., and Melnick S.J. Curcumin inhibits telomerase activity through human telomerase reverse transcriptase in MCF-7 breast cancer cell line. Cancer Lett. 184 (2002) 1-6
46. Surh Y.-J., Hurh Y.J., Kang J.Y., Lee E., Kang G., and Lee S.J. Resveratrol, an antioxidant present in red wine induces apoptosis in human promyelocytic leukaemia (HL-60) cells. Cancer Lett. 136 (1999) 1-10
47. Li P., Nijhawan D., Budihardjo L., Srinivasula S.M., Ahmad M., Alnemri E.S., and Wang X. Cytochrome c and dATP-dependent formation of Apaf-1/caspases-9 complex initiates an apoptotic protease cascade. Cell 91 (1997) 470-489
48. Chowdhury T., Pal S., Agwarwal M.L., Das T., and Sa G. Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction. FEBS Lett. 512 (2002) 334-340
49. Thornberry N.A., and Lazebnick Y. Caspases: enemies within. Science 281 (1998) 1312-1316
50. Ducray C., Pommier J.P., Martins L., Boussin F.D., and Sabatier L. Telomere dynamics, end to end fusions and telomerase activation during the human fibroblast immortalization process. Oncogene 18 (1999) 4211-4223
51. Chang S., Khao C.M., Naylor M.L., Maser R.S., and DePinho R.A. Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression. Genes Dev. 17 (2003) 88-100
52. Shay J.W., and Wright W.E. Senescence and immortalization: role of telomeres and telomerase. Carcinogenesis 26 (2005) 867-874
53. Simpson D.A., Livanos E., Heffernan T.P., and Kauffma W.K. Telomerase expression is sufficient for chromosomal integrity in cells lacking p53 dependent G1 checkpoint function. J. Carcinogenesis 4 (2005) 18
54. Haendeler J., Hoffmann J., Rahman S., Zeiher A.M., and Dimmeler S. Regulation of telomerase activity and anti-apoptotic function by protein-protein interaction and phosphorylation. FEBS Lett. 536 (2003) 180-186