Inhibition of telomerase activity by cisplatin in human testicular cancer cells

European Journal of Cancer Part A

Volumn 33, Issue 4, 1997, Pages 638-644

  Burger, A M ^a   Double, J A ^a   Newell, D R ^b  

^a UNIVERSITY OF BRADFORD   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

cisplatin; cross linking; growth inhibition; human telomerase RNA component; telomerase activity; telomerase inhibition; testicular cancer

Indexed keywords

BLEOMYCIN; CISPLATIN; DOXORUBICIN; MELPHALAN; METHOTREXATE; RIBONUCLEOPROTEIN; RNA; TELOMERASE; TRANSPLATIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MALE; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TANDEM REPEAT; TELOMERE; TESTIS CARCINOMA;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, ALKYLATING; CISPLATIN; GENETIC TECHNIQUES; HUMANS; MALE; MELPHALAN; MICE; POLYMERASE CHAIN REACTION; STEREOISOMERISM; TELOMERASE; TELOMERE; TESTICULAR NEOPLASMS; TUMOR CELLS, CULTURED;

EID: 0030993152     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-8049(96)00521-7     Document Type: Article

References (27)

1. Zakian VA. Telomeres: beginning to understand the end. Science 1995, 270, 1601-1607.
2. Hastie ND, Dempster M, Dunlop MG, Thompson AM, Green DK, Allshire RC. Telomere reduction in human colorectal carcinoma and with ageing. Nature 1990, 346, 866-868.
3. Harley CV, Futcher AB, Greider CW. Telomeres shorten during ageing. Nature 1990, 345, 458-460.
4. Kim NW, Piatyszek MA, Prowse KR, et al. Specific association of human telomerase activity with immortal cells and cancer. Science 1994, 266, 2011-2015.
5. Rhyu MS. Telomeres, telomerase, and immortality. J Natl Cancer Inst 1995, 87, 884-894.
6. Shay JW, Werbin H, Wright WE. Telomere shortening may contribute to ageing and cancer: a perspective. Mol Cell Diff 1994, 2, 1-21.
7. Bednarek A, Budunova I, Slaga TJ, Aldaz CM. Increased telomerase activity in mouse skin premalignant progression. Cancer Res 1995, 55, 4566-4569.
8. Chadeneau C, Hay K, Hirte HW, Gallinger S, Bacchetti S. Telomerase activity associated with acquisition of malignancy in human colorectal cancer. Cancer Res 1995, 55, 2533-2536.
9. Morin GB. Is telomerase a universal cancer target? J Natl Cancer Inst 1995, 87, 859-861.
10. Parkinson EK. Do telomerase antagonists represent a novel anti-cancer strategy? Br J Cancer 1996, 73, 1-4.
11. Strahl C, Blackburn EH. The effects of nucleoside analogs on telomerase and telomeres in tetrahymena. Nucleic Acids Res 1994, 22, 893-900.
12. Strahl C, Blackburn EH. Effect of reverse transcriptase inhibition on telomere length and telomerase activity in two immortalized human cell lines. Mol Cell Biol 1996, 16, 53-65.
13. Feng J, Funk WD, Wang SS, et al. The RNA component of human telomerase. Science 1995, 269, 1236-1241.
14. Norton JC, Piatyszek MA, Wright WE, Shay JW, Corey DR. Inhibition of human telomerase activity by peptide nucleic-acids. Nature Biotechnol 1996, 14, 615-619.
15. Sherman SE, Lippard SJ. Structural aspects of platinum anti-cancer drug-interactions with DNA. Chem Rev 1987, 87, 1153-1181.
16. Walker CM, Povey S, Parrington JM, Riddle PN, Knuechel R, Masters JRW. Development and characterization of cisplatin-resistant human testicular and bladder tumour cell lines. Eur J Cancer 1990, 26, 742-747.
17. Walker MC, Parris CN, Masters JRW. Differential sensitivities of human testicular and bladder tumor cell lines to chemotherapeutic drugs. J Natl Cancer Inst 1987, 79, 213-216.
18. Einhorn LH, Williams SD. Chemotherapy of disseminated testicular cancer. A random prospective study. Cancer 1980, 46, 1339-1344.
19. Masters JRW, Thomas R, Hall AG, Hogarth L, Matheson EC, Cattan AR, Lohrer H. Sensitivity of testis tumour cells to chemotherapeutic drugs: role of detoxifying pathways. Eur J Cancer 1996, 32A, 1248-1253.
20. Bradford M. A rapid and sensitive method for the quantitation of microgram quantities of protein using the principle of protein-dye binding. Anal Biochem 1976, 72, 248-254.
21. Piatyszek MA, Kim NW, Weinrich SL, et al. Detection of telomerase activity in human cells and tumors by a telomeric repeat amplification protocol (TRAP). Meth Cell Sci 1995, 17, 1-15.
22. 2] adducts of d(CCTCGAGTCTCC-d(GGAGACTCGAGG). Biochemistry 1990, 29, 811-823.
23. Hill BT, Scanlon KJ, Hansson J, et al. Deficient repair of cisplatin-DNA adducts identified in human testicular teratoma cell lines established from tumours from untreated patients. Eur J Cancer 1994, 30A, 832-837.
24. Bedford P, Fichtinger-Schepman AMJ, Shellard SA, et al. Differential repair of platinum-DNA adducts in human bladder and testicular continuous cell lines. Cancer Res 1988, 48, 3019-3024.
25. Fry AM, Chresta CM, Davies SM, et al. Relationship between topoisomerase II level and chemosensitivity in human tumor cell lines. Cancer Res 1991, 51, 6592-6595.
26. Huddart RA, Titley J, Robertson D, Williams GT, Horwich A, Cooper CS. Programmed cell death in response to chemotherapeutic agents in human germ cell tumour lines. Eur J Cancer 1995, 31A, 739-746.
27. Mosmann TJ. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983, 65, 55-63.