Gone with the Wnt/Notch: Stem cells in laminopathies, progeria, and aging

Journal of Cell Biology

Volumn 181, Issue 1, 2008, Pages 9-13

  Meshorer, Eran ^a   Gruenbaum, Yosef ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

LAMIN A;

CELL NUCLEUS MEMBRANE; CYTOSKELETON; DNA REPLICATION; EMBRYONIC STEM CELL; GENE EXPRESSION; GENE MUTATION; HUMAN; NOTE; PHENOTYPE; PREMATURE AGING; PRIORITY JOURNAL; PROGERIA; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN STRUCTURE; SOMATIC CELL;

AGING; ANIMALS; LAMINS; MEMBRANE PROTEINS; METALLOENDOPEPTIDASES; MICE; PROGERIA; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; STEM CELLS; WNT PROTEINS;

MUS;

EID: 42049090788     PISSN: 00219525     EISSN: 00219525     Source Type: Journal    
DOI: 10.1083/jcb.200802155     Document Type: Note

References (38)

1. Boguslavsky, R.L., C.L. Stewart, and H.J. Worman. 2006. Nuclear lamin A inhibits adipocyte differentiation: implications for Dunnigan-type familial partial lipodystrophy. Hum. Mol. Genet. 15:653-663.
2. Brack, A.S., M.J. Conboy, S. Roy, M. Lee, C.J. Kuo, C. Keller, and T.A. Rando. 2007. Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science. 317:807-810.
3. Broers, J.L., F.C. Ramaekers, G. Bonne, R.B. Yaou, and C.J. Hutchison. 2006. Nuclear lamins: laminopathies and their role in premature ageing. Physiol. Rev. 86:967-1008.
4. Cao, K., B.C. Capell, M.R. Erdos, K. Djabali, and F.S. Collins. 2007. A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells. Proc. Natl. Acad. Sci. USA. 104:4949-4954.
5. Chambers, S.M., C.A. Shaw, C. Gatza, C.J. Fisk, L.A. Donehower, and M.A. Goodell. 2007. Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation. PLoS Biol. 5:e201.
6. Constantinescu, D., H.L. Gray, P.J. Sammak, G.P. Schatten, and A.B. Csoka. 2006. Lamin A/C expression is a marker of mouse and human embryonic stem cell differentiation. Stem Cells. 24:177-185.
7. Dahl, K.N., P. Scaffidi, M.F. Islam, A.G. Yodh, K.L. Wilson, and T. Misteli. 2006. Distinct structural and mechanical properties of the nuclear lamina in Hutchinson-Gilford progeria syndrome. Proc. Natl. Acad. Sci. USA. 103:10271-10276.
8. De Sandre-Giovannoli, A., R. Bernard, P. Cau, C. Navarro, J. Amiel, I. Boccaccio, S. Lyonnet, C.L. Stewart, A. Munnich, M. Le Merrer, and N. Levy. 2003. Lamin A truncation in Hutchinson-Gilford progeria. Science. 300:2055.
9. Dechat, T., T. Shimi, S.A. Adam, A.E. Rusinol, D.A. Andres, H.P. Spielmann, M.S. Sinensky, and R.D. Goldman. 2007. Alterations in mitosis and cell cycle progression caused by a mutant lamin A known to accelerate human aging. Proc. Natl. Acad. Sci. USA. 104:4955-4960.
10. Eriksson, M., W.T. Brown, L.B. Gordon, M.W. Glynn, J. Singer, L. Scott, M.R. Erdos, C.M. Robbins, T.Y. Moses, P. Berglund, et al. 2003. Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome. Nature. 423:293-298.
11. Espada, J., I. Varela, I. Flores, A.P. Ugalde, J. Cadiñanos, A.M. Pendás, C.L. Stewart, K. Tryggvason, M.A. Blasco, J.M.P. Freije, and C. López-Otín. 2008. Nuclear envelope defects cause stem cell dysfunction in premature-aging mice. 181:27-35.
12. Favreau, C., D. Higuet, J.C. Courvalin, and B. Buendia. 2004. Expression of a mutant lamin A that causes Emery-Dreifuss muscular dystrophy inhibits in vitro differentiation of C2C12 myoblasts. Mol. Cell. Biol. 24:1481-1492.
13. Frock, R.L., B.A. Kudlow, A.M. Evans, S.A. Jameson, S.D. Hauschka, and B.K. Kennedy. 2 006. Lamin A/C and emerin are critical for skeletal muscle satellite cell differentiation. Genes Dev. 20:486-500.
14. Goldman, R.D., D.K. Shumaker, M.R. Erdos, M. Eriksson, A.E. Goldman, L.B. Gordon, Y. Gruenbaum, S. Khuon, M. Mendez, R. Varga, and F.S. Collins. 2004. Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford Progeria Syndrome. Proc. Natl. Acad. Sci. USA. 101:8963-8968.
15. Gotzmann, J., and R. Foisner. 2006. A-type lamin complexes and regenerative potential: a step towards understanding laminopathic diseases? Histochem. Cell Biol. 125:33-41.
16. Gruenbaum, Y., A. Margalit, R.D. Goldman, D.K. Shumaker, and K.L. Wilson. 2005. The nuclear lamina comes of age. Nat. Rev. Mol. Cell Biol. 6:21-31.
17. Halaschek-Wiener, J., and A. Brooks-Wilson. 2007. Progeria of stem cells: stem cell exhaustion in Hutchinson-Gilford progeria syndrome. J. Gerontol. A Biol. Sci. Med. Sci. 62:3-8.
18. Hennekam, R.C. 2006. Hutchinson-Gilford progeria syndrome: review of the phenotype. Am. J. Med. Genet. A. 140:2603-2624.
19. Hofer, A.C., R.T. Tran, O.Z. Aziz, W. Wright, G. Novelli, J. Shay, and M. Lewis. 2005. Shared phenotypes among segmental progeroid syndromes suggest underlying pathways of aging. J. Gerontol. A Biol. Sci. Med. Sci. 60:10-20.
20. Jones, D.L., and A.J. Wagers. 2008. No place like home: anatomy and function of the stem cell niche. Nat. Rev. Mol. Cell Biol. 9:11-21.
21. Liu, H., M.M. Fergusson, R.M. Castilho, J. Liu, L. Cao, J. Chen, D. Malide, I.I. Rovira, D. Schimel, C.J. Kuo, et al. 2007. Augmented Wnt signaling in a mammalian model of accelerated aging. Science. 317:803-806.
22. Lowry, W.E., and L. Richter. 2007. Signaling in adult stem cells. Front. Biosci. 12:3911-3927.
23. Mattout, A., T. Dechat, S.A. Adam, R.D. Goldman, and Y. Gruenbaum. 2006. Nuclear lamins, diseases and aging. Curr. Opin. Cell Biol. 18:335-341.
24. Melcer, S., Y. Gruenbaum, and G. Krohne. 2007. Invertebrate lamins. Exp. Cell Res. 313:2157-2166.
25. Moir, R.D., M. Yoon, S. Khuon, and R.D. Goldman. 2000. Nuclear lamins A and B1. Different pathways of assembly during nuclear envelope formation in living cells. J. Cell Biol. 151:1155-1168.
26. Pendas, A.M., Z. Zhou, J. Cadinanos, J.M. Freije, J. Wang, K. Hultenby, A. Astudillo, A. Wernerson, F. Rodriguez, K. Tryggvason, and C. Lopez-Otin. 2002. Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice. Nat. Genet. 31:94-99.
27. Reya, T., and H. Clevers. 2005. Wnt signalling in stem cells and cancer. Nature. 434:843-850.
28. Rossi, D.J., D. Bryder, J. Seita, A. Nussenzweig, J. Hoeijmakers, and I.L. Weissman. 2007. Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature. 447:725-729.
29. Rusiñol, A.E., and M.S. Sinensky. 2006. Farnesylated lamins, progeroid syndromes and farnesyl transferase inhibitors. J. Cell Sci. 119:3265-3272.
30. Scaffidi, P., and T. Misteli. 2005. Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome. Nat. Med. 11:440-445.
31. Scaffidi, P., and T. Misteli. 2006. Lamin A-dependent nuclear defects in human aging. Science. 312:1059-1063.
32. Scaffidi, P., and T. Misteli. 2008. Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing. Nat. Cell Biol. doi:10.1038/ncb1708.
33. Stewart, C.L., S. Kozlov, L.G. Fong, and S.G. Young. 2007. Mouse models of the laminopathies. Exp. Cell Res. 313:2144-2156.
34. Stuurman, N., S. Heins, and U. Aebi. 1998. Nuclear lamins: their structure, assembly, and interactions. J. Struct. Biol. 122:42-66.
35. Varela, I., J. Cadinanos, A.M. Pendas, A. Gutierrez-Fernandez, A.R. Folgueras, L.M. Sanchez, Z. Zhou, F.J. Rodriguez, C.L. Stewart, J.A. Vega, et al. 2005. Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation. Nature. 437:564-568.
36. Wiesel, N., A. Mattout, S. Melcer, N. Melamed-Book, H. Herrmann, O. Medalia, U. Aebi, and Y. Gruenbaum. 2008. Laminopathic mutations interfere with the assembly, localization and dynamics of nuclear lamins. Proc. Natl. Acad. Sci. USA. 105:180-185.
37. Worman, H.J., and G. Bonne. 2007. "Laminopathies": a wide spectrum of human diseases. Exp. Cell Res. 313:2121-2133.
38. Young, S.G., M. Meta, S.H. Yang, and L.G. Fong. 2006. Prelamin a farnesylation and progeroid syndromes. J. Biol. Chem. 281:39741-39745.