A Natural Product Telomerase Activator Lengthens Telomeres in Humans: A Randomized, Double Blind, and Placebo Controlled Study

Rejuvenation Research

Volumn 19, Issue 6, 2016, Pages 478-484

  Salvador, Laura ^a   Singaravelu, Gunasekaran ^b   Harley, Calvin B ^c   Flom, Peter ^d   Suram, Anitha ^b   Raffaele, Joseph M ^e  

^a Anti aging Group Barcelona   (Spain)

^b TA Sciences   (United States)

^c Peter Flom Consulting ^*  (United States)

^d Peter Flom Consulting   (United States)

^e PhysioAge Systems   (United States)

Author keywords

Astragalus; placebo controlled trial; randomized; TA 65; telomerase; telomere length

Indexed keywords

ENZYME ACTIVATOR; PLACEBO; TA 65; TELOMERASE; UNCLASSIFIED DRUG; BIOLOGICAL PRODUCT;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; DOUBLE BLIND PROCEDURE; DRUG MECHANISM; DRUG MEGADOSE; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; LOADING DRUG DOSE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TELOMERE LENGTH; TELOMERE SHORTENING; VERY ELDERLY; CHINESE MEDICINE; CROSS-SECTIONAL STUDY; DOSE RESPONSE; DRUG EFFECTS; ENZYME ACTIVATION; MIDDLE AGED; PHYSIOLOGY; TELOMERE;

AGED; AGED, 80 AND OVER; BIOLOGICAL PRODUCTS; CROSS-SECTIONAL STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; ENZYME ACTIVATION; HUMANS; MEDICINE, CHINESE TRADITIONAL; MIDDLE AGED; TELOMERASE; TELOMERE;

EID: 85007129468     PISSN: 15491684     EISSN: 15578577     Source Type: Journal    
DOI: 10.1089/rej.2015.1793     Document Type: Article

References (25)

1. Harley CB, Liu W, Blasco M, et al. A natural product telomerase activator as part of a health maintenance program. Rejuvenation Res 2011;14:45-56.
2. Harley CB, Liu W, Flom PL, Raffaele JM. A natural product telomerase activator as part of a health maintenance program: Metabolic and cardiovascular response. Rejuvenation Res 2013;16:386-395.
3. Bernardes de Jesus B, Schneeberger K, Vera E, et al. The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence. Aging Cell 2011;10:604-621.
4. Szabo NJ. Dietary safety of cycloastragenol from Astragalus spp.: Subchronic toxicity and genotoxicity studies. Food Chem Toxicol 2014;64:322-334.
5. Vaziri H, Dragowska W, Allsopp RC, et al. Evidence for a mitotic clock in human hematopoietic stem cells: Loss of telomeric DNA with age. Proc Natl Acad Sci U S A 1994;91:9857-9860.
6. Qian Y, Yang L, Cao S. Telomeres and telomerase in T cells of tumor immunity. Cell Immunol 2014;289:63-69.
7. Shawi M, Autexier C. Telomerase, senescence and ageing. Mech Ageing Dev 2008;129:3-10.
8. Ramunas J, Yakubov E, Brady JJ, et al. Transient delivery of modified mRNA encoding TERT rapidly extends telomeres in human cells. FASEB J 2015;29:1930-1939.
9. Stanley SE, Armanios M. The short and long telomere syndromes: Paired paradigms for molecular medicine. Curr Opin Genet Dev 2015;33:1-9.
10. Bauer ME, Wieck A, Petersen LE, Baptista TS. Neuroendocrine and viral correlates of premature immunosenescence. Ann N Y Acad Sci 2015;1351:11-21.
11. Crumpacker CS. Invited commentary: Human cytomegalovirus, inflammation, cardiovascular disease, and mortality. Am J Epidemiol 2010;172:372-374.
12. Savva GM, Pachnio A, Kaul B, et al. Cytomegalovirus infection is associated with increased mortality in the older population. Aging Cell 2013;12:381-387.
13. Canela A, Vera E, Klatt P, Blasco MA. High-throughput telomere length quantification by FISH and its application to human population studies. Proc Natl Acad Sci U S A 2007;104:5300-5305.
14. Gardner MP, Martin-Ruiz C, Cooper R, et al. Telomere length and physical performance at older ages: An individual participant meta-analysis. PLoS One 2013;8:e69526.
15. Ornish D, Lin J, Daubenmier J, et al. Increased telomerase activity and comprehensive lifestyle changes: A pilot study. Lancet Oncol 2008;9:1048-1057.
16. Aubert G, Hills M, Lansdorp PM. Telomere length measurement-caveats and a critical assessment of the available technologies and tools. Mutat Res 2012;730:59-67.
17. Frenck RW, Jr, Blackburn EH, Shannon KM. The rate of telomere sequence loss in human leukocytes varies with age. Proc Natl Acad Sci U S A 1998;95:5607-5610.
18. van de Berg PJ, Griffiths SJ, Yong SL, et al. Cytomegalovirus infection reduces telomere length of the circulating T cell pool. J Immunol 2010;184:3417-3423.
19. Khan N, Shariff N, Cobbold M, et al. Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals. J Immunol 2002;169:1984-1992.
20. Fauce SR, Jamieson BD, Chin AC, et al. Telomerase-based pharmacologic enhancement of antiviral function of human CD8+ T lymphocytes. J Immunol 2008;181:7400-7406.
21. Le Saux CJ, Davy P, Brampton C, et al. A novel telomerase activator suppresses lung damage in a murine model of idiopathic pulmonary fibrosis. PLoS One 2013;8:e58423.
22. Weischer M, Bojesen SE, Cawthon RM, et al. Short telomere length, myocardial infarction, ischemic heart disease, and early death. Arterioscler Thromb Vasc Biol 2012;32: 822-829.
23. Njajou OT, Cawthon RM, Blackburn EH, et al. Shorter telomeres are associated with obesity and weight gain in the elderly. Int J Obes (Lond) 2012;36:1176-1179.
24. Willeit P, Willeit J, Mayr A, et al. Telomere length and risk of incident cancer and cancer mortality. JAMA 2010;304: 69-75.
25. Cohen S, Janicki-Deverts D, Turner RB, et al. Childhood socioeconomic status, telomere length, and susceptibility to upper respiratory infection. Brain Behav Immun 2013;34: 31-38.