Clearance of p16 Ink4a-positive senescent cells delays ageing-associated disorders

Nature

Volumn 479, Issue 7372, 2011, Pages 232-236

  Baker, Darren J ^a,b   Wijshake, Tobias ^a,c   Tchkonia, Tamar ^a   Lebrasseur, Nathan K ^a   Childs, Bennett G ^a   Van De Sluis, Bart ^c   Kirkland, James L ^a   Van Deursen, Jan M ^a,b  

^a Mayo Clinic   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BUB1 RELATED PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; AP20187; BUB1 SPINDLE CHECKPOINT PROTEIN; CDKN2A PROTEIN, MOUSE; DRUG DERIVATIVE; PROTEIN SERINE THREONINE KINASE; TACROLIMUS;

AGING; BIOENGINEERING; CYTOLOGY; DISEASE CONTROL; DISEASE TREATMENT; MEDICINE; MUSCLE; PHENOTYPE; PUBLIC HEALTH; RISK FACTOR; RODENT; SENESCENCE; TUMOR;

ADIPOSE TISSUE; AGING; ANIMAL CELL; ARTICLE; CELL AGING; DISEASE COURSE; EYE; FEMALE; INK ATTAC TRANSGENE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN METABOLISM; SKELETAL MUSCLE; TRANSGENE; ANIMAL; BONE MARROW CELL; CELL COUNT; CELL CULTURE; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION; GENOTYPE; LONGEVITY; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROGERIA; TIME; TRANSGENIC MOUSE; WEANING;

ADIPOSE TISSUE; AGING; ANIMALS; BONE MARROW CELLS; CELL AGING; CELL COUNT; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P16; EYE; FEMALE; GENE EXPRESSION; GENOTYPE; LONGEVITY; MALE; MICE; MICE, TRANSGENIC; MUSCLE, SKELETAL; PHENOTYPE; PROGERIA; PROTEIN-SERINE-THREONINE KINASES; TACROLIMUS; TIME FACTORS; WEANING;

EID: 80855138775     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature10600     Document Type: Article

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