Perifosine as a potential novel anti-telomerase therapy

Oncotarget

Volumn 6, Issue 26, 2015, Pages 21816-21826

  Holohan, Brody ^a   Hagiopian, Moriah M ^b   Lai, Tsung Po ^a   Huang, Ejun ^a   Friedman, Daphne R ^c   Wright, Woodring E ^a   Shay, Jerry W ^a,d  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c DUKE UNIVERSITY   (United States)

^d KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

CLL; Perifosine; Targeted therapy; Telomerase; Telomeres

Indexed keywords

PERIFOSINE; TELOMERASE; ENZYME INHIBITOR; PHOSPHORYLCHOLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CANCER GROWTH; CHRONIC LYMPHATIC LEUKEMIA; COLONY FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; LOADING DRUG DOSE; LOW DRUG DOSE; METASTASIS POTENTIAL; MOUSE; MULTIPLE CYCLE TREATMENT; NONHUMAN; PROTEIN TARGETING; TELOMERE SHORTENING; TREATMENT DURATION; TREATMENT RESPONSE; TREATMENT WITHDRAWAL; TUMOR VOLUME; TUMOR XENOGRAFT; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BREAST NEOPLASMS; DRUG EFFECTS; DRUG SCREENING; ENZYMOLOGY; GENETICS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; METABOLISM; NEOPLASMS; NONOBESE DIABETIC MOUSE; PHASE 2 CLINICAL TRIAL (TOPIC); SCID MOUSE; TELOMERE; TUMOR CELL LINE;

ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; CLINICAL TRIALS, PHASE II AS TOPIC; ENZYME INHIBITORS; FEMALE; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MICE; MICE, INBRED NOD; MICE, SCID; NEOPLASMS; PHOSPHORYLCHOLINE; TELOMERASE; TELOMERE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84941243573     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.5200     Document Type: Article

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