N-acetyl cysteine mitigates curcumin-mediated telomerase inhibition through rescuing of Sp1 reduction in A549 cells

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 688, Issue 1-2, 2010, Pages 72-77

  Hsin, I Lun ^a   Sheu, Gwo Tarng ^a   Chen, Hung Hsuan ^a   Chiu, Ling Yen ^a   Wang, Horng Dar ^e   Chan, Hsiu Wen ^a   Hsu, Chung Ping ^c,d   Ko, Jiunn Liang ^a,b  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^d NATIONAL YANG MING UNIVERSITY   (Taiwan)

^e NATIONAL TSING HUA UNIVERSITY   (Taiwan)

Author keywords

Curcumin; N acetyl cysteine; Reactive oxygen species; Sp1; Telomerase activity

Indexed keywords

ACETYLCYSTEINE; CURCUMIN; PROTEASOME; REACTIVE OXYGEN METABOLITE; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; TRANSCRIPTION FACTOR SP1;

ARTICLE; BINDING AFFINITY; CELL STRAIN; CELL VIABILITY; CONTROLLED STUDY; DNA BINDING; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REPRESSION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PRECIPITATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; WILD TYPE;

ACETYLCYSTEINE; ADENOCARCINOMA; CELL LINE, TUMOR; CELL SHAPE; CELL SURVIVAL; CURCUMIN; DOWN-REGULATION; HUMANS; LUNG NEOPLASMS; REACTIVE OXYGEN SPECIES; SP1 TRANSCRIPTION FACTOR; TELOMERASE;

EID: 77952882851     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2010.03.011     Document Type: Article

References (45)

1. Mantovani A. Cancer: inflaming metastasis. Nature 2009, 457:36-37.
2. Hsu C.P., Hsu N.Y., Lee L.W., Ko J.L. Ets2 binding site single nucleotide polymorphism at the hTERT gene promoter-effect on telomerase expression and telomere length maintenance in non-small cell lung cancer. Eur. J. Cancer 2006, 42:1466-1474.
3. Takakura M., Kyo S., Kanaya T., Hirano H., Takeda J., Yutsudo M., Inoue M. Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells. Cancer Res. 1999, 59:551-557.
4. Xu D., Dwyer J., Li H., Duan W., Liu J.P. Ets2 maintains hTERT gene expression and breast cancer cell proliferation by interacting with C-myc. J. Biol. Chem. 2008, 283:23567-23580.
5. Kyo S., Takakura M., Fujiwara T., Inoue M. Understanding and exploiting hTERT promoter regulation for diagnosis and treatment of human cancers. Cancer Sci. 2008, 99:1528-1538.
6. Kyo S., Takakura M., Taira T., Kanaya T., Itoh H., Yutsudo M., Ariga H., Inoue M. Sp1 cooperates with C-myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT). Nucleic Acids Res. 2000, 28:669-677.
7. Chakraborty S., Ghosh U., Bhattacharyya N.P., Bhattacharya R.K., Roy M. Inhibition of telomerase activity and induction of apoptosis by curcumin in K-562 cells. Mutat. Res. 2006, 596:81-90.
8. Cui S.X., Qu X.J., Xie Y.Y., Zhou L., Nakata M., Makuuchi M., Tang W. Curcumin inhibits telomerase activity in human cancer cell lines. Int. J. Mol. Med. 2006, 18:227-231.
9. Mukherjee Nee Chakraborty S., Ghosh U., Bhattacharyya N.P., Bhattacharya R.K., Dey S., Roy M. Curcumin-induced apoptosis in human leukemia cell HL-60 is associated with inhibition of telomerase activity. Mol. Cell. Biochem. 2007, 297:31-39.
10. Ramachandran C., Fonseca H.B., Jhabvala P., Escalon E.A., Melnick S.J. Curcumin inhibits telomerase activity through human telomerase reverse transcriptase in MCF-7 breast cancer cell line. Cancer Lett. 2002, 184:1-6.
11. Chadalapaka G., Jutooru I., Chintharlapalli S., Papineni S., Smith R., Li X., Safe S. Curcumin decreases specificity protein expression in bladder cancer cells. Cancer Res. 2008, 68:5345-5354.
12. Liao C.H., Hsiao Y.M., Hsu C.P., Lin M.Y., Wang J.C., Huang Y.L., Ko J.L. Transcriptionally mediated inhibition of telomerase of fungal immunomodulatory protein from Ganoderma tsugae in A549 human lung adenocarcinoma cell line. Mol. Carcinog. 2006, 45:220-229.
13. Ko J.L., Chiao M.C., Chang S.L., Lin P., Lin J.C., Sheu G.T., Lee H. A novel p53 mutant retained functional activity in lung carcinomas. DNA Repair (Amst.) 2002, 1:755-762.
14. Cai B.H., Chen J.Y., Lu M.H., Chang L.T., Lin H.C., Chang Y.M., Chao C.F. Functional four-base A/T gap core sequence CATTAG of P53 response elements specifically bound tetrameric P53 differently than two-base A/T gap core sequence CATG bound both dimeric and tetrameric P53. Nucleic Acids Res. 2009, 37:1984-1990.
15. Woo J.H., Kim Y.H., Choi Y.J., Kim D.G., Lee K.S., Bae J.H., Min D.S., Chang J.S., Jeong Y.J., Lee Y.H., Park J.W., Kwon T.K. Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt. Carcinogenesis 2003, 24:1199-1208.
16. Lin S.S., Huang H.P., Yang J.S., Wu J.Y., Hsai T.C., Lin C.C., Lin C.W., Kuo C.L., Gibson Wood W., Chung J.G. DNA damage and endoplasmic reticulum stress mediated curcumin-induced cell cycle arrest and apoptosis in human lung carcinoma A-549 cells through the activation caspases cascade- and mitochondrial-dependent pathway. Cancer Lett. 2008, 272:77-90.
17. Xu D., Wang Q., Gruber A., Bjorkholm M., Chen Z., Zaid A., Selivanova G., Peterson C., Wiman K.G., Pisa P. Downregulation of telomerase reverse transcriptase mRNA expression by wild type p53 in human tumor cells. Oncogene 2000, 19:5123-5133.
18. DesJardins E., Hay N. Repeated CT elements bound by zinc finger proteins control the absolute and relative activities of the two principal human C-myc promoters. Mol. Cell. Biol. 1993, 13:5710-5724.
19. Majello B., De Luca P., Suske G., Lania L. Differential transcriptional regulation of C-myc promoter through the same DNA binding sites targeted by Sp1-like proteins. Oncogene 1995, 10:1841-1848.
20. Chou W.C., Chen H.Y., Yu S.L., Cheng L., Yang P.C., Dang C.V. Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood 2005, 106:304-310.
21. Sharma R.A., Euden S.A., Platton S.L., Cooke D.N., Shafayat A., Hewitt H.R., Marczylo T.H., Morgan B., Hemingway D., Plummer S.M., Pirmohamed M., Gescher A.J., Steward W.P. Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance. Clin. Cancer Res. 2004, 10:6847-6854.
22. Dhillon N., Aggarwal B.B., Newman R.A., Wolff R.A., Kunnumakkara A.B., Abbruzzese J.L., Ng C.S., Badmaev V., Kurzrock R. Phase II trial of curcumin in patients with advanced pancreatic cancer. Clin. Cancer Res. 2008, 14:4491-4499.
23. Shay J.W., Wright W.E. Telomerase: a target for cancer therapeutics. Cancer Cell. 2002, 2:257-265.
24. Harley C.B. Telomerase and cancer therapeutics. Nat. Rev. Cancer 2008, 8:167-179.
25. Narasimhan M., Ammanamanchi S. Curcumin blocks RON tyrosine kinase-mediated invasion of breast carcinoma cells. Cancer Res. 2008, 68:5185-5192.
26. Aoki H., Takada Y., Kondo S., Sawaya R., Aggarwal B.B., Kondo Y. Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways. Mol. Pharmacol. 2007, 72:29-39.
27. Hussain A.R., Al-Rasheed M., Manogaran P.S., Al-Hussein K.A., Platanias L.C., Al Kuraya K., Uddin S. Curcumin induces apoptosis via inhibition of PI3x-kinase/AKT pathway in acute T cell leukemias. Apoptosis 2006, 11:245-254.
28. Yang F., Lim G.P., Begum A.N., Ubeda O.J., Simmons M.R., Ambegaokar S.S., Chen P.P., Kayed R., Glabe C.G., Frautschy S.A., Cole G.M. Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J. Biol. Chem. 2005, 280:5892-5901.
29. Tsui K.H., Feng T.H., Lin C.M., Chang P.L., Juang H.H. Curcumin blocks the activation of androgen and interlukin-6 on prostate-specific antigen expression in human prostatic carcinoma cells. J. Androl. 2008, 29:661-668.
30. Takahashi M., Ishiko T., Kamohara H., Hidaka H., Ikeda O., Ogawa M., Baba H. Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) blocks the chemotaxis of neutrophils by inhibiting signal transduction through IL-8 receptors. Mediators Inflamm. 2007, 2007:10767.
31. Pan J.S., Hong M.Z., Ren J.L. Reactive oxygen species: a double-edged sword in oncogenesis. World J. Gastroenterol. 2009, 15:1702-1707.
32. Schumacker P.T. Reactive oxygen species in cancer cells: live by the sword, die by the sword. Cancer Cell. 2006, 10:175-176.
33. Benhar M., Engelberg D., Levitzki A. ROS, stress-activated kinases and stress signaling in cancer. EMBO Rep. 2002, 3:420-425.
34. Pelicano H., Carney D., Huang P. ROS stress in cancer cells and therapeutic implications. Drug Resist. Updat. 2004, 7:97-110.
35. Balasubramanyam M., Koteswari A.A., Kumar R.S., Monickaraj S.F., Maheswari J.U., Mohan V. Curcumin-induced inhibition of cellular reactive oxygen species generation: novel therapeutic implications. J. Biosci. 2003, 28:715-721.
36. Sharma O.P. Antioxidant activity of curcumin and related compounds. Biochem. Pharmacol. 1976, 25:1811-1812.
37. Lee K.H., Ab Aziz F.H., Syahida A., Abas F., Shaari K., Israf D.A., Lajis N.H. Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities. Eur. J. Med. Chem. 2009, 44:3195-3200.
38. Balogun E., Hoque M., Gong P., Killeen E., Green C.J., Foresti R., Alam J., Motterlini R. Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element. Biochem. J. 2003, 371:887-895.
39. Scapagnini G., Foresti R., Calabrese V., Giuffrida Stella A.M., Green C.J., Motterlini R. Caffeic acid phenethyl ester and curcumin: a novel class of heme oxygenase-1 inducers. Mol. Pharmacol. 2002, 61:554-561.
40. Motterlini R., Foresti R., Bassi R., Green C.J. Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress. Free Radicals Biol. Med. 2000, 28:1303-1312.
41. Thayyullathil F., Chathoth S., Hago A., Patel M., Galadari S. Rapid reactive oxygen species (ROS) generation induced by curcumin leads to caspase-dependent and -independent apoptosis in L929 cells. Free Radicals Biol. Med. 2008, 45:1403-1412.
42. Tan T.W., Tsai H.R., Lu H.F., Lin H.L., Tsou M.F., Lin Y.T., Tsai H.Y., Chen Y.F., Chung J.G. Curcumin-induced cell cycle arrest and apoptosis in human acute promyelocytic leukemia HL-60 cells via MMP changes and caspase-3 activation. Anticancer Res. 2006, 26:4361-4371.
43. Jung E.M., Park J.W., Choi K.S., Park J.W., Lee H.I., Lee K.S., Kwon T.K. Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through CHOP-independent DR5 upregulation. Carcinogenesis 2006, 27:2008-2017.
44. Jung E.M., Lim J.H., Lee T.J., Park J.W., Choi K.S., Kwon T.K. Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through reactive oxygen species-mediated upregulation of death receptor 5 (DR5). Carcinogenesis 2005, 26:1905-1913.
45. Lin S.S., Huang H.P., Yang J.S., Wu J.Y., Hsia T.C., Lin C.C., Lin C.W., Kuo C.L., Gibson Wood W., Chung J.G. DNA damage and endoplasmic reticulum stress mediated curcumin-induced cell cycle arrest and apoptosis in human lung carcinoma A-549 cells through the activation caspases cascade- and mitochondrial-dependent pathway. Cancer Lett. 2008, 272:77-90.