UV-induced EGFR signal transactivation is dependent on proligand shedding by activated metalloproteases in skin cancer cell lines

International Journal of Cancer

Volumn 124, Issue 3, 2009, Pages 531-539

  Singh, Bhuminder ^a,b   Schneider, Matthias ^a   Knyazev, Pjotr ^a   Ullrich, Axel ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Apoptosis; EGFR; EGFR signal transactivation; Metalloprotease; UV

Indexed keywords

BATIMASTAT; EPIDERMAL GROWTH FACTOR RECEPTOR; METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN ADAM17; PROTEIN ADAM9; PROTEIN KINASE B; UNCLASSIFIED DRUG; REACTIVE OXYGEN METABOLITE;

ARTICLE; CONTROLLED STUDY; DNA REPAIR; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; SKIN CANCER; TRANSACTIVATION; ULTRAVIOLET RADIATION; DNA MICROARRAY; FLOW CYTOMETRY; GENETICS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; METABOLISM; RADIATION EXPOSURE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SKIN TUMOR; TRANSCRIPTION INITIATION; TUMOR CELL LINE;

CELL LINE, TUMOR; FLOW CYTOMETRY; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; METALLOPROTEASES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REACTIVE OXYGEN SPECIES; RECEPTOR, EPIDERMAL GROWTH FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SKIN NEOPLASMS; TRANSCRIPTIONAL ACTIVATION; ULTRAVIOLET RAYS;

EID: 58149288674     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.23974     Document Type: Article

References (43)

1. Ziegler A, Jonason A, Simon J, Leffell D, Brash D. Tumor suppressor gene mutations and photocarcinogenesis. Photochem Photobiol 1996;63:432-5.
2. Armstrong B, Kricker A. How much melanoma is caused by sun exposure? Melanoma Res 1993;3:395-401.
3. Setlow RB. The wavelengths in sunlight effective in producing skin cancer: a theoretical analysis. Proc Natl Acad Sci USA 1974;71:3363-66.
4. Thannickal VJ, Fanburg BL. Reactive oxygen species in cell signaling. Am J Physiol Lung Cell Mol Physiol 2000;279:L1005-28.
5. Setlow RB. Cyclobutane-type pyrimidine dimers in polynucleotides. Science 1966;153:379-86.
6. Black H, deGruijl F, Forbes P, Cleaver J, Ananthaswamy H, deFabo E, Ullrich S, Tyrrell R. Photocarcinogenesis: an overview. J Photochem Photobiol B 1997;40:29-47.
7. Knebel A, Rahmsdorf HJ, Ullrich A, Herrlich P. Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents. Embo J 1996;15:5314-25.
8. Sachsenmaier C, Radler-Pohl A, Zinck R, Nordheim A, Herrlich P, Rahmsdorf H. Involvement of growth factor receptors in the mammalian UVC response. Cell 1994;78:963-72.
9. Tomic S, Greiser U, Lammers R, Kharitonenkov A, Imyanitov E, Ullrich A, Bohmer FD. Association of SH2 domain protein tyrosine phosphatases with the epidermal growth factor receptor in human tumor cells. Phosphatidic acid activates receptor dephosphorylation by PTP1C. J Biol Chem 1995;270:21277-84.
10. Meng T, Fukada T, Tonks N. Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo. Mol Cell 2002;9:387-99.
11. Gross S, Knebel A, Tenev T, Neininger A, Gaestel M, Herrlich P, Bohmer FD. Inactivation ofprotein-tyrosine phosphatases as mechanism of UV-induced signal transduction. J Biol Chem 1999;274:26378-86.
12. Xu Y, Shao Y, Voorhees JJ, Fisher GJ. Oxidative inhibition of receptor-type protein-tyrosine phosphatase (kappa) by ultraviolet irradiation activates epidermal growth factor receptor in human keratinocytes. J Biol Chem 2006;281:27389-97.
13. Gulati P, Markova B, Gottlicher M, Bohmer F, Herrlich P. UVA inactivates protein tyrosine phosphatases by calpain-mediated degradation. EMBO Rep 2004;5:812-7.
14. Daub H, Weiss FU, Wallasch C, Ullrich A. Role of transactivation of the EGF receptor in signaling by G-protein-coupled receptors. Nature 1996;379:557-60.
15. Prenzel N, Zwick E, Daub H, Leserer M, Abraham R, Wallasch C, Ullrich A. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature 1999;402:884-8.
16. Blobel C. ADAMs: key components in EGFR signaling and development. Nat Rev Mol Cell Biol 2005;6:32-43.
17. Fischer OM, Hart S, Gschwind A, Ullrich A. EGFR signal transactivation in cancer cells. Biochem Soc Trans 2003;31:1203-8.
18. Gschwind A, Prenzel N, Ullrich A. Lysophosphatidic acid-induced squamous cell carcinoma cell proliferation and motility involves epidermal growth factor receptor signal transactivation. Cancer Res 2002;62:6329-36.
19. Gschwind A, Hart S, Fischer OM, Ullrich A. TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells. Embo J 2003;22:2411-21.
20. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156-9.
21. Fischer OM, Giordano S, Comoglio PM, Ullrich A. Reactive oxygen species mediate Met receptor transactivation by G protein-coupled receptors and the epidermal growth factor receptor in human carcinoma cells. J Biol Chem 2004;279:28970-8.
22. Schulze W, Deng L, Mann M. Phosphotyrosine interactome of the ErbB-receptor kinase family. Mol Syst Biol 2005;1:2005.0008.
23. Schlessinger J. Ligand-induced, receptor-mediated dimerization and activation of EGF receptor. Cell 2002;110:669-72.
24. Goldstein N, Prewett M, Zuklys K, Rockwell P, Mendelsohn J. Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model. Clin Cancer Res 1995;1:1311-18.
25. Harris R, Chung E, Coffey R. EGF receptor ligands. Exp Cell Res 2003;284:2-13.
26. Sahin U, Weskamp G, Kelly K, Zhou HM, Higashiyama S, Peschon J, Hartmann D, Saftig P, Blobel CP. Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands. J Cell Biol 2004;164:769-79.
27. Schafer B, Gschwind A, Ullrich A. Multiple G-protein-coupled receptor signals converge on the epidermal growth factor receptor to promote migration and invasion. Oncogene 2004;23:991-9.
28. Scovassi A, Poirier G. Poly(ADP-ribosylation) and apoptosis. Mol Cell Biochem 1999;199:125-37.
29. Parsons JL, Dianova II, Allinson SL, Dianov GL. Poly(ADP-ribose) polymerase-1 protects excessive DNA strand breaks from deterioration during repair in human cell extracts. FEBS J 2005;272:2012-21.
30. Masutani M, Nakagama H, Sugimura T. Poly(ADP-ribose) and carcinogenesis. Genes Chromosomes Cancer 2003;38:339-48.
31. Flohr C, Burkle A, Radicella JP, Epe B. Poly(ADP-ribosyl)ation accelerates DNA repair in a pathway dependent on Cockayne syndrome B protein. Nucleic Acids Res 2003;31:5332-7.
32. Gloster H, Brodland D. The epidemiology of skin cancer. Dermatol Surg 1996;22:217-26.
33. Krahn G, Leiter U, Kaskel P, Udart M, Utikal J, Bezold G, Peter R. Coexpression patterns of EGFR, HER2, HER3 and HER4 in non-melanoma skin cancer. Eur J Cancer 2001;37:251-9.
34. Fischer OM, Hart S, Gschwind A, Prenzel N, Ullrich A. Oxidative and osmotic stress signaling in tumor cells is mediated by ADAM proteases and heparin-binding epidermal growth factor. Mol Cell Biol 2004;24:5172-83.
35. Billings SD, Southall MD, Li T, Cook PW, Baldridge L, Moores WB, Spandau DF, Foley JG, Travers JB. Amphiregulin overexpression results in rapidly growing keratinocytic tumors: an in vivo xenograft model of keratoacanthoma. Am J Pathol 2003;163:2451-58.
36. Piepkorn M, Pittelkow M, Cook P. Autocrine regulation of keratinocytes: the emerging role of heparin-binding, epidermal growth factor-related growth factors. J Invest Dermatol 1998;111:715-21.
37. Bardeesy N, Kim M, Xu J, Kim R-S, Shen Q, Bosenberg MW, Wong WH, Chin L. Role of epidermal growth factor receptor signaling in RAS-driven melanoma. Mol Cell Biol 2005;25:4176-88.
38. Zhang Z, Oliver P, Lancaster JJ, Schwarzenberger PO, Joshi MS, Cork J, Kolls JK. Reactive oxygen species mediate tumor necrosis factor alpha-converting, enzyme-dependent ectodomain shedding induced by phorbol myristate acetate. FASEB J 2001;15:303-5.
39. Zigrino P, Mauch C, Fox J, Nischt R. Adam-9 expression and regulation in human skin melanoma and melanoma cell lines. Int J Cancer 2005;116:853-9.
40. Kandel E, Hay N. The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Exp Cell Res 1999;253:210-29.
41. Lazebnik Y, Kaufmann S, Desnoyers S, Poirier G, Earnshaw W. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 1994;371:346-7.
42. Wood RD. Nucleotide excision repair in mammalian cells. J Biol Chem 1997;272:23465-8.
43. Yacoub A, Park J, Qiao L, Dent P, Hagan M. MAPK dependence of DNA damage repair: ionizing radiation and the induction of expression of the DNA repair genes XRCC1 and ERCC1 in DU145 human prostate carcinoma cells in a MEK1/2 dependent fashion. Int J Radiat Biol 2001;77:1067-78.