Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence

PLoS Biology

Volumn 5, Issue 5, 2007, Pages 1138-1151

  Passos, João F ^a,b   Saretzki, Gabriele ^a,b   Ahmed, Shaheda ^a,b   Nelson, Glyn ^a,b   Richter, Torsten ^a   Peters, Heiko ^b   Wappler, Ilka ^b   Birket, Matthew J ^b   Harold, Graham ^b   Schaeuble, Karin ^a   Birch Machin, Mark A ^b   Kirkwood, Thomas B L ^a,b   Von Zglinicki, Thomas ^a,b  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; HISTONE H2AX; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; UNCOUPLING PROTEIN 2; CALCIUM; SMALL INTERFERING RNA;

ADULT; ARTICLE; CALCIUM HOMEOSTASIS; CELL AGING; CELL DIVISION; CELL HETEROGENEITY; CELL PROLIFERATION; CELL SELECTION; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA DAMAGE; ENZYME ACTIVATION; FIBROBLAST; HUMAN; HUMAN CELL; MITOCHONDRION; OXIDATIVE STRESS; PROTEIN EXPRESSION; SENESCENCE; TELOMERE; AGE; CELL LINE; COMPARATIVE STUDY; FLOW CYTOMETRY; FLUORESCENCE IN SITU HYBRIDIZATION; GENETICS; METABOLISM; PHYSIOLOGY; STATISTICS; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

AGE FACTORS; CALCIUM; CELL AGING; CELL LINE; FIBROBLASTS; FLOW CYTOMETRY; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MICROSCOPY, ELECTRON, TRANSMISSION; MITOCHONDRIA; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; STOCHASTIC PROCESSES; TELOMERE;

EID: 34249028642     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.0050110     Document Type: Article

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