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Volumn 62, Issue 9, 2013, Pages 1499-1509

Therapeutic vaccination against autologous cancer stem cells with mRNA-transfected dendritic cells in patients with glioblastoma

Author keywords

Autologous cell culture; Brain cancer stem cell; Dendritic cell; Glioblastoma; Immunotherapy; Tumorsphere

Indexed keywords

CORTICOSTEROID; DENDRITIC CELL VACCINE; MESSENGER RNA; SURVIVIN; TELOMERASE REVERSE TRANSCRIPTASE;

EID: 84883458285     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-013-1453-3     Document Type: Article
Times cited : (242)

References (48)
  • 1
    • 65349121788 scopus 로고    scopus 로고
    • Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
    • 19269895 10.1016/S1470-2045(09)70025-7 1:CAS:528:DC%2BD1MXlsVKhs74%3D
    • Stupp R, Hegi ME, Mason WP, van den Bent MJ, Taphoorn MJ, Janzer RC, et al. (2009) Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol 10:459-466
    • (2009) Lancet Oncol , vol.10 , pp. 459-466
    • Stupp, R.1    Hegi, M.E.2    Mason, W.P.3    Van Den Bent, M.J.4    Taphoorn, M.J.5    Janzer, R.C.6
  • 2
    • 0035499267 scopus 로고    scopus 로고
    • Stem cells, cancer, and cancer stem cells
    • 11689955 10.1038/35102167 1:CAS:528:DC%2BD3MXot1ahs7c%3D
    • Reya T, Morrison SJ, Clarke MF, Weissman IL (2001) Stem cells, cancer, and cancer stem cells. Nature 414:105-111
    • (2001) Nature , vol.414 , pp. 105-111
    • Reya, T.1    Morrison, S.J.2    Clarke, M.F.3    Weissman, I.L.4
  • 3
    • 84856501335 scopus 로고    scopus 로고
    • The developing cancer stem-cell model: Clinical challenges and opportunities
    • 22300863 10.1016/S1470-2045(11)70257-1
    • Vermeulen L, de Sousa e Melo F, Richel DJ, Medema JP (2012) The developing cancer stem-cell model: clinical challenges and opportunities. Lancet Oncol 13:e83-e89
    • (2012) Lancet Oncol , vol.13
    • Vermeulen, L.1    De Sousa Melo, E.F.2    Richel, D.J.3    Medema, J.P.4
  • 4
    • 0036737914 scopus 로고    scopus 로고
    • Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro
    • 12203386 10.1002/glia.10094
    • Ignatova TN, Kukekov VG, Laywell ED, Suslov ON, Vrionis FD, Steindler DA (2002) Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro. Glia 39:193-206
    • (2002) Glia , vol.39 , pp. 193-206
    • Ignatova, T.N.1    Kukekov, V.G.2    Laywell, E.D.3    Suslov, O.N.4    Vrionis, F.D.5    Steindler, D.A.6
  • 5
    • 0026535505 scopus 로고
    • Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system
    • 1553558 10.1126/science.1553558 1:STN:280:DyaK383gsFemsw%3D%3D
    • Reynolds BA, Weiss S (1992) Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 255:1707-1710
    • (1992) Science , vol.255 , pp. 1707-1710
    • Reynolds, B.A.1    Weiss, S.2
  • 6
    • 77950502115 scopus 로고    scopus 로고
    • A hierarchy of self-renewing tumor-initiating cell types in glioblastoma
    • 20385361 10.1016/j.ccr.2009.12.049 1:CAS:528:DC%2BC3cXmsF2msLY%3D
    • Chen R, Nishimura MC, Bumbaca SM, Kharbanda S, Forrest WF, Kasman IM, et al. (2010) A hierarchy of self-renewing tumor-initiating cell types in glioblastoma. Cancer Cell 17:362-375
    • (2010) Cancer Cell , vol.17 , pp. 362-375
    • Chen, R.1    Nishimura, M.C.2    Bumbaca, S.M.3    Kharbanda, S.4    Forrest, W.F.5    Kasman, I.M.6
  • 7
    • 79251565207 scopus 로고    scopus 로고
    • Determination of somatic and cancer stem cell self-renewing symmetric division rate using sphere assays
    • 21246056 10.1371/journal.pone.0015844 1:CAS:528:DC%2BC3MXosVOgtw%3D%3D
    • Deleyrolle LP, Ericksson G, Morrison BJ, Lopez JA, Burrage K, Burrage P, et al. (2011) Determination of somatic and cancer stem cell self-renewing symmetric division rate using sphere assays. PLoS ONE 6:e15844
    • (2011) PLoS ONE , vol.6 , pp. 15844
    • Deleyrolle, L.P.1    Ericksson, G.2    Morrison, B.J.3    Lopez, J.A.4    Burrage, K.5    Burrage, P.6
  • 8
    • 24344432394 scopus 로고    scopus 로고
    • Multipotent progenitor cells from the adult human brain: Neurophysiological differentiation to mature neurons
    • 15958504 10.1093/brain/awh574
    • Moe MC, Varghese M, Danilov AI, Westerlund U, Ramm-Pettersen J, Brundin L, et al. (2005) Multipotent progenitor cells from the adult human brain: neurophysiological differentiation to mature neurons. Brain 128:2189-2199
    • (2005) Brain , vol.128 , pp. 2189-2199
    • Moe, M.C.1    Varghese, M.2    Danilov, A.I.3    Westerlund, U.4    Ramm-Pettersen, J.5    Brundin, L.6
  • 9
    • 4944250781 scopus 로고    scopus 로고
    • Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma
    • 15466194 10.1158/0008-5472.CAN-04-1364 1:CAS:528:DC%2BD2cXotFalsLs%3D
    • Galli R, Binda E, Orfanelli U, Cipelletti B, Gritti A, De Vitis S, et al. (2004) Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res 64:7011-7021
    • (2004) Cancer Res , vol.64 , pp. 7011-7021
    • Galli, R.1    Binda, E.2    Orfanelli, U.3    Cipelletti, B.4    Gritti, A.5    De Vitis, S.6
  • 10
    • 0141842674 scopus 로고    scopus 로고
    • Identification of a cancer stem cell in human brain tumors
    • 14522905 1:CAS:528:DC%2BD3sXnvVSjtbc%3D
    • Singh SK, Clarke ID, Terasaki M, Bonn VE, Hawkins C, Squire J, et al. (2003) Identification of a cancer stem cell in human brain tumors. Cancer Res 63:5821-5828
    • (2003) Cancer Res , vol.63 , pp. 5821-5828
    • Singh, S.K.1    Clarke, I.D.2    Terasaki, M.3    Bonn, V.E.4    Hawkins, C.5    Squire, J.6
  • 11
    • 58149472355 scopus 로고    scopus 로고
    • A comparison between stem cells from the adult human brain and from brain tumors
    • 19057315 10.1227/01.NEU.0000335792.85142.B0
    • Varghese M, Olstorn H, Sandberg C, Vik-Mo EO, Noordhuis P, Nistér M, et al. (2008) A comparison between stem cells from the adult human brain and from brain tumors. Neurosurgery 63:1022-1033
    • (2008) Neurosurgery , vol.63 , pp. 1022-1033
    • Varghese, M.1    Olstorn, H.2    Sandberg, C.3    Vik-Mo, E.O.4    Noordhuis, P.5    Nistér, M.6
  • 12
    • 33845317573 scopus 로고    scopus 로고
    • Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    • 17051156 10.1038/nature05236 1:CAS:528:DC%2BD28Xht1OntbzP
    • Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, Hjelmeland AB, et al. (2006) Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444:756-760
    • (2006) Nature , vol.444 , pp. 756-760
    • Bao, S.1    Wu, Q.2    McLendon, R.E.3    Hao, Y.4    Shi, Q.5    Hjelmeland, A.B.6
  • 13
    • 33750541962 scopus 로고    scopus 로고
    • Glioblastoma-derived tumorspheres identify a population of tumor stem-like cells with angiogenic potential and enhanced multidrug resistance phenotype
    • 16981197 10.1002/glia.20414
    • Salmaggi A, Boiardi A, Gelati M, Russo A, Calatozzolo C, Ciusani E, et al. (2006) Glioblastoma-derived tumorspheres identify a population of tumor stem-like cells with angiogenic potential and enhanced multidrug resistance phenotype. Glia 54:850-860
    • (2006) Glia , vol.54 , pp. 850-860
    • Salmaggi, A.1    Boiardi, A.2    Gelati, M.3    Russo, A.4    Calatozzolo, C.5    Ciusani, E.6
  • 15
    • 80052468964 scopus 로고    scopus 로고
    • Stem cell gene expression programs influence clinical outcome in human leukemia
    • 21873988 10.1038/nm.2415 1:CAS:528:DC%2BC3MXhtV2gsbfM
    • Eppert K, Takenaka K, Lechman ER, Waldron L, Nilsson B, van Galen P, et al. (2011) Stem cell gene expression programs influence clinical outcome in human leukemia. Nat Med 17:1086-1093
    • (2011) Nat Med , vol.17 , pp. 1086-1093
    • Eppert, K.1    Takenaka, K.2    Lechman, E.R.3    Waldron, L.4    Nilsson, B.5    Van Galen, P.6
  • 16
    • 78650444882 scopus 로고    scopus 로고
    • Association of a leukemic stem cell gene expression signature with clinical outcomes in acute myeloid leukemia
    • 21177505 10.1001/jama.2010.1862 1:CAS:528:DC%2BC3cXhs1WhsrrF
    • Gentles AJ, Plevritis SK, Majeti R, Alizadeh AA (2010) Association of a leukemic stem cell gene expression signature with clinical outcomes in acute myeloid leukemia. JAMA 304:2706-2715
    • (2010) JAMA , vol.304 , pp. 2706-2715
    • Gentles, A.J.1    Plevritis, S.K.2    Majeti, R.3    Alizadeh, A.A.4
  • 17
    • 33751516578 scopus 로고    scopus 로고
    • Isolation and characterization of a stem cell population from adult human liver
    • 16945998 10.1634/stemcells.2006-0114 1:CAS:528:DC%2BD2sXkslCrtg%3D%3D
    • Herrera MB, Bruno S, Buttiglieri S, Tetta C, Gatti S, Dereqibus MC, et al. (2006) Isolation and characterization of a stem cell population from adult human liver. Stem Cells 24:2840-2850
    • (2006) Stem Cells , vol.24 , pp. 2840-2850
    • Herrera, M.B.1    Bruno, S.2    Buttiglieri, S.3    Tetta, C.4    Gatti, S.5    Dereqibus, M.C.6
  • 18
    • 80053266054 scopus 로고    scopus 로고
    • Identification and characterization of a novel multipotent sub-population of Sca-1(+) cardiac progenitor cells for myocardial regeneration
    • 21980409 10.1371/journal.pone.0025265 1:CAS:528:DC%2BC3MXhtlCjs7bF
    • Takamiya M, Haider KH, Ashraf M (2011) Identification and characterization of a novel multipotent sub-population of Sca-1(+) cardiac progenitor cells for myocardial regeneration. PLoS ONE 6:e25265
    • (2011) PLoS ONE , vol.6 , pp. 25265
    • Takamiya, M.1    Haider, K.H.2    Ashraf, M.3
  • 19
    • 70349100257 scopus 로고    scopus 로고
    • CD133 as a marker for cancer stem cells: Progresses and concerns
    • 19409053 10.1089/scd.2008.0338 1:CAS:528:DC%2BD1MXhtleitr3I
    • Wu Y, Wu PY (2009) CD133 as a marker for cancer stem cells: progresses and concerns. Stem Cells Dev 18:1127-1134
    • (2009) Stem Cells Dev , vol.18 , pp. 1127-1134
    • Wu, Y.1    Wu, P.Y.2
  • 20
    • 33746910738 scopus 로고    scopus 로고
    • Phase I/II trial of melanoma therapy with dendritic cells transfected with autologous tumor-mRNA
    • 16710345 10.1038/sj.cgt.7700961 1:CAS:528:DC%2BD28XpsVahtr4%3D
    • Kyte JA, Mu L, Aamdal S, Kvalheim G, Dueland S, Hauser M, et al. (2006) Phase I/II trial of melanoma therapy with dendritic cells transfected with autologous tumor-mRNA. Cancer Gene Ther 13:905-918
    • (2006) Cancer Gene Ther , vol.13 , pp. 905-918
    • Kyte, J.A.1    Mu, L.2    Aamdal, S.3    Kvalheim, G.4    Dueland, S.5    Hauser, M.6
  • 21
    • 27144507469 scopus 로고    scopus 로고
    • Immunotherapy with allotumour mRNA-transfected dendritic cells in androgen-resistant prostate cancer patients
    • 16136047 10.1038/sj.bjc.6602761 1:CAS:528:DC%2BD2MXhtVeksbvF
    • Mu LJ, Kyte JA, Kvalheim G, Aamdal S, Dueland S, Hauser M, et al. (2005) Immunotherapy with allotumour mRNA-transfected dendritic cells in androgen-resistant prostate cancer patients. Br J Cancer 93:749-756
    • (2005) Br J Cancer , vol.93 , pp. 749-756
    • Mu, L.J.1    Kyte, J.A.2    Kvalheim, G.3    Aamdal, S.4    Dueland, S.5    Hauser, M.6
  • 23
    • 33751297619 scopus 로고    scopus 로고
    • Neurospheres enriched in cancer stem-like cells are highly effective in eliciting a dendritic cell-mediated immune response against malignant gliomas
    • 17079441 10.1158/0008-5472.CAN-06-2048 1:CAS:528:DC%2BD28XhtFGjsrvO
    • Pellegatta S, Poliani PL, Corno D, Menghi F, Ghielmetti F, Suarez-Merino B, et al. (2006) Neurospheres enriched in cancer stem-like cells are highly effective in eliciting a dendritic cell-mediated immune response against malignant gliomas. Cancer Res 66:10247-10252
    • (2006) Cancer Res , vol.66 , pp. 10247-10252
    • Pellegatta, S.1    Poliani, P.L.2    Corno, D.3    Menghi, F.4    Ghielmetti, F.5    Suarez-Merino, B.6
  • 24
    • 0036133166 scopus 로고    scopus 로고
    • MRNA-based electrotransfection of human dendritic cells and induction of cytotoxic T lymphocyte responses against the telomerase catalytic subunit (hTERT)
    • 11730854 10.1016/S0022-1759(01)00506-3 1:CAS:528:DC%2BD3MXos1ansb0%3D
    • Saeboe-Larssen S, Fossberg E, Gaudernack G (2002) mRNA-based electrotransfection of human dendritic cells and induction of cytotoxic T lymphocyte responses against the telomerase catalytic subunit (hTERT). J Immunol Methods 259:191-203
    • (2002) J Immunol Methods , vol.259 , pp. 191-203
    • Saeboe-Larssen, S.1    Fossberg, E.2    Gaudernack, G.3
  • 25
    • 79959769072 scopus 로고    scopus 로고
    • HTERT mRNA dendritic cell vaccination: Complete response in a pancreatic cancer patient associated with response against several hTERT epitopes
    • 21365467 10.1007/s00262-011-0991-9 1:CAS:528:DC%2BC3MXmsVajtL8%3D
    • Suso EM, Dueland S, Rasmussen AM, Vetrhus T, Aamdal S, Kvalheim G, et al. (2011) hTERT mRNA dendritic cell vaccination: complete response in a pancreatic cancer patient associated with response against several hTERT epitopes. Cancer Immunol Immunother 60:809-818
    • (2011) Cancer Immunol Immunother , vol.60 , pp. 809-818
    • Suso, E.M.1    Dueland, S.2    Rasmussen, A.M.3    Vetrhus, T.4    Aamdal, S.5    Kvalheim, G.6
  • 26
    • 77955293318 scopus 로고    scopus 로고
    • Overall survival, prognostic factors, and repeated surgery in a consecutive series of 516 patients with glioblastoma multiforme
    • 20298491 10.1111/j.1600-0404.2010.01350.x 1:STN:280: DC%2BC3cjjtlGlsQ%3D%3D
    • Helseth R, Helseth E, Johannesen TB, Langberg CW, Lote K, Rønning P, et al. (2010) Overall survival, prognostic factors, and repeated surgery in a consecutive series of 516 patients with glioblastoma multiforme. Acta Neurol Scand 122:159-167
    • (2010) Acta Neurol Scand , vol.122 , pp. 159-167
    • Helseth, R.1    Helseth, E.2    Johannesen, T.B.3    Langberg, C.W.4    Lote, K.5    Rønning, P.6
  • 27
    • 78650126756 scopus 로고    scopus 로고
    • Brain tumor stem cells maintain overall phenotype and tumorigenicity after in vitro culturing in serum-free conditions
    • 20843775
    • Vik-Mo EO, Sandberg C, Olstorn H, Varghese M, Brandal P, Ramm-Pettersen J, et al. (2010) Brain tumor stem cells maintain overall phenotype and tumorigenicity after in vitro culturing in serum-free conditions. Neuro Oncol 12:1220-1230
    • (2010) Neuro Oncol , vol.12 , pp. 1220-1230
    • Vik-Mo, E.O.1    Sandberg, C.2    Olstorn, H.3    Varghese, M.4    Brandal, P.5    Ramm-Pettersen, J.6
  • 28
    • 79952444151 scopus 로고    scopus 로고
    • A comparative study of the structural organization of spheres derived from the adult human subventricular zone and glioblastoma biopsies
    • 21199649 10.1016/j.yexcr.2010.12.022 1:CAS:528:DC%2BC3MXjtFOnsrw%3D
    • Vik-Mo EO, Sandberg C, Joel M, Stangeland B, Watanabe Y, Mackay-Sim A, et al. (2011) A comparative study of the structural organization of spheres derived from the adult human subventricular zone and glioblastoma biopsies. Exp Cell Res 317:1049-1059
    • (2011) Exp Cell Res , vol.317 , pp. 1049-1059
    • Vik-Mo, E.O.1    Sandberg, C.2    Joel, M.3    Stangeland, B.4    Watanabe, Y.5    Mackay-Sim, A.6
  • 29
    • 0034652624 scopus 로고    scopus 로고
    • Induction of tumor immunity and cytotoxic T lymphocyte responses using dendritic cells transfected with messenger RNA amplified from tumor cells
    • 10706120 1:CAS:528:DC%2BD3cXhs1ShsLw%3D
    • Boczkowski D, Nair SK, Nam JH, Lyerly HK, Gilboa E (2000) Induction of tumor immunity and cytotoxic T lymphocyte responses using dendritic cells transfected with messenger RNA amplified from tumor cells. Cancer Res 60:1028-1034
    • (2000) Cancer Res , vol.60 , pp. 1028-1034
    • Boczkowski, D.1    Nair, S.K.2    Nam, J.H.3    Lyerly, H.K.4    Gilboa, E.5
  • 30
    • 18844388926 scopus 로고    scopus 로고
    • Preclinical full-scale evaluation of dendritic cells transfected with autologous tumor-mRNA for melanoma vaccination
    • 15818380 10.1038/sj.cgt.7700837 1:CAS:528:DC%2BD2MXktFOisbk%3D
    • Kyte JA, Kvalheim G, Aamdal S, Saeboe-Larssen S, Gaudernack G (2005) Preclinical full-scale evaluation of dendritic cells transfected with autologous tumor-mRNA for melanoma vaccination. Cancer Gene Ther 12:579-591
    • (2005) Cancer Gene Ther , vol.12 , pp. 579-591
    • Kyte, J.A.1    Kvalheim, G.2    Aamdal, S.3    Saeboe-Larssen, S.4    Gaudernack, G.5
  • 31
    • 57849117384 scopus 로고    scopus 로고
    • New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)
    • 19097774 10.1016/j.ejca.2008.10.026 1:STN:280:DC%2BD1M%2Fgs12rug%3D%3D
    • Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent R, Ford R, et al. (2009) New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer 45:228-247
    • (2009) Eur J Cancer , vol.45 , pp. 228-247
    • Eisenhauer, E.A.1    Therasse, P.2    Bogaerts, J.3    Schwartz, L.H.4    Sargent, R.5    Ford, R.6
  • 32
    • 84859530282 scopus 로고    scopus 로고
    • Maintenance of primary tumor phenotype and genotype in glioblastoma stem cells
    • 22067563 10.1093/neuonc/nor195 1:CAS:528:DC%2BC38Xhtl2hs7vE
    • Wakimoto H, Mohapatra G, Kanai R, Curry WT Jr, Yip S, Nitta M, et al. (2012) Maintenance of primary tumor phenotype and genotype in glioblastoma stem cells. Neuro Oncol 14:132-144
    • (2012) Neuro Oncol , vol.14 , pp. 132-144
    • Wakimoto, H.1    Mohapatra, G.2    Kanai, R.3    Curry, Jr.W.T.4    Yip, S.5    Nitta, M.6
  • 33
    • 77149154049 scopus 로고    scopus 로고
    • Gliosarcoma stem cells undergo glial and mesenchymal differentiation in vivo
    • 19937755 1:CAS:528:DC%2BC3cXktF2qtb8%3D
    • deCarvalho AC, Nelson K, Lemke N, Lehman NL, Arbab AS, Kalkanis S, et al. (2010) Gliosarcoma stem cells undergo glial and mesenchymal differentiation in vivo. Stem Cells 28:181-190
    • (2010) Stem Cells , vol.28 , pp. 181-190
    • Decarvalho, A.C.1    Nelson, K.2    Lemke, N.3    Lehman, N.L.4    Arbab, A.S.5    Kalkanis, S.6
  • 34
    • 6044221204 scopus 로고    scopus 로고
    • Cancer stem cells in nervous system tumors
    • 15378086 10.1038/sj.onc.1207946 1:CAS:528:DC%2BD2cXns1ektL0%3D
    • Singh SK, Clarke ID, Hide T, Dirks PB (2004) Cancer stem cells in nervous system tumors. Oncogene 23:7267-7273
    • (2004) Oncogene , vol.23 , pp. 7267-7273
    • Singh, S.K.1    Clarke, I.D.2    Hide, T.3    Dirks, P.B.4
  • 35
    • 65749087298 scopus 로고    scopus 로고
    • Neurosphere formation is an independent predictor of clinical outcome in malignant glioma
    • 10.1002/stem.15
    • Laks DR, Masterman-Smith M, Visnyei K, Angenieux B, Orozco NM, Foran I, et al. (2009) Neurosphere formation is an independent predictor of clinical outcome in malignant glioma. Stem Cell 27:980-987
    • (2009) Stem Cell , vol.27 , pp. 980-987
    • Laks, D.R.1    Masterman-Smith, M.2    Visnyei, K.3    Angenieux, B.4    Orozco, N.M.5    Foran, I.6
  • 36
    • 58149340463 scopus 로고    scopus 로고
    • Cancer stem cell analysis and clinical outcome in patients with glioblastoma multiforme
    • 19088037 10.1158/1078-0432.CCR-08-0644 1:CAS:528:DC%2BD1cXhsV2it7jN
    • Pallini R, Ricci-Vitiani L, Banna GL, Signore M, Lombardi D, Todaro M, et al. (2008) Cancer stem cell analysis and clinical outcome in patients with glioblastoma multiforme. Clin Cancer Res 14:8205-8212
    • (2008) Clin Cancer Res , vol.14 , pp. 8205-8212
    • Pallini, R.1    Ricci-Vitiani, L.2    Banna, G.L.3    Signore, M.4    Lombardi, D.5    Todaro, M.6
  • 38
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Cancer Research Genome Atlas Network 10.1038/nature07385
    • Cancer Research Genome Atlas Network (2008) Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455:1061-1068
    • (2008) Nature , vol.455 , pp. 1061-1068
  • 39
    • 77950221879 scopus 로고    scopus 로고
    • - glioblastoma-derived cancer stem cell lines suggest different cells of origin
    • 20145155 10.1158/0008-5472.CAN-09-1707 1:CAS:528:DC%2BC3cXisFWis74%3D
    • - glioblastoma-derived cancer stem cell lines suggest different cells of origin. Cancer Res 70:2030-2040
    • (2010) Cancer Res , vol.70 , pp. 2030-2040
    • Lottaz, C.1    Beier, D.2    Meyer, K.3    Kumar, P.4    Hermann, A.5    Schwarz, J.6
  • 42
    • 79960329487 scopus 로고    scopus 로고
    • Telomerase peptide vaccination combined with temozolomide: A clinical trial in stage IV melanoma patients
    • 21586625 10.1158/1078-0432.CCR-11-0184 1:CAS:528:DC%2BC3MXos1SmtbY%3D
    • Kyte JA, Gaudernack G, Dueland S, Trachsel S, Julsrud L, Aamdal S (2011) Telomerase peptide vaccination combined with temozolomide: a clinical trial in stage IV melanoma patients. Clin Cancer Res 17:4568-4580
    • (2011) Clin Cancer Res , vol.17 , pp. 4568-4580
    • Kyte, J.A.1    Gaudernack, G.2    Dueland, S.3    Trachsel, S.4    Julsrud, L.5    Aamdal, S.6
  • 43
    • 84870985481 scopus 로고    scopus 로고
    • Integration of autologous dendritic cell-based immunotherapy in the standard of care treatment for patients with newly diagnosed glioblastoma: Results of the HGG-2006 phase I/II trial
    • 22527250 10.1007/s00262-012-1261-1 1:CAS:528:DC%2BC38Xhs1GlsbjN
    • Ardon H, Van Gool S, Verschuere T, Maes W, Fieuws S, Sciot R, et al. (2012) Integration of autologous dendritic cell-based immunotherapy in the standard of care treatment for patients with newly diagnosed glioblastoma: results of the HGG-2006 phase I/II trial. Cancer Immunol Immunother 61:2033-2044
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 2033-2044
    • Ardon, H.1    Van Gool, S.2    Verschuere, T.3    Maes, W.4    Fieuws, S.5    Sciot, R.6
  • 44
    • 2442438499 scopus 로고    scopus 로고
    • Concomitant regulation of T-cell activation and homeostasis
    • 15122204 10.1038/nri1355 1:CAS:528:DC%2BD2cXjsFChs7o%3D
    • Grossman Z, Min B, Meier-Schellersheim M, Paul WE (2004) Concomitant regulation of T-cell activation and homeostasis. Nat Rev Immunol 4:387-395
    • (2004) Nat Rev Immunol , vol.4 , pp. 387-395
    • Grossman, Z.1    Min, B.2    Meier-Schellersheim, M.3    Paul, W.E.4
  • 45
    • 8744262752 scopus 로고    scopus 로고
    • Systematic comparison of dendritic cell-based immunotherapeutic strategies for malignant gliomas: In vitro induction of cytolytic and natural killer-like T cells
    • 15509326 10.1227/01.NEU.0000141082.20865.48
    • Parajuli P, Mathupala S, Sloan AE (2004) Systematic comparison of dendritic cell-based immunotherapeutic strategies for malignant gliomas: in vitro induction of cytolytic and natural killer-like T cells. Neurosurgery 55:1194-1204
    • (2004) Neurosurgery , vol.55 , pp. 1194-1204
    • Parajuli, P.1    Mathupala, S.2    Sloan, A.E.3
  • 46
    • 57649129192 scopus 로고    scopus 로고
    • A comparison of epithelial and neural properties in progenitor cells derived from the adult human ciliary body and brain
    • 18955049 10.1016/j.exer.2008.09.020 1:CAS:528:DC%2BD1cXhsFajs7bJ
    • Moe MC, Kolberg RS, Sandberg C, Vik-Mo E, Olstorn H, Varghese M, et al. (2009) A comparison of epithelial and neural properties in progenitor cells derived from the adult human ciliary body and brain. Exp Eye Res 88:30-38
    • (2009) Exp Eye Res , vol.88 , pp. 30-38
    • Moe, M.C.1    Kolberg, R.S.2    Sandberg, C.3    Vik-Mo, E.4    Olstorn, H.5    Varghese, M.6
  • 47
    • 69249149701 scopus 로고    scopus 로고
    • Antigen-specific T-cell response from dendritic cell vaccination using cancer stem-like cell-associated antigens
    • 19536809 10.1002/stem.102 1:CAS:528:DC%2BD1MXht1Wqu7fO
    • Xu Q, Liu G, Yuan X, Xu M, Wang H, Ji J, et al. (2009) Antigen-specific T-cell response from dendritic cell vaccination using cancer stem-like cell-associated antigens. Stem Cells 27:1734-1740
    • (2009) Stem Cells , vol.27 , pp. 1734-1740
    • Xu, Q.1    Liu, G.2    Yuan, X.3    Xu, M.4    Wang, H.5    Ji, J.6
  • 48
    • 84872498982 scopus 로고    scopus 로고
    • Phase i trial of a multi-epitope-pulsed dendritic cell vaccine for patients with newly diagnosed glioblastoma
    • 10.1007/s00262-012-1319-0
    • Puphanich S, Wheeler CJ, Rudnick J, Mazer M, Wang HQ, Nuno M, et al. (2013) Phase I trial of a multi-epitope-pulsed dendritic cell vaccine for patients with newly diagnosed glioblastoma. Cancer Immunol Immunother 62:125-135
    • (2013) Cancer Immunol Immunother , vol.62 , pp. 125-135
    • Puphanich, S.1    Wheeler, C.J.2    Rudnick, J.3    Mazer, M.4    Wang, H.Q.5    Nuno, M.6


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