메뉴 건너뛰기




Volumn 59, Issue 13, 2016, Pages 5987-6011

Quadruplex Nucleic Acids as Novel Therapeutic Targets

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEIC ACID; TELOMERASE; GUANINE QUADRUPLEX; MOLECULAR LIBRARY;

EID: 84978759686     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b01835     Document Type: Review
Times cited : (490)

References (289)
  • 1
    • 1042274320 scopus 로고
    • Untersuchungen über die guanylsäre
    • Bang, I. Untersuchungen über die guanylsäre Biochem. Z. 1910, 26, 293-311
    • (1910) Biochem. Z. , vol.26 , pp. 293-311
    • Bang, I.1
  • 3
    • 0016207051 scopus 로고
    • Structures for polyinosinic acid and polyguanylic acid
    • Arnott, S.; Chandrasekaran, R.; Marttila, C. M. Structures for polyinosinic acid and polyguanylic acid Biochem. J. 1974, 141, 537-543 10.1042/bj1410537
    • (1974) Biochem. J. , vol.141 , pp. 537-543
    • Arnott, S.1    Chandrasekaran, R.2    Marttila, C.M.3
  • 4
    • 0016610425 scopus 로고
    • X-ray fiber diffraction and model-building study of polyguanylic acid and polyinosinic acid
    • Zimmerman, S. B.; Cohen, G. H.; Davies, D. R. X-ray fiber diffraction and model-building study of polyguanylic acid and polyinosinic acid J. Mol. Biol. 1975, 92, 181-192 10.1016/0022-2836(75)90222-3
    • (1975) J. Mol. Biol. , vol.92 , pp. 181-192
    • Zimmerman, S.B.1    Cohen, G.H.2    Davies, D.R.3
  • 5
    • 0020488547 scopus 로고
    • Poly(inosinic acid) helices: Essential chelation of alkali metal ions in the axial channel
    • Howard, F. B.; Miles, H. T. Poly(inosinic acid) helices: essential chelation of alkali metal ions in the axial channel Biochemistry 1982, 21, 6736-6745 10.1021/bi00269a019
    • (1982) Biochemistry , vol.21 , pp. 6736-6745
    • Howard, F.B.1    Miles, H.T.2
  • 6
    • 0024843757 scopus 로고
    • Telomeric DNA dimerizes by formation of guanine tetrads between hairpin loops
    • Sundquist, W. I.; Klug, A. Telomeric DNA dimerizes by formation of guanine tetrads between hairpin loops Nature 1989, 342, 825-829 10.1038/342825a0
    • (1989) Nature , vol.342 , pp. 825-829
    • Sundquist, W.I.1    Klug, A.2
  • 7
    • 0025269255 scopus 로고
    • A sodium-potassium switch in the formation of four-stranded G4-DNA
    • Sen, D.; Gilbert, W. A sodium-potassium switch in the formation of four-stranded G4-DNA Nature 1990, 344, 410-414 10.1038/344410a0
    • (1990) Nature , vol.344 , pp. 410-414
    • Sen, D.1    Gilbert, W.2
  • 9
    • 0023663911 scopus 로고
    • Telomeric DNA oligonucleotides form novel intramolecular structures containing guanine-guanine base pairs
    • Henderson, E.; Hardin, C. C.; Walk, S. K.; Tinoco, I., Jr.; Blackburn, E. H. Telomeric DNA oligonucleotides form novel intramolecular structures containing guanine-guanine base pairs Cell 1987, 51, 899-908 10.1016/0092-8674(87)90577-0
    • (1987) Cell , vol.51 , pp. 899-908
    • Henderson, E.1    Hardin, C.C.2    Walk, S.K.3    Tinoco, Jr.I.4    Blackburn, E.H.5
  • 10
    • 1042268168 scopus 로고    scopus 로고
    • G-quartets 40 years later: From 5′-GMP to molecular biology and supramolecular chemistry
    • Davis, J. T. G-quartets 40 years later: from 5′-GMP to molecular biology and supramolecular chemistry Angew. Chem., Int. Ed. 2004, 43, 668-698 10.1002/anie.200300589
    • (2004) Angew. Chem., Int. Ed. , vol.43 , pp. 668-698
    • Davis, J.T.1
  • 12
    • 38049030699 scopus 로고    scopus 로고
    • Human telomere, oncogenic promoter and 5′-UTR G-quadruplexes: Diverse higher order DNA and RNA targets for cancer therapeutics
    • Patel, D. J.; Phan, A. T.; Kuryavyi, V. Human telomere, oncogenic promoter and 5′-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics Nucleic Acids Res. 2007, 35, 7429-7455 10.1093/nar/gkm711
    • (2007) Nucleic Acids Res. , vol.35 , pp. 7429-7455
    • Patel, D.J.1    Phan, A.T.2    Kuryavyi, V.3
  • 13
    • 84867797125 scopus 로고    scopus 로고
    • Tri-G-quadruplex: Controlled assembly of a G-quadruplex structure from three G-rich strands
    • Zhou, J.; Bourdoncle, A.; Rosu, F.; Gabelica, V.; Mergny, J.-L. Tri-G-quadruplex: controlled assembly of a G-quadruplex structure from three G-rich strands Angew. Chem., Int. Ed. 2012, 51, 11002-11005 10.1002/anie.201205390
    • (2012) Angew. Chem., Int. Ed. , vol.51 , pp. 11002-11005
    • Zhou, J.1    Bourdoncle, A.2    Rosu, F.3    Gabelica, V.4    Mergny, J.-L.5
  • 16
    • 0026554887 scopus 로고
    • Quadruplex structure of Oxytricha telomeric DNA oligonucleotides
    • Smith, F. W.; Feigon, J. Quadruplex structure of Oxytricha telomeric DNA oligonucleotides Nature 1992, 356, 164-168 10.1038/356164a0
    • (1992) Nature , vol.356 , pp. 164-168
    • Smith, F.W.1    Feigon, J.2
  • 18
    • 0027750779 scopus 로고
    • Solution structure of a parallel-stranded G-quadruplex DNA
    • Wang, Y.; Patel, D. J. Solution structure of a parallel-stranded G-quadruplex DNA J. Mol. Biol. 1993, 234, 1171-1183 10.1006/jmbi.1993.1668
    • (1993) J. Mol. Biol. , vol.234 , pp. 1171-1183
    • Wang, Y.1    Patel, D.J.2
  • 21
    • 84886626805 scopus 로고    scopus 로고
    • G-quadruplex structures in the human genome as novel therapeutic targets
    • Bidzinska, J.; Cimino-Reale, G.; Zaffaroni, N.; Folini, M. G-quadruplex structures in the human genome as novel therapeutic targets Molecules 2013, 18, 12368-91235 10.3390/molecules181012368
    • (2013) Molecules , vol.18 , pp. 12368-91235
    • Bidzinska, J.1    Cimino-Reale, G.2    Zaffaroni, N.3    Folini, M.4
  • 22
    • 84906252569 scopus 로고    scopus 로고
    • G-quadruplex interacting small molecules and drugs: From bench towards bedside
    • Müller, S.; Rodriguez, R. G-quadruplex interacting small molecules and drugs: from bench towards bedside Expert Rev. Clin. Pharmacol. 2014, 7, 663-679 10.1586/17512433.2014.945909
    • (2014) Expert Rev. Clin. Pharmacol. , vol.7 , pp. 663-679
    • Müller, S.1    Rodriguez, R.2
  • 23
    • 84904726052 scopus 로고    scopus 로고
    • Relevance of G-quadruplex structures to pharmacogenetics
    • Cree, S. L.; Kennedy, M. A. Relevance of G-quadruplex structures to pharmacogenetics Front. Pharmacol. 2014, 5, 160 10.3389/fphar.2014.00160
    • (2014) Front. Pharmacol. , vol.5 , pp. 160
    • Cree, S.L.1    Kennedy, M.A.2
  • 24
    • 84907914558 scopus 로고    scopus 로고
    • Targeting unimolecular G-quadruplex nucleic acids: A new paradigm for the drug discovery?
    • Parrotta, L.; Ortuso, F.; Moraca, F.; Rocca, R.; Costa, G.; Alcaro, S.; Artese, A. Targeting unimolecular G-quadruplex nucleic acids: a new paradigm for the drug discovery? Expert Opin. Drug Discovery 2014, 9, 1167-1187 10.1517/17460441.2014.941353
    • (2014) Expert Opin. Drug Discovery , vol.9 , pp. 1167-1187
    • Parrotta, L.1    Ortuso, F.2    Moraca, F.3    Rocca, R.4    Costa, G.5    Alcaro, S.6    Artese, A.7
  • 25
    • 20144369806 scopus 로고    scopus 로고
    • Highly prevalent putative quadruplex sequence motifs in human DNA
    • Todd, A. K.; Johnston, M.; Neidle, S. Highly prevalent putative quadruplex sequence motifs in human DNA Nucleic Acids Res. 2005, 33, 2901-2907 10.1093/nar/gki553
    • (2005) Nucleic Acids Res. , vol.33 , pp. 2901-2907
    • Todd, A.K.1    Johnston, M.2    Neidle, S.3
  • 26
    • 20144364292 scopus 로고    scopus 로고
    • Prevalence of quadruplexes in the human genome
    • Huppert, J. L.; Balasubramanian, S. Prevalence of quadruplexes in the human genome Nucleic Acids Res. 2005, 33, 2908-2916 10.1093/nar/gki609
    • (2005) Nucleic Acids Res. , vol.33 , pp. 2908-2916
    • Huppert, J.L.1    Balasubramanian, S.2
  • 27
    • 38549092075 scopus 로고    scopus 로고
    • QuadBase: Genome-wide database of G4 DNA - Occurrence and conservation in human, chimpanzee, mouse and rat promoters and 146 microbes
    • Yadav, V. K.; Abraham, J. K.; Mani, P.; Kulshrestha, R.; Chowdhury, S. QuadBase: genome-wide database of G4 DNA-occurrence and conservation in human, chimpanzee, mouse and rat promoters and 146 microbes Nucleic Acids Res. 2008, 36, D381-D385 10.1093/nar/gkm781
    • (2008) Nucleic Acids Res. , vol.36 , pp. D381-D385
    • Yadav, V.K.1    Abraham, J.K.2    Mani, P.3    Kulshrestha, R.4    Chowdhury, S.5
  • 28
    • 77449124427 scopus 로고    scopus 로고
    • Computational approaches to the detection and analysis of sequences with intramolecular G-quadruplex forming potential
    • Ryvkin, P.; Hershman, S. G.; Wang, L. S.; Johnson, F. B. Computational approaches to the detection and analysis of sequences with intramolecular G-quadruplex forming potential Methods Mol. Biol. 2010, 608, 39-50 10.1007/978-1-59745-363-9-3
    • (2010) Methods Mol. Biol. , vol.608 , pp. 39-50
    • Ryvkin, P.1    Hershman, S.G.2    Wang, L.S.3    Johnson, F.B.4
  • 29
    • 84865098888 scopus 로고    scopus 로고
    • Computational detection and analysis of sequences with duplex-derived interstrand G-quadruplex forming potential
    • Cao, K.; Ryvkin, P.; Johnson, F. B. Computational detection and analysis of sequences with duplex-derived interstrand G-quadruplex forming potential Methods 2012, 57, 3-10 10.1016/j.ymeth.2012.05.002
    • (2012) Methods , vol.57 , pp. 3-10
    • Cao, K.1    Ryvkin, P.2    Johnson, F.B.3
  • 30
    • 3042671689 scopus 로고    scopus 로고
    • Influence of loop size on the stability of intramolecular DNA quadruplexes
    • Risitano, A.; Fox, K. R. Influence of loop size on the stability of intramolecular DNA quadruplexes Nucleic Acids Res. 2004, 32, 2598-2606 10.1093/nar/gkh598
    • (2004) Nucleic Acids Res. , vol.32 , pp. 2598-2606
    • Risitano, A.1    Fox, K.R.2
  • 32
    • 38849085810 scopus 로고    scopus 로고
    • A sequence-independent study of the influence of short loop lengths on the stability and topology of intramolecular DNA G-quadruplexes
    • Bugaut, A.; Balasubramanian, S. A sequence-independent study of the influence of short loop lengths on the stability and topology of intramolecular DNA G-quadruplexes Biochemistry 2008, 47, 689-697 10.1021/bi701873c
    • (2008) Biochemistry , vol.47 , pp. 689-697
    • Bugaut, A.1    Balasubramanian, S.2
  • 33
    • 0032508468 scopus 로고    scopus 로고
    • Following G-quartet formation by UV-spectroscopy
    • Mergny, J.-L.; Phan, A. T.; Lacroix, L. Following G-quartet formation by UV-spectroscopy FEBS Lett. 1998, 435, 74-78 10.1016/S0014-5793(98)01043-6
    • (1998) FEBS Lett. , vol.435 , pp. 74-78
    • Mergny, J.-L.1    Phan, A.T.2    Lacroix, L.3
  • 35
    • 66549124907 scopus 로고    scopus 로고
    • The structures of quadruplex nucleic acids and their drug complexes
    • Neidle, S. The structures of quadruplex nucleic acids and their drug complexes Curr. Opin. Struct. Biol. 2009, 19, 239-250 10.1016/j.sbi.2009.04.001
    • (2009) Curr. Opin. Struct. Biol. , vol.19 , pp. 239-250
    • Neidle, S.1
  • 36
    • 84865078986 scopus 로고    scopus 로고
    • NMR spectroscopy of G-quadruplexes
    • Adrian, M.; Heddi, B.; Phan, A. T. NMR spectroscopy of G-quadruplexes Methods 2012, 57, 11-24 10.1016/j.ymeth.2012.05.003
    • (2012) Methods , vol.57 , pp. 11-24
    • Adrian, M.1    Heddi, B.2    Phan, A.T.3
  • 37
    • 84859300230 scopus 로고    scopus 로고
    • Formation of pearl-necklace monomorphic G-quadruplexes in the human CEB25 minisatellite
    • Amrane, S.; Adrian, M.; Heddi, B.; Serero, A.; Nicolas, A.; Mergny, J.-L.; Phan, A. T. Formation of pearl-necklace monomorphic G-quadruplexes in the human CEB25 minisatellite J. Am. Chem. Soc. 2012, 134, 5807-5816 10.1021/ja208993r
    • (2012) J. Am. Chem. Soc. , vol.134 , pp. 5807-5816
    • Amrane, S.1    Adrian, M.2    Heddi, B.3    Serero, A.4    Nicolas, A.5    Mergny, J.-L.6    Phan, A.T.7
  • 38
    • 68249156463 scopus 로고    scopus 로고
    • Formation of a unique end-to-end stacked pair of G-quadruplexes in the hTERT core promoter with implications for inhibition of telomerase by G-quadruplex-interactive ligands
    • Palumbo, S. L.; Ebbinghaus, S. W.; Hurley, L. H. Formation of a unique end-to-end stacked pair of G-quadruplexes in the hTERT core promoter with implications for inhibition of telomerase by G-quadruplex-interactive ligands J. Am. Chem. Soc. 2009, 131, 10878-10891 10.1021/ja902281d
    • (2009) J. Am. Chem. Soc. , vol.131 , pp. 10878-10891
    • Palumbo, S.L.1    Ebbinghaus, S.W.2    Hurley, L.H.3
  • 39
    • 84902651070 scopus 로고    scopus 로고
    • The folding of 5′-UTR human G-quadruplexes possessing a long central loop
    • Jodoin, R.; Bauer, L.; Garant, J.-M.; Mahdi Laaref, A.; Phaneuf, F.; Perreault, J.-P. The folding of 5′-UTR human G-quadruplexes possessing a long central loop RNA 2014, 20, 1129-1141 10.1261/rna.044578.114
    • (2014) RNA , vol.20 , pp. 1129-1141
    • Jodoin, R.1    Bauer, L.2    Garant, J.-M.3    Mahdi Laaref, A.4    Phaneuf, F.5    Perreault, J.-P.6
  • 40
    • 84893766799 scopus 로고    scopus 로고
    • The major G-quadruplex formed in the human BCL-2 proximal promoter adopts a parallel structure with a 13-nt loop in K+ solution
    • Agrawal, P.; Lin, C.; Mathad, R. I.; Carver, M.; Yang, D. Z. The major G-quadruplex formed in the human BCL-2 proximal promoter adopts a parallel structure with a 13-nt loop in K+ solution J. Am. Chem. Soc. 2014, 136, 1750-1753 10.1021/ja4118945
    • (2014) J. Am. Chem. Soc. , vol.136 , pp. 1750-1753
    • Agrawal, P.1    Lin, C.2    Mathad, R.I.3    Carver, M.4    Yang, D.Z.5
  • 41
    • 78649850820 scopus 로고    scopus 로고
    • How long is too long? Effects of loop size on G-quadruplex stability
    • Guédin, A.; Gros, J.; Alberti, P.; Mergny, J.-L. How long is too long? Effects of loop size on G-quadruplex stability Nucleic Acids Res. 2010, 38, 7858-7868 10.1093/nar/gkq639
    • (2010) Nucleic Acids Res. , vol.38 , pp. 7858-7868
    • Guédin, A.1    Gros, J.2    Alberti, P.3    Mergny, J.-L.4
  • 42
    • 34247160470 scopus 로고    scopus 로고
    • Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter
    • Phan, A. T.; Kuryavyi, V.; Burge, S.; Neidle, S.; Patel, D. J. Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter J. Am. Chem. Soc. 2007, 129, 4386-4392 10.1021/ja068739h
    • (2007) J. Am. Chem. Soc. , vol.129 , pp. 4386-4392
    • Phan, A.T.1    Kuryavyi, V.2    Burge, S.3    Neidle, S.4    Patel, D.J.5
  • 43
    • 84861564071 scopus 로고    scopus 로고
    • Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation
    • Wei, D.; Parkinson, G. N.; Reszka, A. P.; Neidle, S. Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation Nucleic Acids Res. 2012, 40, 4691-4700 10.1093/nar/gks023
    • (2012) Nucleic Acids Res. , vol.40 , pp. 4691-4700
    • Wei, D.1    Parkinson, G.N.2    Reszka, A.P.3    Neidle, S.4
  • 44
    • 84941098987 scopus 로고    scopus 로고
    • Flexibility and structural conservation in a c-KIT G-quadruplex
    • Wei, D.; Husby, J.; Neidle, S. Flexibility and structural conservation in a c-KIT G-quadruplex Nucleic Acids Res. 2015, 43, 629-644 10.1093/nar/gku1282
    • (2015) Nucleic Acids Res. , vol.43 , pp. 629-644
    • Wei, D.1    Husby, J.2    Neidle, S.3
  • 46
    • 84930866439 scopus 로고    scopus 로고
    • Short loop length and high thermal stability determine genomic instability induced by G-quadruplex-forming minisatellites
    • Piazza, A.; Adrian, M.; Samazan, F.; Heddi, B.; Hamon, F.; Serero, A.; Lopes, J.; Teulade-Fichou, M.-P.; Phan, A. T.; Nicolas, A. Short loop length and high thermal stability determine genomic instability induced by G-quadruplex-forming minisatellites EMBO J. 2015, 34, 1718-1734 10.15252/embj.201490702
    • (2015) EMBO J. , vol.34 , pp. 1718-1734
    • Piazza, A.1    Adrian, M.2    Samazan, F.3    Heddi, B.4    Hamon, F.5    Serero, A.6    Lopes, J.7    Teulade-Fichou, M.-P.8    Phan, A.T.9    Nicolas, A.10
  • 47
    • 84901036412 scopus 로고    scopus 로고
    • QGRS-Conserve: A computational method for discovering evolutionarily conserved G-quadruplex motifs
    • Frees, S.; Menendez, C.; Crum, M.; Bagga, P. S. QGRS-Conserve: a computational method for discovering evolutionarily conserved G-quadruplex motifs Hum. Genomics 2014, 8, 8 10.1186/1479-7364-8-8
    • (2014) Hum. Genomics , vol.8 , pp. 8
    • Frees, S.1    Menendez, C.2    Crum, M.3    Bagga, P.S.4
  • 48
    • 84905457852 scopus 로고    scopus 로고
    • Sequencing and G-quadruplex folding of the canine proto-oncogene KIT promoter region: Might dog be used as a model for human disease?
    • Da Ros, S.; Zorzan, E.; Giantin, M.; Zorro Shahidian, L.; Palumbo, M.; Dacasto, M.; Sissi, C. Sequencing and G-quadruplex folding of the canine proto-oncogene KIT promoter region: might dog be used as a model for human disease? PLoS One 2014, 9, e103876 10.1371/journal.pone.0103876
    • (2014) PLoS One , vol.9 , pp. e103876
    • Da Ros, S.1    Zorzan, E.2    Giantin, M.3    Zorro Shahidian, L.4    Palumbo, M.5    Dacasto, M.6    Sissi, C.7
  • 49
    • 78049298053 scopus 로고    scopus 로고
    • G-quadruplex DNA sequences are evolutionarily conserved and associated with distinct genomic features in Saccharomyces cerevisiae
    • Capra, J. A.; Paeschke, K.; Singh, M.; Zakian, V. A. G-quadruplex DNA sequences are evolutionarily conserved and associated with distinct genomic features in Saccharomyces cerevisiae PLoS Comput. Biol. 2010, 6, e1000861 10.1371/journal.pcbi.1000861
    • (2010) PLoS Comput. Biol. , vol.6 , pp. e1000861
    • Capra, J.A.1    Paeschke, K.2    Singh, M.3    Zakian, V.A.4
  • 51
    • 84911496603 scopus 로고    scopus 로고
    • A matter of location: Influence of G-quadruplexes on Escherichia coli gene expression
    • Holder, I. T.; Hartig, J. S. A matter of location: influence of G-quadruplexes on Escherichia coli gene expression Chem. Biol. 2014, 21, 1511-1521 10.1016/j.chembiol.2014.09.014
    • (2014) Chem. Biol. , vol.21 , pp. 1511-1521
    • Holder, I.T.1    Hartig, J.S.2
  • 52
    • 84880207699 scopus 로고    scopus 로고
    • The genome-wide distribution of non-B DNA motifs is shaped by operon structure and suggests the transcriptional importance of non-B DNA structures in Escherichia coli
    • Du, X.; Wojtowicz, D.; Bowers, A. A.; Levens, D.; Benham, C. J.; Przytycka, T. M. The genome-wide distribution of non-B DNA motifs is shaped by operon structure and suggests the transcriptional importance of non-B DNA structures in Escherichia coli Nucleic Acids Res. 2013, 41, 5965-5977 10.1093/nar/gkt308
    • (2013) Nucleic Acids Res. , vol.41 , pp. 5965-5977
    • Du, X.1    Wojtowicz, D.2    Bowers, A.A.3    Levens, D.4    Benham, C.J.5    Przytycka, T.M.6
  • 54
    • 84897980191 scopus 로고    scopus 로고
    • Topology of a DNA G-quadruplex structure formed in the HIV-1 promoter: A potential target for anti-HIV drug development
    • Amrane, S.; Kerkour, A.; Bedrat, A.; Vialet, B.; Andreola, M.-L.; Mergny, J.-L. Topology of a DNA G-quadruplex structure formed in the HIV-1 promoter: a potential target for anti-HIV drug development J. Am. Chem. Soc. 2014, 136, 5249-5252 10.1021/ja501500c
    • (2014) J. Am. Chem. Soc. , vol.136 , pp. 5249-5252
    • Amrane, S.1    Kerkour, A.2    Bedrat, A.3    Vialet, B.4    Andreola, M.-L.5    Mergny, J.-L.6
  • 55
    • 84883166324 scopus 로고    scopus 로고
    • Formation of a unique cluster of G-quadruplex structures in the HIV-1 Nef coding region: Implications for antiviral activity
    • Perrone, R.; Nadai, M.; Poe, J. A.; Frasson, I.; Palumbo, M.; Palù, G.; Smithgall, T. E.; Richter, S. N. Formation of a unique cluster of G-quadruplex structures in the HIV-1 Nef coding region: implications for antiviral activity PLoS One 2013, 8, e73121 10.1371/journal.pone.0073121
    • (2013) PLoS One , vol.8 , pp. e73121
    • Perrone, R.1    Nadai, M.2    Poe, J.A.3    Frasson, I.4    Palumbo, M.5    Palù, G.6    Smithgall, T.E.7    Richter, S.N.8
  • 58
    • 0035902465 scopus 로고    scopus 로고
    • In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei
    • Schaffitzel, C.; Berger, I.; Postberg, J.; Hanes, J.; Lipps, H. J.; Pluckthun, A. In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei Proc. Natl. Acad. Sci. U. S. A. 2001, 98, 8572-8577 10.1073/pnas.141229498
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 8572-8577
    • Schaffitzel, C.1    Berger, I.2    Postberg, J.3    Hanes, J.4    Lipps, H.J.5    Pluckthun, A.6
  • 59
    • 84877768759 scopus 로고    scopus 로고
    • G-quadruplex structures are stable and detectable in human genomic DNA
    • Lam, E. Y.; Beraldi, D.; Tannahill, D.; Balasubramanian, S. G-quadruplex structures are stable and detectable in human genomic DNA Nat. Commun. 2013, 4, 1796-1780 10.1038/ncomms2792
    • (2013) Nat. Commun. , vol.4 , pp. 1780-1796
    • Lam, E.Y.1    Beraldi, D.2    Tannahill, D.3    Balasubramanian, S.4
  • 60
    • 84875464903 scopus 로고    scopus 로고
    • Quantitative visualization of DNA G-quadruplex structures in human cells
    • Biffi, G.; Tannahill, D.; McCafferty, J.; Balasubramanian, S. Quantitative visualization of DNA G-quadruplex structures in human cells Nat. Chem. 2013, 5, 182-186 10.1038/nchem.1548
    • (2013) Nat. Chem. , vol.5 , pp. 182-186
    • Biffi, G.1    Tannahill, D.2    McCafferty, J.3    Balasubramanian, S.4
  • 62
    • 84904489184 scopus 로고    scopus 로고
    • Elevated levels of G-quadruplex formation in human stomach and liver cancer tissues
    • Biffi, G.; Tannahill, D.; Miller, J.; Howat, W. J.; Balasubramanian, S. Elevated levels of G-quadruplex formation in human stomach and liver cancer tissues PLoS One 2014, 9, e102711 10.1371/journal.pone.0102711
    • (2014) PLoS One , vol.9 , pp. e102711
    • Biffi, G.1    Tannahill, D.2    Miller, J.3    Howat, W.J.4    Balasubramanian, S.5
  • 63
    • 84886768234 scopus 로고    scopus 로고
    • Fluorescent probe for visualizing guanine-quadruplex DNA by fluorescence lifetime imaging microscopy
    • Tseng, T.-Y.; Chien, C.-H.; Chu, J.-F.; Huang, W.-C.; Lin, M.-Y.; Chang, C.-C.; Chang, T.-C. Fluorescent probe for visualizing guanine-quadruplex DNA by fluorescence lifetime imaging microscopy J. Biomed. Opt. 2013, 18, 101309 10.1117/1.JBO.18.10.101309
    • (2013) J. Biomed. Opt. , vol.18 , pp. 101309
    • Tseng, T.-Y.1    Chien, C.-H.2    Chu, J.-F.3    Huang, W.-C.4    Lin, M.-Y.5    Chang, C.-C.6    Chang, T.-C.7
  • 65
    • 84941069729 scopus 로고    scopus 로고
    • The interactions between a small molecule and G-quadruplexes are visualized by fluorescence lifetime imaging microscopy
    • Shivalingam, A.; Angeles Izquierdo, M.; Le Marois, A.; Vyšniauskas, A.; Suhling, K.; Kuimova, M. K.; Vilar, R. The interactions between a small molecule and G-quadruplexes are visualized by fluorescence lifetime imaging microscopy Nat. Commun. 2015, 6, 8178 10.1038/ncomms9178
    • (2015) Nat. Commun. , vol.6 , pp. 8178
    • Shivalingam, A.1    Angeles Izquierdo, M.2    Le Marois, A.3    Vyšniauskas, A.4    Suhling, K.5    Kuimova, M.K.6    Vilar, R.7
  • 66
    • 84867744921 scopus 로고    scopus 로고
    • DNA secondary structures: Stability and function of G-quadruplex structures
    • Bochman, M. L.; Paeschke, K.; Zakian, V. A. DNA secondary structures: stability and function of G-quadruplex structures Nat. Rev. Genet. 2012, 13, 770-780 10.1038/nrg3296
    • (2012) Nat. Rev. Genet. , vol.13 , pp. 770-780
    • Bochman, M.L.1    Paeschke, K.2    Zakian, V.A.3
  • 67
    • 0030982721 scopus 로고    scopus 로고
    • The terminal DNA structure of mammalian chromosomes
    • McElligott, R.; Wellinger, R. J. The terminal DNA structure of mammalian chromosomes EMBO J. 1997, 16, 3705-3714 10.1093/emboj/16.12.3705
    • (1997) EMBO J. , vol.16 , pp. 3705-3714
    • McElligott, R.1    Wellinger, R.J.2
  • 68
    • 0030731928 scopus 로고    scopus 로고
    • Normal human chromosomes have long G-rich telomeric overhangs at one end
    • Wright, W. E.; Tesmer, V. M.; Huffman, K. E.; Levene, S. D.; Shay, J. W. Normal human chromosomes have long G-rich telomeric overhangs at one end Genes Dev. 1997, 11, 2801-2809 10.1101/gad.11.21.2801
    • (1997) Genes Dev. , vol.11 , pp. 2801-2809
    • Wright, W.E.1    Tesmer, V.M.2    Huffman, K.E.3    Levene, S.D.4    Shay, J.W.5
  • 69
    • 80052398381 scopus 로고    scopus 로고
    • How shelterin solves the telomere end-protection problem
    • De Lange, T. How shelterin solves the telomere end-protection problem Cold Spring Harbor Symp. Quant. Biol. 2010, 75, 167-177 10.1101/sqb.2010.75.017
    • (2010) Cold Spring Harbor Symp. Quant. Biol. , vol.75 , pp. 167-177
    • De Lange, T.1
  • 70
    • 0035844082 scopus 로고    scopus 로고
    • Pot1, the putative telomere end-binding protein in fission yeast and humans
    • Baumann, P.; Cech, T. R. Pot1, the putative telomere end-binding protein in fission yeast and humans Science 2001, 292, 1171-1175 10.1126/science.1060036
    • (2001) Science , vol.292 , pp. 1171-1175
    • Baumann, P.1    Cech, T.R.2
  • 71
    • 23344451160 scopus 로고    scopus 로고
    • Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro
    • Zaug, A. J.; Podell, E. R.; Cech, T. R. Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro Proc. Natl. Acad. Sci. U. S. A. 2005, 102, 10864-10869 10.1073/pnas.0504744102
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 10864-10869
    • Zaug, A.J.1    Podell, E.R.2    Cech, T.R.3
  • 72
    • 84895795314 scopus 로고    scopus 로고
    • TRF2-tethered TIN2 can mediate telomere protection by TPP1/POT1
    • Frescas, D.; de Lange, T. TRF2-tethered TIN2 can mediate telomere protection by TPP1/POT1 Mol. Cell. Biol. 2014, 34, 1349-1362 10.1128/MCB.01052-13
    • (2014) Mol. Cell. Biol. , vol.34 , pp. 1349-1362
    • Frescas, D.1    De Lange, T.2
  • 73
    • 0022402513 scopus 로고
    • Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
    • Greider, C. W.; Blackburn, E. H. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts Cell 1985, 43, 405-413 10.1016/0092-8674(85)90170-9
    • (1985) Cell , vol.43 , pp. 405-413
    • Greider, C.W.1    Blackburn, E.H.2
  • 76
    • 0025877846 scopus 로고
    • Inhibition of telomerase by G-quartet DNA structures
    • Zahler, A. M.; Williamson, J. R.; Cech, T. R.; Prescott, D. M. Inhibition of telomerase by G-quartet DNA structures Nature 1991, 350, 718-750 10.1038/350718a0
    • (1991) Nature , vol.350 , pp. 718-750
    • Zahler, A.M.1    Williamson, J.R.2    Cech, T.R.3    Prescott, D.M.4
  • 78
    • 33847372902 scopus 로고    scopus 로고
    • Physiological relevance of telomeric G-quadruplex formation: A potential drug target
    • Oganesian, L.; Bryan, T. M. Physiological relevance of telomeric G-quadruplex formation: a potential drug target BioEssays 2007, 29, 155-165 10.1002/bies.20523
    • (2007) BioEssays , vol.29 , pp. 155-165
    • Oganesian, L.1    Bryan, T.M.2
  • 80
    • 84911472048 scopus 로고    scopus 로고
    • Telomeric G-quadruplex architecture and interactions with potential drugs
    • Sissi, C.; Palumbo, M. Telomeric G-quadruplex architecture and interactions with potential drugs Curr. Pharm. Des. 2014, 20, 6489-6509 10.2174/1381612820666140630094300
    • (2014) Curr. Pharm. Des. , vol.20 , pp. 6489-6509
    • Sissi, C.1    Palumbo, M.2
  • 81
    • 84890811542 scopus 로고    scopus 로고
    • Telomere maintenance as a target for drug discovery
    • Sekaran, V.; Soares, J.; Jarstfer, M. B. Telomere maintenance as a target for drug discovery J. Med. Chem. 2014, 57, 521-538 10.1021/jm400528t
    • (2014) J. Med. Chem. , vol.57 , pp. 521-538
    • Sekaran, V.1    Soares, J.2    Jarstfer, M.B.3
  • 82
    • 0037028047 scopus 로고    scopus 로고
    • Telomerase inhibition, telomere shortening, and decreased cell proliferation by cell permeable 2′-O-methoxyethyl oligonucleotides
    • Chen, Z.; Monia, B. P.; Corey, D. R. Telomerase inhibition, telomere shortening, and decreased cell proliferation by cell permeable 2′-O-methoxyethyl oligonucleotides J. Med. Chem. 2002, 45, 5423-5425 10.1021/jm025563v
    • (2002) J. Med. Chem. , vol.45 , pp. 5423-5425
    • Chen, Z.1    Monia, B.P.2    Corey, D.R.3
  • 85
    • 26444602415 scopus 로고    scopus 로고
    • P16INK4a as a second effector of the telomere damage pathway
    • Jacobs, J. J.; de Lange, T. p16INK4a as a second effector of the telomere damage pathway Cell Cycle 2005, 4, 1364-1368 10.4161/cc.4.10.2104
    • (2005) Cell Cycle , vol.4 , pp. 1364-1368
    • Jacobs, J.J.1    De Lange, T.2
  • 86
    • 84892731189 scopus 로고    scopus 로고
    • Cellular senescence and its effector programs
    • Salama, R.; Sadaie, M.; Hoare, M.; Narita, M. Cellular senescence and its effector programs Genes Dev. 2014, 28, 99-114 10.1101/gad.235184.113
    • (2014) Genes Dev. , vol.28 , pp. 99-114
    • Salama, R.1    Sadaie, M.2    Hoare, M.3    Narita, M.4
  • 88
    • 7444237059 scopus 로고    scopus 로고
    • A G-quadruplex telomere targeting agent produces p16-associated senescence and chromosomal fusions in human prostate cancer cells
    • Incles, C. M.; Schultes, C. M.; Kempski, H.; Koehler, H.; Kelland, L. R.; Neidle, S. A G-quadruplex telomere targeting agent produces p16-associated senescence and chromosomal fusions in human prostate cancer cells Mol. Cancer Ther. 2004, 3, 1201-1206
    • (2004) Mol. Cancer Ther. , vol.3 , pp. 1201-1206
    • Incles, C.M.1    Schultes, C.M.2    Kempski, H.3    Koehler, H.4    Kelland, L.R.5    Neidle, S.6
  • 89
    • 84873312526 scopus 로고    scopus 로고
    • Telomere shortening and cell senescence induced by perylene derivatives in A549 human lung cancer cells
    • Taka, T.; Huang, L.; Wongnoppavich, A.; Tam-Chang, S. W.; Lee, T. R.; Tuntiwechapikul, W. Telomere shortening and cell senescence induced by perylene derivatives in A549 human lung cancer cells Bioorg. Med. Chem. 2013, 21, 883-890 10.1016/j.bmc.2012.12.020
    • (2013) Bioorg. Med. Chem. , vol.21 , pp. 883-890
    • Taka, T.1    Huang, L.2    Wongnoppavich, A.3    Tam-Chang, S.W.4    Lee, T.R.5    Tuntiwechapikul, W.6
  • 90
    • 13944272246 scopus 로고    scopus 로고
    • The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function
    • Burger, A. M.; Dai, F.; Schultes, C. M.; Reszka, A. P.; Moore, M. J.; Double, J. A.; Neidle, S. The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function Cancer Res. 2005, 65, 1489-1496 10.1158/0008-5472.CAN-04-2910
    • (2005) Cancer Res. , vol.65 , pp. 1489-1496
    • Burger, A.M.1    Dai, F.2    Schultes, C.M.3    Reszka, A.P.4    Moore, M.J.5    Double, J.A.6    Neidle, S.7
  • 91
    • 84935910807 scopus 로고    scopus 로고
    • Water-soluble ruthenium(II) complexes with chiral 4-(2,3-dihydroxypropyl)-formamide oxoaporphine (FOA): In vitro and in vivo anticancer activity by stabilization of G-quadruplex DNA, inhibition of telomerase activity, and induction of tumor cell apoptosis
    • Chen, Z.-F.; Qin, Q.-P.; Qin, J.-L.; Zhou, J.; Li, Y.-L.; Li, N.; Liu, Y.-C.; Liang, H. Water-soluble ruthenium(II) complexes with chiral 4-(2,3-dihydroxypropyl)-formamide oxoaporphine (FOA): in vitro and in vivo anticancer activity by stabilization of G-quadruplex DNA, inhibition of telomerase activity, and induction of tumor cell apoptosis J. Med. Chem. 2015, 58, 4771-4789 10.1021/acs.jmedchem.5b00444
    • (2015) J. Med. Chem. , vol.58 , pp. 4771-4789
    • Chen, Z.-F.1    Qin, Q.-P.2    Qin, J.-L.3    Zhou, J.4    Li, Y.-L.5    Li, N.6    Liu, Y.-C.7    Liang, H.8
  • 92
    • 38849111756 scopus 로고    scopus 로고
    • Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II
    • Schoeftner, S.; Blasco, M. A. Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II Nat. Cell Biol. 2008, 10, 228-236 10.1038/ncb1685
    • (2008) Nat. Cell Biol. , vol.10 , pp. 228-236
    • Schoeftner, S.1    Blasco, M.A.2
  • 93
    • 37349043972 scopus 로고    scopus 로고
    • Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends
    • Azzalin, C. M.; Reichenbach, P.; Khoriauli, L.; Giulotto, E.; Lingner, J. Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends Science 2007, 318, 798-801 10.1126/science.1147182
    • (2007) Science , vol.318 , pp. 798-801
    • Azzalin, C.M.1    Reichenbach, P.2    Khoriauli, L.3    Giulotto, E.4    Lingner, J.5
  • 94
    • 78650153788 scopus 로고    scopus 로고
    • TERRA transcripts are bound by a complex array of RNA-binding proteins
    • López de Silanes, I.; d'Alcontres, M. S.; Blasco, M. A. TERRA transcripts are bound by a complex array of RNA-binding proteins Nat. Commun. 2010, 1, 1-9 10.1038/ncomms1032
    • (2010) Nat. Commun. , vol.1 , pp. 1-9
    • López De Silanes, I.1    D'Alcontres, M.S.2    Blasco, M.A.3
  • 95
    • 67649756727 scopus 로고    scopus 로고
    • Structure of long telomeric RNA transcripts: The G-rich RNA forms a compact repeating structure containing G-quartets
    • Randall, A.; Griffith, J. D. Structure of long telomeric RNA transcripts: the G-rich RNA forms a compact repeating structure containing G-quartets J. Biol. Chem. 2009, 284, 13980-13986 10.1074/jbc.M900631200
    • (2009) J. Biol. Chem. , vol.284 , pp. 13980-13986
    • Randall, A.1    Griffith, J.D.2
  • 97
    • 77956539976 scopus 로고    scopus 로고
    • A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex
    • Collie, G. W.; Haider, S. M.; Neidle, S.; Parkinson, G. N. A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex Nucleic Acids Res. 2010, 38, 5569-5580 10.1093/nar/gkq259
    • (2010) Nucleic Acids Res. , vol.38 , pp. 5569-5580
    • Collie, G.W.1    Haider, S.M.2    Neidle, S.3    Parkinson, G.N.4
  • 99
    • 84927128325 scopus 로고    scopus 로고
    • Telomeric repeat-containing RNA TERRA: A noncoding RNA connecting telomere biology to genome integrity
    • Cusanelli, E.; Chartrand, P. Telomeric repeat-containing RNA TERRA: a noncoding RNA connecting telomere biology to genome integrity Front. Genet. 2015, 6, 143 10.3389/fgene.2015.00143
    • (2015) Front. Genet. , vol.6 , pp. 143
    • Cusanelli, E.1    Chartrand, P.2
  • 100
    • 84949230728 scopus 로고    scopus 로고
    • Telomere elongation chooses TERRA ALTernatives
    • Arora, R.; Azzalin, C. M. Telomere elongation chooses TERRA ALTernatives RNA Biol. 2015, 12, 938-941 10.1080/15476286.2015.1065374
    • (2015) RNA Biol. , vol.12 , pp. 938-941
    • Arora, R.1    Azzalin, C.M.2
  • 102
    • 0032514479 scopus 로고    scopus 로고
    • 1,4- and 2,6-disubstituted amidoanthracene-9,10-dione derivatives as inhibitors of human telomerase
    • Perry, P. J.; Gowan, S. M.; Reszka, A. P.; Polucci, P.; Jenkins, T. C.; Kelland, L. R.; Neidle, S. 1,4- and 2,6-disubstituted amidoanthracene-9,10-dione derivatives as inhibitors of human telomerase J. Med. Chem. 1998, 41, 3253-3260 10.1021/jm9801105
    • (1998) J. Med. Chem. , vol.41 , pp. 3253-3260
    • Perry, P.J.1    Gowan, S.M.2    Reszka, A.P.3    Polucci, P.4    Jenkins, T.C.5    Kelland, L.R.6    Neidle, S.7
  • 104
    • 0033524027 scopus 로고    scopus 로고
    • Molecular modeling studies on G-quadruplex complexes of telomerase inhibitors: Structure-activity relationships
    • Read, M. A.; Wood, A. A.; Harrison, J. R.; Gowan, S. M.; Kelland, L. R.; Dosanjh, H. S.; Neidle, S. Molecular modeling studies on G-quadruplex complexes of telomerase inhibitors: structure-activity relationships J. Med. Chem. 1999, 42, 4538-4546 10.1021/jm990287e
    • (1999) J. Med. Chem. , vol.42 , pp. 4538-4546
    • Read, M.A.1    Wood, A.A.2    Harrison, J.R.3    Gowan, S.M.4    Kelland, L.R.5    Dosanjh, H.S.6    Neidle, S.7
  • 105
    • 0032495774 scopus 로고    scopus 로고
    • Cationic porphyrins as telomerase inhibitors: The interaction of tetra-(N-methyl-4-pyridyl)porphine with quadruplex DNA
    • Wheelhouse, R. T.; Sun, D. K.; Han, H. Y.; Han, F. X. G.; Hurley, L. H. Cationic porphyrins as telomerase inhibitors: the interaction of tetra-(N-methyl-4-pyridyl)porphine with quadruplex DNA J. Am. Chem. Soc. 1998, 120, 3261-3262 10.1021/ja973792e
    • (1998) J. Am. Chem. Soc. , vol.120 , pp. 3261-3262
    • Wheelhouse, R.T.1    Sun, D.K.2    Han, H.Y.3    Han, F.X.G.4    Hurley, L.H.5
  • 107
    • 0034622547 scopus 로고    scopus 로고
    • Inhibition of unwinding of G-quadruplex structures by Sgs1 helicase in the presence of N,N′-bis[2-(1-piperidino)ethyl]-3,4,9,10-perylenetetracarboxylic diimide, a G-quadruplex-interactive ligand
    • Han, H.; Bennett, R. J.; Hurley, L. H. Inhibition of unwinding of G-quadruplex structures by Sgs1 helicase in the presence of N,N′-bis[2-(1-piperidino)ethyl]-3,4,9,10-perylenetetracarboxylic diimide, a G-quadruplex-interactive ligand Biochemistry 2000, 39, 9311-9316 10.1021/bi000482r
    • (2000) Biochemistry , vol.39 , pp. 9311-9316
    • Han, H.1    Bennett, R.J.2    Hurley, L.H.3
  • 108
    • 0034760505 scopus 로고    scopus 로고
    • Potent inhibition of telomerase by small-molecule pentacyclic acridines capable of interacting with G-quadruplexes
    • Gowan, S. M.; Heald, R.; Stevens, M. F.; Kelland, L. R. Potent inhibition of telomerase by small-molecule pentacyclic acridines capable of interacting with G-quadruplexes Mol. Pharmacol. 2001, 60, 981-988
    • (2001) Mol. Pharmacol. , vol.60 , pp. 981-988
    • Gowan, S.M.1    Heald, R.2    Stevens, M.F.3    Kelland, L.R.4
  • 109
    • 39049147645 scopus 로고    scopus 로고
    • A hitchhiker's guide to G-quadruplex ligands
    • Monchaud, D.; Teulade-Fichou, M.-P. A hitchhiker's guide to G-quadruplex ligands Org. Biomol. Chem. 2008, 6, 627-636 10.1039/B714772B
    • (2008) Org. Biomol. Chem. , vol.6 , pp. 627-636
    • Monchaud, D.1    Teulade-Fichou, M.-P.2
  • 110
    • 66149087629 scopus 로고    scopus 로고
    • G-quadruplex DNA structures and organic chemistry: More than one connection
    • Franceschin, M. G-quadruplex DNA structures and organic chemistry: more than one connection Eur. J. Org. Chem. 2009, 2009, 2215-2220 10.1002/ejoc.200990035
    • (2009) Eur. J. Org. Chem. , vol.2009 , pp. 2215-2220
    • Franceschin, M.1
  • 111
    • 79952749516 scopus 로고    scopus 로고
    • Quadruplex DNA: A promising drug target for the medicinal inorganic chemist
    • Ralph, S. F. Quadruplex DNA: a promising drug target for the medicinal inorganic chemist Curr. Top. Med. Chem. 2011, 11, 572-590 10.2174/156802611794785208
    • (2011) Curr. Top. Med. Chem. , vol.11 , pp. 572-590
    • Ralph, S.F.1
  • 112
    • 33646497225 scopus 로고    scopus 로고
    • Stabilization of G-quadruplex DNA and inhibition of telomerase activity by square-planar nickel(II) complexes
    • Reed, J. E.; Arnal, A. A.; Neidle, S.; Vilar, R. Stabilization of G-quadruplex DNA and inhibition of telomerase activity by square-planar nickel(II) complexes J. Am. Chem. Soc. 2006, 128, 5992-5993 10.1021/ja058509n
    • (2006) J. Am. Chem. Soc. , vol.128 , pp. 5992-5993
    • Reed, J.E.1    Arnal, A.A.2    Neidle, S.3    Vilar, R.4
  • 113
    • 84935910807 scopus 로고    scopus 로고
    • Water-soluble ruthenium(II) complexes with chiral 4-(2,3-dihydroxypropyl)-formamide oxoaporphine (FOA): In vitro and in vivo anticancer activity by stabilization of G-Quadruplex DNA, inhibition of telomerase activity, and induction of tumor cell apoptosis
    • Chen, Z.-F.; Qin, Q.-P.; Qin, J.-L.; Zhou, J.; Li, Y.-L.; Li, N.; Liu, Y.-C.; Liang, H. Water-soluble ruthenium(II) complexes with chiral 4-(2,3-dihydroxypropyl)-formamide oxoaporphine (FOA): in vitro and in vivo anticancer activity by stabilization of G-Quadruplex DNA, inhibition of telomerase activity, and induction of tumor cell apoptosis J. Med. Chem. 2015, 58, 4771-4789 10.1021/acs.jmedchem.5b00444
    • (2015) J. Med. Chem. , vol.58 , pp. 4771-4789
    • Chen, Z.-F.1    Qin, Q.-P.2    Qin, J.-L.3    Zhou, J.4    Li, Y.-L.5    Li, N.6    Liu, Y.-C.7    Liang, H.8
  • 114
    • 0037070575 scopus 로고    scopus 로고
    • Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular G-quadruplex
    • Kim, M. Y.; Vankayalapati, H.; Shin-Ya, K.; Wierzba, K.; Hurley, L. H. Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular G-quadruplex J. Am. Chem. Soc. 2002, 124, 2098-2099 10.1021/ja017308q
    • (2002) J. Am. Chem. Soc. , vol.124 , pp. 2098-2099
    • Kim, M.Y.1    Vankayalapati, H.2    Shin-Ya, K.3    Wierzba, K.4    Hurley, L.H.5
  • 115
    • 79851504298 scopus 로고    scopus 로고
    • Telomestatin: Formal total synthesis and cation-mediated interaction of its seco-derivatives with G-quadruplexes
    • Linder, J.; Garner, T. P.; Williams, H. E. L.; Searle, M. S.; Moody, C. J. Telomestatin: formal total synthesis and cation-mediated interaction of its seco-derivatives with G-quadruplexes J. Am. Chem. Soc. 2011, 133, 1044-1051 10.1021/ja109158k
    • (2011) J. Am. Chem. Soc. , vol.133 , pp. 1044-1051
    • Linder, J.1    Garner, T.P.2    Williams, H.E.L.3    Searle, M.S.4    Moody, C.J.5
  • 116
    • 84884177068 scopus 로고    scopus 로고
    • Solution structure of an intramolecular (3 + 1) human telomeric G-quadruplex bound to a telomestatin derivative
    • Chung, W. J.; Heddi, B.; Tera, M.; Iida, K.; Nagasawa, K.; Phan, A. T. Solution structure of an intramolecular (3 + 1) human telomeric G-quadruplex bound to a telomestatin derivative J. Am. Chem. Soc. 2013, 135, 13495-13501 10.1021/ja405843r
    • (2013) J. Am. Chem. Soc. , vol.135 , pp. 13495-13501
    • Chung, W.J.1    Heddi, B.2    Tera, M.3    Iida, K.4    Nagasawa, K.5    Phan, A.T.6
  • 117
    • 77957952254 scopus 로고    scopus 로고
    • Macrocyclic G-quadruplex ligands
    • Nielsen, M. C.; Ulven, T. Macrocyclic G-quadruplex ligands Curr. Med. Chem. 2010, 17, 3438-3448 10.2174/092986710793176320
    • (2010) Curr. Med. Chem. , vol.17 , pp. 3438-3448
    • Nielsen, M.C.1    Ulven, T.2
  • 118
    • 77952045784 scopus 로고    scopus 로고
    • Macrocyclic pyridyl polyoxazoles: Selective RNA and DNA G-quadruplex ligands as antitumor agents
    • Rzuczek, S. G.; Pilch, D. S.; Liu, A.; Liu, L.; LaVoie, E. J.; Rice, J. E. Macrocyclic pyridyl polyoxazoles: selective RNA and DNA G-quadruplex ligands as antitumor agents J. Med. Chem. 2010, 53, 3632-3644 10.1021/jm1000612
    • (2010) J. Med. Chem. , vol.53 , pp. 3632-3644
    • Rzuczek, S.G.1    Pilch, D.S.2    Liu, A.3    Liu, L.4    LaVoie, E.J.5    Rice, J.E.6
  • 119
    • 77952065213 scopus 로고    scopus 로고
    • Macrocyclic hexaoxazoles: Influence of aminoalkyl substituents on RNA and DNA G-quadruplex stabilization and cytotoxicity
    • Satyanarayana, M.; Kim, Y. A.; Rzuczek, S. G.; Pilch, D. S.; Liu, A. A.; Liu, L. F.; Rice, J. E.; LaVoie, E. J. Macrocyclic hexaoxazoles: Influence of aminoalkyl substituents on RNA and DNA G-quadruplex stabilization and cytotoxicity Bioorg. Med. Chem. Lett. 2010, 20, 3150-3154 10.1016/j.bmcl.2010.03.086
    • (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 3150-3154
    • Satyanarayana, M.1    Kim, Y.A.2    Rzuczek, S.G.3    Pilch, D.S.4    Liu, A.A.5    Liu, L.F.6    Rice, J.E.7    LaVoie, E.J.8
  • 120
    • 84872912456 scopus 로고    scopus 로고
    • Finding the end: Recruitment of telomerase to telomeres
    • Nandakumar, J.; Cech, T. R. Finding the end: recruitment of telomerase to telomeres Nat. Rev. Mol. Cell Biol. 2013, 14, 69-82 10.1038/nrm3505
    • (2013) Nat. Rev. Mol. Cell Biol. , vol.14 , pp. 69-82
    • Nandakumar, J.1    Cech, T.R.2
  • 121
    • 77957585971 scopus 로고    scopus 로고
    • Telomeres and telomerase: The means to the end
    • Blackburn, E. H. Telomeres and telomerase: the means to the end Angew. Chem., Int. Ed. 2010, 49, 7405-7421 10.1002/anie.201002387
    • (2010) Angew. Chem., Int. Ed. , vol.49 , pp. 7405-7421
    • Blackburn, E.H.1
  • 122
    • 33746916385 scopus 로고    scopus 로고
    • The G-quadruplex ligand telomestatin inhibits POT1 binding to telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells
    • Gomez, D.; O'Donohue, M. F.; Wenner, T.; Douarre, C.; Macadré, J.; Koebel, P.; Giraud-Panis, M.-J.; Kaplan, H.; Kolkes, A.; Shin-Ya, K.; Riou, J.-F. The G-quadruplex ligand telomestatin inhibits POT1 binding to telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells Cancer Res. 2006, 66, 6908-6912 10.1158/0008-5472.CAN-06-1581
    • (2006) Cancer Res. , vol.66 , pp. 6908-6912
    • Gomez, D.1    O'Donohue, M.F.2    Wenner, T.3    Douarre, C.4    Macadré, J.5    Koebel, P.6    Giraud-Panis, M.-J.7    Kaplan, H.8    Kolkes, A.9    Shin-Ya, K.10    Riou, J.-F.11
  • 125
    • 6944239985 scopus 로고    scopus 로고
    • Biological Activity of the G-quadruplex ligand RHPS4 (3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl] acridinium methosulfate) is associated with telomere capping alteration
    • Leonetti, C.; Amodei, S.; D'Angelo, C.; Rizzo, A.; Benassi, B.; Antonelli, A.; Elli, R.; Stevens, M. F. G.; D'Incalci, M.; Zupi, G.; Biroccio, A. Biological Activity of the G-quadruplex ligand RHPS4 (3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl] acridinium methosulfate) is associated with telomere capping alteration Mol. Pharmacol. 2004, 66, 1138-1146 10.1124/mol.104.001537
    • (2004) Mol. Pharmacol. , vol.66 , pp. 1138-1146
    • Leonetti, C.1    Amodei, S.2    D'Angelo, C.3    Rizzo, A.4    Benassi, B.5    Antonelli, A.6    Elli, R.7    Stevens, M.F.G.8    D'Incalci, M.9    Zupi, G.10    Biroccio, A.11
  • 126
    • 45849099050 scopus 로고    scopus 로고
    • Living on a break: Cellular senescence as a DNA-damage response
    • d'Adda di Fagagna, F. Living on a break: cellular senescence as a DNA-damage response Nat. Rev. Cancer 2008, 8, 512-522 10.1038/nrc2440
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 512-522
    • D'Adda di Fagagna, F.1
  • 127
    • 56749151077 scopus 로고    scopus 로고
    • A novel small molecule that alters shelterin integrity and triggers a DNA-damage response at telomeres
    • Rodriguez, R.; Müller, S.; Yeoman, J. A.; Trentesaux, C.; Riou, J.-F.; Balasubramanian, S. A novel small molecule that alters shelterin integrity and triggers a DNA-damage response at telomeres J. Am. Chem. Soc. 2008, 130, 15758-15759 10.1021/ja805615w
    • (2008) J. Am. Chem. Soc. , vol.130 , pp. 15758-15759
    • Rodriguez, R.1    Müller, S.2    Yeoman, J.A.3    Trentesaux, C.4    Riou, J.-F.5    Balasubramanian, S.6
  • 131
    • 0041353443 scopus 로고    scopus 로고
    • Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: Involvement of ATM-dependent DNA damage response pathways
    • Tauchi, T.; Shin-ya, K.; Sashida, G.; Sumi, M.; Nakajima, A.; Shimamoto, T.; Ohyashiki, J. H.; Ohyashiki, K. Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: involvement of ATM-dependent DNA damage response pathways Oncogene 2003, 22, 5338-5347 10.1038/sj.onc.1206833
    • (2003) Oncogene , vol.22 , pp. 5338-5347
    • Tauchi, T.1    Shin-Ya, K.2    Sashida, G.3    Sumi, M.4    Nakajima, A.5    Shimamoto, T.6    Ohyashiki, J.H.7    Ohyashiki, K.8
  • 134
    • 84904741550 scopus 로고    scopus 로고
    • Cancer-specific defects in DNA repair pathways as targets for personalized therapeutic approaches
    • Dietlein, F.; Thelen, L.; Reinhardt, H. C. Cancer-specific defects in DNA repair pathways as targets for personalized therapeutic approaches Trends Genet. 2014, 30, 326-339 10.1016/j.tig.2014.06.003
    • (2014) Trends Genet. , vol.30 , pp. 326-339
    • Dietlein, F.1    Thelen, L.2    Reinhardt, H.C.3
  • 135
    • 84860854071 scopus 로고    scopus 로고
    • RTEL1 dismantles T loops and counteracts telomeric G4-DNA to maintain telomere integrity
    • Vannier, J.-B.; Pavicic-Kaltenbrunner, V.; Petalcorin, M. I.; Ding, H.; Boulton, S. J. RTEL1 dismantles T loops and counteracts telomeric G4-DNA to maintain telomere integrity Cell 2012, 149, 795-806 10.1016/j.cell.2012.03.030
    • (2012) Cell , vol.149 , pp. 795-806
    • Vannier, J.-B.1    Pavicic-Kaltenbrunner, V.2    Petalcorin, M.I.3    Ding, H.4    Boulton, S.J.5
  • 137
    • 0026541582 scopus 로고
    • Retinoblastoma susceptibility genes contain 5′ sequences with a high propensity to form guanine-tetrad structures
    • Murchie, A. I.; Lilley, D. M. Retinoblastoma susceptibility genes contain 5′ sequences with a high propensity to form guanine-tetrad structures Nucleic Acids Res. 1992, 20, 49-53 10.1093/nar/20.1.49
    • (1992) Nucleic Acids Res. , vol.20 , pp. 49-53
    • Murchie, A.I.1    Lilley, D.M.2
  • 138
    • 0030872683 scopus 로고    scopus 로고
    • Temperature and salt dependence of higher order structure formation by antisense c-myc and c-myb phosphorothioate oligodeoxyribonucleotides containing tetraguanylate tracts
    • Basu, S.; Wickstrom, E. Temperature and salt dependence of higher order structure formation by antisense c-myc and c-myb phosphorothioate oligodeoxyribonucleotides containing tetraguanylate tracts Nucleic Acids Res. 1997, 25, 1327-1332 10.1093/nar/25.7.1327
    • (1997) Nucleic Acids Res. , vol.25 , pp. 1327-1332
    • Basu, S.1    Wickstrom, E.2
  • 139
    • 0032030327 scopus 로고    scopus 로고
    • DNA tetraplex formation in the control region of c-myc
    • Simonsson, T.; Pecinka, P.; Kubista, M. DNA tetraplex formation in the control region of c-myc Nucleic Acids Res. 1998, 26, 1167-1172 10.1093/nar/26.5.1167
    • (1998) Nucleic Acids Res. , vol.26 , pp. 1167-1172
    • Simonsson, T.1    Pecinka, P.2    Kubista, M.3
  • 140
    • 0037015078 scopus 로고    scopus 로고
    • Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription
    • Siddiqui-Jain, A.; Grand, C. L.; Bearss, D. J.; Hurley, L. H. Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription Proc. Natl. Acad. Sci. U. S. A. 2002, 99, 11593-11598 10.1073/pnas.182256799
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 11593-11598
    • Siddiqui-Jain, A.1    Grand, C.L.2    Bearss, D.J.3    Hurley, L.H.4
  • 141
    • 79953313413 scopus 로고    scopus 로고
    • Targeting G-quadruplexes in gene promoters: A novel anticancer strategy?
    • Balasubramanian, S.; Hurley, L. H.; Neidle, S. Targeting G-quadruplexes in gene promoters: a novel anticancer strategy? Nat. Rev. Drug Discovery 2011, 10, 261-275 10.1038/nrd3428
    • (2011) Nat. Rev. Drug Discovery , vol.10 , pp. 261-275
    • Balasubramanian, S.1    Hurley, L.H.2    Neidle, S.3
  • 142
    • 33846928449 scopus 로고    scopus 로고
    • G-quadruplexes in promoters throughout the human genome
    • Huppert, J. L.; Balasubramanian, S. G-quadruplexes in promoters throughout the human genome Nucleic Acids Res. 2007, 35, 406-413 10.1093/nar/gkl1057
    • (2007) Nucleic Acids Res. , vol.35 , pp. 406-413
    • Huppert, J.L.1    Balasubramanian, S.2
  • 143
    • 40249084264 scopus 로고    scopus 로고
    • Conserved elements with potential to form polymorphic G-quadruplex structures in the first intron of human genes
    • Eddy, J.; Maizels, N. Conserved elements with potential to form polymorphic G-quadruplex structures in the first intron of human genes Nucleic Acids Res. 2008, 36, 1321-1333 10.1093/nar/gkm1138
    • (2008) Nucleic Acids Res. , vol.36 , pp. 1321-1333
    • Eddy, J.1    Maizels, N.2
  • 144
    • 73349127073 scopus 로고    scopus 로고
    • Genome-wide colonization of gene regulatory elements by G4 DNA motifs
    • Du, Z.; Zhao, Y.; Li, N. Genome-wide colonization of gene regulatory elements by G4 DNA motifs Nucleic Acids Res. 2009, 37, 6784-6798 10.1093/nar/gkp710
    • (2009) Nucleic Acids Res. , vol.37 , pp. 6784-6798
    • Du, Z.1    Zhao, Y.2    Li, N.3
  • 145
    • 84871728994 scopus 로고    scopus 로고
    • Genome-wide study predicts promoter-G4 DNA motifs regulate selective functions in bacteria: Radioresistance of D. Radiodurans involves G4 DNA-mediated regulation
    • Beaume, N.; Pathak, R.; Yadav, V. K.; Kota, S.; Misra, H. S.; Gautam, H. K.; Chowdhury, S. Genome-wide study predicts promoter-G4 DNA motifs regulate selective functions in bacteria: radioresistance of D. radiodurans involves G4 DNA-mediated regulation Nucleic Acids Res. 2013, 41, 76-89 10.1093/nar/gks1071
    • (2013) Nucleic Acids Res. , vol.41 , pp. 76-89
    • Beaume, N.1    Pathak, R.2    Yadav, V.K.3    Kota, S.4    Misra, H.S.5    Gautam, H.K.6    Chowdhury, S.7
  • 146
    • 33750990787 scopus 로고    scopus 로고
    • NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region
    • Dai, J.; Chen, D.; Jones, R. A.; Hurley, L. H.; Yang, D. NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region Nucleic Acids Res. 2006, 34, 5133-5144 10.1093/nar/gkl610
    • (2006) Nucleic Acids Res. , vol.34 , pp. 5133-5144
    • Dai, J.1    Chen, D.2    Jones, R.A.3    Hurley, L.H.4    Yang, D.5
  • 147
    • 80052532707 scopus 로고    scopus 로고
    • G4-DNA formation in the HRAS promoter and rational design of decoy oligonucleotides for cancer therapy
    • Membrino, A.; Cogoi, S.; Pedersen, E. B.; Xodo, L. E. G4-DNA formation in the HRAS promoter and rational design of decoy oligonucleotides for cancer therapy PLoS One 2011, 6, e24421 10.1371/journal.pone.0024421
    • (2011) PLoS One , vol.6 , pp. e24421
    • Membrino, A.1    Cogoi, S.2    Pedersen, E.B.3    Xodo, L.E.4
  • 148
    • 46349107530 scopus 로고    scopus 로고
    • Structural polymorphism within a regulatory element of the human KRAS promoter: Formation of G4-DNA recognized by nuclear proteins
    • Cogoi, S.; Paramasivam, M.; Spolaore, B.; Xodo, L. E. Structural polymorphism within a regulatory element of the human KRAS promoter: formation of G4-DNA recognized by nuclear proteins Nucleic Acids Res. 2008, 36, 3765-3780 10.1093/nar/gkn120
    • (2008) Nucleic Acids Res. , vol.36 , pp. 3765-3780
    • Cogoi, S.1    Paramasivam, M.2    Spolaore, B.3    Xodo, L.E.4
  • 151
    • 28944442742 scopus 로고    scopus 로고
    • Evidence for the presence of a guanine quadruplex forming region within a polypurine tract of the hypoxia inducible factor 1α promoter
    • De Armond, R.; Wood, S.; Sun, D.; Hurley, L. H.; Ebbinghaus, S. W. Evidence for the presence of a guanine quadruplex forming region within a polypurine tract of the hypoxia inducible factor 1α promoter Biochemistry 2005, 44, 16341-16350 10.1021/bi051618u
    • (2005) Biochemistry , vol.44 , pp. 16341-16350
    • De Armond, R.1    Wood, S.2    Sun, D.3    Hurley, L.H.4    Ebbinghaus, S.W.5
  • 152
    • 84865527719 scopus 로고    scopus 로고
    • A novel series of G-quadruplex ligands with selectivity for HIF-expressing osteosarcoma and renal cancer cell lines
    • Lombardo, C. M.; Welsh, S. J.; Strauss, S. J.; Dale, A. G.; Todd, A. K.; Nanjunda, R.; Wilson, W. D.; Neidle, S. A novel series of G-quadruplex ligands with selectivity for HIF-expressing osteosarcoma and renal cancer cell lines Bioorg. Med. Chem. Lett. 2012, 22, 5984-5988 10.1016/j.bmcl.2012.07.009
    • (2012) Bioorg. Med. Chem. Lett. , vol.22 , pp. 5984-5988
    • Lombardo, C.M.1    Welsh, S.J.2    Strauss, S.J.3    Dale, A.G.4    Todd, A.K.5    Nanjunda, R.6    Wilson, W.D.7    Neidle, S.8
  • 153
    • 84891287672 scopus 로고    scopus 로고
    • Crystal structure of a promoter sequence in the B-raf gene reveals an intertwined dimer quadruplex
    • Wei, D.; Todd, A. K.; Zloh, M.; Gunaratnam, M.; Parkinson, G. N.; Neidle, S. Crystal structure of a promoter sequence in the B-raf gene reveals an intertwined dimer quadruplex J. Am. Chem. Soc. 2013, 135, 19319-19329 10.1021/ja4101358
    • (2013) J. Am. Chem. Soc. , vol.135 , pp. 19319-19329
    • Wei, D.1    Todd, A.K.2    Zloh, M.3    Gunaratnam, M.4    Parkinson, G.N.5    Neidle, S.6
  • 154
    • 84937634820 scopus 로고    scopus 로고
    • Double stranded promoter region of BRAF undergoes to structural rearrangement in nearly physiological conditions
    • Greco, M. L.; Folini, M.; Sissi, C. Double stranded promoter region of BRAF undergoes to structural rearrangement in nearly physiological conditions FEBS Lett. 2015, 589, 2117-2123 10.1016/j.febslet.2015.06.025
    • (2015) FEBS Lett. , vol.589 , pp. 2117-2123
    • Greco, M.L.1    Folini, M.2    Sissi, C.3
  • 155
    • 84874432663 scopus 로고    scopus 로고
    • Downregulation of androgen receptor transcription by promoter G-quadruplex stabilization as a potential alternative treatment for castrate-resistant prostate cancer
    • Mitchell, T.; Ramos-Montoya, A.; Di Antonio, M.; Murat, P.; Ohnmacht, S.; Micco, M.; Jurmeister, S.; Fryer, L.; Balasubramanian, S.; Neidle, S.; Neal, D. E. Downregulation of androgen receptor transcription by promoter G-quadruplex stabilization as a potential alternative treatment for castrate-resistant prostate cancer Biochemistry 2013, 52, 1429-1436 10.1021/bi301349c
    • (2013) Biochemistry , vol.52 , pp. 1429-1436
    • Mitchell, T.1    Ramos-Montoya, A.2    Di Antonio, M.3    Murat, P.4    Ohnmacht, S.5    Micco, M.6    Jurmeister, S.7    Fryer, L.8    Balasubramanian, S.9    Neidle, S.10    Neal, D.E.11
  • 156
    • 34548183518 scopus 로고    scopus 로고
    • Formation of pseudosymmetrical G-quadruplex and i-motif structures in the proximal promoter region of the RET oncogene
    • Guo, K.; Pourpak, A.; Beetz-Rogers, K.; Gokhale, V.; Sun, D.; Hurley, L. H. Formation of pseudosymmetrical G-quadruplex and i-motif structures in the proximal promoter region of the RET oncogene J. Am. Chem. Soc. 2007, 129, 10220-10228 10.1021/ja072185g
    • (2007) J. Am. Chem. Soc. , vol.129 , pp. 10220-10228
    • Guo, K.1    Pourpak, A.2    Beetz-Rogers, K.3    Gokhale, V.4    Sun, D.5    Hurley, L.H.6
  • 157
    • 80055092362 scopus 로고    scopus 로고
    • Solution structure of all parallel G-quadruplex formed by the oncogene RET promoter sequence
    • Tong, X.; Lan, W.; Zhang, X.; Wu, H.; Liu, M.; Cao, C. Solution structure of all parallel G-quadruplex formed by the oncogene RET promoter sequence Nucleic Acids Res. 2011, 39, 6753-6763 10.1093/nar/gkr233
    • (2011) Nucleic Acids Res. , vol.39 , pp. 6753-6763
    • Tong, X.1    Lan, W.2    Zhang, X.3    Wu, H.4    Liu, M.5    Cao, C.6
  • 159
    • 84946177633 scopus 로고    scopus 로고
    • An intramolecular G-quadruplex structure formed in the human MET promoter region and its biological relevance
    • Yan, J.; Zhao, X.; Liu, B.; Yuan, Y.; Guan, Y. An intramolecular G-quadruplex structure formed in the human MET promoter region and its biological relevance Mol. Carcinog. 2015, 10.1002/mc.22330
    • (2015) Mol. Carcinog.
    • Yan, J.1    Zhao, X.2    Liu, B.3    Yuan, Y.4    Guan, Y.5
  • 161
    • 43349085046 scopus 로고    scopus 로고
    • The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements
    • Todd, A. K.; Neidle, S. The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements Nucleic Acids Res. 2008, 36, 2700-2704 10.1093/nar/gkn078
    • (2008) Nucleic Acids Res. , vol.36 , pp. 2700-2704
    • Todd, A.K.1    Neidle, S.2
  • 162
    • 33746841845 scopus 로고    scopus 로고
    • Structure of the biologically relevant G-quadruplex in the c-MYC promoter
    • Yang, D.; Hurley, L. H. Structure of the biologically relevant G-quadruplex in the c-MYC promoter Nucleosides, Nucleotides Nucleic Acids 2006, 25, 951-968 10.1080/15257770600809913
    • (2006) Nucleosides, Nucleotides Nucleic Acids , vol.25 , pp. 951-968
    • Yang, D.1    Hurley, L.H.2
  • 163
    • 80455168261 scopus 로고    scopus 로고
    • C-MYC promoter G-quadruplex formed at the 5′-end of NHE III1 element: Insights into biological relevance and parallel-stranded G-quadruplex stability
    • Mathad, R. I.; Hatzakis, E.; Dai, J.; Yang, D. c-MYC promoter G-quadruplex formed at the 5′-end of NHE III1 element: insights into biological relevance and parallel-stranded G-quadruplex stability Nucleic Acids Res. 2011, 39, 9023-9033 10.1093/nar/gkr612
    • (2011) Nucleic Acids Res. , vol.39 , pp. 9023-9033
    • Mathad, R.I.1    Hatzakis, E.2    Dai, J.3    Yang, D.4
  • 164
    • 33644833219 scopus 로고    scopus 로고
    • Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter
    • Phan, A. T.; Kuryavyi, V.; Gaw, H. Y.; Patel, D. J. Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter Nat. Chem. Biol. 2005, 1, 167-173 10.1038/nchembio723
    • (2005) Nat. Chem. Biol. , vol.1 , pp. 167-173
    • Phan, A.T.1    Kuryavyi, V.2    Gaw, H.Y.3    Patel, D.J.4
  • 166
    • 77956252000 scopus 로고    scopus 로고
    • Coexistence of two distinct G-quadruplex conformations in the hTERT promoter
    • Lim, K. W.; Lacroix, L.; Yue, D. J.; Lim, J. K.; Lim, J. M.; Phan, A. T. Coexistence of two distinct G-quadruplex conformations in the hTERT promoter J. Am. Chem. Soc. 2010, 132, 12331-12342 10.1021/ja101252n
    • (2010) J. Am. Chem. Soc. , vol.132 , pp. 12331-12342
    • Lim, K.W.1    Lacroix, L.2    Yue, D.J.3    Lim, J.K.4    Lim, J.M.5    Phan, A.T.6
  • 169
    • 84876215753 scopus 로고    scopus 로고
    • Structure-based design and evaluation of naphthalene diimide G-quadruplex ligands as telomere targeting agents in pancreatic cancer cells
    • Micco, M.; Collie, G. W.; Dale, A. G.; Ohnmacht, S. A.; Pazitna, I.; Gunaratnam, M.; Reszka, A. P.; Neidle, S. Structure-based design and evaluation of naphthalene diimide G-quadruplex ligands as telomere targeting agents in pancreatic cancer cells J. Med. Chem. 2013, 56, 2959-2974 10.1021/jm301899y
    • (2013) J. Med. Chem. , vol.56 , pp. 2959-2974
    • Micco, M.1    Collie, G.W.2    Dale, A.G.3    Ohnmacht, S.A.4    Pazitna, I.5    Gunaratnam, M.6    Reszka, A.P.7    Neidle, S.8
  • 172
    • 77958092097 scopus 로고    scopus 로고
    • Targeting the c-Kit promoter quadruplexes with 6-substituted indenoisoquinolines, a novel class of G-quadruplex stabilising small molecule ligands
    • Bejugam, M.; Gunaratnam, M.; Müller, S.; Sanders, D. A.; Sewitz, S.; Fletcher, J.; Neidle, S.; Balasubramanian, S. Targeting the c-Kit promoter quadruplexes with 6-substituted indenoisoquinolines, a novel class of G-quadruplex stabilising small molecule ligands ACS Med. Chem. Lett. 2010, 1, 306-310 10.1021/ml100062z
    • (2010) ACS Med. Chem. Lett. , vol.1 , pp. 306-310
    • Bejugam, M.1    Gunaratnam, M.2    Müller, S.3    Sanders, D.A.4    Sewitz, S.5    Fletcher, J.6    Neidle, S.7    Balasubramanian, S.8
  • 173
    • 35848942604 scopus 로고    scopus 로고
    • Trisubstituted isoalloxazines as a new class of G-quadruplex binding ligands: Small molecule regulation of c-kit oncogene expression
    • Bejugam, M.; Sewitz, S.; Shirude, P. S.; Rodriguez, R.; Shahid, R.; Balasubramanian, S. Trisubstituted isoalloxazines as a new class of G-quadruplex binding ligands: small molecule regulation of c-kit oncogene expression J. Am. Chem. Soc. 2007, 129, 12926-12927 10.1021/ja075881p
    • (2007) J. Am. Chem. Soc. , vol.129 , pp. 12926-12927
    • Bejugam, M.1    Sewitz, S.2    Shirude, P.S.3    Rodriguez, R.4    Shahid, R.5    Balasubramanian, S.6
  • 175
    • 79952763614 scopus 로고    scopus 로고
    • Targeting MYC expression through G-quadruplexes
    • Brooks, T. A.; Hurley, L. H. Targeting MYC expression through G-quadruplexes Genes Cancer 2010, 1, 641-649 10.1177/1947601910377493
    • (2010) Genes Cancer , vol.1 , pp. 641-649
    • Brooks, T.A.1    Hurley, L.H.2
  • 176
    • 84896496345 scopus 로고    scopus 로고
    • The dynamic character of the BCL2 promoter i-motif provides a mechanism for modulation of gene expression by compounds that bind selectively to the alternative DNA hairpin structure
    • Kendrick, S.; Kang, H. J.; Alam, M. P.; Madathil, M. M.; Agrawal, P.; Gokhale, V.; Yang, D.; Hecht, S. M.; Hurley, L. H. The dynamic character of the BCL2 promoter i-motif provides a mechanism for modulation of gene expression by compounds that bind selectively to the alternative DNA hairpin structure J. Am. Chem. Soc. 2014, 136, 4161-4171 10.1021/ja410934b
    • (2014) J. Am. Chem. Soc. , vol.136 , pp. 4161-4171
    • Kendrick, S.1    Kang, H.J.2    Alam, M.P.3    Madathil, M.M.4    Agrawal, P.5    Gokhale, V.6    Yang, D.7    Hecht, S.M.8    Hurley, L.H.9
  • 177
    • 84896516232 scopus 로고    scopus 로고
    • The transcriptional complex between the BCL2 i-motif and hnRNP LL is a molecular switch for control of gene expression that can be modulated by small molecules
    • Kang, H. J.; Kendrick, S.; Hecht, S. M.; Hurley, L. H. The transcriptional complex between the BCL2 i-motif and hnRNP LL is a molecular switch for control of gene expression that can be modulated by small molecules J. Am. Chem. Soc. 2014, 136, 4172-4185 10.1021/ja4109352
    • (2014) J. Am. Chem. Soc. , vol.136 , pp. 4172-4185
    • Kang, H.J.1    Kendrick, S.2    Hecht, S.M.3    Hurley, L.H.4
  • 178
    • 84863814733 scopus 로고    scopus 로고
    • Anticancer activity and cellular repression of c-MYC by the G-quadruplex-stabilizing 11-piperazinylquindoline is not dependent on direct targeting of the G-quadruplex in the c-MYC promoter
    • Boddupally, P. V.; Hahn, S.; Beman, C.; De, B.; Brooks, T. A.; Gokhale, V.; Hurley, L. H. Anticancer activity and cellular repression of c-MYC by the G-quadruplex-stabilizing 11-piperazinylquindoline is not dependent on direct targeting of the G-quadruplex in the c-MYC promoter J. Med. Chem. 2012, 55, 6076-6086 10.1021/jm300282c
    • (2012) J. Med. Chem. , vol.55 , pp. 6076-6086
    • Boddupally, P.V.1    Hahn, S.2    Beman, C.3    De, B.4    Brooks, T.A.5    Gokhale, V.6    Hurley, L.H.7
  • 179
    • 81755172447 scopus 로고    scopus 로고
    • Demonstration that drug-targeted down-regulation of MYC in non-Hodgkins lymphoma is directly mediated through the promoter G-quadruplex
    • Brown, R. V.; Danford, F. L.; Gokhale, V.; Hurley, L. H.; Brooks, T. A. Demonstration that drug-targeted down-regulation of MYC in non-Hodgkins lymphoma is directly mediated through the promoter G-quadruplex J. Biol. Chem. 2011, 286, 41018-41027 10.1074/jbc.M111.274720
    • (2011) J. Biol. Chem. , vol.286 , pp. 41018-41027
    • Brown, R.V.1    Danford, F.L.2    Gokhale, V.3    Hurley, L.H.4    Brooks, T.A.5
  • 180
    • 79952763614 scopus 로고    scopus 로고
    • The role of supercoiling in transcriptional control of MYC and its importance in molecular therapeutics
    • Brooks, T. A.; Hurley, L. H. The role of supercoiling in transcriptional control of MYC and its importance in molecular therapeutics Genes Cancer 2010, 1, 641-649 10.1177/1947601910377493
    • (2010) Genes Cancer , vol.1 , pp. 641-649
    • Brooks, T.A.1    Hurley, L.H.2
  • 184
    • 34447541999 scopus 로고    scopus 로고
    • RNA quadruplex-based modulation of gene expression
    • Wieland, M.; Hartig, J. S. RNA quadruplex-based modulation of gene expression Chem. Biol. 2007, 14, 757-763 10.1016/j.chembiol.2007.06.005
    • (2007) Chem. Biol. , vol.14 , pp. 757-763
    • Wieland, M.1    Hartig, J.S.2
  • 185
    • 69949186768 scopus 로고    scopus 로고
    • A comparison of DNA and RNA quadruplex structures and stabilities
    • Joachimi, A.; Benz, A.; Hartig, J. S. A comparison of DNA and RNA quadruplex structures and stabilities Bioorg. Med. Chem. 2009, 17, 6811-6815 10.1016/j.bmc.2009.08.043
    • (2009) Bioorg. Med. Chem. , vol.17 , pp. 6811-6815
    • Joachimi, A.1    Benz, A.2    Hartig, J.S.3
  • 186
    • 76349116980 scopus 로고    scopus 로고
    • Human telomeric G-quadruplex: Thermodynamic and kinetic studies of telomeric quadruplex stability
    • Chaires, J. B. Human telomeric G-quadruplex: thermodynamic and kinetic studies of telomeric quadruplex stability FEBS J. 2010, 277, 1098-1106 10.1111/j.1742-4658.2009.07462.x
    • (2010) FEBS J. , vol.277 , pp. 1098-1106
    • Chaires, J.B.1
  • 187
    • 84891123068 scopus 로고    scopus 로고
    • Noncanonical structures and their thermodynamics of DNA and RNA under molecular crowding: Beyond the Watson-Crick double helix
    • Sugimoto, N. Noncanonical structures and their thermodynamics of DNA and RNA under molecular crowding: beyond the Watson-Crick double helix Int. Rev. Cell Mol. Biol. 2014, 307, 205-273 10.1016/B978-0-12-800046-5.00008-4
    • (2014) Int. Rev. Cell Mol. Biol. , vol.307 , pp. 205-273
    • Sugimoto, N.1
  • 189
    • 84862229118 scopus 로고    scopus 로고
    • 5′-UTR RNA G-quadruplexes: Translation regulation and targeting
    • Bugaut, A.; Balasubramanian, S. 5′-UTR RNA G-quadruplexes: translation regulation and targeting Nucleic Acids Res. 2012, 40, 4727-4741 10.1093/nar/gks068
    • (2012) Nucleic Acids Res. , vol.40 , pp. 4727-4741
    • Bugaut, A.1    Balasubramanian, S.2
  • 190
    • 77957061503 scopus 로고    scopus 로고
    • The BCL-2 5′ untranslated region contains an RNA G-quadruplex-forming motif that modulates protein expression
    • Shahid, R.; Bugaut, A.; Balasubramanian, S. The BCL-2 5′ untranslated region contains an RNA G-quadruplex-forming motif that modulates protein expression Biochemistry 2010, 49, 8300-8306 10.1021/bi100957h
    • (2010) Biochemistry , vol.49 , pp. 8300-8306
    • Shahid, R.1    Bugaut, A.2    Balasubramanian, S.3
  • 191
    • 33947310727 scopus 로고    scopus 로고
    • An RNA G-quadruplex in the 5′ UTR of the NRAS proto-oncogene modulates translation
    • Kumari, S.; Bugaut, A.; Huppert, J. L.; Balasubramanian, S. An RNA G-quadruplex in the 5′ UTR of the NRAS proto-oncogene modulates translation Nat. Chem. Biol. 2007, 3, 218-221 10.1038/nchembio864
    • (2007) Nat. Chem. Biol. , vol.3 , pp. 218-221
    • Kumari, S.1    Bugaut, A.2    Huppert, J.L.3    Balasubramanian, S.4
  • 192
    • 77956160477 scopus 로고    scopus 로고
    • Occurrence of a quadruplex motif in a unique insert within exon C of the bovine estrogen receptor alpha gene (ESR1)
    • Derecka, K.; Balkwill, G. D.; Garner, T. P.; Hodgman, C.; Flint, A. P.; Searle, M. S. Occurrence of a quadruplex motif in a unique insert within exon C of the bovine estrogen receptor alpha gene (ESR1) Biochemistry 2010, 49, 7625-7633 10.1021/bi100804f
    • (2010) Biochemistry , vol.49 , pp. 7625-7633
    • Derecka, K.1    Balkwill, G.D.2    Garner, T.P.3    Hodgman, C.4    Flint, A.P.5    Searle, M.S.6
  • 193
    • 67049134254 scopus 로고    scopus 로고
    • An unusually stable G-quadruplex within the 5′-UTR of the MT3 matrix metalloproteinase mRNA represses translation in eukaryotic cells
    • Morris, M. J.; Basu, S. An unusually stable G-quadruplex within the 5′-UTR of the MT3 matrix metalloproteinase mRNA represses translation in eukaryotic cells Biochemistry 2009, 48, 5313-5319 10.1021/bi900498z
    • (2009) Biochemistry , vol.48 , pp. 5313-5319
    • Morris, M.J.1    Basu, S.2
  • 194
    • 84874595270 scopus 로고    scopus 로고
    • The G-quadruplex augments translation in the 5′ untranslated region of transforming growth factor β2
    • Agarwala, P.; Pandey, S.; Mapa, K.; Maiti, S. The G-quadruplex augments translation in the 5′ untranslated region of transforming growth factor β2 Biochemistry 2013, 52, 1528-1538 10.1021/bi301365g
    • (2013) Biochemistry , vol.52 , pp. 1528-1538
    • Agarwala, P.1    Pandey, S.2    Mapa, K.3    Maiti, S.4
  • 196
    • 79960285267 scopus 로고    scopus 로고
    • Mapping the sequences of potential guanine quadruplex motifs
    • Todd, A. K.; Neidle, S. Mapping the sequences of potential guanine quadruplex motifs Nucleic Acids Res. 2011, 39, 4917-4927 10.1093/nar/gkr104
    • (2011) Nucleic Acids Res. , vol.39 , pp. 4917-4927
    • Todd, A.K.1    Neidle, S.2
  • 197
    • 45749139174 scopus 로고    scopus 로고
    • Inhibition of translation in living eukaryotic cells by an RNA G-quadruplex motif
    • Arora, A.; Dutkiewicz, M.; Scaria, V.; Hariharan, M.; Maiti, S.; Kurreck, J. Inhibition of translation in living eukaryotic cells by an RNA G-quadruplex motif RNA 2008, 14, 1290-1296 10.1261/rna.1001708
    • (2008) RNA , vol.14 , pp. 1290-1296
    • Arora, A.1    Dutkiewicz, M.2    Scaria, V.3    Hariharan, M.4    Maiti, S.5    Kurreck, J.6
  • 199
    • 84890958553 scopus 로고    scopus 로고
    • Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells
    • Biffi, G.; Di Antonio, M.; Tannahill, D.; Balasubramanian, S. Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells Nat. Chem. 2014, 6, 75-80 10.1038/nchem.1805
    • (2014) Nat. Chem. , vol.6 , pp. 75-80
    • Biffi, G.1    Di Antonio, M.2    Tannahill, D.3    Balasubramanian, S.4
  • 200
    • 77953184584 scopus 로고    scopus 로고
    • Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex
    • Bugaut, A.; Rodriguez, R.; Kumari, S.; Hsu, S. T.; Balasubramanian, S. Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex Org. Biomol. Chem. 2010, 8, 2771-2776 10.1039/c002418j
    • (2010) Org. Biomol. Chem. , vol.8 , pp. 2771-2776
    • Bugaut, A.1    Rodriguez, R.2    Kumari, S.3    Hsu, S.T.4    Balasubramanian, S.5
  • 201
    • 84055188686 scopus 로고    scopus 로고
    • Photoactivated cationic alkyl-substituted porphyrin binding to g4-RNA in the 5′-UTR of KRAS oncogene represses translation
    • Faudale, M.; Cogoi, S.; Xodo, L. E. Photoactivated cationic alkyl-substituted porphyrin binding to g4-RNA in the 5′-UTR of KRAS oncogene represses translation Chem. Commun. 2012, 48, 874-876 10.1039/C1CC15850C
    • (2012) Chem. Commun. , vol.48 , pp. 874-876
    • Faudale, M.1    Cogoi, S.2    Xodo, L.E.3
  • 202
    • 84930271972 scopus 로고    scopus 로고
    • G-quadruplexes: Emerging roles in neurodegenerative diseases and the non-coding transcriptome
    • Simone, R.; Fratta, P.; Neidle, S.; Parkinson, G. N.; Isaacs, A. M. G-quadruplexes: Emerging roles in neurodegenerative diseases and the non-coding transcriptome FEBS Lett. 2015, 589, 1653-1668 10.1016/j.febslet.2015.05.003
    • (2015) FEBS Lett. , vol.589 , pp. 1653-1668
    • Simone, R.1    Fratta, P.2    Neidle, S.3    Parkinson, G.N.4    Isaacs, A.M.5
  • 204
    • 84871801926 scopus 로고    scopus 로고
    • C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms RNA G-quadruplexes
    • Fratta, P.; Mizielinska, S.; Nicoll, A. J.; Zloh, M.; Fisher, E. M.; Parkinson, G.; Isaacs, A. M. C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms RNA G-quadruplexes Sci. Rep. 2012, 2, 1016 10.1038/srep01016
    • (2012) Sci. Rep. , vol.2 , pp. 1016
    • Fratta, P.1    Mizielinska, S.2    Nicoll, A.J.3    Zloh, M.4    Fisher, E.M.5    Parkinson, G.6    Isaacs, A.M.7
  • 205
    • 84875981640 scopus 로고    scopus 로고
    • n repeat from the C9orf72 gene forms tract length-dependent uni- and multimolecular RNA G-quadruplex structures
    • n repeat from the C9orf72 gene forms tract length-dependent uni- and multimolecular RNA G-quadruplex structures J. Biol. Chem. 2013, 288, 9860-9866 10.1074/jbc.C113.452532
    • (2013) J. Biol. Chem. , vol.288 , pp. 9860-9866
    • Reddy, K.1    Zamiri, B.2    Stanley, S.Y.3    Macgregor, Jr.R.B.4    Pearson, C.E.5
  • 206
    • 84894465709 scopus 로고    scopus 로고
    • n repeat of the C9orf72 gene and blocks interaction of RNA-binding proteins
    • n repeat of the C9orf72 gene and blocks interaction of RNA-binding proteins J. Biol. Chem. 2014, 289, 4653-4659 10.1074/jbc.C113.502336
    • (2014) J. Biol. Chem. , vol.289 , pp. 4653-4659
    • Zamiri, B.1    Reddy, K.2    Macgregor, R.3    Pearson, C.E.4
  • 208
    • 79961029908 scopus 로고    scopus 로고
    • DNA secondary structures and epigenetic determinants of cancer genome evolution
    • De, S.; Michor, F. DNA secondary structures and epigenetic determinants of cancer genome evolution Nat. Struct. Mol. Biol. 2011, 18, 950-955 10.1038/nsmb.2089
    • (2011) Nat. Struct. Mol. Biol. , vol.18 , pp. 950-955
    • De, S.1    Michor, F.2
  • 209
    • 84887405212 scopus 로고    scopus 로고
    • Genomes and G-quadruplexes: For better or for worse
    • Tarsounas, M.; Tijsterman, M. Genomes and G-quadruplexes: for better or for worse J. Mol. Biol. 2013, 425, 4782-4789 10.1016/j.jmb.2013.09.026
    • (2013) J. Mol. Biol. , vol.425 , pp. 4782-4789
    • Tarsounas, M.1    Tijsterman, M.2
  • 210
    • 84876862930 scopus 로고    scopus 로고
    • The G4 genome
    • Maizels, N.; Gray, L. T. The G4 genome PLoS Genet. 2013, 9, e1003468 10.1371/journal.pgen.1003468
    • (2013) PLoS Genet. , vol.9 , pp. e1003468
    • Maizels, N.1    Gray, L.T.2
  • 211
    • 84891400223 scopus 로고    scopus 로고
    • Existence and consequences of G-quadruplex structures in DNA
    • Murat, P.; Balasubramanian, S. Existence and consequences of G-quadruplex structures in DNA Curr. Opin. Genet. Dev. 2014, 25, 22-29 10.1016/j.gde.2013.10.012
    • (2014) Curr. Opin. Genet. Dev. , vol.25 , pp. 22-29
    • Murat, P.1    Balasubramanian, S.2
  • 213
    • 84948677788 scopus 로고    scopus 로고
    • G-quadruplexes and their regulatory roles in cancer
    • Rhodes, D.; Lipps, H. J. G-quadruplexes and their regulatory roles in cancer Nucleic Acids Res. 2015, 43, 8627-8637 10.1093/nar/gkv862
    • (2015) Nucleic Acids Res. , vol.43 , pp. 8627-8637
    • Rhodes, D.1    Lipps, H.J.2
  • 214
    • 84884771159 scopus 로고    scopus 로고
    • Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability
    • Bharti, S. K.; Sommers, J. A.; George, F.; Kuper, J.; Hamon, F.; Shin-ya, K.; Teulade-Fichou, M.-P.; Kisker, C.; Brosh, R. M., Jr. Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability J. Biol. Chem. 2013, 288, 28217-28229 10.1074/jbc.M113.496463
    • (2013) J. Biol. Chem. , vol.288 , pp. 28217-28229
    • Bharti, S.K.1    Sommers, J.A.2    George, F.3    Kuper, J.4    Hamon, F.5    Shin-Ya, K.6    Teulade-Fichou, M.-P.7    Kisker, C.8    Brosh, Jr.R.M.9
  • 215
    • 84897029094 scopus 로고    scopus 로고
    • G quadruplexes are genomewide targets of transcriptional helicases XPB and XPD
    • Gray, L. T.; Vallur, A. C.; Eddy, J.; Maizels, N. G quadruplexes are genomewide targets of transcriptional helicases XPB and XPD Nat. Chem. Biol. 2014, 10, 313-318 10.1038/nchembio.1475
    • (2014) Nat. Chem. Biol. , vol.10 , pp. 313-318
    • Gray, L.T.1    Vallur, A.C.2    Eddy, J.3    Maizels, N.4
  • 216
    • 67149126812 scopus 로고    scopus 로고
    • The yeast Pif1 helicase prevents genomic instability caused by G-quadruplex-forming CEB1 sequences in vivo
    • Ribeyre, C.; Lopes, J.; Boulé, J.-B.; Piazza, A.; Guédin, A.; Zakian, V. A.; Mergny, J.-L.; Nicolas, A. The yeast Pif1 helicase prevents genomic instability caused by G-quadruplex-forming CEB1 sequences in vivo PLoS Genet. 2009, 5, e1000475 10.1371/journal.pgen.1000475
    • (2009) PLoS Genet. , vol.5 , pp. e1000475
    • Ribeyre, C.1    Lopes, J.2    Boulé, J.-B.3    Piazza, A.4    Guédin, A.5    Zakian, V.A.6    Mergny, J.-L.7    Nicolas, A.8
  • 219
    • 84917742065 scopus 로고    scopus 로고
    • Molecular and cellular functions of the FANCJ DNA helicase defective in cancer and in Fanconi anemia
    • Brosh, R. M., Jr.; Cantor, S. B. Molecular and cellular functions of the FANCJ DNA helicase defective in cancer and in Fanconi anemia Front. Genet. 2014, 5, 372 10.3389/fgene.2014.00372
    • (2014) Front. Genet. , vol.5 , pp. 372
    • Brosh, Jr.R.M.1    Cantor, S.B.2
  • 221
    • 0035909817 scopus 로고    scopus 로고
    • Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands
    • Li, J.-L.; Harrison, R. J.; Reszka, A. P.; Brosh, R. M.,; Bohr, V. A.; Neidle, S.; Hickson, I. D. Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands Biochemistry 2001, 40, 15194-15202 10.1021/bi011067h
    • (2001) Biochemistry , vol.40 , pp. 15194-15202
    • Li, J.-L.1    Harrison, R.J.2    Reszka, A.P.3    Brosh, Jr.R.M.4    Bohr, V.A.5    Neidle, S.6    Hickson, I.D.7
  • 222
    • 84860854071 scopus 로고    scopus 로고
    • RTEL1 dismantles T loops and counteracts telomeric G4-DNA to maintain telomere integrity
    • Vannier, J.-B.; Pavicic-Kaltenbrunner, V.; Petalcorin, M. I.; Ding, H.; Boulton, S. J. RTEL1 dismantles T loops and counteracts telomeric G4-DNA to maintain telomere integrity Cell 2012, 149, 795-806 10.1016/j.cell.2012.03.030
    • (2012) Cell , vol.149 , pp. 795-806
    • Vannier, J.-B.1    Pavicic-Kaltenbrunner, V.2    Petalcorin, M.I.3    Ding, H.4    Boulton, S.J.5
  • 223
    • 84903156621 scopus 로고    scopus 로고
    • RTEL1: Functions of a disease-associated helicase
    • Vannier, J.-B.; Sarek, G.; Boulton, S. J. RTEL1: functions of a disease-associated helicase Trends Cell Biol. 2014, 24, 416-425 10.1016/j.tcb.2014.01.004
    • (2014) Trends Cell Biol. , vol.24 , pp. 416-425
    • Vannier, J.-B.1    Sarek, G.2    Boulton, S.J.3
  • 224
    • 84936747645 scopus 로고    scopus 로고
    • A fluorescence-based helicase assay: Application to the screening of G-quadruplex ligands
    • Mendoza, O.; Gueddouda, N. M.; Boulé, J.-B.; Bourdoncle, A.; Mergny, J.-L. A fluorescence-based helicase assay: application to the screening of G-quadruplex ligands Nucleic Acids Res. 2015, 43, e71 10.1093/nar/gkv193
    • (2015) Nucleic Acids Res. , vol.43 , pp. e71
    • Mendoza, O.1    Gueddouda, N.M.2    Boulé, J.-B.3    Bourdoncle, A.4    Mergny, J.-L.5
  • 225
    • 84938717683 scopus 로고    scopus 로고
    • Insights into G-quadruplex specific recognition by the DEAH-box helicase RHAU: Solution structure of a peptide-quadruplex complex
    • Heddi, B.; Cheong, V. V.; Martadinata, H.; Phan, A. T. Insights into G-quadruplex specific recognition by the DEAH-box helicase RHAU: Solution structure of a peptide-quadruplex complex Proc. Natl. Acad. Sci. U. S. A. 2015, 112, 9608-9613 10.1073/pnas.1422605112
    • (2015) Proc. Natl. Acad. Sci. U. S. A. , vol.112 , pp. 9608-9613
    • Heddi, B.1    Cheong, V.V.2    Martadinata, H.3    Phan, A.T.4
  • 226
    • 84872191844 scopus 로고    scopus 로고
    • Crystallography of DNA and RNA G-quadruplex nucleic acids and their ligand complexes
    • Wiley, Chapter 17, Unit 17.6, DOI
    • Campbell, N.; Collie, G. W.; Neidle, S. Crystallography of DNA and RNA G-quadruplex nucleic acids and their ligand complexes. In Current Protocols in Nucleic Acid Chemistry; Wiley, 2012; Chapter 17, Unit 17.6, DOI: 10.1002/0471142700.nc1706s50.
    • (2012) Current Protocols in Nucleic Acid Chemistry
    • Campbell, N.1    Collie, G.W.2    Neidle, S.3
  • 227
    • 84870190030 scopus 로고    scopus 로고
    • Structural probes in quadruplex nucleic acid structure determination by NMR
    • Karsisiotis, A. I.; Webba da Silva, M. Structural probes in quadruplex nucleic acid structure determination by NMR Molecules 2012, 17, 13073-13086 10.3390/molecules171113073
    • (2012) Molecules , vol.17 , pp. 13073-13086
    • Karsisiotis, A.I.1    Webba da Silva, M.2
  • 228
    • 0027918585 scopus 로고
    • 3] G-tetraplex
    • 3] G-tetraplex Structure 1993, 1, 263-282 10.1016/0969-2126(93)90015-9
    • (1993) Structure , vol.1 , pp. 263-282
    • Wang, Y.1    Patel, D.J.2
  • 229
    • 0345098322 scopus 로고    scopus 로고
    • Two-repeat human telomeric d(TAGGGTTAGGGT) sequence forms interconverting parallel and antiparallel G-quadruplexes in solution: Distinct topologies, thermodynamic properties, and folding/unfolding kinetics
    • Phan, A. T.; Patel, D. J. Two-repeat human telomeric d(TAGGGTTAGGGT) sequence forms interconverting parallel and antiparallel G-quadruplexes in solution: distinct topologies, thermodynamic properties, and folding/unfolding kinetics J. Am. Chem. Soc. 2003, 125, 15021-15027 10.1021/ja037616j
    • (2003) J. Am. Chem. Soc. , vol.125 , pp. 15021-15027
    • Phan, A.T.1    Patel, D.J.2
  • 230
    • 33646943863 scopus 로고    scopus 로고
    • Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution
    • Ambrus, A.; Chen, D.; Dai, J.; Bialis, T.; Jones, R. A.; Yang, D. Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution Nucleic Acids Res. 2006, 34, 2723-2735 10.1093/nar/gkl348
    • (2006) Nucleic Acids Res. , vol.34 , pp. 2723-2735
    • Ambrus, A.1    Chen, D.2    Dai, J.3    Bialis, T.4    Jones, R.A.5    Yang, D.6
  • 235
    • 0037142071 scopus 로고    scopus 로고
    • Crystal structure of parallel quadruplexes from human telomeric DNA
    • Parkinson, G. N.; Lee, M. P. H.; Neidle, S. Crystal structure of parallel quadruplexes from human telomeric DNA Nature 2002, 417, 876-880 10.1038/nature755
    • (2002) Nature , vol.417 , pp. 876-880
    • Parkinson, G.N.1    Lee, M.P.H.2    Neidle, S.3
  • 236
    • 79959509289 scopus 로고    scopus 로고
    • Structure of human telomeric DNA in crowded solution
    • Heddi, B.; Phan, A. T. Structure of human telomeric DNA in crowded solution J. Am. Chem. Soc. 2011, 133, 9824-9833 10.1021/ja200786q
    • (2011) J. Am. Chem. Soc. , vol.133 , pp. 9824-9833
    • Heddi, B.1    Phan, A.T.2
  • 238
    • 44349142304 scopus 로고    scopus 로고
    • Structural basis of DNA quadruplex recognition by an acridine drug
    • Campbell, N. H.; Parkinson, G. N.; Reszka, A. P.; Neidle, S. Structural basis of DNA quadruplex recognition by an acridine drug J. Am. Chem. Soc. 2008, 130, 6722-6724 10.1021/ja8016973
    • (2008) J. Am. Chem. Soc. , vol.130 , pp. 6722-6724
    • Campbell, N.H.1    Parkinson, G.N.2    Reszka, A.P.3    Neidle, S.4
  • 239
    • 48749109524 scopus 로고    scopus 로고
    • Topology conservation and loop flexibility in quadruplex-drug recognition: Crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes
    • Parkinson, G. N.; Cuenca, F.; Neidle, S. Topology conservation and loop flexibility in quadruplex-drug recognition: crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes J. Mol. Biol. 2008, 381, 1145-1156 10.1016/j.jmb.2008.06.022
    • (2008) J. Mol. Biol. , vol.381 , pp. 1145-1156
    • Parkinson, G.N.1    Cuenca, F.2    Neidle, S.3
  • 240
  • 241
    • 84876215753 scopus 로고    scopus 로고
    • Structure-based design and evaluation of naphthalene diimide G-quadruplex ligands as telomere targeting agents in pancreatic cancer cells
    • Micco, M.; Collie, G. W.; Dale, A. G.; Ohnmacht, S. A.; Pazitna, I.; Gunaratnam, M.; Reszka, A. P.; Neidle, S. Structure-based design and evaluation of naphthalene diimide G-quadruplex ligands as telomere targeting agents in pancreatic cancer cells J. Med. Chem. 2013, 56, 2959-2974 10.1021/jm301899y
    • (2013) J. Med. Chem. , vol.56 , pp. 2959-2974
    • Micco, M.1    Collie, G.W.2    Dale, A.G.3    Ohnmacht, S.A.4    Pazitna, I.5    Gunaratnam, M.6    Reszka, A.P.7    Neidle, S.8
  • 242
    • 84855849686 scopus 로고    scopus 로고
    • Molecular basis of structure-activity relationships between salphen metal complexes and human telomeric DNA quadruplexes
    • Campbell, N. H.; Karim, N. H.; Parkinson, G. N.; Gunaratnam, M.; Petrucci, V.; Todd, A. K.; Vilar, R.; Neidle, S. Molecular basis of structure-activity relationships between salphen metal complexes and human telomeric DNA quadruplexes J. Med. Chem. 2012, 55, 209-222 10.1021/jm201140v
    • (2012) J. Med. Chem. , vol.55 , pp. 209-222
    • Campbell, N.H.1    Karim, N.H.2    Parkinson, G.N.3    Gunaratnam, M.4    Petrucci, V.5    Todd, A.K.6    Vilar, R.7    Neidle, S.8
  • 243
    • 84871784359 scopus 로고    scopus 로고
    • The crystal structure of human telomeric DNA complexed with berberine: An interesting case of stacked ligand to G-tetrad ratio higher than 1:1
    • Bazzicalupi, C.; Ferraroni, M.; Bilia, A. R.; Scheggi, F.; Gratteri, P. The crystal structure of human telomeric DNA complexed with berberine: an interesting case of stacked ligand to G-tetrad ratio higher than 1:1 Nucleic Acids Res. 2013, 41, 632-638 10.1093/nar/gks1001
    • (2013) Nucleic Acids Res. , vol.41 , pp. 632-638
    • Bazzicalupi, C.1    Ferraroni, M.2    Bilia, A.R.3    Scheggi, F.4    Gratteri, P.5
  • 244
    • 84871359419 scopus 로고    scopus 로고
    • Optimized end-stacking provides specificity of N-methyl mesoporphyrin IX for human telomeric G-quadruplex DNA
    • Nicoludis, J. M.; Miller, S. T.; Jeffrey, P. D.; Barrett, S. P.; Rablen, P. R.; Lawton, T. J.; Yatsunyk, L. A. Optimized end-stacking provides specificity of N-methyl mesoporphyrin IX for human telomeric G-quadruplex DNA J. Am. Chem. Soc. 2012, 134, 20446-20456 10.1021/ja3088746
    • (2012) J. Am. Chem. Soc. , vol.134 , pp. 20446-20456
    • Nicoludis, J.M.1    Miller, S.T.2    Jeffrey, P.D.3    Barrett, S.P.4    Rablen, P.R.5    Lawton, T.J.6    Yatsunyk, L.A.7
  • 245
    • 84931281667 scopus 로고    scopus 로고
    • Loop flexibility in human telomeric quadruplex small-molecule complexes
    • Collie, G. W.; Campbell, N. H.; Neidle, S. Loop flexibility in human telomeric quadruplex small-molecule complexes Nucleic Acids Res. 2015, 43, 4785-4799 10.1093/nar/gkv427
    • (2015) Nucleic Acids Res. , vol.43 , pp. 4785-4799
    • Collie, G.W.1    Campbell, N.H.2    Neidle, S.3
  • 246
    • 84884177068 scopus 로고    scopus 로고
    • Solution structure of an intramolecular (3 + 1) human telomeric G-quadruplex bound to a telomestatin derivative
    • Chung, W. J.; Heddi, B.; Tera, M.; Iida, K.; Nagasawa, K.; Phan, A. T. Solution structure of an intramolecular (3 + 1) human telomeric G-quadruplex bound to a telomestatin derivative J. Am. Chem. Soc. 2013, 135, 13495-13501 10.1021/ja405843r
    • (2013) J. Am. Chem. Soc. , vol.135 , pp. 13495-13501
    • Chung, W.J.1    Heddi, B.2    Tera, M.3    Iida, K.4    Nagasawa, K.5    Phan, A.T.6
  • 248
    • 79960700765 scopus 로고    scopus 로고
    • Surface area accessibility and the preferred topology of telomeric DNA quadruplex-ligand complexes
    • Haider, S. M.; Autiero, I.; Neidle, S. Surface area accessibility and the preferred topology of telomeric DNA quadruplex-ligand complexes Biochimie 2011, 93, 1275-1279 10.1016/j.biochi.2011.05.014
    • (2011) Biochimie , vol.93 , pp. 1275-1279
    • Haider, S.M.1    Autiero, I.2    Neidle, S.3
  • 249
    • 77956539976 scopus 로고    scopus 로고
    • A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex
    • Collie, G. W.; Haider, S.; Neidle, S.; Parkinson, G. N. A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex Nucleic Acids Res. 2010, 38, 5569-5580 10.1093/nar/gkq259
    • (2010) Nucleic Acids Res. , vol.38 , pp. 5569-5580
    • Collie, G.W.1    Haider, S.2    Neidle, S.3    Parkinson, G.N.4
  • 250
    • 67749143935 scopus 로고    scopus 로고
    • Structure of propeller-type parallel-stranded RNA G-quadruplexes, formed by human telomeric RNA sequences in K+ solution
    • Martadinata, H.; Phan, A. T. Structure of propeller-type parallel-stranded RNA G-quadruplexes, formed by human telomeric RNA sequences in K+ solution J. Am. Chem. Soc. 2009, 131, 2570-2578 10.1021/ja806592z
    • (2009) J. Am. Chem. Soc. , vol.131 , pp. 2570-2578
    • Martadinata, H.1    Phan, A.T.2
  • 251
    • 79952269800 scopus 로고    scopus 로고
    • Structural basis of telomeric RNA quadruplex-acridine ligand recognition
    • Collie, G. W.; Sparapani, S.; Parkinson, G. N.; Neidle, S. Structural basis of telomeric RNA quadruplex-acridine ligand recognition J. Am. Chem. Soc. 2011, 133, 2721-2728 10.1021/ja109767y
    • (2011) J. Am. Chem. Soc. , vol.133 , pp. 2721-2728
    • Collie, G.W.1    Sparapani, S.2    Parkinson, G.N.3    Neidle, S.4
  • 252
    • 13644267721 scopus 로고    scopus 로고
    • Solution structure of the biologically relevant G-quadruplex element in the human c-MYC promoter. Implications for G-quadruplex stabilization
    • Ambrus, A.; Chen, D.; Dai, J.; Jones, R. A.; Yang, D. Solution structure of the biologically relevant G-quadruplex element in the human c-MYC promoter. Implications for G-quadruplex stabilization Biochemistry 2005, 44, 2048-2058 10.1021/bi048242p
    • (2005) Biochemistry , vol.44 , pp. 2048-2058
    • Ambrus, A.1    Chen, D.2    Dai, J.3    Jones, R.A.4    Yang, D.5
  • 253
    • 80455168261 scopus 로고    scopus 로고
    • C-MYC promoter G-quadruplex formed at the 5′-end of NHE III1 element: Insights into biological relevance and parallel-stranded G-quadruplex stability
    • Mathad, R. I.; Hatzakis, E.; Dai, J.; Yang, D. c-MYC promoter G-quadruplex formed at the 5′-end of NHE III1 element: insights into biological relevance and parallel-stranded G-quadruplex stability Nucleic Acids Res. 2011, 39, 9023-9033 10.1093/nar/gkr612
    • (2011) Nucleic Acids Res. , vol.39 , pp. 9023-9033
    • Mathad, R.I.1    Hatzakis, E.2    Dai, J.3    Yang, D.4
  • 254
    • 33750990787 scopus 로고    scopus 로고
    • NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region
    • Dai, J.; Chen, D.; Jones, R. A.; Hurley, L. H.; Yang, D. NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region Nucleic Acids Res. 2006, 34, 5133-5144 10.1093/nar/gkl610
    • (2006) Nucleic Acids Res. , vol.34 , pp. 5133-5144
    • Dai, J.1    Chen, D.2    Jones, R.A.3    Hurley, L.H.4    Yang, D.5
  • 256
    • 84890389008 scopus 로고    scopus 로고
    • Solution structure of the major G-quadruplex formed in the human VEGF promoter in K+: Insights into loop interactions of the parallel G-quadruplexes
    • Agrawal, P.; Hatzakis, E.; Guo, K.; Carver, M.; Yang, D. Solution structure of the major G-quadruplex formed in the human VEGF promoter in K+: insights into loop interactions of the parallel G-quadruplexes Nucleic Acids Res. 2013, 41, 10584-10592 10.1093/nar/gkt784
    • (2013) Nucleic Acids Res. , vol.41 , pp. 10584-10592
    • Agrawal, P.1    Hatzakis, E.2    Guo, K.3    Carver, M.4    Yang, D.5
  • 257
    • 80055092362 scopus 로고    scopus 로고
    • Solution structure of all parallel G-quadruplex formed by the oncogene RET promoter sequence
    • Tong, X.; Lan, W.; Zhang, X.; Wu, H.; Liu, M.; Cao, C. Solution structure of all parallel G-quadruplex formed by the oncogene RET promoter sequence Nucleic Acids Res. 2011, 39, 6753-6763 10.1093/nar/gkr233
    • (2011) Nucleic Acids Res. , vol.39 , pp. 6753-6763
    • Tong, X.1    Lan, W.2    Zhang, X.3    Wu, H.4    Liu, M.5    Cao, C.6
  • 258
    • 34848814236 scopus 로고    scopus 로고
    • Sequence occurrence and structural uniqueness of a G-quadruplex in the human c-kit promoter
    • Todd, A. K.; Haider, S. M.; Parkinson, G. N.; Neidle, S. Sequence occurrence and structural uniqueness of a G-quadruplex in the human c-kit promoter Nucleic Acids Res. 2007, 35, 5799-5808 10.1093/nar/gkm609
    • (2007) Nucleic Acids Res. , vol.35 , pp. 5799-5808
    • Todd, A.K.1    Haider, S.M.2    Parkinson, G.N.3    Neidle, S.4
  • 259
    • 33644833219 scopus 로고    scopus 로고
    • Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter
    • Phan, A. T.; Kuryavyi, V.; Gaw, H. Y.; Patel, D. J. Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter Nat. Chem. Biol. 2005, 1, 167-173 10.1038/nchembio723
    • (2005) Nat. Chem. Biol. , vol.1 , pp. 167-173
    • Phan, A.T.1    Kuryavyi, V.2    Gaw, H.Y.3    Patel, D.J.4
  • 260
    • 84893255474 scopus 로고    scopus 로고
    • Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC(3)
    • Chung, W. J.; Heddi, B.; Hamon, F.; Teulade-Fichou, M.-P.; Phan, A. T. Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC(3) Angew. Chem., Int. Ed. 2014, 53, 999-1002 10.1002/anie.201308063
    • (2014) Angew. Chem., Int. Ed. , vol.53 , pp. 999-1002
    • Chung, W.J.1    Heddi, B.2    Hamon, F.3    Teulade-Fichou, M.-P.4    Phan, A.T.5
  • 261
    • 80455123924 scopus 로고    scopus 로고
    • Solution structure of a 2:1 quindoline-c-MYC G-quadruplex: Insights into G-quadruplex-interactive small molecule drug design
    • Dai, J.; Carver, M.; Hurley, L. H.; Yang, D. Solution structure of a 2:1 quindoline-c-MYC G-quadruplex: insights into G-quadruplex-interactive small molecule drug design J. Am. Chem. Soc. 2011, 133, 17673-17680 10.1021/ja205646q
    • (2011) J. Am. Chem. Soc. , vol.133 , pp. 17673-17680
    • Dai, J.1    Carver, M.2    Hurley, L.H.3    Yang, D.4
  • 262
    • 84942856104 scopus 로고    scopus 로고
    • Crystal structure reveals specific recognition of a G-quadruplex RNA by a β-turn in the RGG motif of FMRP
    • Vasilyev, N.; Polonskaia, A.; Darnell, J. C.; Darnell, R. B.; Patel, D. J.; Serganov, A. Crystal structure reveals specific recognition of a G-quadruplex RNA by a β-turn in the RGG motif of FMRP Proc. Natl. Acad. Sci. U. S. A. 2015, 112, E5391-400 10.1073/pnas.1515737112
    • (2015) Proc. Natl. Acad. Sci. U. S. A. , vol.112 , pp. E5391-E5400
    • Vasilyev, N.1    Polonskaia, A.2    Darnell, J.C.3    Darnell, R.B.4    Patel, D.J.5    Serganov, A.6
  • 265
    • 84900824121 scopus 로고    scopus 로고
    • Small-molecule quadruplex-targeted drug discovery
    • Ohnmacht, S. A.; Neidle, S. Small-molecule quadruplex-targeted drug discovery Bioorg. Med. Chem. Lett. 2014, 24, 2602-2612 10.1016/j.bmcl.2014.04.029
    • (2014) Bioorg. Med. Chem. Lett. , vol.24 , pp. 2602-2612
    • Ohnmacht, S.A.1    Neidle, S.2
  • 268
    • 84870891163 scopus 로고    scopus 로고
    • Beads-on-a-string structure of long telomeric DNAs under molecular crowding conditions
    • Yu, H.; Gu, X.; Nakano, S. I.; Miyoshi, D.; Sugimoto, N. Beads-on-a-string structure of long telomeric DNAs under molecular crowding conditions J. Am. Chem. Soc. 2012, 134, 20060-20069 10.1021/ja305384c
    • (2012) J. Am. Chem. Soc. , vol.134 , pp. 20060-20069
    • Yu, H.1    Gu, X.2    Nakano, S.I.3    Miyoshi, D.4    Sugimoto, N.5
  • 269
    • 84910051731 scopus 로고    scopus 로고
    • Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences
    • Cousins, A. R.; Ritson, D.; Sharma, P.; Stevens, M. F.; Moses, J. E.; Searle, M. S. Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences Chem. Commun. 2014, 50, 15202-15205 10.1039/C4CC07487D
    • (2014) Chem. Commun. , vol.50 , pp. 15202-15205
    • Cousins, A.R.1    Ritson, D.2    Sharma, P.3    Stevens, M.F.4    Moses, J.E.5    Searle, M.S.6
  • 270
    • 84925362357 scopus 로고    scopus 로고
    • Topology specific stabilization of promoter over telomeric G-quadruplex DNAs by bisbenzimidazole carboxamide derivatives
    • Dhamodharan, V.; Harikrishna, S.; Bhasikuttan, A. C.; Pradeepkumar, P. I. Topology specific stabilization of promoter over telomeric G-quadruplex DNAs by bisbenzimidazole carboxamide derivatives ACS Chem. Biol. 2015, 10, 821-833 10.1021/cb5008597
    • (2015) ACS Chem. Biol. , vol.10 , pp. 821-833
    • Dhamodharan, V.1    Harikrishna, S.2    Bhasikuttan, A.C.3    Pradeepkumar, P.I.4
  • 272
    • 84876545072 scopus 로고    scopus 로고
    • G4LDB: A database for discovering and studying G-quadruplex ligands
    • Li, Q.; Xiang, J. F.; Yang, Q. F.; Sun, H. X.; Guan, A. J.; Tang, Y. L. G4LDB: a database for discovering and studying G-quadruplex ligands Nucleic Acids Res. 2013, 41, D1115-23 10.1093/nar/gks1101
    • (2013) Nucleic Acids Res. , vol.41 , pp. D1115-D1123
    • Li, Q.1    Xiang, J.F.2    Yang, Q.F.3    Sun, H.X.4    Guan, A.J.5    Tang, Y.L.6
  • 273
    • 84865091468 scopus 로고    scopus 로고
    • In silico screening of quadruplex-binding ligands
    • Ma, D. L.; Ma, V. P.; Chan, D. S.; Leung, K. H.; Zhong, H. J.; Leung, C. H. In silico screening of quadruplex-binding ligands Methods 2012, 57, 106-114 10.1016/j.ymeth.2012.02.001
    • (2012) Methods , vol.57 , pp. 106-114
    • Ma, D.L.1    Ma, V.P.2    Chan, D.S.3    Leung, K.H.4    Zhong, H.J.5    Leung, C.H.6
  • 274
    • 70450158916 scopus 로고    scopus 로고
    • Tandem application of virtual screening and NMR experiments in the discovery of brand new DNA quadruplex groove binders
    • Cosconati, S.; Marinelli, L.; Trotta, R.; Virno, A.; Mayol, L.; Novellino, E.; Olson, A. J.; Randazzo, A. Tandem application of virtual screening and NMR experiments in the discovery of brand new DNA quadruplex groove binders J. Am. Chem. Soc. 2009, 131, 16336-16337 10.1021/ja9063662
    • (2009) J. Am. Chem. Soc. , vol.131 , pp. 16336-16337
    • Cosconati, S.1    Marinelli, L.2    Trotta, R.3    Virno, A.4    Mayol, L.5    Novellino, E.6    Olson, A.J.7    Randazzo, A.8
  • 278
    • 84884921116 scopus 로고    scopus 로고
    • Small-molecule G-quadruplex interactions: Systematic exploration of conformational space using multiple molecular dynamics
    • Husby, J.; Todd, A. K.; Platts, J. A.; Neidle, S. Small-molecule G-quadruplex interactions: Systematic exploration of conformational space using multiple molecular dynamics Biopolymers 2013, 99, 989-1005 10.1002/bip.22340
    • (2013) Biopolymers , vol.99 , pp. 989-1005
    • Husby, J.1    Todd, A.K.2    Platts, J.A.3    Neidle, S.4
  • 279
    • 84893204918 scopus 로고    scopus 로고
    • Conformation and stability of intramolecular telomeric G-quadruplexes: Sequence effects in the loops
    • Sattin, G.; Artese, A.; Nadai, M.; Costa, G.; Parrotta, L.; Alcaro, S.; Palumbo, M.; Richter, S. N. Conformation and stability of intramolecular telomeric G-quadruplexes: sequence effects in the loops PLoS One 2013, 8, e84113 10.1371/journal.pone.0084113
    • (2013) PLoS One , vol.8 , pp. e84113
    • Sattin, G.1    Artese, A.2    Nadai, M.3    Costa, G.4    Parrotta, L.5    Alcaro, S.6    Palumbo, M.7    Richter, S.N.8
  • 280
    • 84925467397 scopus 로고    scopus 로고
    • In silico identification of novel ligands for G-quadruplex in the c-MYC promoter
    • Kang, H.-J.; Park, H.-J. In silico identification of novel ligands for G-quadruplex in the c-MYC promoter J. Comput.-Aided Mol. Des. 2015, 29, 339-348 10.1007/s10822-014-9826-z
    • (2015) J. Comput.-Aided Mol. Des. , vol.29 , pp. 339-348
    • Kang, H.-J.1    Park, H.-J.2
  • 281
    • 84915819840 scopus 로고    scopus 로고
    • Identification of a selective G-quadruplex DNA binder using a multistep virtual screening approach
    • Hou, J.-Q.; Chen, S.- B.; Zan, L.-P.; Ou, T.-M.; Tan, J. H.; Luyt, L. G.; Huang, Z.-S. Identification of a selective G-quadruplex DNA binder using a multistep virtual screening approach Chem. Commun. 2015, 51, 198-201 10.1039/C4CC06951J
    • (2015) Chem. Commun. , vol.51 , pp. 198-201
    • Hou, J.-Q.1    Chen, S.-B.2    Zan, L.-P.3    Ou, T.-M.4    Tan, J.H.5    Luyt, L.G.6    Huang, Z.-S.7
  • 283
    • 77953381213 scopus 로고    scopus 로고
    • Structural insights into G-quadruplexes: Towards new anticancer drugs
    • Yang, D.; Okamoto, K. Structural insights into G-quadruplexes: towards new anticancer drugs Future Med. Chem. 2010, 2, 619-646 10.4155/fmc.09.172
    • (2010) Future Med. Chem. , vol.2 , pp. 619-646
    • Yang, D.1    Okamoto, K.2
  • 284
    • 84957548658 scopus 로고    scopus 로고
    • Structural insights into the quadruplex-duplex 3′ interface formed from a telomeric repeat: A potential molecular target
    • Russo Krauss, I.; Ramaswamy, S.; Neidle, S.; Haider, S.; Parkinson, G. N. Structural insights into the quadruplex-duplex 3′ interface formed from a telomeric repeat: a potential molecular target J. Am. Chem. Soc. 2016, 138, 1226-1233 10.1021/jacs.5b10492
    • (2016) J. Am. Chem. Soc. , vol.138 , pp. 1226-1233
    • Russo Krauss, I.1    Ramaswamy, S.2    Neidle, S.3    Haider, S.4    Parkinson, G.N.5
  • 285
    • 84922336877 scopus 로고    scopus 로고
    • Unravelling the genomic targets of small molecules using high-throughput sequencing
    • Rodriguez, R.; Miller, K. M. Unravelling the genomic targets of small molecules using high-throughput sequencing Nat. Rev. Genet. 2014, 15, 783-796 10.1038/nrg3796
    • (2014) Nat. Rev. Genet. , vol.15 , pp. 783-796
    • Rodriguez, R.1    Miller, K.M.2
  • 288
    • 0037025173 scopus 로고    scopus 로고
    • Cancer. Addiction to oncogenes - The Achilles heal of cancer
    • Weinstein, I. B. Cancer. Addiction to oncogenes - the Achilles heal of cancer Science 2002, 297, 63-64 10.1126/science.1073096
    • (2002) Science , vol.297 , pp. 63-64
    • Weinstein, I.B.1
  • 289
    • 84924061466 scopus 로고    scopus 로고
    • Oncogene addiction: Pathways of therapeutic response, resistance, and road maps toward a cure
    • Pagliarini, R.; Shao, W.; Sellers, W. R. Oncogene addiction: pathways of therapeutic response, resistance, and road maps toward a cure EMBO Rep. 2015, 16, 280-296 10.15252/embr.201439949
    • (2015) EMBO Rep. , vol.16 , pp. 280-296
    • Pagliarini, R.1    Shao, W.2    Sellers, W.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.