-
1
-
-
1042274320
-
Untersuchungen über die guanylsäre
-
Bang, I. Untersuchungen über die guanylsäre Biochem. Z. 1910, 26, 293-311
-
(1910)
Biochem. Z.
, vol.26
, pp. 293-311
-
-
Bang, I.1
-
2
-
-
85042639894
-
Helix formation by guanylic acid
-
Gellert, M.; Lipsett, M. N.; Davies, D. R. Helix formation by guanylic acid Proc. Natl. Acad. Sci. U. S. A. 1962, 48, 2013-2018 10.1073/pnas.48.12.2013
-
(1962)
Proc. Natl. Acad. Sci. U. S. A.
, vol.48
, pp. 2013-2018
-
-
Gellert, M.1
Lipsett, M.N.2
Davies, D.R.3
-
3
-
-
0016207051
-
Structures for polyinosinic acid and polyguanylic acid
-
Arnott, S.; Chandrasekaran, R.; Marttila, C. M. Structures for polyinosinic acid and polyguanylic acid Biochem. J. 1974, 141, 537-543 10.1042/bj1410537
-
(1974)
Biochem. J.
, vol.141
, pp. 537-543
-
-
Arnott, S.1
Chandrasekaran, R.2
Marttila, C.M.3
-
4
-
-
0016610425
-
X-ray fiber diffraction and model-building study of polyguanylic acid and polyinosinic acid
-
Zimmerman, S. B.; Cohen, G. H.; Davies, D. R. X-ray fiber diffraction and model-building study of polyguanylic acid and polyinosinic acid J. Mol. Biol. 1975, 92, 181-192 10.1016/0022-2836(75)90222-3
-
(1975)
J. Mol. Biol.
, vol.92
, pp. 181-192
-
-
Zimmerman, S.B.1
Cohen, G.H.2
Davies, D.R.3
-
5
-
-
0020488547
-
Poly(inosinic acid) helices: Essential chelation of alkali metal ions in the axial channel
-
Howard, F. B.; Miles, H. T. Poly(inosinic acid) helices: essential chelation of alkali metal ions in the axial channel Biochemistry 1982, 21, 6736-6745 10.1021/bi00269a019
-
(1982)
Biochemistry
, vol.21
, pp. 6736-6745
-
-
Howard, F.B.1
Miles, H.T.2
-
6
-
-
0024843757
-
Telomeric DNA dimerizes by formation of guanine tetrads between hairpin loops
-
Sundquist, W. I.; Klug, A. Telomeric DNA dimerizes by formation of guanine tetrads between hairpin loops Nature 1989, 342, 825-829 10.1038/342825a0
-
(1989)
Nature
, vol.342
, pp. 825-829
-
-
Sundquist, W.I.1
Klug, A.2
-
7
-
-
0025269255
-
A sodium-potassium switch in the formation of four-stranded G4-DNA
-
Sen, D.; Gilbert, W. A sodium-potassium switch in the formation of four-stranded G4-DNA Nature 1990, 344, 410-414 10.1038/344410a0
-
(1990)
Nature
, vol.344
, pp. 410-414
-
-
Sen, D.1
Gilbert, W.2
-
9
-
-
0023663911
-
Telomeric DNA oligonucleotides form novel intramolecular structures containing guanine-guanine base pairs
-
Henderson, E.; Hardin, C. C.; Walk, S. K.; Tinoco, I., Jr.; Blackburn, E. H. Telomeric DNA oligonucleotides form novel intramolecular structures containing guanine-guanine base pairs Cell 1987, 51, 899-908 10.1016/0092-8674(87)90577-0
-
(1987)
Cell
, vol.51
, pp. 899-908
-
-
Henderson, E.1
Hardin, C.C.2
Walk, S.K.3
Tinoco, Jr.I.4
Blackburn, E.H.5
-
10
-
-
1042268168
-
G-quartets 40 years later: From 5′-GMP to molecular biology and supramolecular chemistry
-
Davis, J. T. G-quartets 40 years later: from 5′-GMP to molecular biology and supramolecular chemistry Angew. Chem., Int. Ed. 2004, 43, 668-698 10.1002/anie.200300589
-
(2004)
Angew. Chem., Int. Ed.
, vol.43
, pp. 668-698
-
-
Davis, J.T.1
-
11
-
-
33751020853
-
Quadruplex DNA: Sequence, topology and structure
-
Burge, S.; Parkinson, G. N.; Hazel, P.; Todd, A. K.; Neidle, S. Quadruplex DNA: sequence, topology and structure Nucleic Acids Res. 2006, 34, 5402-5415 10.1093/nar/gkl655
-
(2006)
Nucleic Acids Res.
, vol.34
, pp. 5402-5415
-
-
Burge, S.1
Parkinson, G.N.2
Hazel, P.3
Todd, A.K.4
Neidle, S.5
-
12
-
-
38049030699
-
Human telomere, oncogenic promoter and 5′-UTR G-quadruplexes: Diverse higher order DNA and RNA targets for cancer therapeutics
-
Patel, D. J.; Phan, A. T.; Kuryavyi, V. Human telomere, oncogenic promoter and 5′-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics Nucleic Acids Res. 2007, 35, 7429-7455 10.1093/nar/gkm711
-
(2007)
Nucleic Acids Res.
, vol.35
, pp. 7429-7455
-
-
Patel, D.J.1
Phan, A.T.2
Kuryavyi, V.3
-
13
-
-
84867797125
-
Tri-G-quadruplex: Controlled assembly of a G-quadruplex structure from three G-rich strands
-
Zhou, J.; Bourdoncle, A.; Rosu, F.; Gabelica, V.; Mergny, J.-L. Tri-G-quadruplex: controlled assembly of a G-quadruplex structure from three G-rich strands Angew. Chem., Int. Ed. 2012, 51, 11002-11005 10.1002/anie.201205390
-
(2012)
Angew. Chem., Int. Ed.
, vol.51
, pp. 11002-11005
-
-
Zhou, J.1
Bourdoncle, A.2
Rosu, F.3
Gabelica, V.4
Mergny, J.-L.5
-
16
-
-
0026554887
-
Quadruplex structure of Oxytricha telomeric DNA oligonucleotides
-
Smith, F. W.; Feigon, J. Quadruplex structure of Oxytricha telomeric DNA oligonucleotides Nature 1992, 356, 164-168 10.1038/356164a0
-
(1992)
Nature
, vol.356
, pp. 164-168
-
-
Smith, F.W.1
Feigon, J.2
-
18
-
-
0027750779
-
Solution structure of a parallel-stranded G-quadruplex DNA
-
Wang, Y.; Patel, D. J. Solution structure of a parallel-stranded G-quadruplex DNA J. Mol. Biol. 1993, 234, 1171-1183 10.1006/jmbi.1993.1668
-
(1993)
J. Mol. Biol.
, vol.234
, pp. 1171-1183
-
-
Wang, Y.1
Patel, D.J.2
-
19
-
-
0028024737
-
The high-resolution crystal structure of a parallel-stranded guanine tetraplex
-
Laughlan, G.; Murchie, A. I. H.; Norman, D. G.; Moore, M. H.; Moody, P. C. E.; Lilley, D. M. J.; Luisi, B. The high-resolution crystal structure of a parallel-stranded guanine tetraplex Science 1994, 265, 520-524 10.1126/science.8036494
-
(1994)
Science
, vol.265
, pp. 520-524
-
-
Laughlan, G.1
Murchie, A.I.H.2
Norman, D.G.3
Moore, M.H.4
Moody, P.C.E.5
Lilley, D.M.J.6
Luisi, B.7
-
21
-
-
84886626805
-
G-quadruplex structures in the human genome as novel therapeutic targets
-
Bidzinska, J.; Cimino-Reale, G.; Zaffaroni, N.; Folini, M. G-quadruplex structures in the human genome as novel therapeutic targets Molecules 2013, 18, 12368-91235 10.3390/molecules181012368
-
(2013)
Molecules
, vol.18
, pp. 12368-91235
-
-
Bidzinska, J.1
Cimino-Reale, G.2
Zaffaroni, N.3
Folini, M.4
-
22
-
-
84906252569
-
G-quadruplex interacting small molecules and drugs: From bench towards bedside
-
Müller, S.; Rodriguez, R. G-quadruplex interacting small molecules and drugs: from bench towards bedside Expert Rev. Clin. Pharmacol. 2014, 7, 663-679 10.1586/17512433.2014.945909
-
(2014)
Expert Rev. Clin. Pharmacol.
, vol.7
, pp. 663-679
-
-
Müller, S.1
Rodriguez, R.2
-
23
-
-
84904726052
-
Relevance of G-quadruplex structures to pharmacogenetics
-
Cree, S. L.; Kennedy, M. A. Relevance of G-quadruplex structures to pharmacogenetics Front. Pharmacol. 2014, 5, 160 10.3389/fphar.2014.00160
-
(2014)
Front. Pharmacol.
, vol.5
, pp. 160
-
-
Cree, S.L.1
Kennedy, M.A.2
-
24
-
-
84907914558
-
Targeting unimolecular G-quadruplex nucleic acids: A new paradigm for the drug discovery?
-
Parrotta, L.; Ortuso, F.; Moraca, F.; Rocca, R.; Costa, G.; Alcaro, S.; Artese, A. Targeting unimolecular G-quadruplex nucleic acids: a new paradigm for the drug discovery? Expert Opin. Drug Discovery 2014, 9, 1167-1187 10.1517/17460441.2014.941353
-
(2014)
Expert Opin. Drug Discovery
, vol.9
, pp. 1167-1187
-
-
Parrotta, L.1
Ortuso, F.2
Moraca, F.3
Rocca, R.4
Costa, G.5
Alcaro, S.6
Artese, A.7
-
25
-
-
20144369806
-
Highly prevalent putative quadruplex sequence motifs in human DNA
-
Todd, A. K.; Johnston, M.; Neidle, S. Highly prevalent putative quadruplex sequence motifs in human DNA Nucleic Acids Res. 2005, 33, 2901-2907 10.1093/nar/gki553
-
(2005)
Nucleic Acids Res.
, vol.33
, pp. 2901-2907
-
-
Todd, A.K.1
Johnston, M.2
Neidle, S.3
-
26
-
-
20144364292
-
Prevalence of quadruplexes in the human genome
-
Huppert, J. L.; Balasubramanian, S. Prevalence of quadruplexes in the human genome Nucleic Acids Res. 2005, 33, 2908-2916 10.1093/nar/gki609
-
(2005)
Nucleic Acids Res.
, vol.33
, pp. 2908-2916
-
-
Huppert, J.L.1
Balasubramanian, S.2
-
27
-
-
38549092075
-
QuadBase: Genome-wide database of G4 DNA - Occurrence and conservation in human, chimpanzee, mouse and rat promoters and 146 microbes
-
Yadav, V. K.; Abraham, J. K.; Mani, P.; Kulshrestha, R.; Chowdhury, S. QuadBase: genome-wide database of G4 DNA-occurrence and conservation in human, chimpanzee, mouse and rat promoters and 146 microbes Nucleic Acids Res. 2008, 36, D381-D385 10.1093/nar/gkm781
-
(2008)
Nucleic Acids Res.
, vol.36
, pp. D381-D385
-
-
Yadav, V.K.1
Abraham, J.K.2
Mani, P.3
Kulshrestha, R.4
Chowdhury, S.5
-
28
-
-
77449124427
-
Computational approaches to the detection and analysis of sequences with intramolecular G-quadruplex forming potential
-
Ryvkin, P.; Hershman, S. G.; Wang, L. S.; Johnson, F. B. Computational approaches to the detection and analysis of sequences with intramolecular G-quadruplex forming potential Methods Mol. Biol. 2010, 608, 39-50 10.1007/978-1-59745-363-9-3
-
(2010)
Methods Mol. Biol.
, vol.608
, pp. 39-50
-
-
Ryvkin, P.1
Hershman, S.G.2
Wang, L.S.3
Johnson, F.B.4
-
29
-
-
84865098888
-
Computational detection and analysis of sequences with duplex-derived interstrand G-quadruplex forming potential
-
Cao, K.; Ryvkin, P.; Johnson, F. B. Computational detection and analysis of sequences with duplex-derived interstrand G-quadruplex forming potential Methods 2012, 57, 3-10 10.1016/j.ymeth.2012.05.002
-
(2012)
Methods
, vol.57
, pp. 3-10
-
-
Cao, K.1
Ryvkin, P.2
Johnson, F.B.3
-
30
-
-
3042671689
-
Influence of loop size on the stability of intramolecular DNA quadruplexes
-
Risitano, A.; Fox, K. R. Influence of loop size on the stability of intramolecular DNA quadruplexes Nucleic Acids Res. 2004, 32, 2598-2606 10.1093/nar/gkh598
-
(2004)
Nucleic Acids Res.
, vol.32
, pp. 2598-2606
-
-
Risitano, A.1
Fox, K.R.2
-
31
-
-
11444253374
-
Loop-length dependent folding of G-quadruplexes
-
Hazel, P.; Huppert, J. H.; Balasubramanian, S.; Neidle, S. Loop-length dependent folding of G-quadruplexes J. Am. Chem. Soc. 2004, 126, 16405-16415 10.1021/ja045154j
-
(2004)
J. Am. Chem. Soc.
, vol.126
, pp. 16405-16415
-
-
Hazel, P.1
Huppert, J.H.2
Balasubramanian, S.3
Neidle, S.4
-
32
-
-
38849085810
-
A sequence-independent study of the influence of short loop lengths on the stability and topology of intramolecular DNA G-quadruplexes
-
Bugaut, A.; Balasubramanian, S. A sequence-independent study of the influence of short loop lengths on the stability and topology of intramolecular DNA G-quadruplexes Biochemistry 2008, 47, 689-697 10.1021/bi701873c
-
(2008)
Biochemistry
, vol.47
, pp. 689-697
-
-
Bugaut, A.1
Balasubramanian, S.2
-
33
-
-
0032508468
-
Following G-quartet formation by UV-spectroscopy
-
Mergny, J.-L.; Phan, A. T.; Lacroix, L. Following G-quartet formation by UV-spectroscopy FEBS Lett. 1998, 435, 74-78 10.1016/S0014-5793(98)01043-6
-
(1998)
FEBS Lett.
, vol.435
, pp. 74-78
-
-
Mergny, J.-L.1
Phan, A.T.2
Lacroix, L.3
-
34
-
-
84865091109
-
Circular dichroism and guanine quadruplexes
-
Vorlíčková, M.; Kejnovská, I.; Sagi, J.; Renčiuk, D.; Bednářová, K.; Motlová, J.; Kypr, J. Circular dichroism and guanine quadruplexes Methods 2012, 57, 64-75 10.1016/j.ymeth.2012.03.011
-
(2012)
Methods
, vol.57
, pp. 64-75
-
-
Vorlíčková, M.1
Kejnovská, I.2
Sagi, J.3
Renčiuk, D.4
Bednářová, K.5
Motlová, J.6
Kypr, J.7
-
35
-
-
66549124907
-
The structures of quadruplex nucleic acids and their drug complexes
-
Neidle, S. The structures of quadruplex nucleic acids and their drug complexes Curr. Opin. Struct. Biol. 2009, 19, 239-250 10.1016/j.sbi.2009.04.001
-
(2009)
Curr. Opin. Struct. Biol.
, vol.19
, pp. 239-250
-
-
Neidle, S.1
-
36
-
-
84865078986
-
NMR spectroscopy of G-quadruplexes
-
Adrian, M.; Heddi, B.; Phan, A. T. NMR spectroscopy of G-quadruplexes Methods 2012, 57, 11-24 10.1016/j.ymeth.2012.05.003
-
(2012)
Methods
, vol.57
, pp. 11-24
-
-
Adrian, M.1
Heddi, B.2
Phan, A.T.3
-
37
-
-
84859300230
-
Formation of pearl-necklace monomorphic G-quadruplexes in the human CEB25 minisatellite
-
Amrane, S.; Adrian, M.; Heddi, B.; Serero, A.; Nicolas, A.; Mergny, J.-L.; Phan, A. T. Formation of pearl-necklace monomorphic G-quadruplexes in the human CEB25 minisatellite J. Am. Chem. Soc. 2012, 134, 5807-5816 10.1021/ja208993r
-
(2012)
J. Am. Chem. Soc.
, vol.134
, pp. 5807-5816
-
-
Amrane, S.1
Adrian, M.2
Heddi, B.3
Serero, A.4
Nicolas, A.5
Mergny, J.-L.6
Phan, A.T.7
-
38
-
-
68249156463
-
Formation of a unique end-to-end stacked pair of G-quadruplexes in the hTERT core promoter with implications for inhibition of telomerase by G-quadruplex-interactive ligands
-
Palumbo, S. L.; Ebbinghaus, S. W.; Hurley, L. H. Formation of a unique end-to-end stacked pair of G-quadruplexes in the hTERT core promoter with implications for inhibition of telomerase by G-quadruplex-interactive ligands J. Am. Chem. Soc. 2009, 131, 10878-10891 10.1021/ja902281d
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 10878-10891
-
-
Palumbo, S.L.1
Ebbinghaus, S.W.2
Hurley, L.H.3
-
39
-
-
84902651070
-
The folding of 5′-UTR human G-quadruplexes possessing a long central loop
-
Jodoin, R.; Bauer, L.; Garant, J.-M.; Mahdi Laaref, A.; Phaneuf, F.; Perreault, J.-P. The folding of 5′-UTR human G-quadruplexes possessing a long central loop RNA 2014, 20, 1129-1141 10.1261/rna.044578.114
-
(2014)
RNA
, vol.20
, pp. 1129-1141
-
-
Jodoin, R.1
Bauer, L.2
Garant, J.-M.3
Mahdi Laaref, A.4
Phaneuf, F.5
Perreault, J.-P.6
-
40
-
-
84893766799
-
The major G-quadruplex formed in the human BCL-2 proximal promoter adopts a parallel structure with a 13-nt loop in K+ solution
-
Agrawal, P.; Lin, C.; Mathad, R. I.; Carver, M.; Yang, D. Z. The major G-quadruplex formed in the human BCL-2 proximal promoter adopts a parallel structure with a 13-nt loop in K+ solution J. Am. Chem. Soc. 2014, 136, 1750-1753 10.1021/ja4118945
-
(2014)
J. Am. Chem. Soc.
, vol.136
, pp. 1750-1753
-
-
Agrawal, P.1
Lin, C.2
Mathad, R.I.3
Carver, M.4
Yang, D.Z.5
-
41
-
-
78649850820
-
How long is too long? Effects of loop size on G-quadruplex stability
-
Guédin, A.; Gros, J.; Alberti, P.; Mergny, J.-L. How long is too long? Effects of loop size on G-quadruplex stability Nucleic Acids Res. 2010, 38, 7858-7868 10.1093/nar/gkq639
-
(2010)
Nucleic Acids Res.
, vol.38
, pp. 7858-7868
-
-
Guédin, A.1
Gros, J.2
Alberti, P.3
Mergny, J.-L.4
-
42
-
-
34247160470
-
Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter
-
Phan, A. T.; Kuryavyi, V.; Burge, S.; Neidle, S.; Patel, D. J. Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter J. Am. Chem. Soc. 2007, 129, 4386-4392 10.1021/ja068739h
-
(2007)
J. Am. Chem. Soc.
, vol.129
, pp. 4386-4392
-
-
Phan, A.T.1
Kuryavyi, V.2
Burge, S.3
Neidle, S.4
Patel, D.J.5
-
43
-
-
84861564071
-
Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation
-
Wei, D.; Parkinson, G. N.; Reszka, A. P.; Neidle, S. Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation Nucleic Acids Res. 2012, 40, 4691-4700 10.1093/nar/gks023
-
(2012)
Nucleic Acids Res.
, vol.40
, pp. 4691-4700
-
-
Wei, D.1
Parkinson, G.N.2
Reszka, A.P.3
Neidle, S.4
-
44
-
-
84941098987
-
Flexibility and structural conservation in a c-KIT G-quadruplex
-
Wei, D.; Husby, J.; Neidle, S. Flexibility and structural conservation in a c-KIT G-quadruplex Nucleic Acids Res. 2015, 43, 629-644 10.1093/nar/gku1282
-
(2015)
Nucleic Acids Res.
, vol.43
, pp. 629-644
-
-
Wei, D.1
Husby, J.2
Neidle, S.3
-
45
-
-
84949933642
-
Extended molecular dynamics of a c-kit promoter quadruplex
-
Islam, B.; Stadlbauer, P.; Krepl, M.; Koca, J.; Neidle, S.; Haider, S.; Sponer, J. Extended molecular dynamics of a c-kit promoter quadruplex Nucleic Acids Res. 2015, 43, 8673-8693 10.1093/nar/gkv785
-
(2015)
Nucleic Acids Res.
, vol.43
, pp. 8673-8693
-
-
Islam, B.1
Stadlbauer, P.2
Krepl, M.3
Koca, J.4
Neidle, S.5
Haider, S.6
Sponer, J.7
-
46
-
-
84930866439
-
Short loop length and high thermal stability determine genomic instability induced by G-quadruplex-forming minisatellites
-
Piazza, A.; Adrian, M.; Samazan, F.; Heddi, B.; Hamon, F.; Serero, A.; Lopes, J.; Teulade-Fichou, M.-P.; Phan, A. T.; Nicolas, A. Short loop length and high thermal stability determine genomic instability induced by G-quadruplex-forming minisatellites EMBO J. 2015, 34, 1718-1734 10.15252/embj.201490702
-
(2015)
EMBO J.
, vol.34
, pp. 1718-1734
-
-
Piazza, A.1
Adrian, M.2
Samazan, F.3
Heddi, B.4
Hamon, F.5
Serero, A.6
Lopes, J.7
Teulade-Fichou, M.-P.8
Phan, A.T.9
Nicolas, A.10
-
47
-
-
84901036412
-
QGRS-Conserve: A computational method for discovering evolutionarily conserved G-quadruplex motifs
-
Frees, S.; Menendez, C.; Crum, M.; Bagga, P. S. QGRS-Conserve: a computational method for discovering evolutionarily conserved G-quadruplex motifs Hum. Genomics 2014, 8, 8 10.1186/1479-7364-8-8
-
(2014)
Hum. Genomics
, vol.8
, pp. 8
-
-
Frees, S.1
Menendez, C.2
Crum, M.3
Bagga, P.S.4
-
48
-
-
84905457852
-
Sequencing and G-quadruplex folding of the canine proto-oncogene KIT promoter region: Might dog be used as a model for human disease?
-
Da Ros, S.; Zorzan, E.; Giantin, M.; Zorro Shahidian, L.; Palumbo, M.; Dacasto, M.; Sissi, C. Sequencing and G-quadruplex folding of the canine proto-oncogene KIT promoter region: might dog be used as a model for human disease? PLoS One 2014, 9, e103876 10.1371/journal.pone.0103876
-
(2014)
PLoS One
, vol.9
, pp. e103876
-
-
Da Ros, S.1
Zorzan, E.2
Giantin, M.3
Zorro Shahidian, L.4
Palumbo, M.5
Dacasto, M.6
Sissi, C.7
-
49
-
-
78049298053
-
G-quadruplex DNA sequences are evolutionarily conserved and associated with distinct genomic features in Saccharomyces cerevisiae
-
Capra, J. A.; Paeschke, K.; Singh, M.; Zakian, V. A. G-quadruplex DNA sequences are evolutionarily conserved and associated with distinct genomic features in Saccharomyces cerevisiae PLoS Comput. Biol. 2010, 6, e1000861 10.1371/journal.pcbi.1000861
-
(2010)
PLoS Comput. Biol.
, vol.6
, pp. e1000861
-
-
Capra, J.A.1
Paeschke, K.2
Singh, M.3
Zakian, V.A.4
-
50
-
-
33745121203
-
Genome-wide prediction of G4 DNA as regulatory motifs: Role in Escherichia coli global regulation
-
Rawal, P.; Kummarasetti, V. B.; Ravindran, J.; Kumar, N.; Halder, K.; Sharma, R.; Mukerji, M.; Das, S. K.; Chowdhury, S. Genome-wide prediction of G4 DNA as regulatory motifs: role in Escherichia coli global regulation Genome Res. 2006, 16, 644-655 10.1101/gr.4508806
-
(2006)
Genome Res.
, vol.16
, pp. 644-655
-
-
Rawal, P.1
Kummarasetti, V.B.2
Ravindran, J.3
Kumar, N.4
Halder, K.5
Sharma, R.6
Mukerji, M.7
Das, S.K.8
Chowdhury, S.9
-
51
-
-
84911496603
-
A matter of location: Influence of G-quadruplexes on Escherichia coli gene expression
-
Holder, I. T.; Hartig, J. S. A matter of location: influence of G-quadruplexes on Escherichia coli gene expression Chem. Biol. 2014, 21, 1511-1521 10.1016/j.chembiol.2014.09.014
-
(2014)
Chem. Biol.
, vol.21
, pp. 1511-1521
-
-
Holder, I.T.1
Hartig, J.S.2
-
52
-
-
84880207699
-
The genome-wide distribution of non-B DNA motifs is shaped by operon structure and suggests the transcriptional importance of non-B DNA structures in Escherichia coli
-
Du, X.; Wojtowicz, D.; Bowers, A. A.; Levens, D.; Benham, C. J.; Przytycka, T. M. The genome-wide distribution of non-B DNA motifs is shaped by operon structure and suggests the transcriptional importance of non-B DNA structures in Escherichia coli Nucleic Acids Res. 2013, 41, 5965-5977 10.1093/nar/gkt308
-
(2013)
Nucleic Acids Res.
, vol.41
, pp. 5965-5977
-
-
Du, X.1
Wojtowicz, D.2
Bowers, A.A.3
Levens, D.4
Benham, C.J.5
Przytycka, T.M.6
-
53
-
-
84883182887
-
A dynamic G-quadruplex region regulates the HIV-1 long terminal repeat promoter
-
Perrone, R.; Nadai, M.; Frasson, I.; Poe, J. A.; Butovskaya, E.; Smithgall, T. E.; Palumbo, M.; Palù, G.; Richter, S. N. A dynamic G-quadruplex region regulates the HIV-1 long terminal repeat promoter J. Med. Chem. 2013, 56, 6521-6530 10.1021/jm400914r
-
(2013)
J. Med. Chem.
, vol.56
, pp. 6521-6530
-
-
Perrone, R.1
Nadai, M.2
Frasson, I.3
Poe, J.A.4
Butovskaya, E.5
Smithgall, T.E.6
Palumbo, M.7
Palù, G.8
Richter, S.N.9
-
54
-
-
84897980191
-
Topology of a DNA G-quadruplex structure formed in the HIV-1 promoter: A potential target for anti-HIV drug development
-
Amrane, S.; Kerkour, A.; Bedrat, A.; Vialet, B.; Andreola, M.-L.; Mergny, J.-L. Topology of a DNA G-quadruplex structure formed in the HIV-1 promoter: a potential target for anti-HIV drug development J. Am. Chem. Soc. 2014, 136, 5249-5252 10.1021/ja501500c
-
(2014)
J. Am. Chem. Soc.
, vol.136
, pp. 5249-5252
-
-
Amrane, S.1
Kerkour, A.2
Bedrat, A.3
Vialet, B.4
Andreola, M.-L.5
Mergny, J.-L.6
-
55
-
-
84883166324
-
Formation of a unique cluster of G-quadruplex structures in the HIV-1 Nef coding region: Implications for antiviral activity
-
Perrone, R.; Nadai, M.; Poe, J. A.; Frasson, I.; Palumbo, M.; Palù, G.; Smithgall, T. E.; Richter, S. N. Formation of a unique cluster of G-quadruplex structures in the HIV-1 Nef coding region: implications for antiviral activity PLoS One 2013, 8, e73121 10.1371/journal.pone.0073121
-
(2013)
PLoS One
, vol.8
, pp. e73121
-
-
Perrone, R.1
Nadai, M.2
Poe, J.A.3
Frasson, I.4
Palumbo, M.5
Palù, G.6
Smithgall, T.E.7
Richter, S.N.8
-
56
-
-
69849114882
-
Putative DNA G-quadruplex formation within the promoters of Plasmodium falciparum var genes
-
Smargiasso, N.; Gabelica, V.; Damblon, C.; Rosu, F.; De Pauw, E.; Teulade-Fichou, M.-P.; Rowe, J. A.; Claessens, A. Putative DNA G-quadruplex formation within the promoters of Plasmodium falciparum var genes BMC Genomics 2009, 10, 362 10.1186/1471-2164-10-362
-
(2009)
BMC Genomics
, vol.10
, pp. 362
-
-
Smargiasso, N.1
Gabelica, V.2
Damblon, C.3
Rosu, F.4
De Pauw, E.5
Teulade-Fichou, M.-P.6
Rowe, J.A.7
Claessens, A.8
-
57
-
-
84938866369
-
High-throughput sequencing of DNA G-quadruplex structures in the human genome
-
Chambers, V. S.; Marsico, G.; Boutell, J. M.; Di Antonio, M.; Smith, G. P.; Balasubramanian, S. High-throughput sequencing of DNA G-quadruplex structures in the human genome Nat. Biotechnol. 2015, 33, 877-881 10.1038/nbt.3295
-
(2015)
Nat. Biotechnol.
, vol.33
, pp. 877-881
-
-
Chambers, V.S.1
Marsico, G.2
Boutell, J.M.3
Di Antonio, M.4
Smith, G.P.5
Balasubramanian, S.6
-
58
-
-
0035902465
-
In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei
-
Schaffitzel, C.; Berger, I.; Postberg, J.; Hanes, J.; Lipps, H. J.; Pluckthun, A. In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei Proc. Natl. Acad. Sci. U. S. A. 2001, 98, 8572-8577 10.1073/pnas.141229498
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 8572-8577
-
-
Schaffitzel, C.1
Berger, I.2
Postberg, J.3
Hanes, J.4
Lipps, H.J.5
Pluckthun, A.6
-
59
-
-
84877768759
-
G-quadruplex structures are stable and detectable in human genomic DNA
-
Lam, E. Y.; Beraldi, D.; Tannahill, D.; Balasubramanian, S. G-quadruplex structures are stable and detectable in human genomic DNA Nat. Commun. 2013, 4, 1796-1780 10.1038/ncomms2792
-
(2013)
Nat. Commun.
, vol.4
, pp. 1780-1796
-
-
Lam, E.Y.1
Beraldi, D.2
Tannahill, D.3
Balasubramanian, S.4
-
60
-
-
84875464903
-
Quantitative visualization of DNA G-quadruplex structures in human cells
-
Biffi, G.; Tannahill, D.; McCafferty, J.; Balasubramanian, S. Quantitative visualization of DNA G-quadruplex structures in human cells Nat. Chem. 2013, 5, 182-186 10.1038/nchem.1548
-
(2013)
Nat. Chem.
, vol.5
, pp. 182-186
-
-
Biffi, G.1
Tannahill, D.2
McCafferty, J.3
Balasubramanian, S.4
-
61
-
-
84893303932
-
Detection of G-quadruplex DNA in mammalian cells
-
Henderson, A.; Wu, Y.; Huang, Y. C.; Chavez, E. A.; Platt, J.; Johnson, F. B.; Brosh, R. M., Jr.; Sen, D.; Lansdorp, P. M. Detection of G-quadruplex DNA in mammalian cells Nucleic Acids Res. 2014, 42, 860-869 10.1093/nar/gkt957
-
(2014)
Nucleic Acids Res.
, vol.42
, pp. 860-869
-
-
Henderson, A.1
Wu, Y.2
Huang, Y.C.3
Chavez, E.A.4
Platt, J.5
Johnson, F.B.6
Brosh, Jr.R.M.7
Sen, D.8
Lansdorp, P.M.9
-
62
-
-
84904489184
-
Elevated levels of G-quadruplex formation in human stomach and liver cancer tissues
-
Biffi, G.; Tannahill, D.; Miller, J.; Howat, W. J.; Balasubramanian, S. Elevated levels of G-quadruplex formation in human stomach and liver cancer tissues PLoS One 2014, 9, e102711 10.1371/journal.pone.0102711
-
(2014)
PLoS One
, vol.9
, pp. e102711
-
-
Biffi, G.1
Tannahill, D.2
Miller, J.3
Howat, W.J.4
Balasubramanian, S.5
-
63
-
-
84886768234
-
Fluorescent probe for visualizing guanine-quadruplex DNA by fluorescence lifetime imaging microscopy
-
Tseng, T.-Y.; Chien, C.-H.; Chu, J.-F.; Huang, W.-C.; Lin, M.-Y.; Chang, C.-C.; Chang, T.-C. Fluorescent probe for visualizing guanine-quadruplex DNA by fluorescence lifetime imaging microscopy J. Biomed. Opt. 2013, 18, 101309 10.1117/1.JBO.18.10.101309
-
(2013)
J. Biomed. Opt.
, vol.18
, pp. 101309
-
-
Tseng, T.-Y.1
Chien, C.-H.2
Chu, J.-F.3
Huang, W.-C.4
Lin, M.-Y.5
Chang, C.-C.6
Chang, T.-C.7
-
64
-
-
84936805220
-
Visualization of RNA-quadruplexes in live cells
-
Laguerre, A.; Hukezalie, K.; Winckler, P.; Katranji, F.; Chanteloup, G.; Pirrotta, M.; Perrier-Cornet, J.-M.; Wong, J. M. Y.; Monchaud, D. Visualization of RNA-quadruplexes in live cells J. Am. Chem. Soc. 2015, 137, 8521-8525 10.1021/jacs.5b03413
-
(2015)
J. Am. Chem. Soc.
, vol.137
, pp. 8521-8525
-
-
Laguerre, A.1
Hukezalie, K.2
Winckler, P.3
Katranji, F.4
Chanteloup, G.5
Pirrotta, M.6
Perrier-Cornet, J.-M.7
Wong, J.M.Y.8
Monchaud, D.9
-
65
-
-
84941069729
-
The interactions between a small molecule and G-quadruplexes are visualized by fluorescence lifetime imaging microscopy
-
Shivalingam, A.; Angeles Izquierdo, M.; Le Marois, A.; Vyšniauskas, A.; Suhling, K.; Kuimova, M. K.; Vilar, R. The interactions between a small molecule and G-quadruplexes are visualized by fluorescence lifetime imaging microscopy Nat. Commun. 2015, 6, 8178 10.1038/ncomms9178
-
(2015)
Nat. Commun.
, vol.6
, pp. 8178
-
-
Shivalingam, A.1
Angeles Izquierdo, M.2
Le Marois, A.3
Vyšniauskas, A.4
Suhling, K.5
Kuimova, M.K.6
Vilar, R.7
-
66
-
-
84867744921
-
DNA secondary structures: Stability and function of G-quadruplex structures
-
Bochman, M. L.; Paeschke, K.; Zakian, V. A. DNA secondary structures: stability and function of G-quadruplex structures Nat. Rev. Genet. 2012, 13, 770-780 10.1038/nrg3296
-
(2012)
Nat. Rev. Genet.
, vol.13
, pp. 770-780
-
-
Bochman, M.L.1
Paeschke, K.2
Zakian, V.A.3
-
67
-
-
0030982721
-
The terminal DNA structure of mammalian chromosomes
-
McElligott, R.; Wellinger, R. J. The terminal DNA structure of mammalian chromosomes EMBO J. 1997, 16, 3705-3714 10.1093/emboj/16.12.3705
-
(1997)
EMBO J.
, vol.16
, pp. 3705-3714
-
-
McElligott, R.1
Wellinger, R.J.2
-
68
-
-
0030731928
-
Normal human chromosomes have long G-rich telomeric overhangs at one end
-
Wright, W. E.; Tesmer, V. M.; Huffman, K. E.; Levene, S. D.; Shay, J. W. Normal human chromosomes have long G-rich telomeric overhangs at one end Genes Dev. 1997, 11, 2801-2809 10.1101/gad.11.21.2801
-
(1997)
Genes Dev.
, vol.11
, pp. 2801-2809
-
-
Wright, W.E.1
Tesmer, V.M.2
Huffman, K.E.3
Levene, S.D.4
Shay, J.W.5
-
69
-
-
80052398381
-
How shelterin solves the telomere end-protection problem
-
De Lange, T. How shelterin solves the telomere end-protection problem Cold Spring Harbor Symp. Quant. Biol. 2010, 75, 167-177 10.1101/sqb.2010.75.017
-
(2010)
Cold Spring Harbor Symp. Quant. Biol.
, vol.75
, pp. 167-177
-
-
De Lange, T.1
-
70
-
-
0035844082
-
Pot1, the putative telomere end-binding protein in fission yeast and humans
-
Baumann, P.; Cech, T. R. Pot1, the putative telomere end-binding protein in fission yeast and humans Science 2001, 292, 1171-1175 10.1126/science.1060036
-
(2001)
Science
, vol.292
, pp. 1171-1175
-
-
Baumann, P.1
Cech, T.R.2
-
71
-
-
23344451160
-
Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro
-
Zaug, A. J.; Podell, E. R.; Cech, T. R. Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro Proc. Natl. Acad. Sci. U. S. A. 2005, 102, 10864-10869 10.1073/pnas.0504744102
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 10864-10869
-
-
Zaug, A.J.1
Podell, E.R.2
Cech, T.R.3
-
72
-
-
84895795314
-
TRF2-tethered TIN2 can mediate telomere protection by TPP1/POT1
-
Frescas, D.; de Lange, T. TRF2-tethered TIN2 can mediate telomere protection by TPP1/POT1 Mol. Cell. Biol. 2014, 34, 1349-1362 10.1128/MCB.01052-13
-
(2014)
Mol. Cell. Biol.
, vol.34
, pp. 1349-1362
-
-
Frescas, D.1
De Lange, T.2
-
73
-
-
0022402513
-
Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
-
Greider, C. W.; Blackburn, E. H. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts Cell 1985, 43, 405-413 10.1016/0092-8674(85)90170-9
-
(1985)
Cell
, vol.43
, pp. 405-413
-
-
Greider, C.W.1
Blackburn, E.H.2
-
74
-
-
0028564951
-
Specific association of human telomerase activity with immortal cells and cancer
-
Kim, N. W.; Piatyszek, M. A.; Prowse, K. R.; Harley, C. B.; West, M. D.; Ho, P. L.; Coviello, G. M.; Wright, W. E.; Weinrich, S. L.; Shay, J. W. Specific association of human telomerase activity with immortal cells and cancer Science 1994, 266, 2011-2015 10.1126/science.7605428
-
(1994)
Science
, vol.266
, pp. 2011-2015
-
-
Kim, N.W.1
Piatyszek, M.A.2
Prowse, K.R.3
Harley, C.B.4
West, M.D.5
Ho, P.L.6
Coviello, G.M.7
Wright, W.E.8
Weinrich, S.L.9
Shay, J.W.10
-
75
-
-
0028262113
-
Telomerase activity in human ovarian carcinoma
-
Counter, C. M.; Hirte, H. W.; Bacchetti, S.; Harley, C. B. Telomerase activity in human ovarian carcinoma Proc. Natl. Acad. Sci. U. S. A. 1994, 91, 2900-2904 10.1073/pnas.91.8.2900
-
(1994)
Proc. Natl. Acad. Sci. U. S. A.
, vol.91
, pp. 2900-2904
-
-
Counter, C.M.1
Hirte, H.W.2
Bacchetti, S.3
Harley, C.B.4
-
76
-
-
0025877846
-
Inhibition of telomerase by G-quartet DNA structures
-
Zahler, A. M.; Williamson, J. R.; Cech, T. R.; Prescott, D. M. Inhibition of telomerase by G-quartet DNA structures Nature 1991, 350, 718-750 10.1038/350718a0
-
(1991)
Nature
, vol.350
, pp. 718-750
-
-
Zahler, A.M.1
Williamson, J.R.2
Cech, T.R.3
Prescott, D.M.4
-
77
-
-
0030786928
-
Inhibition of human telomerase by a G-quadruplex-interactive compound
-
Sun, D.; Thompson, B.; Cathers, B. E.; Salazar, M.; Kerwin, S. M.; Trent, J. O.; Jenkins, T. C.; Neidle, S.; Hurley, L. H. Inhibition of human telomerase by a G-quadruplex-interactive compound J. Med. Chem. 1997, 40, 2113-2116 10.1021/jm970199z
-
(1997)
J. Med. Chem.
, vol.40
, pp. 2113-2116
-
-
Sun, D.1
Thompson, B.2
Cathers, B.E.3
Salazar, M.4
Kerwin, S.M.5
Trent, J.O.6
Jenkins, T.C.7
Neidle, S.8
Hurley, L.H.9
-
78
-
-
33847372902
-
Physiological relevance of telomeric G-quadruplex formation: A potential drug target
-
Oganesian, L.; Bryan, T. M. Physiological relevance of telomeric G-quadruplex formation: a potential drug target BioEssays 2007, 29, 155-165 10.1002/bies.20523
-
(2007)
BioEssays
, vol.29
, pp. 155-165
-
-
Oganesian, L.1
Bryan, T.M.2
-
79
-
-
37049004147
-
Targeting telomeres and telomerase
-
De Cian, A.; Lacroix, L.; Douarre, C.; Temime-Smaali, N.; Trentesaux, C.; Riou, J.-F.; Mergny, J.-L. Targeting telomeres and telomerase Biochimie 2008, 90, 131-155 10.1016/j.biochi.2007.07.011
-
(2008)
Biochimie
, vol.90
, pp. 131-155
-
-
De Cian, A.1
Lacroix, L.2
Douarre, C.3
Temime-Smaali, N.4
Trentesaux, C.5
Riou, J.-F.6
Mergny, J.-L.7
-
80
-
-
84911472048
-
Telomeric G-quadruplex architecture and interactions with potential drugs
-
Sissi, C.; Palumbo, M. Telomeric G-quadruplex architecture and interactions with potential drugs Curr. Pharm. Des. 2014, 20, 6489-6509 10.2174/1381612820666140630094300
-
(2014)
Curr. Pharm. Des.
, vol.20
, pp. 6489-6509
-
-
Sissi, C.1
Palumbo, M.2
-
81
-
-
84890811542
-
Telomere maintenance as a target for drug discovery
-
Sekaran, V.; Soares, J.; Jarstfer, M. B. Telomere maintenance as a target for drug discovery J. Med. Chem. 2014, 57, 521-538 10.1021/jm400528t
-
(2014)
J. Med. Chem.
, vol.57
, pp. 521-538
-
-
Sekaran, V.1
Soares, J.2
Jarstfer, M.B.3
-
82
-
-
0037028047
-
Telomerase inhibition, telomere shortening, and decreased cell proliferation by cell permeable 2′-O-methoxyethyl oligonucleotides
-
Chen, Z.; Monia, B. P.; Corey, D. R. Telomerase inhibition, telomere shortening, and decreased cell proliferation by cell permeable 2′-O-methoxyethyl oligonucleotides J. Med. Chem. 2002, 45, 5423-5425 10.1021/jm025563v
-
(2002)
J. Med. Chem.
, vol.45
, pp. 5423-5425
-
-
Chen, Z.1
Monia, B.P.2
Corey, D.R.3
-
83
-
-
0032828652
-
Inhibition of telomerase limits the growth of human cancer cells
-
Hahn, W. C.; Stewart, S. A.; Brooks, M. W.; York, S. G.; Eaton, E.; Kurachi, A.; Beijersbergen, R. L.; Knoll, J. H. M.; Meyerson, M.; Weinberg, R. A. Inhibition of telomerase limits the growth of human cancer cells Nat. Med. 1999, 5, 1164-1170 10.1038/13495
-
(1999)
Nat. Med.
, vol.5
, pp. 1164-1170
-
-
Hahn, W.C.1
Stewart, S.A.2
Brooks, M.W.3
York, S.G.4
Eaton, E.5
Kurachi, A.6
Beijersbergen, R.L.7
Knoll, J.H.M.8
Meyerson, M.9
Weinberg, R.A.10
-
84
-
-
4243937106
-
A highly selective telomerase inhibitor limiting human cancer cell proliferation
-
Damm, K.; Hemmann, U.; Garin-Chesa, P.; Hauel, N.; Kauffmann, I.; Priepke, H.; Niestroj, C.; Daiber, C.; Enenkel, B.; Guilliard, B.; Lauritsch, I.; Muller, E.; Pascolo, E.; Sauter, G.; Pantic, M.; Martens, U. M.; Wenz, C.; Lingner, J.; Kraut, N.; Rettig, W. J.; Schnapp, A. A highly selective telomerase inhibitor limiting human cancer cell proliferation EMBO J. 2001, 20, 6958-6968 10.1093/emboj/20.24.6958
-
(2001)
EMBO J.
, vol.20
, pp. 6958-6968
-
-
Damm, K.1
Hemmann, U.2
Garin-Chesa, P.3
Hauel, N.4
Kauffmann, I.5
Priepke, H.6
Niestroj, C.7
Daiber, C.8
Enenkel, B.9
Guilliard, B.10
Lauritsch, I.11
Muller, E.12
Pascolo, E.13
Sauter, G.14
Pantic, M.15
Martens, U.M.16
Wenz, C.17
Lingner, J.18
Kraut, N.19
Rettig, W.J.20
Schnapp, A.21
more..
-
85
-
-
26444602415
-
P16INK4a as a second effector of the telomere damage pathway
-
Jacobs, J. J.; de Lange, T. p16INK4a as a second effector of the telomere damage pathway Cell Cycle 2005, 4, 1364-1368 10.4161/cc.4.10.2104
-
(2005)
Cell Cycle
, vol.4
, pp. 1364-1368
-
-
Jacobs, J.J.1
De Lange, T.2
-
86
-
-
84892731189
-
Cellular senescence and its effector programs
-
Salama, R.; Sadaie, M.; Hoare, M.; Narita, M. Cellular senescence and its effector programs Genes Dev. 2014, 28, 99-114 10.1101/gad.235184.113
-
(2014)
Genes Dev.
, vol.28
, pp. 99-114
-
-
Salama, R.1
Sadaie, M.2
Hoare, M.3
Narita, M.4
-
87
-
-
0037022658
-
Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands
-
Riou, J.-F.; Guittat, L.; Mailliet, P.; Laoui, A.; Renou, E.; Petitgenet, O.; Mégnin-Chanet, F.; Hélène, C.; Mergny, J.-L. Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands Proc. Natl. Acad. Sci. U. S. A. 2002, 99, 2672-2677 10.1073/pnas.052698099
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 2672-2677
-
-
Riou, J.-F.1
Guittat, L.2
Mailliet, P.3
Laoui, A.4
Renou, E.5
Petitgenet, O.6
Mégnin-Chanet, F.7
Hélène, C.8
Mergny, J.-L.9
-
88
-
-
7444237059
-
A G-quadruplex telomere targeting agent produces p16-associated senescence and chromosomal fusions in human prostate cancer cells
-
Incles, C. M.; Schultes, C. M.; Kempski, H.; Koehler, H.; Kelland, L. R.; Neidle, S. A G-quadruplex telomere targeting agent produces p16-associated senescence and chromosomal fusions in human prostate cancer cells Mol. Cancer Ther. 2004, 3, 1201-1206
-
(2004)
Mol. Cancer Ther.
, vol.3
, pp. 1201-1206
-
-
Incles, C.M.1
Schultes, C.M.2
Kempski, H.3
Koehler, H.4
Kelland, L.R.5
Neidle, S.6
-
89
-
-
84873312526
-
Telomere shortening and cell senescence induced by perylene derivatives in A549 human lung cancer cells
-
Taka, T.; Huang, L.; Wongnoppavich, A.; Tam-Chang, S. W.; Lee, T. R.; Tuntiwechapikul, W. Telomere shortening and cell senescence induced by perylene derivatives in A549 human lung cancer cells Bioorg. Med. Chem. 2013, 21, 883-890 10.1016/j.bmc.2012.12.020
-
(2013)
Bioorg. Med. Chem.
, vol.21
, pp. 883-890
-
-
Taka, T.1
Huang, L.2
Wongnoppavich, A.3
Tam-Chang, S.W.4
Lee, T.R.5
Tuntiwechapikul, W.6
-
90
-
-
13944272246
-
The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function
-
Burger, A. M.; Dai, F.; Schultes, C. M.; Reszka, A. P.; Moore, M. J.; Double, J. A.; Neidle, S. The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function Cancer Res. 2005, 65, 1489-1496 10.1158/0008-5472.CAN-04-2910
-
(2005)
Cancer Res.
, vol.65
, pp. 1489-1496
-
-
Burger, A.M.1
Dai, F.2
Schultes, C.M.3
Reszka, A.P.4
Moore, M.J.5
Double, J.A.6
Neidle, S.7
-
91
-
-
84935910807
-
Water-soluble ruthenium(II) complexes with chiral 4-(2,3-dihydroxypropyl)-formamide oxoaporphine (FOA): In vitro and in vivo anticancer activity by stabilization of G-quadruplex DNA, inhibition of telomerase activity, and induction of tumor cell apoptosis
-
Chen, Z.-F.; Qin, Q.-P.; Qin, J.-L.; Zhou, J.; Li, Y.-L.; Li, N.; Liu, Y.-C.; Liang, H. Water-soluble ruthenium(II) complexes with chiral 4-(2,3-dihydroxypropyl)-formamide oxoaporphine (FOA): in vitro and in vivo anticancer activity by stabilization of G-quadruplex DNA, inhibition of telomerase activity, and induction of tumor cell apoptosis J. Med. Chem. 2015, 58, 4771-4789 10.1021/acs.jmedchem.5b00444
-
(2015)
J. Med. Chem.
, vol.58
, pp. 4771-4789
-
-
Chen, Z.-F.1
Qin, Q.-P.2
Qin, J.-L.3
Zhou, J.4
Li, Y.-L.5
Li, N.6
Liu, Y.-C.7
Liang, H.8
-
92
-
-
38849111756
-
Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II
-
Schoeftner, S.; Blasco, M. A. Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II Nat. Cell Biol. 2008, 10, 228-236 10.1038/ncb1685
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 228-236
-
-
Schoeftner, S.1
Blasco, M.A.2
-
93
-
-
37349043972
-
Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends
-
Azzalin, C. M.; Reichenbach, P.; Khoriauli, L.; Giulotto, E.; Lingner, J. Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends Science 2007, 318, 798-801 10.1126/science.1147182
-
(2007)
Science
, vol.318
, pp. 798-801
-
-
Azzalin, C.M.1
Reichenbach, P.2
Khoriauli, L.3
Giulotto, E.4
Lingner, J.5
-
94
-
-
78650153788
-
TERRA transcripts are bound by a complex array of RNA-binding proteins
-
López de Silanes, I.; d'Alcontres, M. S.; Blasco, M. A. TERRA transcripts are bound by a complex array of RNA-binding proteins Nat. Commun. 2010, 1, 1-9 10.1038/ncomms1032
-
(2010)
Nat. Commun.
, vol.1
, pp. 1-9
-
-
López De Silanes, I.1
D'Alcontres, M.S.2
Blasco, M.A.3
-
95
-
-
67649756727
-
Structure of long telomeric RNA transcripts: The G-rich RNA forms a compact repeating structure containing G-quartets
-
Randall, A.; Griffith, J. D. Structure of long telomeric RNA transcripts: the G-rich RNA forms a compact repeating structure containing G-quartets J. Biol. Chem. 2009, 284, 13980-13986 10.1074/jbc.M900631200
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 13980-13986
-
-
Randall, A.1
Griffith, J.D.2
-
97
-
-
77956539976
-
A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex
-
Collie, G. W.; Haider, S. M.; Neidle, S.; Parkinson, G. N. A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex Nucleic Acids Res. 2010, 38, 5569-5580 10.1093/nar/gkq259
-
(2010)
Nucleic Acids Res.
, vol.38
, pp. 5569-5580
-
-
Collie, G.W.1
Haider, S.M.2
Neidle, S.3
Parkinson, G.N.4
-
99
-
-
84927128325
-
Telomeric repeat-containing RNA TERRA: A noncoding RNA connecting telomere biology to genome integrity
-
Cusanelli, E.; Chartrand, P. Telomeric repeat-containing RNA TERRA: a noncoding RNA connecting telomere biology to genome integrity Front. Genet. 2015, 6, 143 10.3389/fgene.2015.00143
-
(2015)
Front. Genet.
, vol.6
, pp. 143
-
-
Cusanelli, E.1
Chartrand, P.2
-
100
-
-
84949230728
-
Telomere elongation chooses TERRA ALTernatives
-
Arora, R.; Azzalin, C. M. Telomere elongation chooses TERRA ALTernatives RNA Biol. 2015, 12, 938-941 10.1080/15476286.2015.1065374
-
(2015)
RNA Biol.
, vol.12
, pp. 938-941
-
-
Arora, R.1
Azzalin, C.M.2
-
101
-
-
84923355398
-
Functional characterization of the TERRA transcriptome at damaged telomeres
-
Porro, A.; Feuerhahn, S.; Delafontaine, J.; Riethman, H.; Rougemont, J.; Lingner, J. Functional characterization of the TERRA transcriptome at damaged telomeres Nat. Commun. 2014, 5, 5379 10.1038/ncomms6379
-
(2014)
Nat. Commun.
, vol.5
, pp. 5379
-
-
Porro, A.1
Feuerhahn, S.2
Delafontaine, J.3
Riethman, H.4
Rougemont, J.5
Lingner, J.6
-
102
-
-
0032514479
-
1,4- and 2,6-disubstituted amidoanthracene-9,10-dione derivatives as inhibitors of human telomerase
-
Perry, P. J.; Gowan, S. M.; Reszka, A. P.; Polucci, P.; Jenkins, T. C.; Kelland, L. R.; Neidle, S. 1,4- and 2,6-disubstituted amidoanthracene-9,10-dione derivatives as inhibitors of human telomerase J. Med. Chem. 1998, 41, 3253-3260 10.1021/jm9801105
-
(1998)
J. Med. Chem.
, vol.41
, pp. 3253-3260
-
-
Perry, P.J.1
Gowan, S.M.2
Reszka, A.P.3
Polucci, P.4
Jenkins, T.C.5
Kelland, L.R.6
Neidle, S.7
-
103
-
-
7844223625
-
Human telomerase inhibition by regioisomeric disubstituted amidoanthracene-9,10-diones
-
Perry, P. J.; Reszka, A. P.; Wood, A. A.; Read, M. A.; Gowan, S. M.; Dosanjh, H. S.; Trent, J. O.; Jenkins, T. C.; Kelland, L. R.; Neidle, S. Human telomerase inhibition by regioisomeric disubstituted amidoanthracene-9,10-diones J. Med. Chem. 1998, 41, 4873-4884 10.1021/jm981067o
-
(1998)
J. Med. Chem.
, vol.41
, pp. 4873-4884
-
-
Perry, P.J.1
Reszka, A.P.2
Wood, A.A.3
Read, M.A.4
Gowan, S.M.5
Dosanjh, H.S.6
Trent, J.O.7
Jenkins, T.C.8
Kelland, L.R.9
Neidle, S.10
-
104
-
-
0033524027
-
Molecular modeling studies on G-quadruplex complexes of telomerase inhibitors: Structure-activity relationships
-
Read, M. A.; Wood, A. A.; Harrison, J. R.; Gowan, S. M.; Kelland, L. R.; Dosanjh, H. S.; Neidle, S. Molecular modeling studies on G-quadruplex complexes of telomerase inhibitors: structure-activity relationships J. Med. Chem. 1999, 42, 4538-4546 10.1021/jm990287e
-
(1999)
J. Med. Chem.
, vol.42
, pp. 4538-4546
-
-
Read, M.A.1
Wood, A.A.2
Harrison, J.R.3
Gowan, S.M.4
Kelland, L.R.5
Dosanjh, H.S.6
Neidle, S.7
-
105
-
-
0032495774
-
Cationic porphyrins as telomerase inhibitors: The interaction of tetra-(N-methyl-4-pyridyl)porphine with quadruplex DNA
-
Wheelhouse, R. T.; Sun, D. K.; Han, H. Y.; Han, F. X. G.; Hurley, L. H. Cationic porphyrins as telomerase inhibitors: the interaction of tetra-(N-methyl-4-pyridyl)porphine with quadruplex DNA J. Am. Chem. Soc. 1998, 120, 3261-3262 10.1021/ja973792e
-
(1998)
J. Am. Chem. Soc.
, vol.120
, pp. 3261-3262
-
-
Wheelhouse, R.T.1
Sun, D.K.2
Han, H.Y.3
Han, F.X.G.4
Hurley, L.H.5
-
106
-
-
0035853164
-
Telomerase inhibitors based on quadruplex ligands selected by a fluorescence assay
-
Mergny, J.-L.; Lacroix, L.; Teulade-Fichou, T.; Hounsou, C.; Guittat, M.; Hoarau, M.; Arimondo, P. B.; Vigneron, J. P.; Lehn, J.-M.; Riou, J.-F.; Garestier, T.; Hélène, C. Telomerase inhibitors based on quadruplex ligands selected by a fluorescence assay Proc. Natl. Acad. Sci. U. S. A. 2001, 98, 3062-3067 10.1073/pnas.051620698
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 3062-3067
-
-
Mergny, J.-L.1
Lacroix, L.2
Teulade-Fichou, T.3
Hounsou, C.4
Guittat, M.5
Hoarau, M.6
Arimondo, P.B.7
Vigneron, J.P.8
Lehn, J.-M.9
Riou, J.-F.10
Garestier, T.11
Hélène, C.12
-
107
-
-
0034622547
-
Inhibition of unwinding of G-quadruplex structures by Sgs1 helicase in the presence of N,N′-bis[2-(1-piperidino)ethyl]-3,4,9,10-perylenetetracarboxylic diimide, a G-quadruplex-interactive ligand
-
Han, H.; Bennett, R. J.; Hurley, L. H. Inhibition of unwinding of G-quadruplex structures by Sgs1 helicase in the presence of N,N′-bis[2-(1-piperidino)ethyl]-3,4,9,10-perylenetetracarboxylic diimide, a G-quadruplex-interactive ligand Biochemistry 2000, 39, 9311-9316 10.1021/bi000482r
-
(2000)
Biochemistry
, vol.39
, pp. 9311-9316
-
-
Han, H.1
Bennett, R.J.2
Hurley, L.H.3
-
108
-
-
0034760505
-
Potent inhibition of telomerase by small-molecule pentacyclic acridines capable of interacting with G-quadruplexes
-
Gowan, S. M.; Heald, R.; Stevens, M. F.; Kelland, L. R. Potent inhibition of telomerase by small-molecule pentacyclic acridines capable of interacting with G-quadruplexes Mol. Pharmacol. 2001, 60, 981-988
-
(2001)
Mol. Pharmacol.
, vol.60
, pp. 981-988
-
-
Gowan, S.M.1
Heald, R.2
Stevens, M.F.3
Kelland, L.R.4
-
109
-
-
39049147645
-
A hitchhiker's guide to G-quadruplex ligands
-
Monchaud, D.; Teulade-Fichou, M.-P. A hitchhiker's guide to G-quadruplex ligands Org. Biomol. Chem. 2008, 6, 627-636 10.1039/B714772B
-
(2008)
Org. Biomol. Chem.
, vol.6
, pp. 627-636
-
-
Monchaud, D.1
Teulade-Fichou, M.-P.2
-
110
-
-
66149087629
-
G-quadruplex DNA structures and organic chemistry: More than one connection
-
Franceschin, M. G-quadruplex DNA structures and organic chemistry: more than one connection Eur. J. Org. Chem. 2009, 2009, 2215-2220 10.1002/ejoc.200990035
-
(2009)
Eur. J. Org. Chem.
, vol.2009
, pp. 2215-2220
-
-
Franceschin, M.1
-
111
-
-
79952749516
-
Quadruplex DNA: A promising drug target for the medicinal inorganic chemist
-
Ralph, S. F. Quadruplex DNA: a promising drug target for the medicinal inorganic chemist Curr. Top. Med. Chem. 2011, 11, 572-590 10.2174/156802611794785208
-
(2011)
Curr. Top. Med. Chem.
, vol.11
, pp. 572-590
-
-
Ralph, S.F.1
-
112
-
-
33646497225
-
Stabilization of G-quadruplex DNA and inhibition of telomerase activity by square-planar nickel(II) complexes
-
Reed, J. E.; Arnal, A. A.; Neidle, S.; Vilar, R. Stabilization of G-quadruplex DNA and inhibition of telomerase activity by square-planar nickel(II) complexes J. Am. Chem. Soc. 2006, 128, 5992-5993 10.1021/ja058509n
-
(2006)
J. Am. Chem. Soc.
, vol.128
, pp. 5992-5993
-
-
Reed, J.E.1
Arnal, A.A.2
Neidle, S.3
Vilar, R.4
-
113
-
-
84935910807
-
Water-soluble ruthenium(II) complexes with chiral 4-(2,3-dihydroxypropyl)-formamide oxoaporphine (FOA): In vitro and in vivo anticancer activity by stabilization of G-Quadruplex DNA, inhibition of telomerase activity, and induction of tumor cell apoptosis
-
Chen, Z.-F.; Qin, Q.-P.; Qin, J.-L.; Zhou, J.; Li, Y.-L.; Li, N.; Liu, Y.-C.; Liang, H. Water-soluble ruthenium(II) complexes with chiral 4-(2,3-dihydroxypropyl)-formamide oxoaporphine (FOA): in vitro and in vivo anticancer activity by stabilization of G-Quadruplex DNA, inhibition of telomerase activity, and induction of tumor cell apoptosis J. Med. Chem. 2015, 58, 4771-4789 10.1021/acs.jmedchem.5b00444
-
(2015)
J. Med. Chem.
, vol.58
, pp. 4771-4789
-
-
Chen, Z.-F.1
Qin, Q.-P.2
Qin, J.-L.3
Zhou, J.4
Li, Y.-L.5
Li, N.6
Liu, Y.-C.7
Liang, H.8
-
114
-
-
0037070575
-
Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular G-quadruplex
-
Kim, M. Y.; Vankayalapati, H.; Shin-Ya, K.; Wierzba, K.; Hurley, L. H. Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular G-quadruplex J. Am. Chem. Soc. 2002, 124, 2098-2099 10.1021/ja017308q
-
(2002)
J. Am. Chem. Soc.
, vol.124
, pp. 2098-2099
-
-
Kim, M.Y.1
Vankayalapati, H.2
Shin-Ya, K.3
Wierzba, K.4
Hurley, L.H.5
-
115
-
-
79851504298
-
Telomestatin: Formal total synthesis and cation-mediated interaction of its seco-derivatives with G-quadruplexes
-
Linder, J.; Garner, T. P.; Williams, H. E. L.; Searle, M. S.; Moody, C. J. Telomestatin: formal total synthesis and cation-mediated interaction of its seco-derivatives with G-quadruplexes J. Am. Chem. Soc. 2011, 133, 1044-1051 10.1021/ja109158k
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 1044-1051
-
-
Linder, J.1
Garner, T.P.2
Williams, H.E.L.3
Searle, M.S.4
Moody, C.J.5
-
116
-
-
84884177068
-
Solution structure of an intramolecular (3 + 1) human telomeric G-quadruplex bound to a telomestatin derivative
-
Chung, W. J.; Heddi, B.; Tera, M.; Iida, K.; Nagasawa, K.; Phan, A. T. Solution structure of an intramolecular (3 + 1) human telomeric G-quadruplex bound to a telomestatin derivative J. Am. Chem. Soc. 2013, 135, 13495-13501 10.1021/ja405843r
-
(2013)
J. Am. Chem. Soc.
, vol.135
, pp. 13495-13501
-
-
Chung, W.J.1
Heddi, B.2
Tera, M.3
Iida, K.4
Nagasawa, K.5
Phan, A.T.6
-
117
-
-
77957952254
-
Macrocyclic G-quadruplex ligands
-
Nielsen, M. C.; Ulven, T. Macrocyclic G-quadruplex ligands Curr. Med. Chem. 2010, 17, 3438-3448 10.2174/092986710793176320
-
(2010)
Curr. Med. Chem.
, vol.17
, pp. 3438-3448
-
-
Nielsen, M.C.1
Ulven, T.2
-
118
-
-
77952045784
-
Macrocyclic pyridyl polyoxazoles: Selective RNA and DNA G-quadruplex ligands as antitumor agents
-
Rzuczek, S. G.; Pilch, D. S.; Liu, A.; Liu, L.; LaVoie, E. J.; Rice, J. E. Macrocyclic pyridyl polyoxazoles: selective RNA and DNA G-quadruplex ligands as antitumor agents J. Med. Chem. 2010, 53, 3632-3644 10.1021/jm1000612
-
(2010)
J. Med. Chem.
, vol.53
, pp. 3632-3644
-
-
Rzuczek, S.G.1
Pilch, D.S.2
Liu, A.3
Liu, L.4
LaVoie, E.J.5
Rice, J.E.6
-
119
-
-
77952065213
-
Macrocyclic hexaoxazoles: Influence of aminoalkyl substituents on RNA and DNA G-quadruplex stabilization and cytotoxicity
-
Satyanarayana, M.; Kim, Y. A.; Rzuczek, S. G.; Pilch, D. S.; Liu, A. A.; Liu, L. F.; Rice, J. E.; LaVoie, E. J. Macrocyclic hexaoxazoles: Influence of aminoalkyl substituents on RNA and DNA G-quadruplex stabilization and cytotoxicity Bioorg. Med. Chem. Lett. 2010, 20, 3150-3154 10.1016/j.bmcl.2010.03.086
-
(2010)
Bioorg. Med. Chem. Lett.
, vol.20
, pp. 3150-3154
-
-
Satyanarayana, M.1
Kim, Y.A.2
Rzuczek, S.G.3
Pilch, D.S.4
Liu, A.A.5
Liu, L.F.6
Rice, J.E.7
LaVoie, E.J.8
-
120
-
-
84872912456
-
Finding the end: Recruitment of telomerase to telomeres
-
Nandakumar, J.; Cech, T. R. Finding the end: recruitment of telomerase to telomeres Nat. Rev. Mol. Cell Biol. 2013, 14, 69-82 10.1038/nrm3505
-
(2013)
Nat. Rev. Mol. Cell Biol.
, vol.14
, pp. 69-82
-
-
Nandakumar, J.1
Cech, T.R.2
-
121
-
-
77957585971
-
Telomeres and telomerase: The means to the end
-
Blackburn, E. H. Telomeres and telomerase: the means to the end Angew. Chem., Int. Ed. 2010, 49, 7405-7421 10.1002/anie.201002387
-
(2010)
Angew. Chem., Int. Ed.
, vol.49
, pp. 7405-7421
-
-
Blackburn, E.H.1
-
122
-
-
33746916385
-
The G-quadruplex ligand telomestatin inhibits POT1 binding to telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells
-
Gomez, D.; O'Donohue, M. F.; Wenner, T.; Douarre, C.; Macadré, J.; Koebel, P.; Giraud-Panis, M.-J.; Kaplan, H.; Kolkes, A.; Shin-Ya, K.; Riou, J.-F. The G-quadruplex ligand telomestatin inhibits POT1 binding to telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells Cancer Res. 2006, 66, 6908-6912 10.1158/0008-5472.CAN-06-1581
-
(2006)
Cancer Res.
, vol.66
, pp. 6908-6912
-
-
Gomez, D.1
O'Donohue, M.F.2
Wenner, T.3
Douarre, C.4
Macadré, J.5
Koebel, P.6
Giraud-Panis, M.-J.7
Kaplan, H.8
Kolkes, A.9
Shin-Ya, K.10
Riou, J.-F.11
-
123
-
-
34547112050
-
Mechanism of acridine-based telomerase inhibition and telomere shortening
-
Gunaratnam, M.; Greciano, O.; Martins, C.; Reszka, A. P.; Schultes, C. M.; Morjani, H.; Riou, J.-F.; Neidle, S. Mechanism of acridine-based telomerase inhibition and telomere shortening Biochem. Pharmacol. 2007, 74, 679-689 10.1016/j.bcp.2007.06.011
-
(2007)
Biochem. Pharmacol.
, vol.74
, pp. 679-689
-
-
Gunaratnam, M.1
Greciano, O.2
Martins, C.3
Reszka, A.P.4
Schultes, C.M.5
Morjani, H.6
Riou, J.-F.7
Neidle, S.8
-
124
-
-
84929655374
-
The nickel(II) complex of guanidinium phenyl porphyrin, a specific G-quadruplex ligand, targets telomeres and leads to POT1 mislocalization in culture cells
-
Sabater, L.; Nicolau-Travers, M.-L.; De Rache, A.; Prado, E.; Dejeu, J.; Bombarde, O.; Lacroix, J.; Calsou, P.; Defrancq, E.; Mergny, J.-L.; Gomez, D.; Pratviel, G. The nickel(II) complex of guanidinium phenyl porphyrin, a specific G-quadruplex ligand, targets telomeres and leads to POT1 mislocalization in culture cells JBIC, J. Biol. Inorg. Chem. 2015, 20, 729-738 10.1007/s00775-015-1260-8
-
(2015)
JBIC, J. Biol. Inorg. Chem.
, vol.20
, pp. 729-738
-
-
Sabater, L.1
Nicolau-Travers, M.-L.2
De Rache, A.3
Prado, E.4
Dejeu, J.5
Bombarde, O.6
Lacroix, J.7
Calsou, P.8
Defrancq, E.9
Mergny, J.-L.10
Gomez, D.11
Pratviel, G.12
-
125
-
-
6944239985
-
Biological Activity of the G-quadruplex ligand RHPS4 (3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl] acridinium methosulfate) is associated with telomere capping alteration
-
Leonetti, C.; Amodei, S.; D'Angelo, C.; Rizzo, A.; Benassi, B.; Antonelli, A.; Elli, R.; Stevens, M. F. G.; D'Incalci, M.; Zupi, G.; Biroccio, A. Biological Activity of the G-quadruplex ligand RHPS4 (3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl] acridinium methosulfate) is associated with telomere capping alteration Mol. Pharmacol. 2004, 66, 1138-1146 10.1124/mol.104.001537
-
(2004)
Mol. Pharmacol.
, vol.66
, pp. 1138-1146
-
-
Leonetti, C.1
Amodei, S.2
D'Angelo, C.3
Rizzo, A.4
Benassi, B.5
Antonelli, A.6
Elli, R.7
Stevens, M.F.G.8
D'Incalci, M.9
Zupi, G.10
Biroccio, A.11
-
126
-
-
45849099050
-
Living on a break: Cellular senescence as a DNA-damage response
-
d'Adda di Fagagna, F. Living on a break: cellular senescence as a DNA-damage response Nat. Rev. Cancer 2008, 8, 512-522 10.1038/nrc2440
-
(2008)
Nat. Rev. Cancer
, vol.8
, pp. 512-522
-
-
D'Adda di Fagagna, F.1
-
127
-
-
56749151077
-
A novel small molecule that alters shelterin integrity and triggers a DNA-damage response at telomeres
-
Rodriguez, R.; Müller, S.; Yeoman, J. A.; Trentesaux, C.; Riou, J.-F.; Balasubramanian, S. A novel small molecule that alters shelterin integrity and triggers a DNA-damage response at telomeres J. Am. Chem. Soc. 2008, 130, 15758-15759 10.1021/ja805615w
-
(2008)
J. Am. Chem. Soc.
, vol.130
, pp. 15758-15759
-
-
Rodriguez, R.1
Müller, S.2
Yeoman, J.A.3
Trentesaux, C.4
Riou, J.-F.5
Balasubramanian, S.6
-
128
-
-
36049045013
-
Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect
-
Salvati, E.; Leonetti, C.; Rizzo, A.; Scarsella, M.; Mottolese, M.; Galati, R.; Sperduti, I.; Stevens, M. F. G.; D'Incalci, M.; Blasco, M.; Chiorino, G.; Bauwens, S.; Horard, B.; Gilson, E.; Stoppacciaro, A.; Zupi, G.; Biroccio, A. Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect J. Clin. Invest. 2007, 117, 3236-3247 10.1172/JCI32461
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 3236-3247
-
-
Salvati, E.1
Leonetti, C.2
Rizzo, A.3
Scarsella, M.4
Mottolese, M.5
Galati, R.6
Sperduti, I.7
Stevens, M.F.G.8
D'Incalci, M.9
Blasco, M.10
Chiorino, G.11
Bauwens, S.12
Horard, B.13
Gilson, E.14
Stoppacciaro, A.15
Zupi, G.16
Biroccio, A.17
-
129
-
-
70449725230
-
Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway
-
Rizzo, A.; Salvati, E.; Porru, M.; D'Angelo, C.; Stevens, M. F.; D'Incalci, M.; Leonetti, C.; Gilson, E.; Zupi, G.; Biroccio, A. Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway Nucleic Acids Res. 2009, 37, 5353-5364 10.1093/nar/gkp582
-
(2009)
Nucleic Acids Res.
, vol.37
, pp. 5353-5364
-
-
Rizzo, A.1
Salvati, E.2
Porru, M.3
D'Angelo, C.4
Stevens, M.F.5
D'Incalci, M.6
Leonetti, C.7
Gilson, E.8
Zupi, G.9
Biroccio, A.10
-
130
-
-
78649507645
-
PARP1 is activated at telomeres upon G4 stabilization: Possible target for telomere-based therapy
-
Salvati, E.; Scarsella, M.; Porru, M.; Rizzo, A.; Iachettini, S.; Tentori, L.; Graziani, G.; D'Incalci, M.; Stevens, M. F. G.; Orlandi, A.; Passeri, D.; Gilson, E.; Zupi, G.; Leonetti, C.; Biroccio, A. PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy Oncogene 2010, 29, 6280-6293 10.1038/onc.2010.344
-
(2010)
Oncogene
, vol.29
, pp. 6280-6293
-
-
Salvati, E.1
Scarsella, M.2
Porru, M.3
Rizzo, A.4
Iachettini, S.5
Tentori, L.6
Graziani, G.7
D'Incalci, M.8
Stevens, M.F.G.9
Orlandi, A.10
Passeri, D.11
Gilson, E.12
Zupi, G.13
Leonetti, C.14
Biroccio, A.15
-
131
-
-
0041353443
-
Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: Involvement of ATM-dependent DNA damage response pathways
-
Tauchi, T.; Shin-ya, K.; Sashida, G.; Sumi, M.; Nakajima, A.; Shimamoto, T.; Ohyashiki, J. H.; Ohyashiki, K. Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: involvement of ATM-dependent DNA damage response pathways Oncogene 2003, 22, 5338-5347 10.1038/sj.onc.1206833
-
(2003)
Oncogene
, vol.22
, pp. 5338-5347
-
-
Tauchi, T.1
Shin-Ya, K.2
Sashida, G.3
Sumi, M.4
Nakajima, A.5
Shimamoto, T.6
Ohyashiki, J.H.7
Ohyashiki, K.8
-
132
-
-
84857163904
-
Small-molecule-induced DNA damage identifies alternative DNA structures in human genes
-
Rodriguez, R.; Miller, K. M.; Forment, J. V.; Bradshaw, C. R.; Nikan, M.; Britton, S.; Oelschlaegel, T.; Xhemalce, B.; Balasubramanian, S.; Jackson, S. P. Small-molecule-induced DNA damage identifies alternative DNA structures in human genes Nat. Chem. Biol. 2012, 8, 301-310 10.1038/nchembio.780
-
(2012)
Nat. Chem. Biol.
, vol.8
, pp. 301-310
-
-
Rodriguez, R.1
Miller, K.M.2
Forment, J.V.3
Bradshaw, C.R.4
Nikan, M.5
Britton, S.6
Oelschlaegel, T.7
Xhemalce, B.8
Balasubramanian, S.9
Jackson, S.P.10
-
133
-
-
84864447477
-
Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells
-
Müller, S.; Sanders, D. A.; Di Antonio, M.; Matsis, S.; Riou, J.-F.; Rodriguez, R.; Balasubramanian, S. Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells Org. Biomol. Chem. 2012, 10, 6537-6546 10.1039/c2ob25830g
-
(2012)
Org. Biomol. Chem.
, vol.10
, pp. 6537-6546
-
-
Müller, S.1
Sanders, D.A.2
Di Antonio, M.3
Matsis, S.4
Riou, J.-F.5
Rodriguez, R.6
Balasubramanian, S.7
-
134
-
-
84904741550
-
Cancer-specific defects in DNA repair pathways as targets for personalized therapeutic approaches
-
Dietlein, F.; Thelen, L.; Reinhardt, H. C. Cancer-specific defects in DNA repair pathways as targets for personalized therapeutic approaches Trends Genet. 2014, 30, 326-339 10.1016/j.tig.2014.06.003
-
(2014)
Trends Genet.
, vol.30
, pp. 326-339
-
-
Dietlein, F.1
Thelen, L.2
Reinhardt, H.C.3
-
135
-
-
84860854071
-
RTEL1 dismantles T loops and counteracts telomeric G4-DNA to maintain telomere integrity
-
Vannier, J.-B.; Pavicic-Kaltenbrunner, V.; Petalcorin, M. I.; Ding, H.; Boulton, S. J. RTEL1 dismantles T loops and counteracts telomeric G4-DNA to maintain telomere integrity Cell 2012, 149, 795-806 10.1016/j.cell.2012.03.030
-
(2012)
Cell
, vol.149
, pp. 795-806
-
-
Vannier, J.-B.1
Pavicic-Kaltenbrunner, V.2
Petalcorin, M.I.3
Ding, H.4
Boulton, S.J.5
-
136
-
-
84959327297
-
Guanine quadruplex structures localize to heterochromatin
-
Hoffmann, R. F.; Moshkin, Y. M.; Mouton, S.; Grzeschik, N. A.; Kalicharan, R. D.; Kuipers, J.; Wolters, A. H.; Nishida, K.; Romashchenko, A. V.; Postberg, J.; Lipps, H.; Berezikov, E.; Sibon, O. C.; Giepmans, B. N.; Lansdorp, P. M. Guanine quadruplex structures localize to heterochromatin Nucleic Acids Res. 2016, 44, 152 10.1093/nar/gkv900
-
(2016)
Nucleic Acids Res.
, vol.44
, pp. 152
-
-
Hoffmann, R.F.1
Moshkin, Y.M.2
Mouton, S.3
Grzeschik, N.A.4
Kalicharan, R.D.5
Kuipers, J.6
Wolters, A.H.7
Nishida, K.8
Romashchenko, A.V.9
Postberg, J.10
Lipps, H.11
Berezikov, E.12
Sibon, O.C.13
Giepmans, B.N.14
Lansdorp, P.M.15
-
137
-
-
0026541582
-
Retinoblastoma susceptibility genes contain 5′ sequences with a high propensity to form guanine-tetrad structures
-
Murchie, A. I.; Lilley, D. M. Retinoblastoma susceptibility genes contain 5′ sequences with a high propensity to form guanine-tetrad structures Nucleic Acids Res. 1992, 20, 49-53 10.1093/nar/20.1.49
-
(1992)
Nucleic Acids Res.
, vol.20
, pp. 49-53
-
-
Murchie, A.I.1
Lilley, D.M.2
-
138
-
-
0030872683
-
Temperature and salt dependence of higher order structure formation by antisense c-myc and c-myb phosphorothioate oligodeoxyribonucleotides containing tetraguanylate tracts
-
Basu, S.; Wickstrom, E. Temperature and salt dependence of higher order structure formation by antisense c-myc and c-myb phosphorothioate oligodeoxyribonucleotides containing tetraguanylate tracts Nucleic Acids Res. 1997, 25, 1327-1332 10.1093/nar/25.7.1327
-
(1997)
Nucleic Acids Res.
, vol.25
, pp. 1327-1332
-
-
Basu, S.1
Wickstrom, E.2
-
139
-
-
0032030327
-
DNA tetraplex formation in the control region of c-myc
-
Simonsson, T.; Pecinka, P.; Kubista, M. DNA tetraplex formation in the control region of c-myc Nucleic Acids Res. 1998, 26, 1167-1172 10.1093/nar/26.5.1167
-
(1998)
Nucleic Acids Res.
, vol.26
, pp. 1167-1172
-
-
Simonsson, T.1
Pecinka, P.2
Kubista, M.3
-
140
-
-
0037015078
-
Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription
-
Siddiqui-Jain, A.; Grand, C. L.; Bearss, D. J.; Hurley, L. H. Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription Proc. Natl. Acad. Sci. U. S. A. 2002, 99, 11593-11598 10.1073/pnas.182256799
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 11593-11598
-
-
Siddiqui-Jain, A.1
Grand, C.L.2
Bearss, D.J.3
Hurley, L.H.4
-
141
-
-
79953313413
-
Targeting G-quadruplexes in gene promoters: A novel anticancer strategy?
-
Balasubramanian, S.; Hurley, L. H.; Neidle, S. Targeting G-quadruplexes in gene promoters: a novel anticancer strategy? Nat. Rev. Drug Discovery 2011, 10, 261-275 10.1038/nrd3428
-
(2011)
Nat. Rev. Drug Discovery
, vol.10
, pp. 261-275
-
-
Balasubramanian, S.1
Hurley, L.H.2
Neidle, S.3
-
142
-
-
33846928449
-
G-quadruplexes in promoters throughout the human genome
-
Huppert, J. L.; Balasubramanian, S. G-quadruplexes in promoters throughout the human genome Nucleic Acids Res. 2007, 35, 406-413 10.1093/nar/gkl1057
-
(2007)
Nucleic Acids Res.
, vol.35
, pp. 406-413
-
-
Huppert, J.L.1
Balasubramanian, S.2
-
143
-
-
40249084264
-
Conserved elements with potential to form polymorphic G-quadruplex structures in the first intron of human genes
-
Eddy, J.; Maizels, N. Conserved elements with potential to form polymorphic G-quadruplex structures in the first intron of human genes Nucleic Acids Res. 2008, 36, 1321-1333 10.1093/nar/gkm1138
-
(2008)
Nucleic Acids Res.
, vol.36
, pp. 1321-1333
-
-
Eddy, J.1
Maizels, N.2
-
144
-
-
73349127073
-
Genome-wide colonization of gene regulatory elements by G4 DNA motifs
-
Du, Z.; Zhao, Y.; Li, N. Genome-wide colonization of gene regulatory elements by G4 DNA motifs Nucleic Acids Res. 2009, 37, 6784-6798 10.1093/nar/gkp710
-
(2009)
Nucleic Acids Res.
, vol.37
, pp. 6784-6798
-
-
Du, Z.1
Zhao, Y.2
Li, N.3
-
145
-
-
84871728994
-
Genome-wide study predicts promoter-G4 DNA motifs regulate selective functions in bacteria: Radioresistance of D. Radiodurans involves G4 DNA-mediated regulation
-
Beaume, N.; Pathak, R.; Yadav, V. K.; Kota, S.; Misra, H. S.; Gautam, H. K.; Chowdhury, S. Genome-wide study predicts promoter-G4 DNA motifs regulate selective functions in bacteria: radioresistance of D. radiodurans involves G4 DNA-mediated regulation Nucleic Acids Res. 2013, 41, 76-89 10.1093/nar/gks1071
-
(2013)
Nucleic Acids Res.
, vol.41
, pp. 76-89
-
-
Beaume, N.1
Pathak, R.2
Yadav, V.K.3
Kota, S.4
Misra, H.S.5
Gautam, H.K.6
Chowdhury, S.7
-
146
-
-
33750990787
-
NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region
-
Dai, J.; Chen, D.; Jones, R. A.; Hurley, L. H.; Yang, D. NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region Nucleic Acids Res. 2006, 34, 5133-5144 10.1093/nar/gkl610
-
(2006)
Nucleic Acids Res.
, vol.34
, pp. 5133-5144
-
-
Dai, J.1
Chen, D.2
Jones, R.A.3
Hurley, L.H.4
Yang, D.5
-
147
-
-
80052532707
-
G4-DNA formation in the HRAS promoter and rational design of decoy oligonucleotides for cancer therapy
-
Membrino, A.; Cogoi, S.; Pedersen, E. B.; Xodo, L. E. G4-DNA formation in the HRAS promoter and rational design of decoy oligonucleotides for cancer therapy PLoS One 2011, 6, e24421 10.1371/journal.pone.0024421
-
(2011)
PLoS One
, vol.6
, pp. e24421
-
-
Membrino, A.1
Cogoi, S.2
Pedersen, E.B.3
Xodo, L.E.4
-
148
-
-
46349107530
-
Structural polymorphism within a regulatory element of the human KRAS promoter: Formation of G4-DNA recognized by nuclear proteins
-
Cogoi, S.; Paramasivam, M.; Spolaore, B.; Xodo, L. E. Structural polymorphism within a regulatory element of the human KRAS promoter: formation of G4-DNA recognized by nuclear proteins Nucleic Acids Res. 2008, 36, 3765-3780 10.1093/nar/gkn120
-
(2008)
Nucleic Acids Res.
, vol.36
, pp. 3765-3780
-
-
Cogoi, S.1
Paramasivam, M.2
Spolaore, B.3
Xodo, L.E.4
-
149
-
-
23044485047
-
Putative DNA quadruplex formation within the human c-kit oncogene
-
Rankin, S.; Reszka, A. P.; Huppert, J.; Zloh, M.; Parkinson, G. N.; Todd, A. K.; Ladame, S.; Balasubramanian, S.; Neidle, S. Putative DNA quadruplex formation within the human c-kit oncogene J. Am. Chem. Soc. 2005, 127, 10584-10589 10.1021/ja050823u
-
(2005)
J. Am. Chem. Soc.
, vol.127
, pp. 10584-10589
-
-
Rankin, S.1
Reszka, A.P.2
Huppert, J.3
Zloh, M.4
Parkinson, G.N.5
Todd, A.K.6
Ladame, S.7
Balasubramanian, S.8
Neidle, S.9
-
150
-
-
33746908213
-
A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene
-
Fernando, H.; Reszka, A. P.; Huppert, J.; Ladame, S.; Rankin, S.; Venkitaraman, A. R.; Neidle, S.; Balasubramanian, S. A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene Biochemistry 2006, 45, 7854-7860 10.1021/bi0601510
-
(2006)
Biochemistry
, vol.45
, pp. 7854-7860
-
-
Fernando, H.1
Reszka, A.P.2
Huppert, J.3
Ladame, S.4
Rankin, S.5
Venkitaraman, A.R.6
Neidle, S.7
Balasubramanian, S.8
-
151
-
-
28944442742
-
Evidence for the presence of a guanine quadruplex forming region within a polypurine tract of the hypoxia inducible factor 1α promoter
-
De Armond, R.; Wood, S.; Sun, D.; Hurley, L. H.; Ebbinghaus, S. W. Evidence for the presence of a guanine quadruplex forming region within a polypurine tract of the hypoxia inducible factor 1α promoter Biochemistry 2005, 44, 16341-16350 10.1021/bi051618u
-
(2005)
Biochemistry
, vol.44
, pp. 16341-16350
-
-
De Armond, R.1
Wood, S.2
Sun, D.3
Hurley, L.H.4
Ebbinghaus, S.W.5
-
152
-
-
84865527719
-
A novel series of G-quadruplex ligands with selectivity for HIF-expressing osteosarcoma and renal cancer cell lines
-
Lombardo, C. M.; Welsh, S. J.; Strauss, S. J.; Dale, A. G.; Todd, A. K.; Nanjunda, R.; Wilson, W. D.; Neidle, S. A novel series of G-quadruplex ligands with selectivity for HIF-expressing osteosarcoma and renal cancer cell lines Bioorg. Med. Chem. Lett. 2012, 22, 5984-5988 10.1016/j.bmcl.2012.07.009
-
(2012)
Bioorg. Med. Chem. Lett.
, vol.22
, pp. 5984-5988
-
-
Lombardo, C.M.1
Welsh, S.J.2
Strauss, S.J.3
Dale, A.G.4
Todd, A.K.5
Nanjunda, R.6
Wilson, W.D.7
Neidle, S.8
-
153
-
-
84891287672
-
Crystal structure of a promoter sequence in the B-raf gene reveals an intertwined dimer quadruplex
-
Wei, D.; Todd, A. K.; Zloh, M.; Gunaratnam, M.; Parkinson, G. N.; Neidle, S. Crystal structure of a promoter sequence in the B-raf gene reveals an intertwined dimer quadruplex J. Am. Chem. Soc. 2013, 135, 19319-19329 10.1021/ja4101358
-
(2013)
J. Am. Chem. Soc.
, vol.135
, pp. 19319-19329
-
-
Wei, D.1
Todd, A.K.2
Zloh, M.3
Gunaratnam, M.4
Parkinson, G.N.5
Neidle, S.6
-
154
-
-
84937634820
-
Double stranded promoter region of BRAF undergoes to structural rearrangement in nearly physiological conditions
-
Greco, M. L.; Folini, M.; Sissi, C. Double stranded promoter region of BRAF undergoes to structural rearrangement in nearly physiological conditions FEBS Lett. 2015, 589, 2117-2123 10.1016/j.febslet.2015.06.025
-
(2015)
FEBS Lett.
, vol.589
, pp. 2117-2123
-
-
Greco, M.L.1
Folini, M.2
Sissi, C.3
-
155
-
-
84874432663
-
Downregulation of androgen receptor transcription by promoter G-quadruplex stabilization as a potential alternative treatment for castrate-resistant prostate cancer
-
Mitchell, T.; Ramos-Montoya, A.; Di Antonio, M.; Murat, P.; Ohnmacht, S.; Micco, M.; Jurmeister, S.; Fryer, L.; Balasubramanian, S.; Neidle, S.; Neal, D. E. Downregulation of androgen receptor transcription by promoter G-quadruplex stabilization as a potential alternative treatment for castrate-resistant prostate cancer Biochemistry 2013, 52, 1429-1436 10.1021/bi301349c
-
(2013)
Biochemistry
, vol.52
, pp. 1429-1436
-
-
Mitchell, T.1
Ramos-Montoya, A.2
Di Antonio, M.3
Murat, P.4
Ohnmacht, S.5
Micco, M.6
Jurmeister, S.7
Fryer, L.8
Balasubramanian, S.9
Neidle, S.10
Neal, D.E.11
-
156
-
-
34548183518
-
Formation of pseudosymmetrical G-quadruplex and i-motif structures in the proximal promoter region of the RET oncogene
-
Guo, K.; Pourpak, A.; Beetz-Rogers, K.; Gokhale, V.; Sun, D.; Hurley, L. H. Formation of pseudosymmetrical G-quadruplex and i-motif structures in the proximal promoter region of the RET oncogene J. Am. Chem. Soc. 2007, 129, 10220-10228 10.1021/ja072185g
-
(2007)
J. Am. Chem. Soc.
, vol.129
, pp. 10220-10228
-
-
Guo, K.1
Pourpak, A.2
Beetz-Rogers, K.3
Gokhale, V.4
Sun, D.5
Hurley, L.H.6
-
157
-
-
80055092362
-
Solution structure of all parallel G-quadruplex formed by the oncogene RET promoter sequence
-
Tong, X.; Lan, W.; Zhang, X.; Wu, H.; Liu, M.; Cao, C. Solution structure of all parallel G-quadruplex formed by the oncogene RET promoter sequence Nucleic Acids Res. 2011, 39, 6753-6763 10.1093/nar/gkr233
-
(2011)
Nucleic Acids Res.
, vol.39
, pp. 6753-6763
-
-
Tong, X.1
Lan, W.2
Zhang, X.3
Wu, H.4
Liu, M.5
Cao, C.6
-
158
-
-
84865469110
-
A sequence in the HSP90 promoter forms G-quadruplex structures with selectivity for phenyl bis-oxazole derivatives
-
Ohnmacht, S. A.; Micco, M.; Petrucci, V.; Todd, A. K.; Reszka, A. P.; Gunaratnam, M.; Carvalho, M. A.; Zloh, M.; Neidle, S. A sequence in the HSP90 promoter forms G-quadruplex structures with selectivity for phenyl bis-oxazole derivatives Bioorg. Med. Chem. Lett. 2012, 22, 5930-5935 10.1016/j.bmcl.2012.07.065
-
(2012)
Bioorg. Med. Chem. Lett.
, vol.22
, pp. 5930-5935
-
-
Ohnmacht, S.A.1
Micco, M.2
Petrucci, V.3
Todd, A.K.4
Reszka, A.P.5
Gunaratnam, M.6
Carvalho, M.A.7
Zloh, M.8
Neidle, S.9
-
159
-
-
84946177633
-
An intramolecular G-quadruplex structure formed in the human MET promoter region and its biological relevance
-
Yan, J.; Zhao, X.; Liu, B.; Yuan, Y.; Guan, Y. An intramolecular G-quadruplex structure formed in the human MET promoter region and its biological relevance Mol. Carcinog. 2015, 10.1002/mc.22330
-
(2015)
Mol. Carcinog.
-
-
Yan, J.1
Zhao, X.2
Liu, B.3
Yuan, Y.4
Guan, Y.5
-
161
-
-
43349085046
-
The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements
-
Todd, A. K.; Neidle, S. The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements Nucleic Acids Res. 2008, 36, 2700-2704 10.1093/nar/gkn078
-
(2008)
Nucleic Acids Res.
, vol.36
, pp. 2700-2704
-
-
Todd, A.K.1
Neidle, S.2
-
162
-
-
33746841845
-
Structure of the biologically relevant G-quadruplex in the c-MYC promoter
-
Yang, D.; Hurley, L. H. Structure of the biologically relevant G-quadruplex in the c-MYC promoter Nucleosides, Nucleotides Nucleic Acids 2006, 25, 951-968 10.1080/15257770600809913
-
(2006)
Nucleosides, Nucleotides Nucleic Acids
, vol.25
, pp. 951-968
-
-
Yang, D.1
Hurley, L.H.2
-
163
-
-
80455168261
-
C-MYC promoter G-quadruplex formed at the 5′-end of NHE III1 element: Insights into biological relevance and parallel-stranded G-quadruplex stability
-
Mathad, R. I.; Hatzakis, E.; Dai, J.; Yang, D. c-MYC promoter G-quadruplex formed at the 5′-end of NHE III1 element: insights into biological relevance and parallel-stranded G-quadruplex stability Nucleic Acids Res. 2011, 39, 9023-9033 10.1093/nar/gkr612
-
(2011)
Nucleic Acids Res.
, vol.39
, pp. 9023-9033
-
-
Mathad, R.I.1
Hatzakis, E.2
Dai, J.3
Yang, D.4
-
164
-
-
33644833219
-
Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter
-
Phan, A. T.; Kuryavyi, V.; Gaw, H. Y.; Patel, D. J. Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter Nat. Chem. Biol. 2005, 1, 167-173 10.1038/nchembio723
-
(2005)
Nat. Chem. Biol.
, vol.1
, pp. 167-173
-
-
Phan, A.T.1
Kuryavyi, V.2
Gaw, H.Y.3
Patel, D.J.4
-
165
-
-
84884524540
-
Frequency of TERT promoter mutations in human cancers
-
Vinagre, J.; Almeida, A.; Pópulo, H.; Batista, R.; Lyra, J.; Pinto, V.; Coelho, R.; Celestino, R.; Prazeres, H.; Lima, L.; Melo, M.; da Rocha, A. G.; Preto, A.; Castro, P.; Castro, L.; Pardal, F.; Lopes, J. M.; Santos, L. L.; Reis, R. M.; Cameselle-Teijeiro, J.; Sobrinho-Simões, M.; Lima, J.; Máximo, V.; Soares, P. Frequency of TERT promoter mutations in human cancers Nat. Commun. 2013, 4, 2185 10.1038/ncomms3185
-
(2013)
Nat. Commun.
, vol.4
, pp. 2185
-
-
Vinagre, J.1
Almeida, A.2
Pópulo, H.3
Batista, R.4
Lyra, J.5
Pinto, V.6
Coelho, R.7
Celestino, R.8
Prazeres, H.9
Lima, L.10
Melo, M.11
Da Rocha, A.G.12
Preto, A.13
Castro, P.14
Castro, L.15
Pardal, F.16
Lopes, J.M.17
Santos, L.L.18
Reis, R.M.19
Cameselle-Teijeiro, J.20
Sobrinho-Simões, M.21
Lima, J.22
Máximo, V.23
Soares, P.24
more..
-
166
-
-
77956252000
-
Coexistence of two distinct G-quadruplex conformations in the hTERT promoter
-
Lim, K. W.; Lacroix, L.; Yue, D. J.; Lim, J. K.; Lim, J. M.; Phan, A. T. Coexistence of two distinct G-quadruplex conformations in the hTERT promoter J. Am. Chem. Soc. 2010, 132, 12331-12342 10.1021/ja101252n
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 12331-12342
-
-
Lim, K.W.1
Lacroix, L.2
Yue, D.J.3
Lim, J.K.4
Lim, J.M.5
Phan, A.T.6
-
167
-
-
84919633073
-
An improved model for the hTERT promoter quadruplex
-
Chaires, J. B.; Trent, J. O.; Gray, R. D.; Dean, W. L.; Buscaglia, R.; Thomas, S. D.; Miller, D. M. An improved model for the hTERT promoter quadruplex PLoS One 2014, 9, e115580 10.1371/journal.pone.0115580
-
(2014)
PLoS One
, vol.9
, pp. e115580
-
-
Chaires, J.B.1
Trent, J.O.2
Gray, R.D.3
Dean, W.L.4
Buscaglia, R.5
Thomas, S.D.6
Miller, D.M.7
-
168
-
-
77953211752
-
Turning off transcription of the bcl-2 gene by stabilizing the bcl-2 promoter quadruplex with quindoline derivatives
-
Wang, X.-D.; Ou, T.-M.; Lu, Y.-J.; Li, Z.; Xu, Z.; Xi, C.; Tan, J.-H.; Huang, S.-L.; An, L.-K.; Li, D.; Gu, L.-Q.; Huang, Z.-S. Turning off transcription of the bcl-2 gene by stabilizing the bcl-2 promoter quadruplex with quindoline derivatives J. Med. Chem. 2010, 53, 4390-4398 10.1021/jm100445e
-
(2010)
J. Med. Chem.
, vol.53
, pp. 4390-4398
-
-
Wang, X.-D.1
Ou, T.-M.2
Lu, Y.-J.3
Li, Z.4
Xu, Z.5
Xi, C.6
Tan, J.-H.7
Huang, S.-L.8
An, L.-K.9
Li, D.10
Gu, L.-Q.11
Huang, Z.-S.12
-
169
-
-
84876215753
-
Structure-based design and evaluation of naphthalene diimide G-quadruplex ligands as telomere targeting agents in pancreatic cancer cells
-
Micco, M.; Collie, G. W.; Dale, A. G.; Ohnmacht, S. A.; Pazitna, I.; Gunaratnam, M.; Reszka, A. P.; Neidle, S. Structure-based design and evaluation of naphthalene diimide G-quadruplex ligands as telomere targeting agents in pancreatic cancer cells J. Med. Chem. 2013, 56, 2959-2974 10.1021/jm301899y
-
(2013)
J. Med. Chem.
, vol.56
, pp. 2959-2974
-
-
Micco, M.1
Collie, G.W.2
Dale, A.G.3
Ohnmacht, S.A.4
Pazitna, I.5
Gunaratnam, M.6
Reszka, A.P.7
Neidle, S.8
-
170
-
-
84935920509
-
A G-quadruplex-binding compound showing anti-tumour activity in an in vivo model for pancreatic cancer
-
Ohnmacht, S. A.; Marchetti, C.; Gunaratnam, M.; Besser, R. J.; Haider, S. M.; Di Vita, G.; Lowe, H. L.; Mellinas-Gomez, M.; Diocou, S.; Robson, M.; Šponer, J.; Islam, B.; Pedley, R. B.; Hartley, J. A.; Neidle, S. A G-quadruplex-binding compound showing anti-tumour activity in an in vivo model for pancreatic cancer Sci. Rep. 2015, 5, 11385 10.1038/srep11385
-
(2015)
Sci. Rep.
, vol.5
, pp. 11385
-
-
Ohnmacht, S.A.1
Marchetti, C.2
Gunaratnam, M.3
Besser, R.J.4
Haider, S.M.5
Di Vita, G.6
Lowe, H.L.7
Mellinas-Gomez, M.8
Diocou, S.9
Robson, M.10
Šponer, J.11
Islam, B.12
Pedley, R.B.13
Hartley, J.A.14
Neidle, S.15
-
171
-
-
84917710619
-
Assessment of gene promoter G-quadruplex binding and modulation by a naphthalene diimide derivative in tumor cells
-
Nadai, M.; Cimino-Reale, G.; Sattin, G.; Doria, F.; Butovskaya, E.; Zaffaroni, N.; Freccero, M.; Palumbo, M.; Richter, S. N.; Folini, M. Assessment of gene promoter G-quadruplex binding and modulation by a naphthalene diimide derivative in tumor cells Int. J. Oncol. 2015, 46, 369-380 10.3892/ijo.2014.2723
-
(2015)
Int. J. Oncol.
, vol.46
, pp. 369-380
-
-
Nadai, M.1
Cimino-Reale, G.2
Sattin, G.3
Doria, F.4
Butovskaya, E.5
Zaffaroni, N.6
Freccero, M.7
Palumbo, M.8
Richter, S.N.9
Folini, M.10
-
172
-
-
77958092097
-
Targeting the c-Kit promoter quadruplexes with 6-substituted indenoisoquinolines, a novel class of G-quadruplex stabilising small molecule ligands
-
Bejugam, M.; Gunaratnam, M.; Müller, S.; Sanders, D. A.; Sewitz, S.; Fletcher, J.; Neidle, S.; Balasubramanian, S. Targeting the c-Kit promoter quadruplexes with 6-substituted indenoisoquinolines, a novel class of G-quadruplex stabilising small molecule ligands ACS Med. Chem. Lett. 2010, 1, 306-310 10.1021/ml100062z
-
(2010)
ACS Med. Chem. Lett.
, vol.1
, pp. 306-310
-
-
Bejugam, M.1
Gunaratnam, M.2
Müller, S.3
Sanders, D.A.4
Sewitz, S.5
Fletcher, J.6
Neidle, S.7
Balasubramanian, S.8
-
173
-
-
35848942604
-
Trisubstituted isoalloxazines as a new class of G-quadruplex binding ligands: Small molecule regulation of c-kit oncogene expression
-
Bejugam, M.; Sewitz, S.; Shirude, P. S.; Rodriguez, R.; Shahid, R.; Balasubramanian, S. Trisubstituted isoalloxazines as a new class of G-quadruplex binding ligands: small molecule regulation of c-kit oncogene expression J. Am. Chem. Soc. 2007, 129, 12926-12927 10.1021/ja075881p
-
(2007)
J. Am. Chem. Soc.
, vol.129
, pp. 12926-12927
-
-
Bejugam, M.1
Sewitz, S.2
Shirude, P.S.3
Rodriguez, R.4
Shahid, R.5
Balasubramanian, S.6
-
174
-
-
79952253500
-
G-quadruplex-binding benzo[a]phenoxazines down-regulate c-KIT expression in human gastric carcinoma cells
-
McLuckie, K. I.; Waller, Z. A.; Sanders, D. A.; Alves, D.; Rodriguez, R.; Dash, J.; McKenzie, G. J.; Venkitaraman, A. R.; Balasubramanian, S. G-quadruplex-binding benzo[a]phenoxazines down-regulate c-KIT expression in human gastric carcinoma cells J. Am. Chem. Soc. 2011, 133, 2658-2663 10.1021/ja109474c
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 2658-2663
-
-
McLuckie, K.I.1
Waller, Z.A.2
Sanders, D.A.3
Alves, D.4
Rodriguez, R.5
Dash, J.6
McKenzie, G.J.7
Venkitaraman, A.R.8
Balasubramanian, S.9
-
175
-
-
79952763614
-
Targeting MYC expression through G-quadruplexes
-
Brooks, T. A.; Hurley, L. H. Targeting MYC expression through G-quadruplexes Genes Cancer 2010, 1, 641-649 10.1177/1947601910377493
-
(2010)
Genes Cancer
, vol.1
, pp. 641-649
-
-
Brooks, T.A.1
Hurley, L.H.2
-
176
-
-
84896496345
-
The dynamic character of the BCL2 promoter i-motif provides a mechanism for modulation of gene expression by compounds that bind selectively to the alternative DNA hairpin structure
-
Kendrick, S.; Kang, H. J.; Alam, M. P.; Madathil, M. M.; Agrawal, P.; Gokhale, V.; Yang, D.; Hecht, S. M.; Hurley, L. H. The dynamic character of the BCL2 promoter i-motif provides a mechanism for modulation of gene expression by compounds that bind selectively to the alternative DNA hairpin structure J. Am. Chem. Soc. 2014, 136, 4161-4171 10.1021/ja410934b
-
(2014)
J. Am. Chem. Soc.
, vol.136
, pp. 4161-4171
-
-
Kendrick, S.1
Kang, H.J.2
Alam, M.P.3
Madathil, M.M.4
Agrawal, P.5
Gokhale, V.6
Yang, D.7
Hecht, S.M.8
Hurley, L.H.9
-
177
-
-
84896516232
-
The transcriptional complex between the BCL2 i-motif and hnRNP LL is a molecular switch for control of gene expression that can be modulated by small molecules
-
Kang, H. J.; Kendrick, S.; Hecht, S. M.; Hurley, L. H. The transcriptional complex between the BCL2 i-motif and hnRNP LL is a molecular switch for control of gene expression that can be modulated by small molecules J. Am. Chem. Soc. 2014, 136, 4172-4185 10.1021/ja4109352
-
(2014)
J. Am. Chem. Soc.
, vol.136
, pp. 4172-4185
-
-
Kang, H.J.1
Kendrick, S.2
Hecht, S.M.3
Hurley, L.H.4
-
178
-
-
84863814733
-
Anticancer activity and cellular repression of c-MYC by the G-quadruplex-stabilizing 11-piperazinylquindoline is not dependent on direct targeting of the G-quadruplex in the c-MYC promoter
-
Boddupally, P. V.; Hahn, S.; Beman, C.; De, B.; Brooks, T. A.; Gokhale, V.; Hurley, L. H. Anticancer activity and cellular repression of c-MYC by the G-quadruplex-stabilizing 11-piperazinylquindoline is not dependent on direct targeting of the G-quadruplex in the c-MYC promoter J. Med. Chem. 2012, 55, 6076-6086 10.1021/jm300282c
-
(2012)
J. Med. Chem.
, vol.55
, pp. 6076-6086
-
-
Boddupally, P.V.1
Hahn, S.2
Beman, C.3
De, B.4
Brooks, T.A.5
Gokhale, V.6
Hurley, L.H.7
-
179
-
-
81755172447
-
Demonstration that drug-targeted down-regulation of MYC in non-Hodgkins lymphoma is directly mediated through the promoter G-quadruplex
-
Brown, R. V.; Danford, F. L.; Gokhale, V.; Hurley, L. H.; Brooks, T. A. Demonstration that drug-targeted down-regulation of MYC in non-Hodgkins lymphoma is directly mediated through the promoter G-quadruplex J. Biol. Chem. 2011, 286, 41018-41027 10.1074/jbc.M111.274720
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 41018-41027
-
-
Brown, R.V.1
Danford, F.L.2
Gokhale, V.3
Hurley, L.H.4
Brooks, T.A.5
-
180
-
-
79952763614
-
The role of supercoiling in transcriptional control of MYC and its importance in molecular therapeutics
-
Brooks, T. A.; Hurley, L. H. The role of supercoiling in transcriptional control of MYC and its importance in molecular therapeutics Genes Cancer 2010, 1, 641-649 10.1177/1947601910377493
-
(2010)
Genes Cancer
, vol.1
, pp. 641-649
-
-
Brooks, T.A.1
Hurley, L.H.2
-
181
-
-
84927944758
-
KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines
-
Lavrado, J.; Brito, H.; Borralho, P. M.; Ohnmacht, S. A.; Kim, N. S.; Leitão, C.; Pisco, S.; Gunaratnam, M.; Rodrigues, C. M.; Moreira, R.; Neidle, S.; Paulo, A. KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines Sci. Rep. 2015, 5, 9696 10.1038/srep09696
-
(2015)
Sci. Rep.
, vol.5
, pp. 9696
-
-
Lavrado, J.1
Brito, H.2
Borralho, P.M.3
Ohnmacht, S.A.4
Kim, N.S.5
Leitão, C.6
Pisco, S.7
Gunaratnam, M.8
Rodrigues, C.M.9
Moreira, R.10
Neidle, S.11
Paulo, A.12
-
182
-
-
0035553175
-
Design and synthesis of fluoroquinophenoxazines that interact with human telomeric G-quadruplexes and their biological effects
-
Duan, W.; Rangan, A.; Vankayalapati, H.; Kim, M. Y.; Zeng, Q.; Sun, D.; Han, H.; Fedoroff, O. Y.; Nishioka, D.; Rha, S. Y.; Izbicka, E.; Von Hoff, D. D.; Hurley, L. H. Design and synthesis of fluoroquinophenoxazines that interact with human telomeric G-quadruplexes and their biological effects Mol. Cancer Ther. 2001, 1, 103-120
-
(2001)
Mol. Cancer Ther.
, vol.1
, pp. 103-120
-
-
Duan, W.1
Rangan, A.2
Vankayalapati, H.3
Kim, M.Y.4
Zeng, Q.5
Sun, D.6
Han, H.7
Fedoroff, O.Y.8
Nishioka, D.9
Rha, S.Y.10
Izbicka, E.11
Von Hoff, D.D.12
Hurley, L.H.13
-
183
-
-
70350220557
-
Anticancer activity of CX-3543: A direct inhibitor of rRNA biogenesis
-
Drygin, D.; Siddiqui-Jain, A.; O'Brien, S.; Schwaebe, M.; Lin, A.; Bliesath, J.; Ho, C. B.; Proffitt, C.; Trent, K.; Whitten, J. P.; Lim, J. K.; Von Hoff, D.; Anderes, K.; Rice, W. G. Anticancer activity of CX-3543: a direct inhibitor of rRNA biogenesis Cancer Res. 2009, 69, 7653-7661 10.1158/0008-5472.CAN-09-1304
-
(2009)
Cancer Res.
, vol.69
, pp. 7653-7661
-
-
Drygin, D.1
Siddiqui-Jain, A.2
O'Brien, S.3
Schwaebe, M.4
Lin, A.5
Bliesath, J.6
Ho, C.B.7
Proffitt, C.8
Trent, K.9
Whitten, J.P.10
Lim, J.K.11
Von Hoff, D.12
Anderes, K.13
Rice, W.G.14
-
184
-
-
34447541999
-
RNA quadruplex-based modulation of gene expression
-
Wieland, M.; Hartig, J. S. RNA quadruplex-based modulation of gene expression Chem. Biol. 2007, 14, 757-763 10.1016/j.chembiol.2007.06.005
-
(2007)
Chem. Biol.
, vol.14
, pp. 757-763
-
-
Wieland, M.1
Hartig, J.S.2
-
185
-
-
69949186768
-
A comparison of DNA and RNA quadruplex structures and stabilities
-
Joachimi, A.; Benz, A.; Hartig, J. S. A comparison of DNA and RNA quadruplex structures and stabilities Bioorg. Med. Chem. 2009, 17, 6811-6815 10.1016/j.bmc.2009.08.043
-
(2009)
Bioorg. Med. Chem.
, vol.17
, pp. 6811-6815
-
-
Joachimi, A.1
Benz, A.2
Hartig, J.S.3
-
186
-
-
76349116980
-
Human telomeric G-quadruplex: Thermodynamic and kinetic studies of telomeric quadruplex stability
-
Chaires, J. B. Human telomeric G-quadruplex: thermodynamic and kinetic studies of telomeric quadruplex stability FEBS J. 2010, 277, 1098-1106 10.1111/j.1742-4658.2009.07462.x
-
(2010)
FEBS J.
, vol.277
, pp. 1098-1106
-
-
Chaires, J.B.1
-
187
-
-
84891123068
-
Noncanonical structures and their thermodynamics of DNA and RNA under molecular crowding: Beyond the Watson-Crick double helix
-
Sugimoto, N. Noncanonical structures and their thermodynamics of DNA and RNA under molecular crowding: beyond the Watson-Crick double helix Int. Rev. Cell Mol. Biol. 2014, 307, 205-273 10.1016/B978-0-12-800046-5.00008-4
-
(2014)
Int. Rev. Cell Mol. Biol.
, vol.307
, pp. 205-273
-
-
Sugimoto, N.1
-
188
-
-
56049121180
-
G-quadruplexes: The beginning and end of UTRs
-
Huppert, J. L.; Bugaut, A.; Kumari, S.; Balasubramanian, S. G-quadruplexes: the beginning and end of UTRs Nucleic Acids Res. 2008, 36, 6260-6268 10.1093/nar/gkn511
-
(2008)
Nucleic Acids Res.
, vol.36
, pp. 6260-6268
-
-
Huppert, J.L.1
Bugaut, A.2
Kumari, S.3
Balasubramanian, S.4
-
189
-
-
84862229118
-
5′-UTR RNA G-quadruplexes: Translation regulation and targeting
-
Bugaut, A.; Balasubramanian, S. 5′-UTR RNA G-quadruplexes: translation regulation and targeting Nucleic Acids Res. 2012, 40, 4727-4741 10.1093/nar/gks068
-
(2012)
Nucleic Acids Res.
, vol.40
, pp. 4727-4741
-
-
Bugaut, A.1
Balasubramanian, S.2
-
190
-
-
77957061503
-
The BCL-2 5′ untranslated region contains an RNA G-quadruplex-forming motif that modulates protein expression
-
Shahid, R.; Bugaut, A.; Balasubramanian, S. The BCL-2 5′ untranslated region contains an RNA G-quadruplex-forming motif that modulates protein expression Biochemistry 2010, 49, 8300-8306 10.1021/bi100957h
-
(2010)
Biochemistry
, vol.49
, pp. 8300-8306
-
-
Shahid, R.1
Bugaut, A.2
Balasubramanian, S.3
-
191
-
-
33947310727
-
An RNA G-quadruplex in the 5′ UTR of the NRAS proto-oncogene modulates translation
-
Kumari, S.; Bugaut, A.; Huppert, J. L.; Balasubramanian, S. An RNA G-quadruplex in the 5′ UTR of the NRAS proto-oncogene modulates translation Nat. Chem. Biol. 2007, 3, 218-221 10.1038/nchembio864
-
(2007)
Nat. Chem. Biol.
, vol.3
, pp. 218-221
-
-
Kumari, S.1
Bugaut, A.2
Huppert, J.L.3
Balasubramanian, S.4
-
192
-
-
77956160477
-
Occurrence of a quadruplex motif in a unique insert within exon C of the bovine estrogen receptor alpha gene (ESR1)
-
Derecka, K.; Balkwill, G. D.; Garner, T. P.; Hodgman, C.; Flint, A. P.; Searle, M. S. Occurrence of a quadruplex motif in a unique insert within exon C of the bovine estrogen receptor alpha gene (ESR1) Biochemistry 2010, 49, 7625-7633 10.1021/bi100804f
-
(2010)
Biochemistry
, vol.49
, pp. 7625-7633
-
-
Derecka, K.1
Balkwill, G.D.2
Garner, T.P.3
Hodgman, C.4
Flint, A.P.5
Searle, M.S.6
-
193
-
-
67049134254
-
An unusually stable G-quadruplex within the 5′-UTR of the MT3 matrix metalloproteinase mRNA represses translation in eukaryotic cells
-
Morris, M. J.; Basu, S. An unusually stable G-quadruplex within the 5′-UTR of the MT3 matrix metalloproteinase mRNA represses translation in eukaryotic cells Biochemistry 2009, 48, 5313-5319 10.1021/bi900498z
-
(2009)
Biochemistry
, vol.48
, pp. 5313-5319
-
-
Morris, M.J.1
Basu, S.2
-
194
-
-
84874595270
-
The G-quadruplex augments translation in the 5′ untranslated region of transforming growth factor β2
-
Agarwala, P.; Pandey, S.; Mapa, K.; Maiti, S. The G-quadruplex augments translation in the 5′ untranslated region of transforming growth factor β2 Biochemistry 2013, 52, 1528-1538 10.1021/bi301365g
-
(2013)
Biochemistry
, vol.52
, pp. 1528-1538
-
-
Agarwala, P.1
Pandey, S.2
Mapa, K.3
Maiti, S.4
-
195
-
-
84907221438
-
RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer
-
Wolfe, A. L.; Singh, K.; Zhong, Y.; Drewe, P.; Rajasekhar, V. K.; Sanghvi, V. R.; Mavrakis, K. J.; Jiang, M.; Roderick, J. E.; Van der Meulen, J.; Schatz, J. H.; Rodrigo, C. M.; Zhao, C.; Rondou, P.; de Stanchina, E.; Teruya-Feldstein, J.; Kelliher, M. A.; Speleman, F.; Porco, J. A., Jr.; Pelletier, J.; Rätsch, G.; Wendel, H. G. RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer Nature 2014, 513, 65-70 10.1038/nature13485
-
(2014)
Nature
, vol.513
, pp. 65-70
-
-
Wolfe, A.L.1
Singh, K.2
Zhong, Y.3
Drewe, P.4
Rajasekhar, V.K.5
Sanghvi, V.R.6
Mavrakis, K.J.7
Jiang, M.8
Roderick, J.E.9
Van Der Meulen, J.10
Schatz, J.H.11
Rodrigo, C.M.12
Zhao, C.13
Rondou, P.14
De Stanchina, E.15
Teruya-Feldstein, J.16
Kelliher, M.A.17
Speleman, F.18
Porco, Jr.J.A.19
Pelletier, J.20
Rätsch, G.21
Wendel, H.G.22
more..
-
196
-
-
79960285267
-
Mapping the sequences of potential guanine quadruplex motifs
-
Todd, A. K.; Neidle, S. Mapping the sequences of potential guanine quadruplex motifs Nucleic Acids Res. 2011, 39, 4917-4927 10.1093/nar/gkr104
-
(2011)
Nucleic Acids Res.
, vol.39
, pp. 4917-4927
-
-
Todd, A.K.1
Neidle, S.2
-
197
-
-
45749139174
-
Inhibition of translation in living eukaryotic cells by an RNA G-quadruplex motif
-
Arora, A.; Dutkiewicz, M.; Scaria, V.; Hariharan, M.; Maiti, S.; Kurreck, J. Inhibition of translation in living eukaryotic cells by an RNA G-quadruplex motif RNA 2008, 14, 1290-1296 10.1261/rna.1001708
-
(2008)
RNA
, vol.14
, pp. 1290-1296
-
-
Arora, A.1
Dutkiewicz, M.2
Scaria, V.3
Hariharan, M.4
Maiti, S.5
Kurreck, J.6
-
198
-
-
77957082956
-
A G-quadruplex structure within the 5′-UTR of TRF2 mRNA represses translation in human cells
-
Gomez, D.; Guédin, A.; Mergny, J.-L.; Salles, B.; Riou, J.-F.; Teulade-Fichou, M.-P.; Calsou, P. A G-quadruplex structure within the 5′-UTR of TRF2 mRNA represses translation in human cells Nucleic Acids Res. 2010, 38, 7187-7198 10.1093/nar/gkq563
-
(2010)
Nucleic Acids Res.
, vol.38
, pp. 7187-7198
-
-
Gomez, D.1
Guédin, A.2
Mergny, J.-L.3
Salles, B.4
Riou, J.-F.5
Teulade-Fichou, M.-P.6
Calsou, P.7
-
199
-
-
84890958553
-
Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells
-
Biffi, G.; Di Antonio, M.; Tannahill, D.; Balasubramanian, S. Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells Nat. Chem. 2014, 6, 75-80 10.1038/nchem.1805
-
(2014)
Nat. Chem.
, vol.6
, pp. 75-80
-
-
Biffi, G.1
Di Antonio, M.2
Tannahill, D.3
Balasubramanian, S.4
-
200
-
-
77953184584
-
Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex
-
Bugaut, A.; Rodriguez, R.; Kumari, S.; Hsu, S. T.; Balasubramanian, S. Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex Org. Biomol. Chem. 2010, 8, 2771-2776 10.1039/c002418j
-
(2010)
Org. Biomol. Chem.
, vol.8
, pp. 2771-2776
-
-
Bugaut, A.1
Rodriguez, R.2
Kumari, S.3
Hsu, S.T.4
Balasubramanian, S.5
-
201
-
-
84055188686
-
Photoactivated cationic alkyl-substituted porphyrin binding to g4-RNA in the 5′-UTR of KRAS oncogene represses translation
-
Faudale, M.; Cogoi, S.; Xodo, L. E. Photoactivated cationic alkyl-substituted porphyrin binding to g4-RNA in the 5′-UTR of KRAS oncogene represses translation Chem. Commun. 2012, 48, 874-876 10.1039/C1CC15850C
-
(2012)
Chem. Commun.
, vol.48
, pp. 874-876
-
-
Faudale, M.1
Cogoi, S.2
Xodo, L.E.3
-
202
-
-
84930271972
-
G-quadruplexes: Emerging roles in neurodegenerative diseases and the non-coding transcriptome
-
Simone, R.; Fratta, P.; Neidle, S.; Parkinson, G. N.; Isaacs, A. M. G-quadruplexes: Emerging roles in neurodegenerative diseases and the non-coding transcriptome FEBS Lett. 2015, 589, 1653-1668 10.1016/j.febslet.2015.05.003
-
(2015)
FEBS Lett.
, vol.589
, pp. 1653-1668
-
-
Simone, R.1
Fratta, P.2
Neidle, S.3
Parkinson, G.N.4
Isaacs, A.M.5
-
203
-
-
84896259966
-
C9orf72 nucleotide repeat structures initiate molecular cascades of disease
-
Haeusler, A. R.; Donnelly, C. J.; Periz, G.; Simko, E. A.; Shaw, P. G.; Kim, M. S.; Maragakis, N. J.; Troncoso, J. C.; Pandey, A.; Sattler, R.; Rothstein, J. D.; Wang, J. C9orf72 nucleotide repeat structures initiate molecular cascades of disease Nature 2014, 507, 195-200 10.1038/nature13124
-
(2014)
Nature
, vol.507
, pp. 195-200
-
-
Haeusler, A.R.1
Donnelly, C.J.2
Periz, G.3
Simko, E.A.4
Shaw, P.G.5
Kim, M.S.6
Maragakis, N.J.7
Troncoso, J.C.8
Pandey, A.9
Sattler, R.10
Rothstein, J.D.11
Wang, J.12
-
204
-
-
84871801926
-
C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms RNA G-quadruplexes
-
Fratta, P.; Mizielinska, S.; Nicoll, A. J.; Zloh, M.; Fisher, E. M.; Parkinson, G.; Isaacs, A. M. C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms RNA G-quadruplexes Sci. Rep. 2012, 2, 1016 10.1038/srep01016
-
(2012)
Sci. Rep.
, vol.2
, pp. 1016
-
-
Fratta, P.1
Mizielinska, S.2
Nicoll, A.J.3
Zloh, M.4
Fisher, E.M.5
Parkinson, G.6
Isaacs, A.M.7
-
205
-
-
84875981640
-
n repeat from the C9orf72 gene forms tract length-dependent uni- and multimolecular RNA G-quadruplex structures
-
n repeat from the C9orf72 gene forms tract length-dependent uni- and multimolecular RNA G-quadruplex structures J. Biol. Chem. 2013, 288, 9860-9866 10.1074/jbc.C113.452532
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 9860-9866
-
-
Reddy, K.1
Zamiri, B.2
Stanley, S.Y.3
Macgregor, Jr.R.B.4
Pearson, C.E.5
-
206
-
-
84894465709
-
n repeat of the C9orf72 gene and blocks interaction of RNA-binding proteins
-
n repeat of the C9orf72 gene and blocks interaction of RNA-binding proteins J. Biol. Chem. 2014, 289, 4653-4659 10.1074/jbc.C113.502336
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 4653-4659
-
-
Zamiri, B.1
Reddy, K.2
Macgregor, R.3
Pearson, C.E.4
-
207
-
-
84908027765
-
Discovery of a biomarker and lead small molecules to target r(GGGGCC)-associated defects in c9FTD/ALS
-
Su, Z.; Zhang, Y.; Gendron, T. F.; Bauer, P. O.; Chew, J.; Yang, W. Y.; Fostvedt, E.; Jansen-West, K.; Belzil, V. V.; Desaro, P.; Johnston, A.; Overstreet, K.; Oh, S. Y.; Todd, P. K.; Berry, J. D.; Cudkowicz, M. E.; Boeve, B. F.; Dickson, D.; Floeter, M. K.; Traynor, B. J.; Morelli, C.; Ratti, A.; Silani, V.; Rademakers, R.; Brown, R. H.; Rothstein, J. D.; Boylan, K. B.; Petrucelli, L.; Disney, M. D. Discovery of a biomarker and lead small molecules to target r(GGGGCC)-associated defects in c9FTD/ALS Neuron 2014, 83, 1043-1050 10.1016/j.neuron.2014.07.041
-
(2014)
Neuron
, vol.83
, pp. 1043-1050
-
-
Su, Z.1
Zhang, Y.2
Gendron, T.F.3
Bauer, P.O.4
Chew, J.5
Yang, W.Y.6
Fostvedt, E.7
Jansen-West, K.8
Belzil, V.V.9
Desaro, P.10
Johnston, A.11
Overstreet, K.12
Oh, S.Y.13
Todd, P.K.14
Berry, J.D.15
Cudkowicz, M.E.16
Boeve, B.F.17
Dickson, D.18
Floeter, M.K.19
Traynor, B.J.20
Morelli, C.21
Ratti, A.22
Silani, V.23
Rademakers, R.24
Brown, R.H.25
Rothstein, J.D.26
Boylan, K.B.27
Petrucelli, L.28
Disney, M.D.29
more..
-
208
-
-
79961029908
-
DNA secondary structures and epigenetic determinants of cancer genome evolution
-
De, S.; Michor, F. DNA secondary structures and epigenetic determinants of cancer genome evolution Nat. Struct. Mol. Biol. 2011, 18, 950-955 10.1038/nsmb.2089
-
(2011)
Nat. Struct. Mol. Biol.
, vol.18
, pp. 950-955
-
-
De, S.1
Michor, F.2
-
209
-
-
84887405212
-
Genomes and G-quadruplexes: For better or for worse
-
Tarsounas, M.; Tijsterman, M. Genomes and G-quadruplexes: for better or for worse J. Mol. Biol. 2013, 425, 4782-4789 10.1016/j.jmb.2013.09.026
-
(2013)
J. Mol. Biol.
, vol.425
, pp. 4782-4789
-
-
Tarsounas, M.1
Tijsterman, M.2
-
210
-
-
84876862930
-
The G4 genome
-
Maizels, N.; Gray, L. T. The G4 genome PLoS Genet. 2013, 9, e1003468 10.1371/journal.pgen.1003468
-
(2013)
PLoS Genet.
, vol.9
, pp. e1003468
-
-
Maizels, N.1
Gray, L.T.2
-
211
-
-
84891400223
-
Existence and consequences of G-quadruplex structures in DNA
-
Murat, P.; Balasubramanian, S. Existence and consequences of G-quadruplex structures in DNA Curr. Opin. Genet. Dev. 2014, 25, 22-29 10.1016/j.gde.2013.10.012
-
(2014)
Curr. Opin. Genet. Dev.
, vol.25
, pp. 22-29
-
-
Murat, P.1
Balasubramanian, S.2
-
212
-
-
79951567895
-
Formation of a G-quadruplex at the BCL2 major breakpoint region of the t(14;18) translocation in follicular lymphoma
-
Nambiar, M.; Goldsmith, G.; Moorthy, B. T.; Lieber, M. R.; Joshi, M. V.; Choudhary, B.; Hosur, R. V.; Raghavan, S. C. Formation of a G-quadruplex at the BCL2 major breakpoint region of the t(14;18) translocation in follicular lymphoma Nucleic Acids Res. 2011, 39, 936-948 10.1093/nar/gkq824
-
(2011)
Nucleic Acids Res.
, vol.39
, pp. 936-948
-
-
Nambiar, M.1
Goldsmith, G.2
Moorthy, B.T.3
Lieber, M.R.4
Joshi, M.V.5
Choudhary, B.6
Hosur, R.V.7
Raghavan, S.C.8
-
213
-
-
84948677788
-
G-quadruplexes and their regulatory roles in cancer
-
Rhodes, D.; Lipps, H. J. G-quadruplexes and their regulatory roles in cancer Nucleic Acids Res. 2015, 43, 8627-8637 10.1093/nar/gkv862
-
(2015)
Nucleic Acids Res.
, vol.43
, pp. 8627-8637
-
-
Rhodes, D.1
Lipps, H.J.2
-
214
-
-
84884771159
-
Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability
-
Bharti, S. K.; Sommers, J. A.; George, F.; Kuper, J.; Hamon, F.; Shin-ya, K.; Teulade-Fichou, M.-P.; Kisker, C.; Brosh, R. M., Jr. Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability J. Biol. Chem. 2013, 288, 28217-28229 10.1074/jbc.M113.496463
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 28217-28229
-
-
Bharti, S.K.1
Sommers, J.A.2
George, F.3
Kuper, J.4
Hamon, F.5
Shin-Ya, K.6
Teulade-Fichou, M.-P.7
Kisker, C.8
Brosh, Jr.R.M.9
-
215
-
-
84897029094
-
G quadruplexes are genomewide targets of transcriptional helicases XPB and XPD
-
Gray, L. T.; Vallur, A. C.; Eddy, J.; Maizels, N. G quadruplexes are genomewide targets of transcriptional helicases XPB and XPD Nat. Chem. Biol. 2014, 10, 313-318 10.1038/nchembio.1475
-
(2014)
Nat. Chem. Biol.
, vol.10
, pp. 313-318
-
-
Gray, L.T.1
Vallur, A.C.2
Eddy, J.3
Maizels, N.4
-
216
-
-
67149126812
-
The yeast Pif1 helicase prevents genomic instability caused by G-quadruplex-forming CEB1 sequences in vivo
-
Ribeyre, C.; Lopes, J.; Boulé, J.-B.; Piazza, A.; Guédin, A.; Zakian, V. A.; Mergny, J.-L.; Nicolas, A. The yeast Pif1 helicase prevents genomic instability caused by G-quadruplex-forming CEB1 sequences in vivo PLoS Genet. 2009, 5, e1000475 10.1371/journal.pgen.1000475
-
(2009)
PLoS Genet.
, vol.5
, pp. e1000475
-
-
Ribeyre, C.1
Lopes, J.2
Boulé, J.-B.3
Piazza, A.4
Guédin, A.5
Zakian, V.A.6
Mergny, J.-L.7
Nicolas, A.8
-
217
-
-
84878122437
-
Pif1 family helicases suppress genome instability at G-quadruplex motifs
-
Paeschke, K.; Bochman, M. L.; Garcia, P. D.; Cejka, P.; Friedman, K. L.; Kowalczykowski, S. C.; Zakian, V. A. Pif1 family helicases suppress genome instability at G-quadruplex motifs Nature 2013, 497, 458-462 10.1038/nature12149
-
(2013)
Nature
, vol.497
, pp. 458-462
-
-
Paeschke, K.1
Bochman, M.L.2
Garcia, P.D.3
Cejka, P.4
Friedman, K.L.5
Kowalczykowski, S.C.6
Zakian, V.A.7
-
218
-
-
84922222299
-
FANCJ promotes DNA synthesis through G-quadruplex structures
-
Castillo Bosch, P.; Segura-Bayona, S.; Koole, W.; van Heteren, J. T.; Dewar, J. M.; Tijsterman, M.; Knipscheer, P. FANCJ promotes DNA synthesis through G-quadruplex structures EMBO J. 2014, 33, 2521-2533 10.15252/embj.201488663
-
(2014)
EMBO J.
, vol.33
, pp. 2521-2533
-
-
Castillo Bosch, P.1
Segura-Bayona, S.2
Koole, W.3
Van Heteren, J.T.4
Dewar, J.M.5
Tijsterman, M.6
Knipscheer, P.7
-
219
-
-
84917742065
-
Molecular and cellular functions of the FANCJ DNA helicase defective in cancer and in Fanconi anemia
-
Brosh, R. M., Jr.; Cantor, S. B. Molecular and cellular functions of the FANCJ DNA helicase defective in cancer and in Fanconi anemia Front. Genet. 2014, 5, 372 10.3389/fgene.2014.00372
-
(2014)
Front. Genet.
, vol.5
, pp. 372
-
-
Brosh, Jr.R.M.1
Cantor, S.B.2
-
220
-
-
84903973907
-
Regulation of gene expression by the BLM helicase correlates with the presence of G-quadruplex DNA motifs
-
Nguyen, G. H.; Tang, W.; Robles, A. I.; Beyer, R. P.; Gray, L. T.; Welsh, J. A.; Schetter, A. J.; Kumamoto, K.; Wang, X. W.; Hickson, I. D.; Maizels, N.; Monnat, R. J., Jr.; Harris, C. C. Regulation of gene expression by the BLM helicase correlates with the presence of G-quadruplex DNA motifs Proc. Natl. Acad. Sci. U. S. A. 2014, 111, 9905-9910 10.1073/pnas.1404807111
-
(2014)
Proc. Natl. Acad. Sci. U. S. A.
, vol.111
, pp. 9905-9910
-
-
Nguyen, G.H.1
Tang, W.2
Robles, A.I.3
Beyer, R.P.4
Gray, L.T.5
Welsh, J.A.6
Schetter, A.J.7
Kumamoto, K.8
Wang, X.W.9
Hickson, I.D.10
Maizels, N.11
Monnat, Jr.R.J.12
Harris, C.C.13
-
221
-
-
0035909817
-
Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands
-
Li, J.-L.; Harrison, R. J.; Reszka, A. P.; Brosh, R. M.,; Bohr, V. A.; Neidle, S.; Hickson, I. D. Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands Biochemistry 2001, 40, 15194-15202 10.1021/bi011067h
-
(2001)
Biochemistry
, vol.40
, pp. 15194-15202
-
-
Li, J.-L.1
Harrison, R.J.2
Reszka, A.P.3
Brosh, Jr.R.M.4
Bohr, V.A.5
Neidle, S.6
Hickson, I.D.7
-
222
-
-
84860854071
-
RTEL1 dismantles T loops and counteracts telomeric G4-DNA to maintain telomere integrity
-
Vannier, J.-B.; Pavicic-Kaltenbrunner, V.; Petalcorin, M. I.; Ding, H.; Boulton, S. J. RTEL1 dismantles T loops and counteracts telomeric G4-DNA to maintain telomere integrity Cell 2012, 149, 795-806 10.1016/j.cell.2012.03.030
-
(2012)
Cell
, vol.149
, pp. 795-806
-
-
Vannier, J.-B.1
Pavicic-Kaltenbrunner, V.2
Petalcorin, M.I.3
Ding, H.4
Boulton, S.J.5
-
223
-
-
84903156621
-
RTEL1: Functions of a disease-associated helicase
-
Vannier, J.-B.; Sarek, G.; Boulton, S. J. RTEL1: functions of a disease-associated helicase Trends Cell Biol. 2014, 24, 416-425 10.1016/j.tcb.2014.01.004
-
(2014)
Trends Cell Biol.
, vol.24
, pp. 416-425
-
-
Vannier, J.-B.1
Sarek, G.2
Boulton, S.J.3
-
224
-
-
84936747645
-
A fluorescence-based helicase assay: Application to the screening of G-quadruplex ligands
-
Mendoza, O.; Gueddouda, N. M.; Boulé, J.-B.; Bourdoncle, A.; Mergny, J.-L. A fluorescence-based helicase assay: application to the screening of G-quadruplex ligands Nucleic Acids Res. 2015, 43, e71 10.1093/nar/gkv193
-
(2015)
Nucleic Acids Res.
, vol.43
, pp. e71
-
-
Mendoza, O.1
Gueddouda, N.M.2
Boulé, J.-B.3
Bourdoncle, A.4
Mergny, J.-L.5
-
225
-
-
84938717683
-
Insights into G-quadruplex specific recognition by the DEAH-box helicase RHAU: Solution structure of a peptide-quadruplex complex
-
Heddi, B.; Cheong, V. V.; Martadinata, H.; Phan, A. T. Insights into G-quadruplex specific recognition by the DEAH-box helicase RHAU: Solution structure of a peptide-quadruplex complex Proc. Natl. Acad. Sci. U. S. A. 2015, 112, 9608-9613 10.1073/pnas.1422605112
-
(2015)
Proc. Natl. Acad. Sci. U. S. A.
, vol.112
, pp. 9608-9613
-
-
Heddi, B.1
Cheong, V.V.2
Martadinata, H.3
Phan, A.T.4
-
226
-
-
84872191844
-
Crystallography of DNA and RNA G-quadruplex nucleic acids and their ligand complexes
-
Wiley, Chapter 17, Unit 17.6, DOI
-
Campbell, N.; Collie, G. W.; Neidle, S. Crystallography of DNA and RNA G-quadruplex nucleic acids and their ligand complexes. In Current Protocols in Nucleic Acid Chemistry; Wiley, 2012; Chapter 17, Unit 17.6, DOI: 10.1002/0471142700.nc1706s50.
-
(2012)
Current Protocols in Nucleic Acid Chemistry
-
-
Campbell, N.1
Collie, G.W.2
Neidle, S.3
-
227
-
-
84870190030
-
Structural probes in quadruplex nucleic acid structure determination by NMR
-
Karsisiotis, A. I.; Webba da Silva, M. Structural probes in quadruplex nucleic acid structure determination by NMR Molecules 2012, 17, 13073-13086 10.3390/molecules171113073
-
(2012)
Molecules
, vol.17
, pp. 13073-13086
-
-
Karsisiotis, A.I.1
Webba da Silva, M.2
-
228
-
-
0027918585
-
3] G-tetraplex
-
3] G-tetraplex Structure 1993, 1, 263-282 10.1016/0969-2126(93)90015-9
-
(1993)
Structure
, vol.1
, pp. 263-282
-
-
Wang, Y.1
Patel, D.J.2
-
229
-
-
0345098322
-
Two-repeat human telomeric d(TAGGGTTAGGGT) sequence forms interconverting parallel and antiparallel G-quadruplexes in solution: Distinct topologies, thermodynamic properties, and folding/unfolding kinetics
-
Phan, A. T.; Patel, D. J. Two-repeat human telomeric d(TAGGGTTAGGGT) sequence forms interconverting parallel and antiparallel G-quadruplexes in solution: distinct topologies, thermodynamic properties, and folding/unfolding kinetics J. Am. Chem. Soc. 2003, 125, 15021-15027 10.1021/ja037616j
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 15021-15027
-
-
Phan, A.T.1
Patel, D.J.2
-
230
-
-
33646943863
-
Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution
-
Ambrus, A.; Chen, D.; Dai, J.; Bialis, T.; Jones, R. A.; Yang, D. Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution Nucleic Acids Res. 2006, 34, 2723-2735 10.1093/nar/gkl348
-
(2006)
Nucleic Acids Res.
, vol.34
, pp. 2723-2735
-
-
Ambrus, A.1
Chen, D.2
Dai, J.3
Bialis, T.4
Jones, R.A.5
Yang, D.6
-
233
-
-
67749124298
-
+ solution: A stable basket-type G-quadruplex with only two G-tetrad layers
-
+ solution: a stable basket-type G-quadruplex with only two G-tetrad layers J. Am. Chem. Soc. 2009, 131, 4301-4309 10.1021/ja807503g
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 4301-4309
-
-
Lim, K.W.1
Amrane, S.2
Bouaziz, S.3
Xu, W.4
Mu, Y.5
Patel, D.J.6
Luu, K.N.7
Phan, A.T.8
-
235
-
-
0037142071
-
Crystal structure of parallel quadruplexes from human telomeric DNA
-
Parkinson, G. N.; Lee, M. P. H.; Neidle, S. Crystal structure of parallel quadruplexes from human telomeric DNA Nature 2002, 417, 876-880 10.1038/nature755
-
(2002)
Nature
, vol.417
, pp. 876-880
-
-
Parkinson, G.N.1
Lee, M.P.H.2
Neidle, S.3
-
236
-
-
79959509289
-
Structure of human telomeric DNA in crowded solution
-
Heddi, B.; Phan, A. T. Structure of human telomeric DNA in crowded solution J. Am. Chem. Soc. 2011, 133, 9824-9833 10.1021/ja200786q
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 9824-9833
-
-
Heddi, B.1
Phan, A.T.2
-
237
-
-
71049152800
-
+ solutions
-
+ solutions Nucleic Acids Res. 2009, 37, 6625-6634 10.1093/nar/gkp701
-
(2009)
Nucleic Acids Res.
, vol.37
, pp. 6625-6634
-
-
Renčiuk, D.1
Kejnovská, I.2
Školáková, P.3
Bednářová, K.4
Motlová, J.5
Vorlíčková, M.6
-
238
-
-
44349142304
-
Structural basis of DNA quadruplex recognition by an acridine drug
-
Campbell, N. H.; Parkinson, G. N.; Reszka, A. P.; Neidle, S. Structural basis of DNA quadruplex recognition by an acridine drug J. Am. Chem. Soc. 2008, 130, 6722-6724 10.1021/ja8016973
-
(2008)
J. Am. Chem. Soc.
, vol.130
, pp. 6722-6724
-
-
Campbell, N.H.1
Parkinson, G.N.2
Reszka, A.P.3
Neidle, S.4
-
239
-
-
48749109524
-
Topology conservation and loop flexibility in quadruplex-drug recognition: Crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes
-
Parkinson, G. N.; Cuenca, F.; Neidle, S. Topology conservation and loop flexibility in quadruplex-drug recognition: crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes J. Mol. Biol. 2008, 381, 1145-1156 10.1016/j.jmb.2008.06.022
-
(2008)
J. Mol. Biol.
, vol.381
, pp. 1145-1156
-
-
Parkinson, G.N.1
Cuenca, F.2
Neidle, S.3
-
240
-
-
84856708526
-
Structural basis for telomeric G-quadruplex naphthalene diimide ligand targeting
-
Collie, G. W.; Promontorio, R.; Hampel, S. M.; Micco, M.; Neidle, S.; Parkinson, G. N. Structural basis for telomeric G-quadruplex naphthalene diimide ligand targeting J. Am. Chem. Soc. 2012, 134, 2723-2731 10.1021/ja2102423
-
(2012)
J. Am. Chem. Soc.
, vol.134
, pp. 2723-2731
-
-
Collie, G.W.1
Promontorio, R.2
Hampel, S.M.3
Micco, M.4
Neidle, S.5
Parkinson, G.N.6
-
241
-
-
84876215753
-
Structure-based design and evaluation of naphthalene diimide G-quadruplex ligands as telomere targeting agents in pancreatic cancer cells
-
Micco, M.; Collie, G. W.; Dale, A. G.; Ohnmacht, S. A.; Pazitna, I.; Gunaratnam, M.; Reszka, A. P.; Neidle, S. Structure-based design and evaluation of naphthalene diimide G-quadruplex ligands as telomere targeting agents in pancreatic cancer cells J. Med. Chem. 2013, 56, 2959-2974 10.1021/jm301899y
-
(2013)
J. Med. Chem.
, vol.56
, pp. 2959-2974
-
-
Micco, M.1
Collie, G.W.2
Dale, A.G.3
Ohnmacht, S.A.4
Pazitna, I.5
Gunaratnam, M.6
Reszka, A.P.7
Neidle, S.8
-
242
-
-
84855849686
-
Molecular basis of structure-activity relationships between salphen metal complexes and human telomeric DNA quadruplexes
-
Campbell, N. H.; Karim, N. H.; Parkinson, G. N.; Gunaratnam, M.; Petrucci, V.; Todd, A. K.; Vilar, R.; Neidle, S. Molecular basis of structure-activity relationships between salphen metal complexes and human telomeric DNA quadruplexes J. Med. Chem. 2012, 55, 209-222 10.1021/jm201140v
-
(2012)
J. Med. Chem.
, vol.55
, pp. 209-222
-
-
Campbell, N.H.1
Karim, N.H.2
Parkinson, G.N.3
Gunaratnam, M.4
Petrucci, V.5
Todd, A.K.6
Vilar, R.7
Neidle, S.8
-
243
-
-
84871784359
-
The crystal structure of human telomeric DNA complexed with berberine: An interesting case of stacked ligand to G-tetrad ratio higher than 1:1
-
Bazzicalupi, C.; Ferraroni, M.; Bilia, A. R.; Scheggi, F.; Gratteri, P. The crystal structure of human telomeric DNA complexed with berberine: an interesting case of stacked ligand to G-tetrad ratio higher than 1:1 Nucleic Acids Res. 2013, 41, 632-638 10.1093/nar/gks1001
-
(2013)
Nucleic Acids Res.
, vol.41
, pp. 632-638
-
-
Bazzicalupi, C.1
Ferraroni, M.2
Bilia, A.R.3
Scheggi, F.4
Gratteri, P.5
-
244
-
-
84871359419
-
Optimized end-stacking provides specificity of N-methyl mesoporphyrin IX for human telomeric G-quadruplex DNA
-
Nicoludis, J. M.; Miller, S. T.; Jeffrey, P. D.; Barrett, S. P.; Rablen, P. R.; Lawton, T. J.; Yatsunyk, L. A. Optimized end-stacking provides specificity of N-methyl mesoporphyrin IX for human telomeric G-quadruplex DNA J. Am. Chem. Soc. 2012, 134, 20446-20456 10.1021/ja3088746
-
(2012)
J. Am. Chem. Soc.
, vol.134
, pp. 20446-20456
-
-
Nicoludis, J.M.1
Miller, S.T.2
Jeffrey, P.D.3
Barrett, S.P.4
Rablen, P.R.5
Lawton, T.J.6
Yatsunyk, L.A.7
-
245
-
-
84931281667
-
Loop flexibility in human telomeric quadruplex small-molecule complexes
-
Collie, G. W.; Campbell, N. H.; Neidle, S. Loop flexibility in human telomeric quadruplex small-molecule complexes Nucleic Acids Res. 2015, 43, 4785-4799 10.1093/nar/gkv427
-
(2015)
Nucleic Acids Res.
, vol.43
, pp. 4785-4799
-
-
Collie, G.W.1
Campbell, N.H.2
Neidle, S.3
-
246
-
-
84884177068
-
Solution structure of an intramolecular (3 + 1) human telomeric G-quadruplex bound to a telomestatin derivative
-
Chung, W. J.; Heddi, B.; Tera, M.; Iida, K.; Nagasawa, K.; Phan, A. T. Solution structure of an intramolecular (3 + 1) human telomeric G-quadruplex bound to a telomestatin derivative J. Am. Chem. Soc. 2013, 135, 13495-13501 10.1021/ja405843r
-
(2013)
J. Am. Chem. Soc.
, vol.135
, pp. 13495-13501
-
-
Chung, W.J.1
Heddi, B.2
Tera, M.3
Iida, K.4
Nagasawa, K.5
Phan, A.T.6
-
247
-
-
84865091109
-
Circular dichroism and guanine quadruplexes
-
Vorlíčková, M.; Kejnovská, I.; Sagi, J.; Renčiuk, D.; Bednářová, K.; Motlová, J.; Kypr, J. Circular dichroism and guanine quadruplexes Methods 2012, 57, 64-75 10.1016/j.ymeth.2012.03.011
-
(2012)
Methods
, vol.57
, pp. 64-75
-
-
Vorlíčková, M.1
Kejnovská, I.2
Sagi, J.3
Renčiuk, D.4
Bednářová, K.5
Motlová, J.6
Kypr, J.7
-
248
-
-
79960700765
-
Surface area accessibility and the preferred topology of telomeric DNA quadruplex-ligand complexes
-
Haider, S. M.; Autiero, I.; Neidle, S. Surface area accessibility and the preferred topology of telomeric DNA quadruplex-ligand complexes Biochimie 2011, 93, 1275-1279 10.1016/j.biochi.2011.05.014
-
(2011)
Biochimie
, vol.93
, pp. 1275-1279
-
-
Haider, S.M.1
Autiero, I.2
Neidle, S.3
-
249
-
-
77956539976
-
A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex
-
Collie, G. W.; Haider, S.; Neidle, S.; Parkinson, G. N. A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex Nucleic Acids Res. 2010, 38, 5569-5580 10.1093/nar/gkq259
-
(2010)
Nucleic Acids Res.
, vol.38
, pp. 5569-5580
-
-
Collie, G.W.1
Haider, S.2
Neidle, S.3
Parkinson, G.N.4
-
250
-
-
67749143935
-
Structure of propeller-type parallel-stranded RNA G-quadruplexes, formed by human telomeric RNA sequences in K+ solution
-
Martadinata, H.; Phan, A. T. Structure of propeller-type parallel-stranded RNA G-quadruplexes, formed by human telomeric RNA sequences in K+ solution J. Am. Chem. Soc. 2009, 131, 2570-2578 10.1021/ja806592z
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 2570-2578
-
-
Martadinata, H.1
Phan, A.T.2
-
251
-
-
79952269800
-
Structural basis of telomeric RNA quadruplex-acridine ligand recognition
-
Collie, G. W.; Sparapani, S.; Parkinson, G. N.; Neidle, S. Structural basis of telomeric RNA quadruplex-acridine ligand recognition J. Am. Chem. Soc. 2011, 133, 2721-2728 10.1021/ja109767y
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 2721-2728
-
-
Collie, G.W.1
Sparapani, S.2
Parkinson, G.N.3
Neidle, S.4
-
252
-
-
13644267721
-
Solution structure of the biologically relevant G-quadruplex element in the human c-MYC promoter. Implications for G-quadruplex stabilization
-
Ambrus, A.; Chen, D.; Dai, J.; Jones, R. A.; Yang, D. Solution structure of the biologically relevant G-quadruplex element in the human c-MYC promoter. Implications for G-quadruplex stabilization Biochemistry 2005, 44, 2048-2058 10.1021/bi048242p
-
(2005)
Biochemistry
, vol.44
, pp. 2048-2058
-
-
Ambrus, A.1
Chen, D.2
Dai, J.3
Jones, R.A.4
Yang, D.5
-
253
-
-
80455168261
-
C-MYC promoter G-quadruplex formed at the 5′-end of NHE III1 element: Insights into biological relevance and parallel-stranded G-quadruplex stability
-
Mathad, R. I.; Hatzakis, E.; Dai, J.; Yang, D. c-MYC promoter G-quadruplex formed at the 5′-end of NHE III1 element: insights into biological relevance and parallel-stranded G-quadruplex stability Nucleic Acids Res. 2011, 39, 9023-9033 10.1093/nar/gkr612
-
(2011)
Nucleic Acids Res.
, vol.39
, pp. 9023-9033
-
-
Mathad, R.I.1
Hatzakis, E.2
Dai, J.3
Yang, D.4
-
254
-
-
33750990787
-
NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region
-
Dai, J.; Chen, D.; Jones, R. A.; Hurley, L. H.; Yang, D. NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region Nucleic Acids Res. 2006, 34, 5133-5144 10.1093/nar/gkl610
-
(2006)
Nucleic Acids Res.
, vol.34
, pp. 5133-5144
-
-
Dai, J.1
Chen, D.2
Jones, R.A.3
Hurley, L.H.4
Yang, D.5
-
256
-
-
84890389008
-
Solution structure of the major G-quadruplex formed in the human VEGF promoter in K+: Insights into loop interactions of the parallel G-quadruplexes
-
Agrawal, P.; Hatzakis, E.; Guo, K.; Carver, M.; Yang, D. Solution structure of the major G-quadruplex formed in the human VEGF promoter in K+: insights into loop interactions of the parallel G-quadruplexes Nucleic Acids Res. 2013, 41, 10584-10592 10.1093/nar/gkt784
-
(2013)
Nucleic Acids Res.
, vol.41
, pp. 10584-10592
-
-
Agrawal, P.1
Hatzakis, E.2
Guo, K.3
Carver, M.4
Yang, D.5
-
257
-
-
80055092362
-
Solution structure of all parallel G-quadruplex formed by the oncogene RET promoter sequence
-
Tong, X.; Lan, W.; Zhang, X.; Wu, H.; Liu, M.; Cao, C. Solution structure of all parallel G-quadruplex formed by the oncogene RET promoter sequence Nucleic Acids Res. 2011, 39, 6753-6763 10.1093/nar/gkr233
-
(2011)
Nucleic Acids Res.
, vol.39
, pp. 6753-6763
-
-
Tong, X.1
Lan, W.2
Zhang, X.3
Wu, H.4
Liu, M.5
Cao, C.6
-
258
-
-
34848814236
-
Sequence occurrence and structural uniqueness of a G-quadruplex in the human c-kit promoter
-
Todd, A. K.; Haider, S. M.; Parkinson, G. N.; Neidle, S. Sequence occurrence and structural uniqueness of a G-quadruplex in the human c-kit promoter Nucleic Acids Res. 2007, 35, 5799-5808 10.1093/nar/gkm609
-
(2007)
Nucleic Acids Res.
, vol.35
, pp. 5799-5808
-
-
Todd, A.K.1
Haider, S.M.2
Parkinson, G.N.3
Neidle, S.4
-
259
-
-
33644833219
-
Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter
-
Phan, A. T.; Kuryavyi, V.; Gaw, H. Y.; Patel, D. J. Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter Nat. Chem. Biol. 2005, 1, 167-173 10.1038/nchembio723
-
(2005)
Nat. Chem. Biol.
, vol.1
, pp. 167-173
-
-
Phan, A.T.1
Kuryavyi, V.2
Gaw, H.Y.3
Patel, D.J.4
-
260
-
-
84893255474
-
Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC(3)
-
Chung, W. J.; Heddi, B.; Hamon, F.; Teulade-Fichou, M.-P.; Phan, A. T. Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC(3) Angew. Chem., Int. Ed. 2014, 53, 999-1002 10.1002/anie.201308063
-
(2014)
Angew. Chem., Int. Ed.
, vol.53
, pp. 999-1002
-
-
Chung, W.J.1
Heddi, B.2
Hamon, F.3
Teulade-Fichou, M.-P.4
Phan, A.T.5
-
261
-
-
80455123924
-
Solution structure of a 2:1 quindoline-c-MYC G-quadruplex: Insights into G-quadruplex-interactive small molecule drug design
-
Dai, J.; Carver, M.; Hurley, L. H.; Yang, D. Solution structure of a 2:1 quindoline-c-MYC G-quadruplex: insights into G-quadruplex-interactive small molecule drug design J. Am. Chem. Soc. 2011, 133, 17673-17680 10.1021/ja205646q
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 17673-17680
-
-
Dai, J.1
Carver, M.2
Hurley, L.H.3
Yang, D.4
-
262
-
-
84942856104
-
Crystal structure reveals specific recognition of a G-quadruplex RNA by a β-turn in the RGG motif of FMRP
-
Vasilyev, N.; Polonskaia, A.; Darnell, J. C.; Darnell, R. B.; Patel, D. J.; Serganov, A. Crystal structure reveals specific recognition of a G-quadruplex RNA by a β-turn in the RGG motif of FMRP Proc. Natl. Acad. Sci. U. S. A. 2015, 112, E5391-400 10.1073/pnas.1515737112
-
(2015)
Proc. Natl. Acad. Sci. U. S. A.
, vol.112
, pp. E5391-E5400
-
-
Vasilyev, N.1
Polonskaia, A.2
Darnell, J.C.3
Darnell, R.B.4
Patel, D.J.5
Serganov, A.6
-
263
-
-
84905639191
-
Structural basis for activity of highly efficient RNA mimics of green fluorescent protein
-
Warner, K. D.; Chen, M. C.; Song, W.; Strack, R. L.; Thorn, A.; Jaffrey, S. R.; Ferré-D'Amaré, A. R. Structural basis for activity of highly efficient RNA mimics of green fluorescent protein Nat. Struct. Mol. Biol. 2014, 21, 658-663 10.1038/nsmb.2865
-
(2014)
Nat. Struct. Mol. Biol.
, vol.21
, pp. 658-663
-
-
Warner, K.D.1
Chen, M.C.2
Song, W.3
Strack, R.L.4
Thorn, A.5
Jaffrey, S.R.6
Ferré-D'Amaré, A.R.7
-
264
-
-
84904731281
-
A G-quadruplex-containing RNA activates fluorescence in a GFP-like fluorophore
-
Huang, H.; Suslov, N. B.; Li, N. S.; Shelke, S. A.; Evans, M. E.; Koldobskaya, Y.; Rice, P. A.; Piccirilli, J. A. A G-quadruplex-containing RNA activates fluorescence in a GFP-like fluorophore Nat. Chem. Biol. 2014, 10, 686-691 10.1038/nchembio.1561
-
(2014)
Nat. Chem. Biol.
, vol.10
, pp. 686-691
-
-
Huang, H.1
Suslov, N.B.2
Li, N.S.3
Shelke, S.A.4
Evans, M.E.5
Koldobskaya, Y.6
Rice, P.A.7
Piccirilli, J.A.8
-
265
-
-
84900824121
-
Small-molecule quadruplex-targeted drug discovery
-
Ohnmacht, S. A.; Neidle, S. Small-molecule quadruplex-targeted drug discovery Bioorg. Med. Chem. Lett. 2014, 24, 2602-2612 10.1016/j.bmcl.2014.04.029
-
(2014)
Bioorg. Med. Chem. Lett.
, vol.24
, pp. 2602-2612
-
-
Ohnmacht, S.A.1
Neidle, S.2
-
266
-
-
84890821948
-
Discovery of new G-quadruplex binding chemotypes
-
Ohnmacht, S. A.; Varavipour, E.; Nanjunda, R.; Pazitna, I.; Di Vita, G.; Gunaratnam, M.; Kumar, A.; Ismail, M. A.; Boykin, D. W.; Wilson, W. D.; Neidle, S. Discovery of new G-quadruplex binding chemotypes Chem. Commun. 2014, 50, 960-963 10.1039/C3CC48616H
-
(2014)
Chem. Commun.
, vol.50
, pp. 960-963
-
-
Ohnmacht, S.A.1
Varavipour, E.2
Nanjunda, R.3
Pazitna, I.4
Di Vita, G.5
Gunaratnam, M.6
Kumar, A.7
Ismail, M.A.8
Boykin, D.W.9
Wilson, W.D.10
Neidle, S.11
-
267
-
-
80052478355
-
An acyclic oligoheteroaryle that discriminates strongly between diverse G-quadruplex topologies
-
Hamon, F.; Largy, E.; Guédin-Beaurepaire, A.; Rouchon-Dagois, M.; Sidibe, A.; Monchaud, D.; Mergny, J.-L.; Riou, J.-F.; Nguyen, C.-H.; Teulade-Fichou, M.-P. An acyclic oligoheteroaryle that discriminates strongly between diverse G-quadruplex topologies Angew. Chem., Int. Ed. 2011, 50, 8745-8749 10.1002/anie.201103422
-
(2011)
Angew. Chem., Int. Ed.
, vol.50
, pp. 8745-8749
-
-
Hamon, F.1
Largy, E.2
Guédin-Beaurepaire, A.3
Rouchon-Dagois, M.4
Sidibe, A.5
Monchaud, D.6
Mergny, J.-L.7
Riou, J.-F.8
Nguyen, C.-H.9
Teulade-Fichou, M.-P.10
-
268
-
-
84870891163
-
Beads-on-a-string structure of long telomeric DNAs under molecular crowding conditions
-
Yu, H.; Gu, X.; Nakano, S. I.; Miyoshi, D.; Sugimoto, N. Beads-on-a-string structure of long telomeric DNAs under molecular crowding conditions J. Am. Chem. Soc. 2012, 134, 20060-20069 10.1021/ja305384c
-
(2012)
J. Am. Chem. Soc.
, vol.134
, pp. 20060-20069
-
-
Yu, H.1
Gu, X.2
Nakano, S.I.3
Miyoshi, D.4
Sugimoto, N.5
-
269
-
-
84910051731
-
Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences
-
Cousins, A. R.; Ritson, D.; Sharma, P.; Stevens, M. F.; Moses, J. E.; Searle, M. S. Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences Chem. Commun. 2014, 50, 15202-15205 10.1039/C4CC07487D
-
(2014)
Chem. Commun.
, vol.50
, pp. 15202-15205
-
-
Cousins, A.R.1
Ritson, D.2
Sharma, P.3
Stevens, M.F.4
Moses, J.E.5
Searle, M.S.6
-
270
-
-
84925362357
-
Topology specific stabilization of promoter over telomeric G-quadruplex DNAs by bisbenzimidazole carboxamide derivatives
-
Dhamodharan, V.; Harikrishna, S.; Bhasikuttan, A. C.; Pradeepkumar, P. I. Topology specific stabilization of promoter over telomeric G-quadruplex DNAs by bisbenzimidazole carboxamide derivatives ACS Chem. Biol. 2015, 10, 821-833 10.1021/cb5008597
-
(2015)
ACS Chem. Biol.
, vol.10
, pp. 821-833
-
-
Dhamodharan, V.1
Harikrishna, S.2
Bhasikuttan, A.C.3
Pradeepkumar, P.I.4
-
271
-
-
84954470546
-
Small Molecule microarrays enable the identification of a selective, quadruplex-binding inhibitor of MYC expression
-
Felsenstein, K. M.; Saunders, L. B.; Simmons, J. K.; Leon, E.; Calabrese, D. R.; Zhang, S.; Michalowski, A.; Gareiss, P.; Mock, B. A.; Schneekloth, J. S., Jr. Small Molecule microarrays enable the identification of a selective, quadruplex-binding inhibitor of MYC expression ACS Chem. Biol. 2016, 11, 139-148 10.1021/acschembio.5b00577
-
(2016)
ACS Chem. Biol.
, vol.11
, pp. 139-148
-
-
Felsenstein, K.M.1
Saunders, L.B.2
Simmons, J.K.3
Leon, E.4
Calabrese, D.R.5
Zhang, S.6
Michalowski, A.7
Gareiss, P.8
Mock, B.A.9
Schneekloth, Jr.J.S.10
-
272
-
-
84876545072
-
G4LDB: A database for discovering and studying G-quadruplex ligands
-
Li, Q.; Xiang, J. F.; Yang, Q. F.; Sun, H. X.; Guan, A. J.; Tang, Y. L. G4LDB: a database for discovering and studying G-quadruplex ligands Nucleic Acids Res. 2013, 41, D1115-23 10.1093/nar/gks1101
-
(2013)
Nucleic Acids Res.
, vol.41
, pp. D1115-D1123
-
-
Li, Q.1
Xiang, J.F.2
Yang, Q.F.3
Sun, H.X.4
Guan, A.J.5
Tang, Y.L.6
-
273
-
-
84865091468
-
In silico screening of quadruplex-binding ligands
-
Ma, D. L.; Ma, V. P.; Chan, D. S.; Leung, K. H.; Zhong, H. J.; Leung, C. H. In silico screening of quadruplex-binding ligands Methods 2012, 57, 106-114 10.1016/j.ymeth.2012.02.001
-
(2012)
Methods
, vol.57
, pp. 106-114
-
-
Ma, D.L.1
Ma, V.P.2
Chan, D.S.3
Leung, K.H.4
Zhong, H.J.5
Leung, C.H.6
-
274
-
-
70450158916
-
Tandem application of virtual screening and NMR experiments in the discovery of brand new DNA quadruplex groove binders
-
Cosconati, S.; Marinelli, L.; Trotta, R.; Virno, A.; Mayol, L.; Novellino, E.; Olson, A. J.; Randazzo, A. Tandem application of virtual screening and NMR experiments in the discovery of brand new DNA quadruplex groove binders J. Am. Chem. Soc. 2009, 131, 16336-16337 10.1021/ja9063662
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 16336-16337
-
-
Cosconati, S.1
Marinelli, L.2
Trotta, R.3
Virno, A.4
Mayol, L.5
Novellino, E.6
Olson, A.J.7
Randazzo, A.8
-
275
-
-
77952017562
-
Structural and conformational requisites in DNA quadruplex groove binding: Another piece to the puzzle
-
Cosconati, S.; Marinelli, L.; Trotta, R.; Virno, A.; De Tito, S.; Romagnoli, R.; Pagano, B.; Limongelli, V.; Giancola, C.; Baraldi, P. G.; Mayol, L.; Novellino, E.; Randazzo, A. Structural and conformational requisites in DNA quadruplex groove binding: another piece to the puzzle J. Am. Chem. Soc. 2010, 132, 6425-6433 10.1021/ja1003872
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 6425-6433
-
-
Cosconati, S.1
Marinelli, L.2
Trotta, R.3
Virno, A.4
De Tito, S.5
Romagnoli, R.6
Pagano, B.7
Limongelli, V.8
Giancola, C.9
Baraldi, P.G.10
Mayol, L.11
Novellino, E.12
Randazzo, A.13
-
276
-
-
84873894447
-
Identification and characterization of new DNA G-quadruplex binders selected by a combination of ligand and structure-based virtual screening approaches
-
Alcaro, S.; Musetti, C.; Distinto, S.; Casatti, M.; Zagotto, G.; Artese, A.; Parrotta, L.; Moraca, F.; Costa, G.; Ortuso, F.; Maccioni, E.; Sissi, C. Identification and characterization of new DNA G-quadruplex binders selected by a combination of ligand and structure-based virtual screening approaches J. Med. Chem. 2013, 56, 843-855 10.1021/jm3013486
-
(2013)
J. Med. Chem.
, vol.56
, pp. 843-855
-
-
Alcaro, S.1
Musetti, C.2
Distinto, S.3
Casatti, M.4
Zagotto, G.5
Artese, A.6
Parrotta, L.7
Moraca, F.8
Costa, G.9
Ortuso, F.10
Maccioni, E.11
Sissi, C.12
-
277
-
-
84890516811
-
Exploring the chemical space of G-quadruplex binders: Discovery of a novel chemotype targeting the human telomeric sequence
-
Di Leva, F. S.; Zizza, P.; Cingolani, C.; D'Angelo, C.; Pagano, B.; Amato, J.; Salvati, E.; Sissi, C.; Pinato, O.; Marinelli, L.; Cavalli, A.; Cosconati, S.; Novellino, E.; Randazzo, A.; Biroccio, A. Exploring the chemical space of G-quadruplex binders: discovery of a novel chemotype targeting the human telomeric sequence J. Med. Chem. 2013, 56, 9646-9654 10.1021/jm401185b
-
(2013)
J. Med. Chem.
, vol.56
, pp. 9646-9654
-
-
Di Leva, F.S.1
Zizza, P.2
Cingolani, C.3
D'Angelo, C.4
Pagano, B.5
Amato, J.6
Salvati, E.7
Sissi, C.8
Pinato, O.9
Marinelli, L.10
Cavalli, A.11
Cosconati, S.12
Novellino, E.13
Randazzo, A.14
Biroccio, A.15
-
278
-
-
84884921116
-
Small-molecule G-quadruplex interactions: Systematic exploration of conformational space using multiple molecular dynamics
-
Husby, J.; Todd, A. K.; Platts, J. A.; Neidle, S. Small-molecule G-quadruplex interactions: Systematic exploration of conformational space using multiple molecular dynamics Biopolymers 2013, 99, 989-1005 10.1002/bip.22340
-
(2013)
Biopolymers
, vol.99
, pp. 989-1005
-
-
Husby, J.1
Todd, A.K.2
Platts, J.A.3
Neidle, S.4
-
279
-
-
84893204918
-
Conformation and stability of intramolecular telomeric G-quadruplexes: Sequence effects in the loops
-
Sattin, G.; Artese, A.; Nadai, M.; Costa, G.; Parrotta, L.; Alcaro, S.; Palumbo, M.; Richter, S. N. Conformation and stability of intramolecular telomeric G-quadruplexes: sequence effects in the loops PLoS One 2013, 8, e84113 10.1371/journal.pone.0084113
-
(2013)
PLoS One
, vol.8
, pp. e84113
-
-
Sattin, G.1
Artese, A.2
Nadai, M.3
Costa, G.4
Parrotta, L.5
Alcaro, S.6
Palumbo, M.7
Richter, S.N.8
-
280
-
-
84925467397
-
In silico identification of novel ligands for G-quadruplex in the c-MYC promoter
-
Kang, H.-J.; Park, H.-J. In silico identification of novel ligands for G-quadruplex in the c-MYC promoter J. Comput.-Aided Mol. Des. 2015, 29, 339-348 10.1007/s10822-014-9826-z
-
(2015)
J. Comput.-Aided Mol. Des.
, vol.29
, pp. 339-348
-
-
Kang, H.-J.1
Park, H.-J.2
-
281
-
-
84915819840
-
Identification of a selective G-quadruplex DNA binder using a multistep virtual screening approach
-
Hou, J.-Q.; Chen, S.- B.; Zan, L.-P.; Ou, T.-M.; Tan, J. H.; Luyt, L. G.; Huang, Z.-S. Identification of a selective G-quadruplex DNA binder using a multistep virtual screening approach Chem. Commun. 2015, 51, 198-201 10.1039/C4CC06951J
-
(2015)
Chem. Commun.
, vol.51
, pp. 198-201
-
-
Hou, J.-Q.1
Chen, S.-B.2
Zan, L.-P.3
Ou, T.-M.4
Tan, J.H.5
Luyt, L.G.6
Huang, Z.-S.7
-
282
-
-
84892846530
-
Targeting a c-MYC G-quadruplex DNA with a fragment library
-
Nasiri, H. R.; Bell, N. M.; McLuckie, K. I.; Husby, J.; Abell, C.; Neidle, S.; Balasubramanian, S. Targeting a c-MYC G-quadruplex DNA with a fragment library Chem. Commun. 2014, 50, 1704-1707 10.1039/c3cc48390h
-
(2014)
Chem. Commun.
, vol.50
, pp. 1704-1707
-
-
Nasiri, H.R.1
Bell, N.M.2
McLuckie, K.I.3
Husby, J.4
Abell, C.5
Neidle, S.6
Balasubramanian, S.7
-
283
-
-
77953381213
-
Structural insights into G-quadruplexes: Towards new anticancer drugs
-
Yang, D.; Okamoto, K. Structural insights into G-quadruplexes: towards new anticancer drugs Future Med. Chem. 2010, 2, 619-646 10.4155/fmc.09.172
-
(2010)
Future Med. Chem.
, vol.2
, pp. 619-646
-
-
Yang, D.1
Okamoto, K.2
-
284
-
-
84957548658
-
Structural insights into the quadruplex-duplex 3′ interface formed from a telomeric repeat: A potential molecular target
-
Russo Krauss, I.; Ramaswamy, S.; Neidle, S.; Haider, S.; Parkinson, G. N. Structural insights into the quadruplex-duplex 3′ interface formed from a telomeric repeat: a potential molecular target J. Am. Chem. Soc. 2016, 138, 1226-1233 10.1021/jacs.5b10492
-
(2016)
J. Am. Chem. Soc.
, vol.138
, pp. 1226-1233
-
-
Russo Krauss, I.1
Ramaswamy, S.2
Neidle, S.3
Haider, S.4
Parkinson, G.N.5
-
285
-
-
84922336877
-
Unravelling the genomic targets of small molecules using high-throughput sequencing
-
Rodriguez, R.; Miller, K. M. Unravelling the genomic targets of small molecules using high-throughput sequencing Nat. Rev. Genet. 2014, 15, 783-796 10.1038/nrg3796
-
(2014)
Nat. Rev. Genet.
, vol.15
, pp. 783-796
-
-
Rodriguez, R.1
Miller, K.M.2
-
286
-
-
84908099048
-
Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities
-
Rizzo, A.; Iachettini, S.; Zizza, P.; Cingolani, C.; Porru, M.; Artuso, S.; Stevens, M.; Hummersone, M.; Biroccio, A.; Salvati, E.; Leonetti, C. Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities J. Exp. Clin. Cancer Res. 2014, 33, 81 10.1186/s13046-014-0081-x
-
(2014)
J. Exp. Clin. Cancer Res.
, vol.33
, pp. 81
-
-
Rizzo, A.1
Iachettini, S.2
Zizza, P.3
Cingolani, C.4
Porru, M.5
Artuso, S.6
Stevens, M.7
Hummersone, M.8
Biroccio, A.9
Salvati, E.10
Leonetti, C.11
-
287
-
-
84958168950
-
Targeting G-quadruplex DNA structures by EMICORON has a strong antitumor efficacy against advanced models of human colon cancer
-
Porru, M.; Artuso, S.; Salvati, E.; Bianco, A.; Franceschin, M.; Diodoro, M. G.; Passeri, D.; Orlandi, A.; Savorani, F.; D'Incalci, M.; Biroccio, A.; Leonetti, C. Targeting G-quadruplex DNA structures by EMICORON has a strong antitumor efficacy against advanced models of human colon cancer Mol. Cancer Ther. 2015, 14, 2541-2551 10.1158/1535-7163.MCT-15-0253
-
(2015)
Mol. Cancer Ther.
, vol.14
, pp. 2541-2551
-
-
Porru, M.1
Artuso, S.2
Salvati, E.3
Bianco, A.4
Franceschin, M.5
Diodoro, M.G.6
Passeri, D.7
Orlandi, A.8
Savorani, F.9
D'Incalci, M.10
Biroccio, A.11
Leonetti, C.12
-
288
-
-
0037025173
-
Cancer. Addiction to oncogenes - The Achilles heal of cancer
-
Weinstein, I. B. Cancer. Addiction to oncogenes - the Achilles heal of cancer Science 2002, 297, 63-64 10.1126/science.1073096
-
(2002)
Science
, vol.297
, pp. 63-64
-
-
Weinstein, I.B.1
-
289
-
-
84924061466
-
Oncogene addiction: Pathways of therapeutic response, resistance, and road maps toward a cure
-
Pagliarini, R.; Shao, W.; Sellers, W. R. Oncogene addiction: pathways of therapeutic response, resistance, and road maps toward a cure EMBO Rep. 2015, 16, 280-296 10.15252/embr.201439949
-
(2015)
EMBO Rep.
, vol.16
, pp. 280-296
-
-
Pagliarini, R.1
Shao, W.2
Sellers, W.R.3
|